• Journal of Preventive Medicine and Public Health
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• 제26권3호
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• pp.332-346
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• 1993

성인 남성들에서 여가시간의 육체적 활동량의 분포를 파악하고 관상동맥질환의 위험인자들과의 관련성을 보기위해 경상북도에 소재하는 일개 제철회사의 남성 근로자 277명을 연구대상자로 선정하였다. CARDIA 연구의 Physical Activity History questionnaire를 변형한 설문지를 이용하여 연구대상자들의 여가시간의 육체적 활동에 대해 면담조사하였다. 공복시 혈액 5ml를 채취하여 혈청 총콜레스테롤, 중성지방 및 혈당량을 측정하였고, 신장, 체중 및 혈압을 측정하였다. 흡연습관과 음주습관, 교육 수준 및 그 밖의 사항들은 설문지를 이용하여 면담조사하였다. 연구대상자들의 여가시간의 육체적 활동에 의한 에너지 소모량의 기하 평균치는 212.80 kcal/week이었고, 전체 대상자 중 여가시간에 2,000 kcal/week이상 육체적 활동을 하는 사람의 비율은 22. 4%이었다. 설문지의 항목들 중 대상자들이 여가시간에 하는 운동으로 가장 많은 것은 산보나 등산, 조깅 혹은 달리기 등이었다. 전체 대상자들에서 연령별, 교육수준별, 근무기간별, 흡연 및 음주습관별 주당 여가시간의 육체적 활동량이 유의한 차이를 보이지 않았으나, 작업 중 격렬한 노동을 하는 사람들이 안 하는 사람들에 비해 주당 여가시간의 육체적 활동량이 많은 것으로 나타났다(p<0.05). 여가시간의 육체적 활동량과 관상동맥질환의 위험인자들과의 관련성을 보고자 여가시간의 육체적 활동량을 중등도 이상의 활동을 전혀 안 하는 경우, 총 활동량이 2,000 kcal/week 미만인 경우 그리고 총 활동량이 2,000 kcal/week 미만인 경우의 세 군으로 나눈 후 BMI, 수축기 및 이완기혈압, 혈청 총콜레스테롤, 중성지방, 공복시 혈당량의 평균을 비교하였으나 통계적으로 유의한 차이를 보인 것은 없었다.

• 대한수의학회지
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• 제14권1호
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• pp.59-71
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• 1974

The studies were conducted on the allergic skin reaction of bovine eurytremiasis. In order to confirm the appearance of allergic skin reaction in this disease, a protein fraction of Eurytrema SPP(EPF) was extracted, and it's antigenicity was studied by means of intradermal reaction on the rabbits, goats and bovine. Rabbits used in this studies were divided into three groups: the first group was sensitized with EPF, the second group was sensitized with EPF, and the third group was served as control which is consisted with 5 non-sensitized and 2 saline injected rabbits. Three healthy native goats and bovine also used. Among these, 86 cases were eurytremiasis, 31 cases were fascioliasis and 71 cases non-infected. A protein fraction was also made from adult worm of Fasciola SPP(FPF) and tested the cross reaction between these two different fluke infestations. The results obtained were as follow: 1. Intradermal reaction was appeared in the infected cattle(bovine eurytremiasis) as well as in the EPF sensitized rabbits and goats. 2. In the EPF sensitized rabbits, the wheal of the intradermal reaction reacted the maximum size (increased wheal size of 5.0 to 9.0 mm) in 40 to 60 minutes and erythema in 60 minutes after intradermal injection of EPF antigen. In the EPF sensitized goats, the size of wheal reacted the maximum(increased wheal size of 5.5 to 8.0 mm) in 30 to 40 minutes, and then disappeared in 120 to 180 minutes after injection of EPF antgen. On the contrary, in the control groups of rabbits and goats, the wheal (7.0 mm) produced following antigen injection reached only to 7.5 to 8.5 mm. in 10 minutes without developing erythema, and then perished in 40 to 60 minutes after injection of EPF antigen. In the infected cattle, the wheal of the intradermal reaction reached the maximal sizes(increased wheal size of 4.0 to 11.0 mm) in 15 to 20 minutes and perished in 60 to 90 minutes after injection of EPF antigen. 3. It would be standardized that the positive reaction is above 4.0 mm, the negative below 2.0 mm and the suspective is 3.0 mm of the infected cattle. In the results of intradermal reaction, 87.2%(75 of 86 cases) was positive, 4.7%(4 of 86 cases) negative and 8.1% (7 of 86 cases) was suspective. However, in the non-infected control cattle, the wheal produced following injection disappeared in 30 to 40 minutes without increasing the wheal size in the most subjects or with incresing only to 1.0 to 2.0 mm in a few cattle. 4. In the results of intradermal reaction which were reciprocally tested in EPF sensitized rabbits by FPF antigen and in FPF sensitized. rabbits by EPF antigen, there were cross reacted. In the 31 cases if fascioliasis tested by EPF antigen, 11 cases were not specifically reacted with EPF antigen. Judging from the results of cross reaction in experimental rabbits and natural bovine fascioliasis, it would be expected when both EPF and EPF antigens are given intracutaneously on the same bovine patients of eurytremiasis or fascioliasis, the former antigen will produce the larger wheal in eurytremiasis, while the latter antigen will produce also the larger wheal in fascioliasis.

