• 대한치과교정학회지
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• 제23권4호
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• pp.455-474
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• 1993

Degenerative joint disease(DJD) has hun known as one of the diseases which affect the middleor old-aged people. But as orthodontists are getting interested in the adult orthodontics, it is not rare for them to meet the open-bite patients with the TMJ DJD in their clinics. The purpose of this article is to investigate the cephalometric characteristics of the open-bite cases with TMJ DJD. Twelve TMJ DJD patients($15.1\~39.5$ years old) were selected from the patients who visited Department of Orthodontics, Seoul National University Hospital. Cephalograms were taken and means from 60 measurements were compared by t-test with those of the fifty four healthy adults($20.0\~26.7$ years old) who have normal occlusion and TMJ. In this study male and female are compared respectively, for in the normal samples 26 measurements showed significant differences between the male and the female. The results and conclusions axe as follows: 1 In DJD group, ANB and Angle of convexity decreased, which means the retruding of the mandible. The interincisal angle was smaller than that of the normal group. The means of the overbite were -2.1mm in male and -3.0mm in female, and the means of the overjet were 5.6mm in male and 6.7mm in female. The profile was similar to that of Angle's Class II div.1 open-bite. 2. SN-GoMe and FMA increased in DJD but SN-PP and FH-PP did not show any significant difference. In TMJ DJD open-bite cases, the bony structure lower than the palatal plane seemed to play an important role in developing open-bite. 3. In DJD group, PH-ArGo, SArGo and Y-sxis angle increased significantly, but genial angle showed no significant difference. The means of hか were 50.1mm in male and 40.2mm in female, which were significantly smaller than those of the normal(56.5mm in male, 50.9mm in female). These findings seemed to indicate the posterior rotation of mandible resulted from the shortening of the ramus height. 4. Anterior faical height(AFH), upper anterior facial height(UAFH) and lower anterior facial height (LAEH) of DJD showed no significant increase as compared with those of the noraml group. There was no significant difference in the ratio of upper anterior facial height to lower anterior facial height(UAFH/LAFH). But, lower posterior facial height(LPFH) was significantly smaller than that of the normal group. 5. It was thought that the peculiar profile of the TMJ DJD open-bite was resulted from the posterior rotation of mandible as the ramus became short following the degerative destruction of of the condylar head and neck.

• 기본간호학회지
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• 제3권1호
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• pp.68-80
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• 1996

Long-term hemodialysis(HD) patients manifest various signs of protein and caloric malutrition due to poor intake of nutrients and other causes. Poor nutritional status increases the mortality and morbidity rates in HD patients. Thus, mataintnance of adequate nutritional status has been a major task in taking care of patients receiving HD. This study was to evaluate the nutritional status of HD patients and to clarify the degree of nutritional deficit based on usual dietary intake, anthropometric and biochemical indicators. Sixty HD patients comprised a HD group, while the control group consisted of 60 healthy adults whose age and sex matched those of the HD group. Nutritional status was evaluated by dietrary intake using instant nutritional scale, anthropometric measures, serum protein concentrations and the number of lymphocytes. The data were analyzed by using Chi-square test and unpaired t-test. The results are as follows. 1. Regarding usual dietary intake of HD group. 1) Estimated caloric intake was significantly lower than the recommended daily allowance(RDA) and among them, 35% were taking calories less than 85% of the RDA. 2) Estimated protein intake was significantly higher than the RDA and among them 40% were taking protein more than 115% of the RDA. 3) Estimated fat intake was lower than the RDA. 4) Vitamin A, B, $B_1,\;B_2$, C and niacin in take was lower than the RDA respectively. 5) Estimated ferrous intake was within the normal limit the RDA while estimated calcium intake was higher than the RDA. 6) Both calorie and protein intake were higher for the 10 patients who had been under continuous ambulatory peritoneal dialysis than for the patients under HD from the beginning. 2. Regarding anthropometric measures : 1) Body mass index(BMI), midarm circumference(MAC), and triceps skinfold thickness(TSF) were lower in the HD group than in the control group. 2) Among HD group, 47.1% were within the normal limit of BMI, while 86.7% were within the same limit in the control group. 3) Among HD group, 35.0% were within the normal limit of MAC, while 83.3% were within the same limit in the control group. 4) Among HD group, only 8.3% were normal, 30.3% were mild deficit status of TSF, while 50% were normal and 48.3% were mild deficit status in the control group. 3. Regarding biochemical laboratory tests 1) Albumin, transferrin concentrations and the number of lymphocytes were lower in HD group than in the control group. 2) Among HD group, 98.3% were within the normal limit of albumin concentration and all were within the same limit in the control group. 3) Among HD group, only 11.7% were within the normal limit of transferrin concentration, while 81.7% were within the same limit in the control group. 4) Among HD group, 25% were within the normal limit, while 93.3% were within the same limit in the control group. The above findings suggest that HD patients were in nutritional deficit status. Adequate diet therapy and periodical evaluation of the nutritional status in HD patients are needed. Accordingly, it turned out that anthropometric measures were very reliable parameters and easy to use to evaluate nutritional status. So nurses are encouraged to adopt anthropometric measures to examine nutritional deficit status of HD patients.

