• Journal of Ginseng Research
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• 제43권4호
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• pp.676-683
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• 2019

Background: Korean Red Ginseng (KRG) is widely used for strengthening the immune system and fighting fatigue, especially in people with deficiency syndrome. However, there is concern that the long-term application or a high dose of KRG can cause "fireness" (上火 in Chinese) because of its "dryness" (燥性 in Chinese). The aim of this study was to assess the safety and efficacy of a 4-week treatment with KRG in participants with deficiency syndrome. Methods: This was a 4-week, randomized, double-blind, placebo-controlled clinical trial. A total of 180 Chinese participants were randomly allocated to three groups: placebo control group, participants were given a placebo, 3.6 g/d; KRG 1.8 g and 3.6 g groups. The primary outcomes were the changes in fireness and safety evaluation (adverse events, laboratory tests, and electrocardiogram). The secondary outcomes were the efficacy of KRG on fatigue, which include the following: traditional Chinese medicine (TCM) symptom scale and fatigue self-assessment scale. Results: Of the 180 patients, 174 completed the full study. After 4 weeks of KRG treatment, the Fire-heat symptoms score including Excess fire-heat score and Deficient fire-heat score showed no significant change as compared with placebo treatment, and no clinically significant changes in any safety parameter were observed. Based on the TCM syndrome score and fatigue self-assessment score, TCM symptoms and fatigue were greatly improved after treatment with KRG, which showed a dose- and time-dependent effect. The total effective rate was also significantly increased in the KRG groups. Conclusion: Our study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of "fireness" related to KRG.

• 한국응급구조학회지
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• 제2권1호
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• pp.26-35
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• 1998

This study was to exhibit the effective emergency care method for the drowning and non-drowning who are reached two-thousand peoples every year in our country. For investigate the effective emergency care, this study was discussed as follows ; Pathophysiology of the water submersion, Fresh-water & sea-water drowning, Factors affecting survival, and Prehospital management. The conclusions from this study were summarized as follows; 1. Remove the patient from the water. If you suspect neck or spinal injuries, Always support the head and neck level with the back and, begin rescue breathing. 2. Maintain the airway and support ventilation in the water use the jaw-thrust technique to avoid farther injury to the neck or spine. We might encounter more resistance to ventilations than you expect because of water in the airway. Once you have determined that there are no foreign objects in the airway, apply ventilations with more force; adjust ventilations until you see the patient's chest rise and fall but not until you see gastric distention. Do not attempt to remove water from the patient's lungs or stomach. 3. If there is no pulse, begin CPR. 4. Administer high-flow supplemental oxygen; suction as needed. 5. Once the patient is breathing and has a pulse, assess for hemorrhage; control any serious bleeding that you find. 6. Cover the patient to conserve body heat, Handle the patient very gently, and, Transport the patient as quickly as possible to Emergency Department, Continuing resuscitative measures during transport. If the patient have the hypothermia, follow hypothermia management.

• Child Health Nursing Research
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• 제16권4호
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• pp.268-276
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• 2010

Purpose: The purpose of this study was to provide basic data to improve coping abilities of elementary school students in emergency situations. Method: The data were collected from 1633 3-6th grade elementary school students using a self-report questionnaire. Results: 1) The mean score for the coping ability of the students was low at .38(${\pm}.36$). 2) The mean scores for the 8 categories were, [Care for common symptoms], .54(${\pm}.48$), [Call for help & check], .47(${\pm}.43$), [Care for injury by heat cold & foreign body], .39(${\pm}.45$), [Care for tissue damage], .36(${\pm}.44$), [Offering help], .36(${\pm}.42$), [Rescue & escape], .31(${\pm}.51$), [Evacuation], .28(${\pm}.49$), and [Appropriate response for the situation], .27(${\pm}.43$). The mean scores for 2 areas were, 'Acting tips', .35(${\pm}.36$) and 'First aid', .42(${\pm}.40$). There were significant differences in coping ability according to students' gender (t=4.964, p<.001), and family type (t=-2.484, p=.013). 4) Among the categories, there were significant correlations between all 8 categories and significant correlation between 'Acting tips' and 'First aid' (r=.808, p<.001), 'Acting tips' and 'Coping ability' (r=.956, p<.001), and 'First aid' and 'Coping ability' (r=.946, p<.001). Conclusion: The findings indicate a need for programs to improve the coping ability of elementary school students in emergency situations.

