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A Philological Study on the prescription of Beriberi (각기(脚氣)의 처방(處方)에 대한 문헌적(文獻的) 고찰(考察))

  • Kim Ki-Hyung;Sin Mi-Suk;Sul Jae-Uk;Choi Jin-Bong
    • Herbal Formula Science
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    • v.12 no.1
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    • pp.29-77
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    • 2004
  • After this study: I report the following result from it. 1. Beriberi is defined as sensory or motor disorder of leg with a painful-swelling and pyrexia. If it progress severely, the disease transmits to heart and cause numbness of the lower abdomen, vomiting, anorexia, palpitation, chest distress and confusion. 2. The external etiologic factors of Beriberi are wind-toxic pathogen, dampness, improper diet and climate sickness, the internal etiologic factors are deficiencies of the kidney, both Gi and blood and original vital energy. 3. The treatment of Beriberi is free-going of blockage, because it is a blocked disease. 4. Danggwiy-juntongtang and Ganghwar-dochetang is the most in the order of frequency of use. Mahwang-juagyongtang, Banha-juagyongtang, Daehwang-juagyongtang, Shinbi-juagyongtang are used in sequence. 5. The prescriptions of Beriberi are made up of the herbs that clear heat, for example, Ganghwar, Changchul, Mahwang and Bangpung, and the herbs that reinforces Gi, for example, Insam and Bakchul.

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A Literatual study on the diet treatment of JungPung(C.V.A) (뇌졸중(腦卒中) 식이요법(食餌療法)에 대(對)한 문헌적(文獻的) 고찰(考察))

  • Ahn, Jong-seok;Seo, In-chan
    • Journal of Haehwa Medicine
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    • v.10 no.1
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    • pp.187-200
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    • 2001
  • In the literatual study on the diet treatment of JungPung(C.V.A) the results were as follows : 1. The principle of oriental medical dietary treatment is based on the YumYang Oh Haeng(陰陽五行) and QiMiLon (氣味論). 2. The principle of western medical dietary treatment attachs importance to the treatment of the total heat capacity control and balanced nutrition. 3. The western diet treatment of C.V.A was used to low salt diet, low fat diet and low calory diet, the oriental diet treatment was used to cereals and fruit composed of Qi(氣) of HanYeulOnLang (寒熱溫凉) and Mi(味)of San Go Gam Sin Ham(酸苦甘辛鹹). 4. In the analysis of oriental diet treatment of C.V.A used for cereals and fruits, the results were that Sung(性) is MiHan(微寒), Mi(味)is GamMiHan(甘微酸), Sung(性)is descending, Qi(氣) is YangJungJiYum(陽中之陰) and QiBak(氣薄), the effcet is ChungYulYiSub(淸熱利水) GunBi(健脾) YikQi(益氣) etc.

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Thermal Properties of Diglycidy1 ether of bisphenol A-4,4'- Methylene dianiline Succinonitrile Hydroquinone system (Diglycidy1 ether of bisphenol A-Mthylene dianiline Succinonitrile Hydroquinone계의 열적 성지)

  • Jeong, Sin-Gyeong;Cheon, In-Suk;Sim, Mi-Ja;Kim, Sang-Uk
    • Korean Journal of Materials Research
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    • v.4 no.8
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    • pp.915-920
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    • 1994
  • The thermal properties of Iliglycldyl ether of bisphenol A(DGEBA)-4, 4'-methylene dianiline (MDA)system with SN(Succinonitri1e) as a chain extender and HQ(Hydroquinone) as a reactive accelerator were investigated. Glass transition ternperature(Tg), heat deflection ternperature(HDT) and decomposition ternperature(Td) were measured with IiQ content in wh~ch SN : HQ content was fixed 4 : 1. Tg and HIIT were slightly decreased with increasing IIQ content. Td was stable at about $360^{\circ}C$ according to the changing HQ content and cure temperature.