• 한국산업보건학회지
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• 제24권3호
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• pp.310-320
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• 2014

Backgrounds: Endotoxin, which found in the outer membrane of the gram-negative bacteria cell wall, makes up almost all of the lipopolysaccharide(LPS). When people are exposed to endotoxin,it can result in diverse health effects such as an airway irritation and inflammation, fever, malaise, bronchitis, allergic asthma, toxic pneumonitis, hypersensitivity lung disease. Cases among the elderly, children or pregnant can occur more frequently than a healthy adult if they are repeatedly exposed to the existing endotoxin. Therefore, we investigated and assessed the environmental characteristics associated with the airborne endotoxin concentration level in six hospital lobbies. Method: Endotoxin from indoor air in six hospital lobbies was measured by an area sampling method and analyzed according to American Society for Testing and Materials International(ASTM international) E2144-01. Total suspended particulate(TSP), carbon dioxide($CO_2$), temperature and humidity were also measured by using direct reading measurements or airborne sampling equipment at the same time. Environmental characteristics were appropriately divided into two or three groups for a statistics analysis. One-way analysis variable(one-way ANOVA) was used to examine a difference of the endotoxin concentration, depending on the environmental characteristics. In addition, only variables with p-value(p<0.25) were eventually designed to the best model by using multiple regression analysis. Results: The correlation analysis result indicated that TSP(p=0.003) and $CO_2$(p<0.0001) levels were significantly associated with endotoxin concentration levels. In contrast, temperature(p<0.068) and humidity(p<0.365) were not associated with endotoxin concentration. Levels of endotoxin concentration were statistically different among the environmental characteristics of Service time(p=0.01), Establishment of hospital(p<0.001), Scale of hospital(p=0.01), Day average people using hospital(p=0.03), Cleaning time of lobby(p=0.05), Season(p<0.001), and Cleaning of ventilation system(p<0.001) according to ANOVA. Finally, the best model(Adjusted R-square=72%) that we designed through a multiple regression test included environmental characteristics related to Service time, Area of lobby, Season, Cleaning of ventilation system, and Temperature. Conclusions: According to this study, our result showed a normal level of endotoxin concentration in the hospital lobbies and found environmental management methods to reduce the level of endotoxin concentration to a minimum. Consequently, this study recognized to be requirement for the management of ventilation systems and an indoor temperature in order to reduce the level of endotoxin concentration in the hospital lobbies.

• 한국치위생학회지
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• 제13권1호
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• pp.89-97
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• 2013

Objectives : For investigating relationship between oral condition and body mass of adolescent period and helping to make basic data which make oral care systematically while performing health care for adolescent. Methods : This research was carried out by performing oral and physical test of 273 high school students in some reasons from July 2nd to 16th in 2012. Results : There were significant differences, since the more subjects had irregular occlusion, the more they had loosing tooth(p<0.05). There was a significant difference, since when subjects had more numbers of regular occlusion, they had higher BMI and heavier weight.(p<0.001). There are significant different, since when the subjects had worse peridontal condition, they had more numbers of DT(p<0.001). There was a significant difference in occlusion and body mass group, since when subjects had regular occlusion, 46.4% of subjects were standard body weight, 41.0% of subjects were overweight and when subjects needed orthodontics, 52.7% of subjects were standard body weight, 33.8% of subjects were low-weight, and 13.5% of subjects were overweight(p<0.001). In the correlation between oral condition and BMI, DT index showed negative interrelation with FT index(r=-0.179) and positive interrelation with periodontal condition(r=0.221), MT index showed positive interrelation with occlusion(r=0.137) and FT index showed positive interrelation with height(r=0.136). BMI showed highly positive interrelation with weight(r=0.940), and when occlusion was worse, it shows negative interrelation with BMI(r=-0.293). Height showed highly positive interrelation with weight(r=0.447), and when the more subjects had malocclusion, it showed low negative interrelation with weight (r=-0.257). Conclusions : It was considered that an adolescent period forms health habits, so it was important to increase health action through education for growing healthy adult and not only guiding improvement of dietary life for keeping normal weight, but also conducting oral health education for treating regular occlusion of oral condition and prosthetic procedures for loosing tooth right time.

