• 디지털융복합연구
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• 제18권11호
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• pp.433-441
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• 2020

연구목적은 혈액투석환자의 활동과 건강정도의 관계를 확인하기 위하여, 걷기가 혈액투석 환자의 체성분 및 혈액학적 지수에 미치는 영향을 파악하는 것이다. 연구방법은 혈액투석환자를 대상으로 이루어진 횡단적 서술적 조사연구이다. 연구대상은 B 광역시에서 혈액투석 치료를 받고 있는 66명의 혈액투석환자였다. 연구결과, 혈액투석환자의 걷기는 감소되어 있었고, 걷기에 따른 혈액학적 지수는 차이가 있었으나 체성분은 차이가 없었다. 대상자의 체중이 증가하면 골격량, 체지방량, 체질량지수, 복부지방률, 기초대사량과 단백질이 증가하는 것으로 나타났으나 총콜레스테롤과 고밀도 콜레스테롤은 감소하는 것으로 나타났다. 본 연구는 혈액투석환자의 대상자 수를 확대하여 걷기, 체성분 및 혈액학적 지수 외에 영양섭취를 추가하여 조사해 볼 것을 제언한다.

• 대한수의학회지
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• 제44권4호
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• pp.649-653
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• 2004

To estimate the source of variance components for some hematological parameters and assess the utility of the conventional population-based reference interval, this study computed index of individuality for blood samples, which were from 13 dogs drawn once weekly for 4 consecutive weeks. Results were subjected to nested analysis of variance. For all parameters measured between-dog variations were greater than within-dog variation. Except for the parameters RBC and MCHC the index of individuality was <1.4. The low reliability coefficient and high index of individuality of ${\leq}0.8$ were found for the majority of hematological parameters. In practical term, the present study indicated that use of hemogram profiles alone in the evaluating clinical state of a single patient should be avoided because of their physiological or natural random variations, and that comparing a single measurement on the blood analytes from an individual dog to the conventional population-based reference range may be too insensitive to detect any significant changes in the blood components of that particular dog. A single measurement may not characterize an individual's average concentration of the parameters even shortterm period.

• Journal of Community Nutrition
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• 제8권2호
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• pp.63-68
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• 2006

This research analyzed the hematological index and health related habits such as alcohol drinking, smoking and exercise, by classifying 539 middle-aged men (age: 40 - 59) into a normal weight group, an overweight group and an obese group, according to BMI (body mass index). As a result, 33.6% (n = 181) of subjects had a BMI of 23 or less and 30.2% (n = 163) were overweight and 36.2% (n = 195) were obese (BMI > 25). The average systolic/diastolic blood pressures of total subjects were 130.96mmHg and 80.38mmHg, respectively. And the average pressure of normal subjects was 126.85/77.57mmHg, which was significantly lower than in overweight and obese subjects. Diastolic blood pressure shows significant differences among the three groups. The overall average cholesterol level of normal subjects was 193.81mg/dl, which was significantly lower than those in overweight subjects. Those in obese subjects were significantly higher than in overweight subjects. The GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyrutic transaminase), ${\gamma}$-GTP (gamma-glutamyl transpeptidase) levels of obese subjects were significantly higher than in the overweight subjects. Frequency of alcohol drinking showed no significant difference among the groups. The smoking ratio in the obese group was higher than in the normal and overweight groups. The ratio of smokers was 53.1 %, and the alcohol drinking ratio was 81.0% of the total subjects. The frequency of drinking showed significant correlations with systolic blood pressure (p < 0.05) and diastolic blood pressures (p < 0.01) and ${\gamma}$-GTP (p < 0.01). The duration of smoking showed a negative correlation (p < 0.01) with diastolic blood pressure, total cholesterol and ${\gamma}$-GTP. On the other hand, exercising frequency showed negative correlations with blood glucose, ${\gamma}$-GTP and GPT(p < 0.01). These hematological indices were correlated with health related habits such as alcohol drinking, smoking and lack of exercise, and to be the cause of chronic diseases. Therefore, proper nutritional education is needed to establish advisable health related habits to maintain proper body weight. (J Community Nutrition 8(2): 63-68, 2006)

• 한국임상수의학회지
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• 제38권2호
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• pp.69-74
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• 2021

This study investigated hematological index from clinically healthy Korean Domestic Shorthair (KDSH) cats and characterized breed-specific hematological features. Blood samples from clinically healthy and FIV/FeLV-negative KDSH cats were used in this study (n = 34). After hematological analysis, reference intervals (RIs) of KDSH cats were established and compared with published feline RIs. Most of the RIs were similar to published RIs, however, the RI of MCV tends to be lower than the published RIs and the RIs of Hgb, MCH, MCHC, and CHCM were higher than the published RIs. This study suggests that breed-specific RIs, especially MCV, Hgb, MCH, MCHC, and CHCM, may be required for KDSH cats rather than applying the published RIs.

