• Proceedings of the PSK Conference
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• 2003.04a
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• pp.172.2-173
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• 2003

Naringenin, a phytoalexin found in grapefruit. has been reported to exhibit a wide range of pharmacological properties. The aim of the present study is to evaluate the protective effect of naringenin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Fibrosis was induced by intraperitoneal injection of DMN. Naringenin was given orally at 20 mg/kg and 50 mg/kg daily for 4 weeks. (omitted)

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.11a
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• pp.149-149
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• 2004

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2003.10a
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• pp.17-17
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• 2003

Accumulation of cholesterol may occur due to liver injury like hepatic steatosis and fibrosis as well as athrosclerosis and coronary heart disease. The aim of this study was search for protective effect of active ceramic water on experimental hepatic injury induced by high cholesterol diet(containing 1.0 ％ cholesterol and 0.3 ％ sodium cholate) in rats. (omitted)

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.41-41
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• 2003

To evaluate whether mangafodipir trisodium (Mn-DPDP)-enhanced magnetic resonance (MR) imagingimproves the detection and characterization of small (2 cm) hepatic lesions in patients with colorectal carcinoma, compared with spiral CT.

• Toxicological Research
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• v.13 no.4
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• pp.327-330
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• 1997

Hepatitis, liver cirrhosis and liver cancer caused by viral infection are among the most prevalent causes of death in Korea. Several medicines have been in use despite their nonsatisfactory effects on these disease. Some herbal medicines put to use recently have not shown beneficial effects, either. This paper evaluates the effects of extracts from 10 traditional Korean herbal medicines on rats with hepatic damage induced by galactosamine. Rubus coreanus showed an anti-inflammatory effect as shown on the data of activities of serum transaminases.

• Korean Journal of Veterinary Research
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• v.14 no.1
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• pp.45-48
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• 1974

Four water monitors at Zoological Garden, Chang Gyeong Won, Seoul, died within a week after signs of anorexia, lethargy, and discharge from eyes, nasal and oral cavities. The autopsy findings of the four animals were similar. As a main lesion, the liver was congested and diffuse necrosis was observed. The terminal portions of the rectum were studded with numerous small ulcers causing rectal stenosis. Histopathologically, massive hepatic necrosis preceded by fatty changes were evident. The rectal lesions manifested coagulative necrosis and thrombosis in the mucosa and submucosa.

• YAKHAK HOEJI
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• v.30 no.2
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• pp.68-72
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• 1986

Effect of sodium taurodeoxycholate (TDC) on the pharmacokinetics of methylene blue (MB) was investigated in the rats of experimental hepatic failure induced by $CCI_4$. Intravenous infusion of TDC increased the distribution volume of central compartment ($Vd_1$) and the total body clearance ($CL_t$) of MB. Increased lipophilicity through ion-pair formation with TDC seemed to be the probable cause of increased $Vd_1$ and $CL_t$.

• Proceedings of the Ginseng society Conference
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• 1980.09a
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• pp.131-135
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• 1980

The influence of Panax ginseng on alcohol-induced hyperuricemia were observed. Changes of uric acid blood levels and hepatic xanthine oxidase activities were studied by means of treating alcohol intoxication with ginseng. It was found that a single dose (4 mg/Kg) of ginseng saponin administered intraperitoneally significantly inhibits the hepatic xanthine oxidase activities and decrease urate blood levels in ethanol-induced hyperuricemic mice. It was also observed that there were some difference in pharmacological aspect between Panax ginseng and allopurinol which is a potent inhibitor of xanthine oxidase from any sources.

• Toxicological Research
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• v.5 no.1
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• pp.17-25
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• 1989

Chronic adminstraction of morphine to adult male rats has long been known to lower hepatic cytochrome p-450 content and its dependent mixed-function oxidase activity. Following the treatment of adult male rats with morphine, pethidine pentazocine and codeine and also by concomitant adminstration of naloxone activities of microsomal electron transfer in the adult male rats were examined. In present study, the acute treatment of mature male rats with a dose of narcotic drugs higher than that used chronically also reduces their hepatic cytochrome p-450.

• Toxicological Research
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• v.5 no.1
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• pp.27-35
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• 1989

When acetaminophen (25mM) was introduced into the perfused rat liver, the hepatic O2 uptake was rapidly inhibited first and then later slow-down. The rapid inhibition was found to be due to mitochondrial blockade, whereas the so-called slow inhibition" was associated with microcirulatory aberrations as evidenced by inhomogneous staining of the liver tissue by trypan blue infusion (0.1%). NaCN (0.5mM) also caused rapid and slow respiratory inhibitions, giving heterogeneous trypan blue staining.ning.