• 대한소아치과학회지
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• 제36권3호
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• pp.377-384
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• 2009

이 연구의 목적은 카르복시메틸셀룰로오스 기저재에 불소를 분사하여 제작한 불소 테잎을 피실험자의 구강 내에 도포 후 잔류하는 불소의 농도를 측정하고자 하는 것이다. APF gel(60seconds $taste^{(R)}$, 1.23% APF gel, Group I), Fluoride varnish($CavityShield^{TM}$, 5% NaF, Group II), Fluoride tape(SCMC-T-5, 5% NaF, Trial product, Group III)을 군별로 9명씩 건강한 20대 남녀성인의 구강에 도포 후 1시간, 3시간, 5시간, 7시간, 1일, 2일, 3일 후 비자극성 전타액내 불소농도를 불소이온전극을 이용하여 측정하였으며 다음과 같은 결과를 얻었다. 1. 1, 2, 3일 후와 비교하여 모든 그룹에서 7시간 까지 초기농도보다 유의하게 높은 불소농도를 보였다. 도포 후 1, 2, 3일에는 초기농도와 통계적으로 유의한 차이를 보이지 않았다(p>0.05). 2. 도포 후 1, 3, 5, 7시간에 타액 내 불소농도는 모든 시간에서 2군, 3군, 1군 순으로 높았다. 3. 도포 후 1시간과 3시간 후에 2군의 불소농도는 3군에 비하여 유의하게 높았으나(p<0.05) 1군과 3군 사이에는 통계적으로 유의한 차이가 없었다(p>0.05).

• 대한한의학회지
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• 제35권1호
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• pp.50-57
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• 2014

Objectives: The purpose of this study was to examine whether Temporomandibular Joint Balance Appliance-Golf (TBA-G) can improve postural control ability of healthy adults. Methods: Twenty participants (10 male, 10 female) aged 20 to 39 years were involved. Postural control ability of all participants was assessed before and after applying TBA-G with Balance $Master^{(R)}$ system. Modified clinical test sensory interaction on balance (mCTSIB), unilateral stance, weight bearing and rhythmic weight shift were used to evaluate postural control ability. Results: After applying TBA-G, mCTSIB on a firm plate with eyes open increased from 0.2 to 0.23 (p<0.05) but directional control was improved in slow and moderate velocity of front/back rhythmic weight shift test (P<0.05). In two cases with postural imbalance, most of the postural control measures improved after applying TBA-G. Conclusions: The results suggest that TBA-G could improve balance control ability. A larger controlled trial is needed to determine more accurately the effect of TBA-G on balance control ability.

• Clinical and Experimental Pediatrics
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• 제54권8호
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• pp.335-339
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• 2011

Purpose: Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in elevated plasma homocysteine concentrations and are known to be associated with the development of coronary artery disease. Our hypothesis is that single nucleotide polymorphisms (SNPs) of the MTHFR gene are related to the development of KD and coronary artery lesions (CALs). Methods: For this study, we selected 3 candidate single nucleotide polymorphisms (SNPs) (rs2274976, rs1801131, and rs1801133) of MTHFR. These SNPs are located on chromosome 1p36.3. We included 101 KD patients and 306 healthy adults as controls in this study. CALs were seen in 38 patients. Genotypes of the selected SNPs were determined by direct sequencing and analyzed with SNPAlyze. Results: The genetic distribution and allelic frequency of the 3 MTHFR SNPs (rs2274976, rs1801131, and rs1801133) were not significantly different in patients with KD compared to the control group (P=0.71, 0.17, and 0.96, respectively). There was no difference in the genetic distribution of the MTHFR SNPs between the normal control group and the CAL group (P=0.43, 0.39, 0.52 respectively). Conclusion: The genetic distribution of the MTHFR SNPs (rs2274976, rs1801131, and rs1801133) was not different in the KD group compared to the control group. In addition, the genetic distribution of these SNPs was not different in the CAL group compared to the control group in the Korean population.

