• Title/Summary/Keyword: Herbal Formula Science

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Comparison of skin damage recovery between natural and cultivated Angelicae Gigantis Radix (자연산 당귀와 재배 당귀의 피부 손상 회복 효능 비교)

  • Sun-Young Hwang;Mee-Hyun Lee;Kwanhwan Wi;Do-Hyun Kim;Soong-in Lee;Jong-Gil Jeong
    • The Korea Journal of Herbology
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    • v.38 no.5
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    • pp.1-7
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    • 2023
  • Purpose : To compare the skin damage recovery efficacy of natural Angelicae Gigantis Radix extract (N-AGR) and cultivated A. Gigantis Radix extract (C-AGR). Through this, we confirmed whether the quality standards of herbal medicines recorded in the classic books make a difference in the experimental efficacy using epithelial cells. Methods : The quality standards of medicinal herbs in the classic books and the cultivation and processing conditions of two types of A. gigas were compared. After inducing oxidative stress with H2O2, cytoprotective property of N-AGR and C-AGR were evaluated through cell viability. Additionally, after wound formation of epithelial JB6 cells, N-AGR and C-AGR were treated to evaluate wound healing efficacy. Result : The natural A, gigas met the excellent quality standards of the classic books. N-AGR inhibited cell death by oxidative stress induced by H2O2, and was superior to C-AGR. Both N-AGR and C-AGR showed dose-dependent wound healing efficacy, but N-AGR was significantly superior to C-AGR. Conclusions : Through the oxidative stress of skin and skin wound healing efficacy experiments using epithelial cells, natural A. gigas showed superior efficacy compared to cultivated A. gigas.

A Study on the Interrelation Establishment of Herbal Formulas that Clear Heat (청열방제간(淸熱方劑間)의 연관성(聯關性) 확립(確立)에 대(對)한 문헌적(文獻的) 연구(硏究))

  • Yoo, Jea Hyun;Jegal, Kyung Hwan;Yoon, Ji Seok;Roh, Jong Seong;Byun, Sung Hui;Kim, Sang Chan
    • Herbal Formula Science
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    • v.29 no.4
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    • pp.297-310
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    • 2021
  • Objectives : In traditional herbal medicine, as clinical experience increased, the number of herbal formulas also increased. For example, there are 61,739 herbal formulas in Pujifang, and 96,592 in Dictionary of Traditional Chinese Medicine Prescriptions. In chapter of Clear Heat (CH; 淸熱劑) of textbook, the 38 formulas were presented. For enhancing understanding of herbal formula, a large majority of books explained each individual formula with description or figure about interactions between constituent herbs. But there is no study on the interrelationship of each CH herbal formulas. This study investigated the interrelationship of CH herbal formulas. Methods : The CH herbal formula were analyzed with the ingredients, actions and clinical applications by literature study. Results : To improve cognition the interrelationship of CH herbal formulas, we analyzed the formulas and established the 16 interrelations of herbal formulas. Conclusions : Finally, this study established the interrelation of herbal formula as one figure. This result could contribute to improve cognition on the interrelationship of CH herbal formulas.

Cytoprotective Effects of Artemisia princeps Extract through Inhibition of Mitochondrial Dysfunction (애엽(艾葉)의 미토콘드리아 보호 효과)

  • Choi, Hee Yoon;Jeggal, Kyung Hwan;Kim, Young Woo;Lee, Jung Woo;Jo, Soo A;Cho, Il Je;Kim, Sang Chan
    • Herbal Formula Science
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    • v.21 no.2
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    • pp.63-71
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    • 2013
  • Objectives : Artemisia princeps is used as moxa in moxibustion and traditional herbal medicine. And its extracts or compounds is known to have an efficacy of antioxidant, anti-diabete, anti-cancer, anti-inflammation and neuroprotection. This study was performed to investigate the cytoprotective effect of Artemisia princeps extract (APE) against arachidonic acid (AA)+iron-induced oxidative stress on HepG2 cell. Methods : The effects of APE on cell viability has been assessed using MTT assay. And flow cytometric analysis was performed to estimate APE's effects on mitochondrial function. To investigate its underlying mechanism, related protein was analysed by using immunoblot analysis. Results : Treatment of APE increased relative cell viability, prevented a decline of B-cell lymphoma-extra large (Bcl-xL) and cleavage of poly(ADP-ribose) polymerase (PARP) and procaspase-3, and also protected mitochondrial membrane permeability (MMP) against oxidative stress induced by AA+iron. In addition, APE treatment increased phosphorylation of AMP-activated protein kinase (AMPK) exerts a cytoprotective effect. Conclusions : This results demonstrate that APE has an ability to activation of AMPK which protects cells from AA+iron-induced oxidative stress and restores MMP.