• Korean Journal of Veterinary Research
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• v.39 no.5
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• pp.986-994
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• 1999

This study was carried out (a) to investigate the variations of blood chemistry and (b) to examine the secretion trend of endocrine substances in a dog model after electroacupuncture and laser stimulation at different time period(9 to 11a.m. and 6 to 8p.m.). Two acupuncture points ; Da Zhui(GV-14) and Shen Shu(BL-23) were electroacupunctured for 20 minutes with 2Vol, 20Hz and irradiated for 5 minutes with 8,000Hz. Before stimulation and after a lapse of time(10-minutes, 30-minutes and 60-minutes) all dogs were checked the following parameters ; cortisol, ACTH, RBC, hemoglobin, hematocrit, WBC, Ca, P, SGPT, SGOT and creatinine. The results were as follow : The levels of cortisol and ACTH have been increased 10 minutes after the stimulation of the electroacupuncture and laser. The higher levels of cortisol and ACTH have been decreased to keep the normal levels from 30 minutes after the stimulation of the electroacupuncture and laser. The RBC, hemoglobin, hematocrit and WBC showed the physiological phenomena in the electroacupuncture and laser stimulation. In sero chemical analysis, calcium, phosphate, SGOT, SGPT and creatinine levels were within normal physiological ranges.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.29 no.6
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• pp.828-836
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• 1996

The histological changes of gill, liver, spleen and muscle, and respiration and blood variables and liver glycogen content were examined in black seabream, Acanthopagrus schlegeli. Fish were exposed to a high level of total ammonia nitrogen (10.4 mg/l) and recovered from exposure $(0.4{\pm}0.2mg/l)$ in a closed recirculating seawater system. In the process of exposure, mortality was $9\%$, and hyperplasia, necrosis or inflammation appeared in all tissues except for muscle. Oxygen consumption was decreased by $49\%$, and red blood cell (RBC) number, hematocrit and hemoglobin concentration were significantly decreased, while plasma glucose contents, activities of glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) increased. Liver glycogen content significantly increased from $6.6\%\;to\;10.4\%$. A large amount of hemosiderin was observed in the splenic tissue. During the recovery period, RBC number, hematocrit, hemoglobin concentration, GOT and GPT activities were returned to the normal status. Histological status of liver tissue was returned to the normal, but liver glycogen content was not recovered. During the recovery period, spleen melanin-macrophages temporarily increased, but subsequently decreased to the normal status.

• Proceedings of the Ginseng society Conference
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• 1978.09a
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• pp.79-84
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• 1978

Ginseng has been widely used in the Oriental world for more than 2,000 years. Its chemical and pharmacological studies have been published by many investigators of many countries. But its clinical studies have not been performed in satsifactory amount. This study was carried out to evaluate the effect of ginsenoside-triol on the postoperative recovery in 120 cases of gynecological laparotomies. Daily dose of 0.23 gram of ginsenoside-triol was administered orally for three weeks after surgery to 60 cases, and placebo to 60 cases as control. Hemoglobin, hematocrit, leukocyte count, serum total protein, albumin, cholesterol and glucose were studied at pre- and postadministration. At the same time, body weight, blood pressure and subjective symptoms such as appetite, bowel movement and digestion were checked. The results obtained were summarized as follows: 1) The side effect was nil. 2) Hemoglobin and hematocrit Were more increased in treated group than in control group, but the changes were not significant. 3) Serum total protein was more significantly increased in treated group than in control group. 4) Serum cholesterol was significantly less increased in treated group than in control group. 5) Serum glucose level was significantly decreased in both groups, more significantly in control group. 6) Body weight was significantly increased in treated group.

• Korean Journal of Veterinary Research
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• v.35 no.3
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• pp.595-601
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• 1995

Hemodynamic values were assessed in the cows diseased with mastitis. Hemodynamic testes were performed for white blood cell(WBC), red blood cell(RBC), packed cell volume(PCV), hemoglobin concentration, monocyte, eosinophil, neutrophil, lymphocyte, prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, platelet concentrations, antithrombin-III and plasminogen activities. Significant alterations were observed in the mean values of most analytes. The numbers of monocytes, eosinophil, and neutrophil, and prothrombin time were increased while the number of lymphocyte, activated partial thromboplastin time, thrombin time, fibrinogen concentration, plasminogen activity and platelet concentration were decreased. The number of RBC, PCV, hemoglobin and antithrombin-III activity were unchanged compared with normal mean values. These data indicated that activation of hemodynamic mechanisms was initiated either directly by the endotoxin-releasing or indirectly by the inflammatory mediators released by response to etiologic agents. We suspected that the changes of hemodynamic values in the cows diseased with mastitis were very similar to those of experimental endotoxin-induced mastitis.

