• Journal of the Ergonomics Society of Korea
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• v.18 no.2
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• pp.1-9
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• 1999

The objective of this study was to make comparison of the physical work capacities(PWCs) for three different types of tasks. For this purpose, an ergometer exercise, a treadmill exercise, and lifting activities with four different frequencies (2, 5, 8, 11 lifts/min) for the lifting range from floor to 76cm were considered. Oxygen consumption rates and heart rates were measured during the exercises and lifting activities. The PWC values for ergometer exercise test was $2562.71ml-O_2/min$ and the one for treadmill exercise was $2874.89ml-O_2/min$. The value of lifting PWC increased from $1774.07ml-O_2/min$ to $2296.76ml-O_2/min$ as the lifting frequency increased from 2 to 11 lifts/min. The ratio of the lifting PWCs to the ergometer PWC increased from 69.36% to 89.77% as the lifting frequency increased. To the treadmill PWC, the ratio increased from 62.21% to 85.24% as the lifting frequency increased. From this result, it appears that the PWCs based on the lifting tasks rather than PWCs by ergometer or treadmill exercise should be considered to determine the physiological criterion for safe weights for lifting tasks. Therefore, the physiological criteria of the NIOSH Guideline should be reexamined.

• Journal of Veterinary Clinics
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• v.9 no.2
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• pp.391-399
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• 1992

This study was carried out to evaluate the effects of doxapram after medetomidine treatment. Twenty dogs were sedated with medetomidine(0.04mg/kg IM) Ten dogs were injected doxapram(2mg/kg IV) as a experimental group and ten dogs were injected with saline(5$m\ell$ IV) as a control group in twenty minutes after the injection of medetomidine. Recovery time, heart rate, respiratory rate, body temperature. blood chemistry, electrocardiogram findings (ECG) were recorded. The results obtained were as follows ; 1. Medetomidine revealed fast and excellent sedative effect. 2. Recovery time was shorted by doxapram(p<0.01) 3. Respiratory rates were decreased significantly by medetommidine, but increased remarkably after the injection of doxapram and them decreased gradually and revealed normal levels(p<0.01). 4. Herts rates were decreased significantly by medetomidine but increased remarkably after the injection of doxapram and then decreased gradually and revealed normal levels(p<0.01). 5. Body temperature were increased slightly and then decreased by medetomldine and in experimental group revealed with higher levels than those of control group(p<0.01) 6. Arrhythmias were observed after the injection of medetomidine, but relieved after the injection of doxapram . There was no another change on electrocardiograms.

• Journal of Chest Surgery
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• v.22 no.1
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• pp.106-115
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• 1989

Clinical results with the xenograft cardiac valves were reviewed for 212 patients who underwent heart valve replacement from January 1981 to December 1987. One hundred and twenty-four Carpentier-Edwards k 88 Ionescu Shiley valves were used. Overall operative mortality was 11 out of 212[5.1%]: 5 out of 153[3.39o] for mitral valve replacement [MVR], 2 out of 34[5.9%] for aortic valve replacement [AVR], 0 out of 4[0%] for Tricuspid valve replacement [TVR], and 4 out of 21[19.1%] for double valve replacement [DVR;MVR+ AVR]. Two hundred and one operative survivors were followed up for a total of 824.3 patient-years [a mean 3.9*1.8 yrs], and the follow up was 78.1%. The linealized complication rates were 0.1% emboli / patient-year, 1.0% endocarditis/ patient-year and 2.2% overall valve failure / patient-year. A linealized rate of primary tissue failure was 0.7*/o/ patient-year. The actuarial survival rates including the operative mortality were 92*2.8% at 4 years and 85*4.3% at 7 years after surgery using the Xenograft cardiac valves. Probabilities of freedom from thromboembolism and overall valve failure were 73*11.0% and 69*2.4% at 7 years after surgery using the Xenograft cardiac valves respectively. The intrinsic durability of the Xenograft cardiac valves appears to be relatively well satisfactory over the long term [4 to 7 years] and the risk of failure appears well balanced by the advantages of a low incidence of thromboembolism and no mandatory anticoagulant therapy.