• Applied Microscopy
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• 제27권1호
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• pp.13-30
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• 1997

The experiment was performed to study the morphological responses of the thymus of the mice, to antitumour agents (5-Fluorouracil or mitomycin C). Healthy adult mice weighing 25 gm each were divided into normal and experimental groups. 5-Fluorouracil (60 mg/kg) or Mitomycin-C $(400{\mu}g/kg)$ were injected subcutaneously to the animals every other day. Animals were sacrificed at 4 days and 7 days following the first injection. Pieces of the tissue taken from the thymus were prefixed with 2.5% paraformaldehyde-l.5% glutaraldehyde, followed by post-fixation with 1% osmium tetroxide. Ultrathin sections stained with uranyl acetate and lead citrate were observed with a JEM 100 CX-II electron microscope. The observed results were as follow: 1. Apoptoses of T-lymphocytes were observed more frequently in the thymus of the experimental groups than in those of a normal group. 2. In the experimental group, the plasma cells with distended cisternae of the granular endoplasmic reticulum and the eosinophile leukocytes were observed frequently. 3. In the experimental group, newly forming Hassall's corpurscles were observed frequently. 4. In the mitomycin-treated group, the epithelial reticular cells containing distended perinuclear cisternae, distended the granular endoplasmic reticula and pyknotic nuclei were observed in the cortico-medullary junctional area. 5. In the mitomycin-treated group, nuclear bodies with medium electron dense materials were often observed in the T lymphocyte. 6. In the 5-fluorouracil-treated groups, fused and dissolved tonofilament bundles and apoptotic bodies were observed in the some epithelial reticular cells in the medullary area. 7. In the 5-fluorouracil-treated groups, some elongated and bar-shaped lysosomes with electron lucent gap were often observed in the macrophages. 8. In the 5-fluorouracil-treated group, membrane complex of the smooth endoplasmic reticulum were ofen observed in the macrophage. From the above results, it was suggested that 5-fluorouracil or mitomycin could induce rapid involution of the thymus, and disturb maturation and differentiation of T lymphocytes, and, in turn, supress immunity.

• 보건교육건강증진학회지
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• 제21권4호
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• pp.35-49
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• 2004

The purpose of this study was to analyze variables associated with smoking and selected health behaviors. This study targeted adult men and women over 20 of age. The sample population was drawn from the national sample, and the samples were chosen from the telephone book. A total of 1,500 cases were collected through a telephone based interview survey. As a tool for this study, a structured questionnaire was developed. the variables included self-perceived health status, and selected 7 health behaviors; smoking behavior, physical activities, eating habit, weight control, alcohol consumption, stress management, and cancer exam. The healthy life practice actions of Trans-theoretical model have been classified into five stages. Smokers were more likely than non-smokers to positive attitudes toward smoking and the impact of smoking in this study. This means that smokers's awareness toward the impact of smoking is very week. Smoking behavior was significantly related to other health related behaviors based on the correlation analysis. However, gender, engaging in regular physical activities, moderate consumption of alcoholic beverages, and receiving a cancer examination were the variables that can explain and predict a person's stages of adopting a non-smoking behavior. Self perceived health status was closely related to other health behaviors. Gender, age, and monthly household income were important demographic variables that have significant relationship with the self-perceived health status. Among the health behaviors, regular physical activities and weight control were significant predictable variables. Similar results have been found in the National health and Nutrition examination survey in Korea. As a result of this study, it was found that among the selected health behaviors, engaging in physical activity was an important variable to increase positive sense of health and non-smoking behaviors. Educational and policy level input is needed to increase awareness and provide chances to participate in fitness activities. To those who maintain exercise, the environmental support and diffusion of knowledge information and education data should be strengthened. To change attitudes toward smoking, more in-dept awareness campaign and education should be provided according to people's different behavioral status. In addition, not only diffusing health education data and delivering knowledge information through related programs, but also environmental support system that helps an individual maintain his/her action is required. Such a support system means settlement of the health enhancement base of school, workplace and community should be carried out, and the policy level support and regular programs should be provided and spread to the unit of community.