• Child Health Nursing Research
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• 제15권3호
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• pp.271-281
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• 2009

Purpose: This study was conducted to develop an instrument to measure coping in emergency situations. Methods: The process included construction of a conceptual framework, generation 60 primary items, verification of construct validity and extraction of final items. The.60 preliminary items were reviewed for content validity by seven experts and were tested to evaluate inter-item correlation coefficient by three groups of elementary school students. From November 1 to December 10, 2008, data were collected from 920 elementary school students according to residential characters (major city, small town, rural area). Item analysis, factor analysis with rotation Varimax and Cronbach's alpha were used to analyze the data. Results: 1) There were 45 items in the final instrument categorized into 8 factors. 2) The factors were labeled as "Call for help and check" (8 items), "Care for common symptoms" (6 items), "Appropriate response for the situation" (5 items), "Evacuation" (6 items), "Care for tissue damage" (8 items), "Care for injury by heat, cold or foreign body" (6 items), "Offer help" (4 items) and "Rescue & escape" (2 items). 3) Cumulative percent of variance was 53.10% and eigen values ranged from 1.04 to 13.38. 4) Cronbach's alpha for the total was .943 and ranged from .527 to .869. Conclusion: Validity and reliability of the scale are confirmed in this study showing its utility for measuring coping in emergency situations with elementary school students. Utilization of the scale will also contribute to designing appropriate coping education programs for elementary school students.

• 대한화장품학회지
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• 제49권3호
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• pp.225-230
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• 2023

본 연구에서는 모발 내부의 다공성 구조를 광학 현미경을 이용하여 모발의 손상 없이 관찰하였으며, 해당 결과를 이용하여 모발 내부 다공성을 정량적으로 표현하고자 하였다. 모발 내부 밀도 저하가 모발의 굽힘 및 인장 특성에 미치는 영향에 대한 실험을 진행하였으며, 모발 내부의 밀도 저하를 발생시키는 원인에 대하여 알아보고자 내인적 요인과 외인적 요인에 대한 실험을 실시하였다. 내인적 요인으로는 노화의 대표 증상의 하나인 흰머리의 다공성을 평가 정상 모발과 비교하였다. 외인적 요인으로는 일상생활에서 대표적으로 모발의 손상을 유발할 수 있는 요인인 계면활성제와 열에 의하여 모발 내부 밀도가 감소 하는 것을 관찰하였다. 또한, 아미노산과 모발 지질 소질을 방지할 수 있는 소재를 이용하여 모발 내부 밀도를 증가시키고 윤기를 증가시킬 수 있음을 확인하였다.

• 대한한의학원전학회지
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• 제31권1호
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• pp.29-43
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• 2018

Objectives : This paper studies how the people of the past deal with constipation before the introduction of modern medical knowledge. Then, the paper selected some of the methods that use food ingredients with little to no side effects, and studied them to find a basic set of data that can be applied to today's medical practices. Methods : This paper reviewed six literatures: China's Eumsunjungyo, Nonohangeon, and Shiggamboncho, and Chosun's Singnyochanyo, Donguibogam, and Jejungsinpyeon. The food cures related to constipation were studied to discover what ingredients and preparation forms were used, how they were taken, what types of prescriptions existed, and how they were applied. Results : The food cure for constipation included ingredients such as mazi, suzi, sesame, honey, yiyiren, yuliren, xingren, taoren, and rice. These ingredients are known for replenishing the body's fluid and humor and allowing the better flow of qi. Mazi porridge, suma porridge, raw sesame oil, suzhu porridge, and suxing porridge were effective in dealing with the conspitation caused by heat, and jingshen wan, yiyiren porridge, yuliren porridge, yulirenyiyiren porridge, xingren porridge, and taoren porridge were effective in taking care of conspitation caused by qi deficiency. Conclusions : With a constipation caused by heat, it is good to take mazi and spinach regularly which is helpful in cooling down the heat. For senior citizens, constipations occur due to the qi deficiency that leads to the lack of fluid and humor. In this case, suzhu porridge should be taken regularly together with milk and sesame oil in order to replenish the qi. This will tonify the amount of qi and moisten the large intestines, which will be also helpful in tonifying the body itself.

• International Journal of Oral Biology
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• 제44권4호
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• pp.152-159
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• 2019

The oral care probiotic strain Weissella cibaria CMU (oraCMU) inhibits volatile sulphur compounds associated with halitosis, presumably by inhibiting the growth of associated oral pathogens. In the present study, we investigated whether oraCMU inhibits the production of these compounds by suppressing the expression of mgl. This gene encodes L-methionine-α-deamino-γ-mercaptomethane-lyase (METase) and is involved in the production of methyl mercaptan (CH₃SH) by Porphyromonas gingivalis. Therefore, we specifically investigated the effects of oraCMU on the growth, CH₃SH production, METase activity, and mgl expression of P. gingivalis. The minimum inhibitory concentrations of cell-free supernatant and secreted proteins from oraCMU were 125 mg/mL and 800 ㎍/mL, respectively. At sub-minimum inhibitory concentration levels, these metabolites inhibited CH₃SH production, but they also reduced P. gingivalis viability. Only heat-killed oraCMU decreased CH₃SH production without affecting P. gingivalis viability. Heat-killed oraCMU also inhibited METase activity toward L-methionine and mgl mRNA expression (p < 0.05). In summary, we demonstrated the inhibition of volatile sulphur compounds via the antimicrobial action of oraCMU and, for the first time, the inhibition of such compounds by heat-killed oraCMU, which occurred at the molecular level.