• 농촌의학ㆍ지역보건
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• 제25권2호
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• pp.315-326
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• 2000

본 연구는 농촌지역 청소년들의 건강 행태와 최근 청소년들에게 중요한 문제가 되고있는 성 문제, 약물 남용, 청소년 폭력과 정신 보건 관련 문제를 전반적으로 파악하고 이들간의 관련성을 분석하고자 시도되었다. 본 연구에서 얻은 연구 결과를 요약하면 다음과 같다. 첫째, 조사 대상 학생들의 대부분이 자신의 건강상태를 건강하다고 인지하고 있었으나 건강에 대한 관심도는 70% 정도만이 관심을 가지고 있었다. 둘째, 대상 학생들의 건강행태와 비행행태 조사결과 타지역에 비하여 성경험률, 약물 사용률은 낮았으나 흡연률, 음주율은 오히려 높았으며 수면 시간도 부족한 것으로 나타났다. 셋째, 건강관련 행태와의 관련 요인을 분석한 결과 인구 사회학적 특성 중에서는 남자인 경우에서, 중학생에서, 용돈이 적은 경우와 성적이 높은 경우에서 건강행태 실천률이 높았고 건강에 대한 관심이 높을수록, 자살시도를 한 경우보다는 자살 시도 경험이 없는 경우에서, 중학생에서, 건강행태가 양호하였다. 이러한 결과를 종합할 때 농촌 지역 청소년들이 다양한 건강관련 문제점에 직면하고 있음을 알 수 있다. 따라서 대상지역 학생들의 다양한 건강관련 문제점을 파악하고 이를 바탕으로 사업의 우선순위를 선정하여 건강행태를 긍정적으로 개선하고 관리 해나자는 한편 건강에 대한 관심을 증대시키려는 노력이 더욱 활성화되어져야 하겠다.

• 대한화장품학회지
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• 제45권4호
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• pp.353-361
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• 2019

본 연구에서는 Fervidobacterium islandicum AW-1를 이용하여 케라틴 펩타이드를 생산하고, 두피 및 모발에 관련된 인자를 확인하여, 화장품 원료로서 케라틴 펩타이드의 가능성을 알아보았다. 모유두 세포주에 케라틴 펩타이드를 농도에 따라 세포 독성 및 증식을 살펴본 결과, 세포 독성은 나타나지 않았고, 세포증식에도 효과가 없었다. 케라틴 펩타이드를 함유한 헤어 샴푸, 헤어 에센스를 제조하여 인체 첩포 시험을 거쳐 무자극을 확인하였다. 30 명의 건강한 성인 피험자를 대상으로 4 주 동안 샴푸 및 에센스를 2 그룹으로 나누어 사용한 결과, 육안평가에서 윤기, 탈모, 두피 트러블, 푸석거림에서 통계적으로 유의한 긍정적 결과를 나타내었다. 두피 수분량은 샴푸와 에센스 사용 전 대비 2, 4 주 후에 통계적으로 유의한 증가를 나타내었다. 두피에 대한 경피수분손실양은 에센스를 사용한 그룹에서 사용 전 대비 4주 후에 통계적으로 유의한 감소를 나타내었다. 두피 피지량 역시, 에센스를 사용한 그룹에서 사용 전 대비 4 주 후에 통계적으로 유의한 감소를 나타내었다. 정상 모발, 손상 모발을 이용한 헤어 샴푸와 에센스의 사용 전후의 빗질에 의한 마찰력을 측정한 결과, 사용 전 대비 모두 통계적으로 유의한 변화를 나타내었다. 정상 모발의 경우, 사용 전보다 빗질의 마찰력이 증가하였고, 손상 모발의 경우 사용 전보다 빗질의 마찰력이 감소하였다. 이를 통해 케라틴 펩타이드는 모발 및 두피 관련한 제품에 사용할 수 있는 원료로 확인하였다.

• 대한바이러스학회지
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• 제27권2호
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• pp.161-168
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• 1997

The present study was designed to estimate the seroprevalence of NLVs among diarrheagenic children and in healthy adults in Seoul and its vicinity with the use of an EIA and an Western blot (WB) based on recombinant Norwalk virus capsid protein (rNV) and crude virus preparations as antigen. Seroconversion was observed in 34 (83%) of 41 tested using the EIA and in 21 (54%) of 39 using the WB, suggesting that the NLVs with epitopes common to rNV are prevalent in Seoul area. Diarrheal children who were known to have been infected with several other strains of the NLVs showed no significant antibody response to the rNV. Infection with rNV occurred earlier in life: primary infections with rNV were common before the age of 6 months and over 91 % of children had evidence of infection by that age by the EIA. Since the amount of the NLV antigens available for seroepidemiologic surveys is limited, we tried to detect NLV antibody by using crude virus preparations as antigen. One crude virus preparation of a child whose stool yielded genetically distinct NLV revealed the presence of the plural number of bands upon SDS-PAGE, but precipitated only one band (62 kDa) after the WB with a serum (collected 10 days after the onset of symptoms) of another diarrheal child. The WB assay we present in this report revealed that the NLVs are prevalent among Korean population and that the sera contained antibody to a single major structural protein, with molecular sizes of 58 to 62 kDa, compatible with the sizes reported for the Norwalk virus and Snow Mountain agent proteins, respectively. When the results of the WB were compared with those obtained by the EIA, the EIA antibody assay was sensitive enough to detect an antibody rise of as much as 4096-fold but not as specific as the WB. The WB assay presented in this paper will provide a powerful tool to elucidate not only antigenic structures of the NL Vs but also seroepidemiology of the NLV infection. The availability of an unlimited source of antigen will enable a large scale serologic studies that will greatly increase our understanding of the role of NLVs in human enteric illness.

