• Journal of Chest Surgery
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• 제44권6호
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• pp.432-436
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• 2011

We herein present a case of a successful correction of cor triatriatum associated with thrombotic pulmonary hypertension diagnosed in an adult female patient. We confirmed diagnosis using transthoracic and transesophageal echocardiography in addition to cardiac computed tomography and magnetic resonance imaging. Surgical repair comprised excision of the fibromuscular membranous septum in the left atrium, patch closure of an atrial septal defect, and reconstruction of the pulmonary arteries with a vascular graft. Cor triatriatum complicated pulmonary thrombotic hypertension with atrial septal defect is amenable to surgical correction with satisfactory results.

• Journal of Chest Surgery
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• 제49권6호
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• pp.421-426
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• 2016

Background: Median sternotomy is the standard approach for atrial septal defect (ASD) closure. However, minimally invasive cardiac surgery (MICS) has been introduced at many centers in adult/grown-up congenital heart patients. We retrospectively reviewed the results of right anterolateral thoracotomy compared with conventional median sternotomy (CMS) for ASD closure at Seoul National University Hospital. Methods: We retrospectively analyzed 60 adult patients who underwent isolated ASD closure from January 2004 to December 2013 (42 in the CMS group, 18 in the MICS group). Preoperative, operative, and postoperative data were collected and compared between the 2 groups. Results: The MICS group was younger (44.6 years vs. 32.4 years, p=0.002) and included more females (66.7% vs. 94.4%, p=0.025) than the CMS group. Operation time (188.4 minutes vs. 286.7 minutes, p<0.001), cardiopulmonary bypass time (72.7 minutes vs. 125.8 minutes, p<0.001), and aortic cross-clamp time (25.5 minutes vs. 45.6 minutes, p<0.001) were significantly longer in the MICS group. However, there were no significant differences in morbidity and mortality between groups. Only chest tube drainage in the first 24 hours (627.1 mL vs. 306.1 mL, p<0.001) exhibited a significant difference. Conclusion: MICS via right anterolateral thoracotomy is an alternative choice for ASD closure. The results demonstrated similar morbidity and mortality between groups, and favored MICS in chest tube drainage in the first 24 hours.

• Journal of Chest Surgery
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• 제54권1호
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• pp.45-52
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• 2021

Background: Atrial septal defect (ASD) is the most common congenital heart disease. However, the details of cardiac chamber remodeling after surgery are not well known, although this is an important issue that should be analyzed to understand long-term outcomes. Methods: Between November 2017 and January 2019, cardiac magnetic resonance imaging was performed preoperatively, at a 1-month postoperative follow-up, and at a 1-year postoperative follow-up. Cardiac chamber volume, valve regurgitation volume, and ejection fraction were measured as functions of time. Results: Thirteen patients (10 men and 3 women) were included. The median age at surgery was 51.4 years. The preoperative median ratio of flow in the pulmonary and systemic circulation was 2.3. The preoperative mean right ventricular (RV) end-diastolic volume index (EDVi) and RV end-systolic volume index (ESVi) had significantly decreased at the 1-month postoperative follow-up (p<0.001, p=0.001, respectively). The decrease in the RVEDVi (p=0.085) and RVESVi (p=0.023) continued until the postoperative 1-year follow-up, although the rate of decrease was slower. Tricuspid valve regurgitation had also decreased at the 1-month postoperative follow-up (p=0.022), and continued to decrease at a reduced rate (p=0.129). Although the RVEDVi and RVESVi improved after ASD closure, the RV volume parameters were still larger than the left ventricular (LV) volume parameters at the 1-year follow-up (RVEDVi vs. LVEDVi: p=0.016; RVESVi vs. LVESVi: p=0.001). Conclusion: Cardiac remodeling after ASD closure is common and mainly occurs in the early postoperative period. However, complete normalization does not occur.