• Journal of Korean Critical Care Nursing
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• v.3 no.1
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• pp.41-51
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• 2010

Purpose: The purpose of this study was to identify the effects of family visits upon the stress response of patients and their families, Methods: This study was the interrupted time series design, The subjects consisted of 197 patients and 197 family members in the cardiac intensive care unit of S Hospital in Bucheon. Physiological stress responses such as blood pressure, heart rates, respiration rates, and oxygen saturation were measured using HP monitors. VAS was used to measure the emotional stress. Collected data was analyzed using repeated measure ANOVA, t-test by SPSS 17.0 statistical program. Results: The family visits did not change patients' blood pressure, pulse rate, respiration rate and oxygen saturation, However the anxiety level of patients and their family members were decreased significantly during family visits. Furthermore, 30-minute family visit reduced more effectively patient's anxiety than 15-minute family visit. Conclusion: Family visits need to be used as a means of nursing intervention to ease the emotional stress of patients and their families. In addition, increasing of visiting time should be considered.

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.394-398
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• 1998

This study was performed to assess clinical signs, sedative effect and clinicschemical profile of a mixture of fentanyl-azapemne-xylazine(Fentazine$^{(R)}$) in formed elk Twelve male elk(Cervus canadensis) were immobilized with Fentazine, and blood samples were taken of femoral venous blood. Samples were analyzed in the conditions of 10- and 30-minute after administration of the drug. Heart rates, respiratory rates, and body temperatures were in normal ranges during Fentazine anesthesia. After iqiection of Fentazine, most of elk were recumbency and did not respond to needle prick In young adult(3.5.4.5 years old) elk a high dose(>3.0 ml/head) of Fentazine does not result in more sedation, but it does prolong the duration of sedative effect. Fentazine induced sufficient analgesia far velvet antler removal and hoof trimming in elk Salivation, urination, intermittent apnea and mild bloat were observed in elk Globulin, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, calcium, magnesium and phosphorus values were in normal ranges for at least 30 minutes after Fentazine administration. Total protein, albumins cortisol and prothrombin values were slightly increased during sedation(p<0.05). It was concluded that Fentazine is effective analgesic drug being useful for velvet antler removal and hoof trimming.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.151-160
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• 1997

This study was performed to assess clinical signs, sedative and physiologic effects of a combination of fentanyl, azaperone and xylazine (F-A-X). The experiments were divided into four groups; xylazine 0.1mg/kg (X 0.1), F-A-X 0.05 MG/KG (F-A-X 0.05), F-A-X 0.1 MG/KG (F-A-X 0.1) and F-A-X 0.2mg/kg (F-A-X 0.2). Heart rates were decreased in all groups. Respiratory rates were decreased in other groups, but increased in F-A-X 0.2. Body temperatures were in normal ranges. After administration of F-A-X, most of cattle were recumbency and did not respond to needle prick. Duration of sedation was prolonged with increasing dosages. F-A-X did not induce sufficient analgesia for dehorning. Side effects were salivation and urination in all, but they were much less in F-A-X groups than those in X 0.1. Intermittent apnea and bloat were observed in F-A-X 0.2. Serum chemistry values were in normal ranges exvept for hyperglycemia invreased thorough experimental time. Based on above results, it may be concluded that F-A-X is effective preanesthetic with low dosage of 0.05~0.1 mg/kg being useful for immobilization or manipulation without tissue incision in cattle.

• Proceedings of the ESK Conference
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• 1997.10a
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• pp.286-294
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• 1997

The objective of this study was to make comparison of the physical work capacities(PWCs) for three different types of tasks. For this purpose, an ergometer exercise, a treadmill exercise, and lifting activities with four different frequencies (2, 5, 8, 11 lifts/min) for the lifting range from floor to 76cm were considered. Oxygen consumption rates and heart rates were measured during the exercises and lifting activities. The PWC values for ergometer exercise test was 2562.71 ml-O$_{2}$/min and the one for treadmill exercise was 2874.89 ml-0$_{2}$/min. The value of lifting PWC increased from 1774.07ml-0$_{2}$/min to 2296.76 ml-0$_{2}$/min as the lifting frequency increased from 2 to 11 lifts/min. The ratio of the lifting PWCs to the ergometer PWCs increased from 69.36% to 89.77% as the lifting frequency increased. To the treadmill PWCs, the ratio increased from 62.21% to 85.24% as the lifting frequency increased. From this result, it is appears that the PWCs based on the lifting tasks rather than PWCs by ergometer or treadmill exercise should be considered to determine the physiological criterion for safe weights for lifting tasks. Therefore, the physiological criteria of the NIOSH Guideline should be reexamined.