• 한국운동역학회지
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• 제25권3호
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• pp.275-281
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• 2015

Objective : In order for Taekwondo athletes to perform destructive kicking performance, they are expected to have Taekwondo-specific muscle properties such as high muscle strength and power. The purpose of this study was to investigate the joint angle-dependent force-producing property of Taekwondo athletes' knee extensor muscles, which is one of the primary muscle groups involved in kicking performance. Method : Ten Taekwondo male athletes (age: $19.9{\pm}0.7yrs$, height: $180.6{\pm}6.2cm$, body mass: $75.9{\pm}8.9kg$, career: $9.2{\pm}2.9yrs$.) and 10 healthy male non-athletes (age: $26.3{\pm}2.6yrs$, height: $174.2{\pm}4.8cm$, body mass: $72.8{\pm}7.7kg$) participated in this study. Subjects performed maximum isometric knee extension at knee joint angles of $40^{\circ}$, $60^{\circ}$, $80^{\circ}$, and $100^{\circ}$ (the full knee extension was set to $0^{\circ}$) with the hip joint angles of $0^{\circ}$ and $80^{\circ}$ (the full extension was set to $0^{\circ}$). During the contractions, knee extension torque using an isokinetic dynamometer simultaneously with muscle activities of the rectus femoris (RF), and the vastus lateralis (VL) and vastus medialis (VM) using surface electromyography were recorded. Based on the torque values at systematically different knee-hip joint angles, the joint torque-angle relationships were established and then the optimal joint angle for the knee extensor was estimated. Results : The results of this study showed that the isometric knee extension torque values were greater for the Taekwondo athletes compared with the non-athlete group at all hip-knee joint angle combinations (p<.05). When the hip joint was set at $80^{\circ}$, the peak isometric torque was greater for the Taekwondo athletes compared with the non-athlete group ($313.61{\pm}36.79Nm$ and $221.43{\pm}35.92Nm$, respectively; p<.05) but the estimated optimum knee joint angles were similar ($62.33{\pm}5.71^{\circ}$ and $62.30{\pm}4.67^{\circ}$ for the Taekwondo athletes and non-athlete group, respectively). When the hip joint was set at $0^{\circ}$, the peak isometric torque was greater for the Taekwondo athletes compared with the non-athlete group ($296.29{\pm}45.13Nm$ and $199.58{\pm}25.23Nm$, respectively; p<.05) and the estimated optimum knee joint angle was larger for the Taekwondo athletes compared with the non-athlete group ($78.47{\pm}5.14^{\circ}$ and $67.54{\pm}5.77^{\circ}$, respectively; p<.05). Conclusion : The results of this study suggests that, compared with non-athletes, Taekwondo athletes have stronger knee extensor strength at all hip-knee joint angle combinations as well as longer optimum muscle length, which might be optimized for the event-specific required performance through prolonged training period.

• 대한임상전기생리학회지
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• 제10권2호
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• pp.7-14
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• 2012

Purpose : This study investigated the validity of crosswalk signal time length with regards to elderly stroke patients. Methods : We recruited 60 elderly adults sixty years of age or older for our study. The participants were divided into three groups.Group A consisted of 20 healthy participants with no walking aids. Group B consisted of 20 stroke patients with no walking aids. Group C consisted of 20 stroke patients using a cane as a walking aid. We measured the walking times of participants for 7 m, 14 m and 21 m lengths. Results : Using an independent t test, there was a statistically significant difference in the walking times between Group A and Group B for all lengths. There was a statistically significant difference in the walking times between Group A and Group C for all lengths. There was no statistically significant difference in the walking times between Group B and Group C. There was a statistically significant difference between the three group when using ANOVA. Conclusion : From the results of this study, we infer that the signal times at crosswalks are inappropriate for elderly stroke participants who use a cane as a walking aid. Therefore further research should be conducted to determine the appropriate amount of additional time needed for the elderly to safely cross the street.