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Methane Gas Sensing Properties of the Zinc Oxide Nanowhisker-derived Gas Sensor

  • Moon, Hyung-Sin;Kim, Sung-Eun;Choi, Woo-Chang
    • Transactions on Electrical and Electronic Materials
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    • v.13 no.2
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    • pp.106-109
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    • 2012
  • A low power methane gas sensor with microheater was fabricated by silicon bulk micromachining technology. In order to heat up the sensing layer to operating temperature, a platinum (Pt) micro heater was embedded in the gas sensor. The line width and gap of the microheater was 20 ${\mu}m$ and 4.5 ${\mu}m$, respectively. Zinc oxide (ZnO) nanowhisker arrays were grown on a sensor from a ZnO seed layer using a hydrothermal method. A 200 ml aqueous solution of 0.1 mol zinc nitrate hexahydrate, 0.1 mol hexamethylenetetramine, and 0.02 mol polyethylenimine was used for growing ZnO nanowhiskers. Temperature distribution of the sensor was analyzed by infrared thermal camera. The optimum temperature for highest sensitivity was found to be $250^{\circ}C$ although relatively high (64%) sensitivity was obtained even at as low a temperature as $150^{\circ}C$. The power consumption was 72 mW at $250^{\circ}C$, and only 25 mW at $150^{\circ}C$.

Numerical study of double diffusive convection due to lateral heating in a rotating annulus (회전하는 환형용기내의 옆면 가열에 의한 이중확산대류에 관한 수치해석)

  • Gang, Sin-Hyeong;Lee, Gyo-Seung;Lee, Jin-Ho
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.21 no.11
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    • pp.1422-1436
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    • 1997
  • Numerical investigations were conducted to study the convective phenomena of an initially stably stratified salt water solution with lateral heating in a uniformly rotating annulus. The method of investigation is the finite difference analysis of the basic conservation equation for an axisymmetric, unsteady, double-diffusive convection and calculation is made for R $a_{\eta}$=2*10$^{5}$ and Ta=10$^{7}$ ~ 2.5*10$^{8}$ . Formation of layered flow structure, merging process of layers, the corresponding temperature and concentration distributions, Nu variation with time are examined. Numerical results show that in each layer, the temperature profile looks 'S'-shaped and the concentration profile is uniform due to the convective mixing. At the interface between adjacent layers, the temperature changes smoothly but the concentration changes rapidly. As the effect of the rotation increases, the generation of rolls at hot wall, the formation and merging of layers are delayed. The average Nu shows the trend of conduction heat transferees the effect of the rotation increases.n increases.

Modulation of $Ca^{2+}-Activated$ Potassium Channels by cGMP-Dependent Signal Transduction Mechanism in Cerebral Arterial Smooth Muscle Cell of the Rabbit