• The Journal of Advanced Prosthodontics
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• v.11 no.5
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• pp.247-252
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• 2019

PURPOSE. To evaluate the effect of periodontal and prosthodontic therapy on glycated hemoglobin A(HbA1c) level in patients with diabetes. MATERIALS AND METHODS. This is a retrospective study of 70 patients suffering from diabetes who visited the Kyungpook National University Hospital between January 2016 and May 2018. Patients underwent medical evaluation for their routine check-up, which includes laboratory test for HbA1c levels. Among the 70 patients, 35 patients also visited Kyungpook National University Dental Hospital during the same period to receive periodontal and prosthodontic therapy, while the other 35 patients did not receive such therapy. The HbA1c levels were compared before and after periodontal and prosthodontic therapy. Comparisons between groups and within groups were performed using independent t-test. RESULTS. The HbA1c levels in the group who have received periodontal and prosthodontic therapy decreased from 7.2 to 6.7 (P=.001). The HbA1c levels in the control group decreased from 7.2 to 7.1 (P=.580). The difference in changes between the two patient groups was statistically significant (P=.011). CONCLUSION. Periodontal and prosthodontic therapy can be effective on glycemic control in patients with diabetes.

• Journal of Chest Surgery
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• v.23 no.5
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• pp.864-870
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• 1990

This study was undertaken to evaluate current technique of extracorporeal circulation by analyzing the results in 73 cases. We performed standard cardiopulmonary bypass using Polystan roller pump, bubble[Polystan] and membrane[Cobe] oxygenator. There were 42 males and 31 females. We studied the changes of hemoglobin. hemodynamics, speed of cooling and warming, methods of cannulation and ACT. Arterial cannula was inserted on ascending aorta except for 7 cases of femoral cannulation. Preoperative hemoglobin was 13.2 gm% and this value dropped to 7.5 gm% during perfusion. Blood pressure of 113 mmHg in systolic dropped 57mmHg in 10 minutes of perfusion and became 98 mmHg at the end of perfusion. Initial drop of blood pressure was marked in pediatric patient. Mean cooling time was 19.4 min[0.54 Q /min] and warming time was 34 minutes[0.25 Q /min]. During perfusion, ACT was maintained above 600 sec and 44 patient did not need additional Heparin.

• Tuberculosis and Respiratory Diseases
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• v.66 no.2
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• pp.104-109
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• 2009

Background: Anemia is quite common in lung cancer patients and known to decrease the quality of life. Darbepoetin alfa is an erythropoiesis-stimulating protein approved for administration to cancer patients. This study examined the efficacy and safety of darbepoetin alfa in lung cancer patients with a hemoglobin concentration <10 g/dl during chemotherapy. Methods: Lung cancer patients (n=178) received darbepoetin alfa at doses of 1.91 ${\mu}g/kg$ per week until the hemoglobin concentration increased to >10 g/dl. The efficacy and safety were measured by comparing the hemoglobin concentration and assessing the adverse events. Results: After chemotherapy, the hemoglobin concentration decreased to 9.03${\pm}$0.64 g/dl. With the darbepoetin alfa treatment, the hemoglobin concentration increased to 10.09${\pm}$1.17 g/dl after 4 weeks reaching a peak hemoglobin concentration of 10.45${\pm}$1.18 g/dl. The changes in hemoglobin after 4 and 8 weeks with treatment were 1.08${\pm}$1.24 g/dl and 1.38${\pm}$1.59 g/dl (p<0.01). At least a 1 g/dl or more increase in hemoglobin was observed in 62.4% of patients. There were no serious adverse effects except for some mild reactions. Conclusion: Darbepoetin alfa administered to lung cancer patients appears to be an effective, well-tolerated treatment for chemotherapy induced anemia.