• 한방안이비인후피부과학회지
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• 제24권3호
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• pp.84-107
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• 2011

Purposes : The purpose of present study is to detect the effects of ointment contained Takrisodok-Eum on the skin barrier's recovery of the Atopic dermatitis. Methods : A total of 44 patients who visited Semyung Oriental Medical Center from April 27th, 2011 to September 20th, 2011 were included in the study. In this study, the patients were treated with Takrisodok-Eum (experimental group) and positive control group. For 8 weeks of gross examination, hematological examination and instrumental asessment were made before and after the study to examine how well the products for experimental group with those for control group in recovering the damaged skin barriers by Atopic dermatitis. Results : 1. In the primary endpoint, SCORAD Index showed a statistically significant decline in experimental group. 2. In the secondary endpoint index of skin hydration, both the experimental group and the control group showed statistical significance. 3. In the secondary endpoint index of TEWL, the experimental group showed greater statistical significance than the control group. 4. In the secondary endpoint index of skin pH, skin pH showed a statistically significant decline in both the control group and the experimental group within the normal range. 5. In the secondary endpoint index of Total IgE, Eosinophil count, IL-10, IL-13, both the experimental group and the control group showed no statistical significance. 6. To evaluate the safety of the products for the human body, hematological examination and hematological biochemical examination, vital sign check were conducted; both control group and experimental group showed no abnormal level. And There were no severe adverse events during this study. Therefore, it is suggested that the safety of the products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that Takrisodok-Eum should be effective for the Atopic dermatitis.

• Fisheries and Aquatic Sciences
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• 제15권3호
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• pp.233-239
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• 2012

Hematological analysis can provide crucial information for monitoring the health of fish. However, there is no current information available regarding hematological changes in olive flounder following infection by Vibrio scophthalmi. In this study, hematological and biochemical alterations were determined in olive flounder infected by the high virulence strain (HVS) and low virulence strain (LVS) of V. scophthalmi. Survival in serum, skin mucus, and macrophages of olive flounder was also compared between the HVS and LVS. The results demonstrated that the hematocrit value in infected fish declined from 23.4% at 0 h to 18.0% at 168 h post infection. The total protein concentration in fish infected with the HVS was significantly higher than in fish infected with the LVS and a non-infected control. Lysozyme activity was significantly different between infected and control fish. The HVS survived in serum and cell numbers increased substantially, while cell numbers of the LVS in serum decreased. These changes in hematological characteristics in fish infected by V. scophthalmi can be used as an effective and sensitive index to monitor the physiological and pathological conditions of fish. The survival and reproduction of V. scophthalmi in host serum, skin mucus, and macrophages play a major role in systemic infection and can serve as a virulence indicator for different strains.

• Fisheries and Aquatic Sciences
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• 제22권5호
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• pp.9.1-9.7
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• 2019

The study investigated the changes in growth performance, hematological parameters, plasma components, and stress indicators of juvenile starry flounder, Platichthys stellatus, depending on varying exposure to hexavalent chromium. P. stellatus was exposed to waterborne chromium at 0, 50, 100, 200, and 400 ppb for 4 weeks. The result showed that Cr exposure resulted in decreased daily length gain (DLG), daily weight gain (DWG), condition factor (CF), and hepatosomatic index (HIS) in P. stellatus. In terms of hematological parameters, red blood cell (RBC) count, hematocrit (Ht), and hemoglobin (Hb) significantly decreased at 400 ppb after 2 weeks. In terms of plasma components, inorganic analysis was unchanged and cholesterol, an organic component, considerably increased at 400 ppb after 4 weeks. Plasma enzyme components including glutamic oxalate transaminase (GOT) and glutamic pyruvate transaminase (GPT) were significantly increased. Stress indicators such as cortisol and glucose were notably increased over 100 ppb after 4 weeks with increasing chromium concentration. The results indicate that exposure to waterborne Cr induced toxic effects on growth, hematological parameters, plasma components, and stress indicators.