• Journal of Veterinary Clinics
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• v.10 no.1
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• pp.37-46
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• 1993

This study was carried out to evaluate the effects of yohimbine on medetomidine sedation. Twenty dogs were sedated with medetomidine(0.04mg/kg, IM). Twen쇼 minutes after the injection, ten dogs were injected with saline(0.1mg/, IV)for the control group and the others were injected wi yohimbine(0.1mg/kg, IV)for the experimental group. Onset, recovery time, respiratory rate, body temperature, blood chemistry, electrocardiogram(ECG) finding were recorded. The results obtained were summarized as follows; 1. Onset of the sedation was fast and favorable. 2. Recovery time was shorted significantly by yohimbine treatment(p<0.01). 3. Respiratory rates were decreased significantly, but increased to normal level after the yohimblne treatment(p<0.01). 4. Heart rates were decreased significantly; but increased to normal level after the yohimbine treatment(p<0.01). 5. Body temperatures of dogs in the experimental group revealed higher level than those of control group(p<0.01). 6. Arrythmias were observed in both groups but relieved to normal after the yohimbine treatment. 7. Blood chemistry values were not changed significantly by medetomidine and yohimbine treatment. 8. These results showed that yohimbine is an excellent antagonist of medetomidine.

• Toxicological Research
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• v.35 no.4
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• pp.343-351
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• 2019

Many in vitro developmental toxicity assays have been proposed over several decades. Since the late 1980s, we have made intermittent attempts to introduce in vitro assays as screening tests for developmental toxicity of inhouse candidate products. Two cell-based assays which were developed two decades apart were intensively studied. One was an assay of inhibitory effects on mouse ascites tumor cell attachment to a concanavalin A-coated plastic sheet surface (MOT assay), which we studied in the early days of assay development. The other was an assay of inhibitory effects on the differentiation of mouse embryonic stem cell to beating heart cells (EST assay), which we assessed more recently. We evaluated the suitability of the assays for screening in-house candidates. The concordance rates with in vivo developmental toxicity were at the 60% level. The EST assay classified chemicals that inhibited cell proliferation as embryo-toxic. Both assays had a significant false positive rate. The assays were generally considered unsuitable for screening the developmental toxicity of our candidate compounds. Recent test systems adopt advanced technologies. Despite such evolution of materials and methods, the concordance rates of the EST and MOT systems were similar. This may suggest that the fundamental predictivity of in vitro developmental toxicity assays has remained basically unchanged for decades. To improve their predictivity, in vitro developmental toxicity assays should be strictly based on elucidated pathogenetic mechanisms of developmental toxicity.

• Hip & pelvis
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• v.34 no.2
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• pp.115-121
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• 2022

Purpose: The purpose of this study was to evaluate the wear and survival rates of third-generation ceramic heads on a conventional ultra-high molecular weight polyethylene liner. Materials and Methods: A total of 160 hips (147 patients with a mean age of 55.9 years) who underwent total hip arthroplasty using the third-generation ceramic head on a conventional polyethylene liner from March 1998 to August 2003 were reviewed retrospectively. Evaluation of the wear rate for 56 hips (49 patients) followed-up for at least 15 years was performed using the PolyWare program version 8 (Draftware Developers, USA). The Kaplan-Meier survivorship was also evaluated. Results: Linear wear and volumetric wear rates were 0.11±0.47 mm/year and 32.75±24.50 mm³/year, respectively. Nine revisions were performed during the follow-up period because of cup or stem loosening. The Kaplan-Meier survival rate, using cup revision or total revision total hip arthroplasty (THA) as the endpoint of analysis, was 93.7% at 15 years and 73.6% at 20 years. Conclusion: Because all revisions were performed between 15 and 20 years in our study, surgeons should pay greater attention to patients who underwent THA with ceramic-on-polyethylene bearing from 15 years postoperatively. Contemporary alumina ceramic on highly cross-linked polyethylene could certainly be a good alternative bearing couple providing better longevity.