  • Han, Jin;Kim, Na-Ri;Lee, Kwang-Bok;Kim, Eui-Yong
    • The Korean Journal of Physiology and Pharmacology
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    • v.4 no.6
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    • pp.445-453
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    • 2000
  • The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of $Ca^{2+}-activated$ potassium channel $(K_{Ca}\;channel)$ and is involved in the activation of $K_{Ca}$ channel activity in cerebral arterial smooth muscle cells of the rabbit. Single-channel currents were recorded in cell-attached and inside-out patch configurations of patch-clamp techniques. Both molsidomine derivative 3-morpholinosydnonimine-N-ethylcarbamide $(SIN-1,\;50\;{\mu}M)$ and 8-(4-Chlorophenylthio)-guanosine-3',5'-cyclic monophosphate $(8-pCPT-cGMP,\;100\;{\mu}M),$ a membrane-permeable analogue of cGMP, increased the $K_{Ca}$ channel activity in the cell-attached patch configuration, and the effect was removed upon washout of the drugs. In inside-out patches, single-channel current amplitude was not changed by SIN-1 and 8-pCPT-cGMP. Application of ATP $(100\;{\mu}M),$ cGMP $(100\;{\mu}M),$ ATP+cGMP $(100\;{\mu}M\;each),$ PKG $(5\;U/{\mu}l),$ ATP $(100\;{\mu}M)+PKG\;(5\;U/{\mu}l),$ or cGMP $(100\;{\mu}M)+PKG\;(5\;U/{\mu}l)$ did not increase the channel activity. ATP $(100\;{\mu}M)+cGMP\;(100\;{\mu}M)+PKG\;(5\;U/{\mu}l)$ added directly to the intracellular phase of inside-out patches increased the channel activity with no changes in the conductance. The heat-inactivated PKG had no effect on the channel activity, and the effect of PKG was inhibited by 8-(4-Chlorophenylthio)-guanosine-3',5'-cyclic monophosphate, Rp-isomer $(Rp-pCPT-cGMP,\;100\;{\mu}M),$ a potent inhibitor of PKG or protein phosphatase 2A (PP2A, 1 U/ml). In the presence of okadaic acid (OA, 5 nM), PP2A had no effect on the channel activity. The $K_{Ca}$ channel activity spontaneously decayed to the control level upon washout of ATP, cGMP and PKG, and this was prevented by OA (5 nM) in the medium. These results suggest that the PKG-mediated phosphorylations of $K_{Ca}$ channels, or some associated proteins in the membrane patch increase the activity of the $K_{Ca}$ channel, and the activation may be associated with the vasodilating action.

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The Study on Performance Characteristics of $NH_3$ Refrigeration System for Various Degree of Superheat - Part II : The Change of Heat Exchanger Type - ($NH_3$ 냉동장치의 과열도 변화에 의한 성능 특성 연구 II -열교환기 타입 변경-)

  • Ha Ok-Nam;Kwon Il-Wook;Jeon Sang-Sin;Lee Seung-Jae;Jung Song-Tae;Ha Kyung-Soo;Yun Kab-Sig;Lee Jong-In;Hong Kyung-Han
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.17 no.4
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    • pp.297-302
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    • 2005
  • Since the use of CFC and HCFC refrigerants are to be restricted due to the depletion of ozone layer, this experiment applies the $NH_3$ gas to study the performance characteristics of $NH_3$ refrigeration system by the superheat control for improving the energy efficiency. The experiments are carried out for the condensing pressure of refrigeration system from 1,500 kPa to 1,600 kPa and for degree of superheat from $0^{\circ}C\;to\;10^{\circ}C$ at each condensing pressure. As a result of experiment, when the degree of superheat is $0^{\circ}C$ at each condensing pressure, the refrigeration system has the highest performance.

Superconducting Properties of Mg(B1-xCx)2 Bulk Synthesized Using Magnesium and Glycerin-treated Boron Powder (마그네슘과 글리세린 처리한 붕소 분말로 합성한 Mg(B1-xCx)2의 초전도 특성)

  • Kim, Yi-Jeong;Jun, Byung-Hyuk;Park, Soon-Dong;Tan, Kai Sin;Kim, Bong-Goo;Sohn, Jae-Min;Kim, Chan-Joong
    • Journal of Powder Materials
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    • v.15 no.3
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    • pp.182-187
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    • 2008
  • Carbon was known to be one of effective additives which can improve the flux pinning of $MgB_2$ at high magnetic fields. In this study, glycerin $(C_3H_8O_3)$ was selected as a chemical carbon source for the improvement of critical current density of $MgB_2$. In order to replace some of boron atoms by carbon atoms, the boron powder was heat-treated with liquid glycerin. The glycerin-treated boron powder was mixed with an appropriate amount of magnesium powder to $MgB_2$ composition and the powder pallets were heat treated at $650^{\circ}C\;and\;900^{\circ}C$ for 30 min in a flowing argon gas. It was found that the superconducting transition temperature $(T_c)$ of $Mg(B_{1-x}C_x)_2$ prepared using glycerin-treated boron powder was 36.6 K, which is slightly smaller than $T_c$(37.1 K) of undoped $MgB_2$. The critical current density $(J_c)$ of $Mg(B_{1-x}C_x)_2$ was higher than that of undoped $MgB_2$ and the $T_c$ improvement effect was more remarkable at higher magnetic fields. The $T_c$, decrease and $J_c$ increase associated with the glycerin treatment for boron powder was explained in terms of the carbon substitution to boron site.