• 근관절건강학회지
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• 제18권2호
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• pp.192-202
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• 2011

Purpose: This study examined the effects of heat therapy combined with aromatherapy on pain, flexibility, sleep, and depression in elderly women with osteoarthritis. Methods: This study was designed as a nonequivalent control group quasi-experimental study based upon data acquired through a pre-post test. The experimental group (n=21) was treated using an aroma-permeated hot compress applied to the knee. The cotton towel was heated in a microwave to $45^{\circ}C$, and 2~3 drops of lavender were applied on it. The towel was wrapped with plastic bag to prevent aroma leakage and retain heat. The treatment was applied the towel for 20 minutes, three times a day for 3 weeks. The control group (n=24) was not given any treatment. Data were collected using a VAS(100mm) for pain, questionnaire for sleep and depression, and a goniometer for knee flexibility. The data were analyzed with ${\chi}^2$-test and t-test using SPSS/Win18.0. Results: There were significant differences in knee pain (p=.001) and flexibility (p<.001), subjective quality of sleep (p=.020) and depression (p=.003) between the groups. Conclusion: Heat therapy combined with aromatherapy may be an effective nursing intervention and self-care technique to ameliorate pain and depression and to improve flexibility and sleep in elderly suffering from osteoarthritis.

• 사상체질의학회지
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• 제32권4호
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• pp.29-44
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• 2020

Objectives We surveyed clinical status of Sasang Constitutional Medicine (SCM) for preparation of adaptation of Clinical Practice Guidelines for Sasang Constitutional Symptomatology. Methods We emailed Google survey form to Doctors of Korean Medicine registered the Association of Korean Medicine on 10/13/2020 and 10/21/2020 and closed survey 10/23/2020. We got a data of 654 cases, removed a case of error, analyzed data of 620 responses by frequency analysis Results and Conclusions Out of 620 respondents, 499 have answered that they refer to or make use of SCM. SCM is mainly applied in the field of treatments using Herbal Medicine. Doctors of Korean Medicine participated in survey of SCM, they think Diseases of digestive system are the most effectively treated by the methods of SCM. Sasang Constitutional Symptomatology most frequently observed are Soeumin Congestive Hyperpsychotic symptomatology, Soyangin Chest-Heat congested Symptomatology, Taeeumin Liver Heat-based Interior Heat disease. The diseases that are mainly applied by SCM are 'Diseases of digestive system' for Soeumin, 'Diseases of digestive system' for Soyangin, 'Diseases of respiratory system' for Taeeumin and 'not applicable' for Taeyangin. The important diagnostic methods of SCM are Inspection-listening and smelling examination-Inquiry-Palpation and survey. In the majority of cases, Prescription of Herbal medicine is used by adding or subtracting some herbal medicine from the original prescription suggested in the oriental medical classics and Saam acupuncture method is the most frequently used for the acupuncture therapy. Diet therapy is the most frequently used for the method of prevention and care.

• 한국미생물·생명공학회지
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• 제46권4호
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• pp.326-333
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• 2018

본 연구에서는 성장인자, 효소, 펩타이드 등과 같은 기능성 생체 고분자를 대상으로 열에 대한 안정성 및 피부 투과성을 향상시키는 연구를 수행하였다. 이들은 생체 내에서 세포를 활성화 하거나 촉매 작용을 담당하고 있다. 따라서 화장품 등의 외용제에 적용 시, 그 효능의 우수함이 예상되나 열에 대한 불안정성과 높은 분자량으로 피부 투과성이 낮은 단점이 있다. 이를 극복하기 위해 먼저 열에 대한 안정성을 확보할 수 있는 조성을 탐색하였다. 그 결과, 단분자 구조의 humectant 대비 PEG의 길이가 긴 polymeric humectant를 사용한 경우 열에 대한 안정성이 높아지는 것을 확인 할 수 있었다. 한편 이들의 피부 투과를 촉진시키기 위하여 투과 촉진 펩타이드를 phage library로부터 선별하고자 하였다. 투과 촉진 펩타이드는 성장인자, 효소, 펩타이드의 투과 촉진을 위해 공통적으로 사용할 수 있는 구조이다. 그러나 피부의 투과정도는 물질자체의 특성도 영향을 미칠 수 있으나 제형의 성분에 따라서 영향을 받을 수 있다. 본 연구에서는 성장인자를 안정화 할 수 있는 polymeric humectant 제형을 기반으로 투과 촉진 펩타이드 선별을 수행하였다. 그 결과 대조군 펩타이드 대비 투과촉진이 향상된 결과를 확인했을 뿐만 아니라 PBS를 기반으로 선별된 투과 촉진 펩타이드 보다 polymeric humectant 제형에서는 투과도가 우수한 것을 확인 할 수 있었다. 본 연구의 결과는 기능성 생체고분자의 열 안정성 개선 및 피부 투과도 향상에 기여할 수 있을 것으로 기대된다.