• Clinical and Experimental Pediatrics
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• 제51권4호
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• pp.401-408
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• 2008

목 적 : 이차공 심방 중격 결손의 경피적 폐쇄술은 수술을 대체할 수 있어 안전하고 효과적인 치료로서 자리를 잡아가고 있으나, 드물게 합병증의 발생이 보고되고 있어, Amplatzer septal occluder를 이용한 심방 중격 결손의 경피적 폐쇄술 후 발생한 초․중기 합병증 및 그 대책을 살펴보고자 하였다. 방 법 : 2003년 6월부터 2006년 5월까지 부천세종병원과 고려대학교 의료원에서 이차공 심방 중격 결손을 진단 받은 64명의 환자를 대상으로 하였다. 남녀 비는 1:2.4였고, 시술 당시 나이는 2.6에서 64세(중앙값 : 17세), 시술 당시 체중은 13 kg에서 100 kg (중앙값 : 47.5 kg)이었다. 결 과 : 경흉부 또는 경식도 심장 초음파 검사상 결손의 크기는 6 mm에서 28 mm (중앙값 : 15 mm), 풍선 확장 시 결손의 크기는 6.5 mm에서 34 mm (중앙값 : 18 mm)이었고, 사용한 Amplatzer septal occluder의 크기는 6 mm에서 36 mm (중앙값 : 19.5 mm)로 풍선 확장 시 결손의 크기와 같거나 1-2 mm 큰 크기의 기구가 사용되었다. 시술 후 발생한 합병증으로는 부정맥(2례), 기구 변형(2례), 대동맥 우심방 간 누공 형성 및 용혈성 빈혈(1례), 승모판 잠식(1례), 기구 위치 이상(1례), 잔류 단락(1례), 하대 정맥 천공(1례) 등이 있었다. 결 론 : ASO를 이용한 심방 중격 결손의 경피적 폐쇄술은 안전성이나 효과, 기술적인 면에서 수술을 대체할 수 있는 효율적인 치료로 생각된다. 그러나 드물게 발생하는 기구 이탈이나 부정맥, 심장막 삼출, 누공 형성 등의 합병증이 발생할 수 있으므로 시술 전 주의 깊게 대상 환자를 선정하고, 심방 중격 결손의 정확한 해부학적 이해와 기구 선택이 필요하며 시술 후 추적 관찰을 통해 합병증의 조기 발견 및 예방이 필요할 것으로 판단된다.

• Journal of Chest Surgery
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• 제56권3호
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• pp.155-161
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• 2023

Background: Surgical closure of an atrial septal defect (ASD) is infrequently indicated during infancy. We evaluated the clinical characteristics and outcomes of patients who underwent surgical ASD closure during infancy. Methods: A single-center retrospective review was performed for 39 patients (19 males) who underwent surgical ASD closure during infancy between 1993 and 2020. The median body weight percentile at the time of operation was 9.3. Results: During a median follow-up of 60.9 months, 4 late deaths occurred due to chronic respiratory failure. A preoperative history of bronchopulmonary dysplasia (BPD) was the only risk factor for late mortality identified in Cox regression (hazard ratio, 3.54; 95% confidence interval [CI], 1.75-163.04; p=0.015). The 5-year survival rate was significantly lower in patients with preoperative history of BPD (97.0% vs. 50.0%, p<0.001) and preoperative ventilatory support (97.1% vs. 40.4%, p<0.001). There were significant postoperative increases in left ventricular end-diastolic (p=0.017), end-systolic (p=0.014), and stroke volume (p=0.013) indices. A generalized estimated equation model showed significantly better postoperative improvement in body weight percentiles in patients with lower weight percentiles at the time of operation (<10th percentile, p=0.01) and larger indexed ASD diameter (≥45 mm/m², p=0.025). Conclusion: Patients with ASD necessitating surgical closure during infancy are extremely small preoperatively and remain small even after surgical closure. However, postoperative somatic growth was more prominent in smaller patients with larger defects, which may be attributable to an increase in postoperative cardiac output due to changes in ventricular septal configuration. The benefits of ASD closure in patients with BPD are undetermined.