Transduction of Tat-Superoxide Dismutase into Insulin-producing MIN6N Cells Reduces Streptozotocin-induced Cytotoxicity

  • Choung, In-Soon;Eum, Won-Sik;Li, Ming-Zhen;Sin, Gye-Suk;Kang, Jung-Hoon;Park, Jin-Seu;Choi, Soo-Young;Kwon, Hyeok-Yil
    • The Korean Journal of Physiology and Pharmacology
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    • v.7 no.3
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    • pp.163-168
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    • 2003
  • The reactive oxygen species (ROS) are considered to be an important mediator in pancreatic ${\beta}$ cell destruction, thereby triggering the development of insulin-dependent diabetes mellitus. In the present study, HIV-1 Tat-mediated transduction of Cu,Zn-superoxide dismutase (SOD) was investigated to evaluate its protective potential against streptozotocin (STZ)-induced cytotoxicity in insulin-producing MIN6N cells. Tat-SOD fusion protein was successfully delivered into MIN6N cells in a dose-dependent manner and the transduced fusion protein was enzymatically active for 48 h. The STZ induced-cell destruction, superoxide anion radical production, and DNA fragmentation of MIN6N cells were significantly decreased in the cells pretreated with Tat-SOD for 1 h. Furthermore, the transduction of Tat-SOD increased Bcl-2 and heat shock protein 70 (hsp70) expressions in cells exposed to STZ, which might be partly responsible for the effect of Tat-SOD. These results suggest that an increased of free radical scavenging activity by transduction of Tat-SOD enhanced the tolerance of the cell against oxidative stress in STZ-treated MIN6N cells. Therefore, this Tat-SOD transduction technique may provide a new strategy to protect the pancreatic ${\beta}$ cell destruction in ROS-mediated diabetes.

The Characterization of V Based Self-Forming Barriers on Low-k Samples with or Without UV Curing Treatment

  • Park, Jae-Hyeong;Han, Dong-Seok;Gang, Yu-Jin;Sin, So-Ra;Park, Jong-Wan
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.214.2-214.2
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    • 2013
  • Device performance for the 45 and 32 nm node CMOS technology requires the integration of ultralow-k materials. To lower the dielectric constant for PECVD and spin-on materials, partial replacement of the solid network with air (k=1.01) appears to be more intuitive and direct option. This can be achieved introducting of second "labile" phase during depositoin that is removed during a subsequent UV curing and annealing step. Besides, with shrinking line dimensions the resistivity of barrier films cannot meet the International Technology Roadmap for Semiconductors (ITRS) requirements. To solve this issue self-forming diffusion barriers have drawn attention for great potential technique in meeting all ITRS requirments. In this present work, we report a Cu-V alloy as a materials for the self-forming barrier process. And we investigated diffusion barrier properties of self-formed layer on low-k dielectrics with or without UV curing treatment. Cu alloy films were directly deposited onto low-k dielectrics by co-sputtering, followed by annealing at various temperatures. X-ray diffraction revealed Cu (111), Cu (200) and Cu (220) peaks for both of Cu alloys. The self-formed layers were investigated by transmission electron microscopy. In order to compare barrier properties between V-based interlayer on low-k dielectric with UV curing and interlayer on low-k dielectric without UV curing, thermal stability was measured with various heat treatment temperature. X-ray photoelectron spectroscopy analysis showed that chemical compositions of self-formed layer. The compositions of the V based self-formed barriers after annealing were strongly dominated by the O concentration in the dielectric layers.

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