• Journal of the Korean Dietetic Association
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• v.18 no.1
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• pp.16-29
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• 2012

The purpose of this study was to investigate the changes in nutritional status of gastrectomy patients. The anthropometric and biochemical data were measured at pre-operation, at discharge, 1 month after discharge, and 3 months after discharge. Nutrient intake levels, nutrients adequacy ratio (NAR), mean adequacy ratio (MAR), and the proportion of patients with intake levels inferior to those of dietary reference intakes (DRIs) were analyzed at discharge, 1 month after discharge, and 3 months after discharge. Finally, the data on 23 patients (15 male and 8 female) were collected and used for statistical analysis. Fifteen patients underwent subtotal gastrectomy, and 8 patients underwent total gastrectomy. Compared to pre-operation, body weight and body mass index of subjects significantly decreased at discharge, 1 month after discharge, and 3 months after discharge (P<0.001). Serum albumin (P<0.001), total lympocyte count (P<0.001), total cholesterol (P<0.001), hemoglobin (P<0.001), hematocrit (P<0.001), and mean corpuscular hemoglobin concentration (P<0.05) were significantly different between pre-operation, at discharge, 1 month after discharge, and 3 months after discharge. The proportions of patients with lower nutrient intake levels than DRIs were substantial. MAR at discharge, 1 month after discharge, and 3 months after discharge were 0.70, 0.80 and 0.91, respectively. Especially, the NARs of folate, niacin, vitamin $B_2$, vitamin C, and zinc were all low. Considering the various nutritional problems of gastrectomy patients, systematic medical nutrition therapy is needed after gastrectomy.

• Journal of Chest Surgery
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• v.10 no.2
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• pp.299-314
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• 1977

Clinical experience on 16 cases of open heart surgery under the extracorporeal circulation with mild or moderate hypothermia and partial hemodilution technique at the National Medical Center during the period from June 1976 to October 1977. Nine of sixteen were congenital heart disease and seven were acquired heart disease. The age of the patient ranged between 6 and 48 years. The body weight varied from 18.5kg to 60kg and body surface area 0. 79-1.70m2. The average priming volume of pump oxygenator was 2080 ml, which was consisted fresh ACD blood, buffered Hartmann`s solution, Mannitol, 50% dextrose in water and Vit. C. The average hemodilution rate was 27%. The average flow 2.3 L/min/m2 or 80 ml/min and the duration of perfusion varied from 31 min to 270 min with average of 107 min. The perfusion was carried out under the mild or moderate hypothermia using core cooling alone in 10 cases, core cooling and local myocardial cooling with $0-4^{\circ}C$ physiologic saline in 2 cases. From a hemodynamic point of view, the blood pressure dropped down around 80 mmHg after the initiation of perfusion follwed by increase to safety level and stable during the perfusion. The central venous pressure remained within normal limits. In most cases, hemoglobin and hematocrit decreased during and after the perfusion. Hemogiobin level was decreased, average of 20.6 %, hematocrit 18.6%, pletelets 55% postoperatively. Plasma hemoglobin increased moderately, from preperfusion average valve of 7.79 mg % to post-perfusion value of 54.7 mg %. Electrolytes changes during cardiopulmonary bypass showed definite hypokalemia but changes of Na, Ca were not definite. Arterial blood gas analysis during cardiopulmonary bypass suggested that the metabolic acidosis which was accompanied by respiratory alkalosis which was corrected postoperatively. As the opera tive complication, transient hemoglobinuria in 4 cases and neurological signs in 2 cases were all cured. There were 2 death cases and operative mortality rate was 12.5%.

• Korean Journal of Ichthyology
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• v.19 no.2
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• pp.93-100
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• 2007

The effects of sudden changes of water temperature (WT) on the physiological response and hematological characteristics of the goldfish (Carassius auratus) were examined by manipulating WT in a flow through freshwater culture system with tanks. The WT was dropped from $15^{\circ}C$ to $10^{\circ}C$ within 1 hour and then returned to the original water temperature within 12 hours and maintained for 12 hours at the normal WT. The WT stress give continued for 3 days. Plasma levels of cortisol, glucose and lactic acid were higher in stress group than that of non-stressed group until 72 hours. However, The $Na^+,\;Cl^-$, osmolality and aspartate aminotransferase (AST) levels showed no significant differences in two groups. This results in stress group showed that goldfish exhibit "typical" physiological responses (in cortisol, glucose, lactic acid, hematocrit, red blood cell and hemoglobin) to the stress induced by WT changes.