• 한국산업보건학회지
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• 제30권3호
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• pp.313-320
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• 2020

Objectives: The aim of this study is to evaluate the association between vibration exposure and skeletal muscle mass index through a single university health check-up. Methods: We used data from 134,067 male subjects who received a general health check-up or vibration exposure health check-up out of the 1,515,322 people who underwent medical check-up at a local university hospital from 2002 to 2018. Pearson correlation analysis was conducted for comparing the association between skeletal muscle mass index and demographic and hematological variables in both groups. Mixed linear model analysis after controlling demographic and hematological variables was used to analyze the differences in skeletal muscle mass index between groups at every visit over 10 years. Results: In the Pearson correlation test, the variables that showed different results when comparing the two groups were C-reactive protein (p=0.001) and glycated hemoglobin (p=0.002) in the vibration exposure group and erythrocyte sedimentation rate (p<0.001) and vitamin D (p<0.001) in the general group. After the adjustment of demographic and hematologic variables, the skeletal muscle mass index at every visit was markedly decreased in the vibration exposure group (p<0.001). Conclusions: In the vibration exposure group, the skeletal muscle mass index showed a tendency to decrease markedly over time compared to the general health check-up group, which showed that C-reactive protein and glycated hemoglobin would have an influence on skeletal muscle index in male workers exposed to vibration.

• 한국산업보건학회지
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• 제32권3호
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• pp.221-230
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• 2022

Objectives: The aim of this study is to evaluate the association between shiftwork and skeletal muscle mass index in a single university health check-up. Methods: We used data from 98,227 workers who answered in a special interview on health check-up at a local university hospital from 2014 to 2020. Pearson correlation analysis was conducted for comparing the association between skeletal muscle mass index and demographic and hematological variables in shiftwork and non-shiftwork groups. Mixed linear model analysis after controlling demographic and hematological variables was used to analyze the difference of skeletal muscle mass index between groups at every visit for seven years. Results: In linear regression analysis, the variables most significantly correlated with skeletal muscle index in both groups were shiftwork(p=0.049), BMI(p<0.001), hypertension(p=0.024), platelet(p<0.001), total protein (p<0.001), AST(p=0.028), ALT(p=0.003), ALP(p<0.001), total cholesterol(p=0.002), triglyceride(p=0.019), BUN (p=0.001), creatinine(p<0.001), and uric acid(p=0.002). After the adjustment for demographic and hematologic variables, the skeletal muscle mass index at every visit was decreased both in the shiftwork group and non-shiftwork group. The slope of the shiftwork group was -0.240 and non-shiftwork group -0.149, showing a significant difference (p<0.001). Conclusions: In the shiftwork group, the skeletal muscle mass index showed a tendency to decrease markedly over time compared to the non-shiftwork group. It is presumed that shift workers' skeletal muscle health was adversely affected by changes in the biological clock due to changes in wake-up and sleep patterns, and changes in food intake.

• 한국수산과학회지
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• 제57권3호
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• pp.227-238
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• 2024

This study aimed to evaluate the effects of polyethylene microplastic (PE-MPs) via measuring the growth performance, hematological parameters, and antioxidant responses in Korean rockfish Sebastes schlegelii exposed to waterborne polyethylene microplastic with dimensions of 22-71 ㎛. S. schlegelii (mean weight, 34.55±5.82 g; mean length, 12.59±0.79 cm) were exposed to PE-MPs at concentrations of 0, 400, 800, 1,600 and 3,200 ㎍/L for 10 and 20 days. PE-MPs significantly affected growth performance, hematological parameters, plasma components, and antioxidant responses in a concentration-dependent manner. At a concentration ≥1,600 ㎍/L, PE-MPs significantly decreased body weight gain and specific growth rate, and significantly increased the hepatosomatic index. Hematological parameters showed a significant decrease in total red blood cell count and hemoglobin levels. Plasma components showed a significant increase in glucose, aspartate aminotransferase, and alanine transaminase levels, whereas total protein, calcium, and magnesium levels significantly decreased. Exposure to ≥1,600 ㎍/L PE-MPs also induced reactive oxygen species generation in the gill and liver, significantly increasing superoxide dismutase and catalase activity. These findings suggest that exposure to ≥1,600 ㎍/L PE-MPs could significantly change growth performance, hematological parameters, plasma components, and antioxidant responses, resulting in physiological toxicity.