• Journal of Chest Surgery
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• 제29권9호
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• pp.940-944
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• 1996

경북대학교 병원에서는 1990년 1월부터 1994년 10월까지 그 연령이 15세 이상인 선천성 심장병 환자 를 수술적 치료로 교정하였다 이 기간동안 총 628례의 선천성 심장병 환자중 22.4%인 143명이 성인 환자였다. 그중 10대가 23례, 20대가 58례, 30대가 34례, 40대가 18례, 50대가 10례였다. 가장 많은 질환은 전체의 51.1 % (73례)를 차지한 심방중격결손이었고, 39.9 % (57례)의 심실중격결손, 2.8 % (4례)의 활로씨 4징후순이었다. 술후 합병증은 10례 (6.9 %)에서 있었고 수술 사망은 없었다 이상의 결과로 성인에 있어서 수술이 가능한 예의 빈도를 알수 있었으며,이러한 경우에는적은수술 사망과 술후 합병증으로 수술이 가능하였다.

• Journal of Chest Surgery
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• 제46권5호
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• pp.340-345
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• 2013

Background: This study aims to evaluate whether or not the method of right vertical axillary minithoracotomy (RVAM) is preferable to and as reliable as conventional sternotomy surgery, and also assesses its cosmetic results. Methods: Thirty-three patients (7 males, 26 females) with atrial septal defect were admitted to the Cardiovascular Surgery Clinic of Cukurova University from December 2005 until January 2010. The patients' ages ranged from 3 to 22. Patients who underwent vertical axillary minithracotomy were assigned to group I, and those undergoing conventional sternotomy, to group II. Group I and group II were compared with regard to the preoperative, perioperative and postoperative variables. Group I included 12 females and 4 males with an average age of $16.5{\pm}9.7$. Group II comprised 14 female and 3 male patients with an average age of $18.5{\pm}9.8$ showing similar features and pathologies. The cases were in Class I-II according to the New York Heart Association (NYHA) Classification, and patients with other cardiac and systemic problems were not included in the study. The ratio of the systemic blood flow to the pulmonary blood flow (Qp/Qs) was $1.8{\pm}0.2$. The average pulmonary artery pressure was $35{\pm}10$ mmHg. Following the diagnosis, performing elective surgery was planned. Results: No significant difference was detected in the average time of the patients' extraportal circulation, cross-clamp and surgery (p>0.05). In the early postoperative period of the cases, the duration of mechanical ventilator support, the drainage volume in the first 24 hours, and the hospitalization time in the intensive care unit were similar (p>0.05). Postoperative pains were evaluated together with narcotic analgesics taken intravenously or orally. While 7 cases (43.7%) in group I needed postoperative analgesics, 12 cases (70.6%) in group II needed them. No mortality or major morbidity has occurred in the patients. The incision style and sizes in all of the patients undergoing RVAM were preserved as they were at the beginning. Furthermore, the patients of group I were mobilized more quickly than the patients of group II. The patients of group I were quite pleased with the psychological and cosmetic results. No residual defects have been found in the early postoperative period and after the end of the follow-up periods. All of the patients achieved functional capacity per NYHA. No deformation of breast growth has been detected during 18 months of follow-up for the group I patients, who underwent RVAM. Conclusion: To conclude, the repair of atrial septal defect by RVAM, apart from the limited working zone for the surgeon in these pathologies as compared to sternotomymay be considered in terms of the outcomes, and early and late complications. And this has accounted for less need of analgesics and better cosmetic results in recent years.

• Journal of Chest Surgery
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• 제32권4호
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• pp.368-372
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• 1999

