Effect of Sodium Taurodeoxycholate on the Disposition and Elimination of Methylene Blue in the Rats of Experimental Hepatic Failure

Sodium Taurodeoxycholate가 간장해 Rat에서 메틸렌 블루의 체내분포와 소실에 미치는 영향

Effect of sodium taurodeoxycholate (TDC) on the pharmacokinetics of methylene blue (MB) was investigated in the rats of experimental hepatic failure induced by $CCI_4$. Intravenous infusion of TDC increased the distribution volume of central compartment ($Vd_1$) and the total body clearance ($CL_t$) of MB. Increased lipophilicity through ion-pair formation with TDC seemed to be the probable cause of increased $Vd_1$ and $CL_t$.