배경: 선천성 심장 질환에서의 최소 피부 절개에 대한 보고는 매우 적다. 저자등은 수술상처를 최소화하면서 통상적인 수술수기 및 시야를 확보할 수 있는 방법을 고려하였다. 대상 및 방법: 저자등은 1997년 4월부터 1997년 9월까지 선천성 심장 질환 환자 40명을 대상으로 최소 피부 절개술과 정중 전 흉골 절단을 통해서 개심술을 시행하였다. 환자 질병 분포는 성인 환자가 5명(남:여=1:4)이며 이중, 심방 중격 결손증 3명, 심실 중격 결손증 1명, 부분 심내막상 결손증 1명이었고, 소아 35명(남:여=17:18)에서는 심방 중격 결손증 4명, 심실 중격 결손증 30명, 발살바 동맥류 1명이었다. 정중 피부 절개는 흉골 두번째 늑간하부에서 검상돌기 1~2cm상방까지 실시하였다. 흉골 하부 절단에는 일반 전기톱을, 흉골 상부 절단에는 특수 전기톱을 피부 밑에 삽입하여 전장의 흉골을 절단하였다. 그리고, 흉골 견인은 좌우 & 상하 양방향에 2개의 견인기를 각각 직각으로 거치하여 수술시야를 확보하였다. 결과: 흉골길이대비 피부절개의 길이는, 성인에서는 55.0$\pm$3.5%로 절개길이가 평균 12cm(10~13.5cm)였고, 소아에서는 63.1$\pm$3.9%로 평균 7.3cm(5.2~11cm)였다. 모든 증례에서 체외 순환시 필요한 동정맥 삽관을 추가적인 서혜부 피부 절개 없이 직접 대동맥 및 상하공 대정맥에 시행할 수 있었으며 좌심방벤트관은 필요시 삽입하였다. 전 례에서 수술사망이나 합병증은 발생하지 않았으며, 최소 피부 절개술에 따른 창상 감염 및 피부 괴사, 혈종 형성, 출혈에 의한 합병증은 없었다. 결론: 이상의 결과로 최소 피부 절개술과 정중 전 흉골 절개를 이용한 선천성 심장 질환 수술은, 통상적인 체외 심폐 순환을 할 수 있으며, 외관상 미용의 효과가 뚜렷하였고, 다양한 선천성 심질환에서 안전하고 효과적으로 사용될 수 있다고 판단된다.

• Journal of Chest Surgery
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• 제28권8호
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• pp.747-753
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• 1995

Patients over 14 years of age who have undergone a surgical correction of a congenital cardiac malformations during period of August 1959 through December 1993 have been reviewed. During this period, there were 6894 cases of congenital cardiac lesions consisting of 4576 acyanotic and 2318 cyanotic cases. Among them, a total of 1389 adults [20.1%with various congenital cardiac malformations, 1126 acyanotic group and 263 cyanotic group were operated on. 677 patients were male and 712 patients were female. There were 444 patients under 20 years of age, 365 patients between 20-24 years, 220 patients between 25-29 years, 138 patients between 30-34 years and 222 patients over 34 years. The most common defects were atrial septal defect which accounted for 500 cases [36.0%and another common malformations were ventricular septal defect [276 cases, 19.9% , patent ductus arteriosus [207 cases, 14.9% , tetralogy of Fallot [185 cases, 13.3%and pulmonary stenosis [44 cases, 3.2%in order of incidence. Overall operative mortality for this series was 2.7% [1.5% of acyanotic group and 7.9% of cyanotic groupcompared with 4.6% of operative mortality of total cases of congenital cardiac malformations [2.9% of acyanotic group and 16.7% of cyanotic group . This reviewed series reveals the incidence of operable congenital heart defects appearing in any adult life and demonstrates that surgical repair can be accomplished with a satisfactory low mortality rate.

• Journal of Genetic Medicine
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• 제15권1호
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• pp.20-23
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• 2018

Point mutations in the human cardiac homeobox gene NKX2.5 are associated with familial atrial septal defect (ASD), atrioventricular (AV) conduction disturbance, as well as sudden cardiac death. To date, more than 60 NKX2.5 mutations have been documented, but there are no reports in Korea. We are reporting the first Korean family with ASD and AV block associated with a novel mutation in the NKX2.5 coding region. A 9-year-old boy presented with a slow and irregular pulse, and was diagnosed with secundum ASD and first degree AV block. The boy's father, who had a history of ASD correction surgery, presented with second degree AV block and atrial fibrillation. The boy's brother was also found to have secundum ASD and first degree AV block. There were two sudden deaths in the family. Genetic testing revealed a novel mutation of NKX2.5 in all affected members of the family.