• 대한임상독성학회지
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• 제11권2호
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• pp.114-118
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• 2013

Purpose: The aim of this study is to estimate one mouthful volume in a single swallow and average volume per swallow (AVS) in multiple swallows in the situation of toxic liquid poisoning. Methods: Thirty five men and 35 women were included in this study. Each subject was asked to drink one swallow and three consecutive swallows from bottle containing water and a bottle containing saline separately. We calculated one mouthful volume in a single swallow and AVS in three swallows. One mouthful volume and AVS were compared according to sex and content, respectively. One mouthful volume of water and saline was then compared with AVS of each. Results: Sixty seven adults(34 men; $26.9{\pm}3.2$ years, 33 women; $25.6{\pm}2.4$ years) completed the study. Men had larger one mouthful volume of water($49.1{\pm}19.9$ ml vs $39.7{\pm}10.2$ ml, p=0.02) and saline($20.7{\pm}10.9$ ml vs $14.0{\pm}4.6$ ml, p=0.004) and AVS of water($28.5{\pm}11.9$ ml vs $21.5{\pm}5.9$ ml, p=0.004) and saline($11.9{\pm}6.3$ ml vs $7.9{\pm}2.0$ ml, p=0.001) than women. One mouthful volume and AVS of saline swallow were lower than those of water swallow. AVS of three consecutive swallows was lower than one mouthful volume in water and saline swallow. Conclusion: We suggest that one mouthful volume in a single swallow is 21 ml in men and 14 ml in women and AVS in multiple swallows is 12 ml in men and 8 ml in women. AVS in multiple swallows is two-threefold lower than reference values(20~30 ml) commonly used in poisoning study.

• 동아시아식생활학회지
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• 제16권1호
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• pp.54-64
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• 2006

The traditional Korean diet, which is high in rice and vegetables, is fast being replaced by a Western style diet as the standard of living goes up. In addition to this, cigarette smoking has taken on serious proportions, especially amongst those of the younger generation. Because Seoul (and it's surrounding areas) is the hub of Education and Business, it is densely populated and heavily polluted Consequently health-related issues and diseases are starting to resemble those prevalent in Western communities. Historically, stomach cancer was the #1 killer-disease in Korea, but nowadays lung cancer ranks either 1st or 2nd on the list of killer-disease in Korea. This is presumably due to the lethal combination of heavy smoking and pervasive air pollution. Despite these disquieting facts, almost no study had been made of the nutritional patterns and dietary habits of smoking and non-smoking young adults in the Seoul area. Therefore the purpose of this study is to compare the dietary and nutritional patterns of young smokers with those of young non-smokers in and around Seoul. This is done with regards to their eating habits and lifestyles, as well as the dietary components that contribute towards maintaining good health. The results showed that compared to non-smokers, smokers manifested irregular eating patterns and also tended to overindulge on fast- or junk foods. In contrast to this, non-smokers enjoyed a healthier diet, which was high in brown rice, grains, legumes, fresh fruit and vegetables, and 'kimchi'. Amongst the male subjects of this study, it was found that smokers consumed significantly less vitamin $B_2$, calcium, and phosphorous than non-smokers. It was also established that in general, stress-generated smoking habits were formed during the high school years of the younger generation. In conclusion: Because smokers maintain a less healthy diet and life-style, it is to recommended that a 'Health Education Program' be developed which could guide young smokers into adopting better dietary habits and life styles.

• 치위생과학회지
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• 제15권3호
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• pp.333-339
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• 2015

본 연구는 성인의 치아우식증에 영향을 미치는 관련요인을 알아보고자 제6기 1차년도(2013년) 국민건강영양조사중 건강설문 검진조사, 영양조사를 완료한 10,113명 중 만 19세 이상의 성인과 영구치우식 유병자 여부 카테코리에 대한 정보가 갖춰진 4,843명을 최종 분석대상자로 복합표본분석을 실시하였으며, 연구결과는 다음과 같다. 사회 경제적 특성에 따른 치아우식증 유병률은 성별에서 남자가 여자보다 높았으며(p<0.001), 연령별로는 30대, 20대, 40대, 60대 이상, 50대 순으로 나타났다(p<0.05). 교육수준에 따라서는 고졸, 중졸, 대졸 이상 순으로 나타났고(p<0.05), 월 소득수준은 '하'인 경우 가장 높게 나타났다(p<0.001). 건강관련 생활양식에 따른 치아우식증 유병률은 흡연자가 비흡연자보다 높게 나타났으며(p<0.001), 비만의 경우 정상보다 다소 높았으며(p<0.05), 구강검진을 받지 않은 경우가 받는 경우보다 높았다(p<0.001). 일일 칫솔질 횟수가 증가할수록(p<0.05), 치실, 치간칫솔을 사용하는 경우 치아우식증 유병률이 감소하는 것으로 유의하게 나타났다. 치아우식증 여부를 종속변수로 로지스틱 회귀분석을 실시한 결과 치아우식증에 영향을 미치는 변수로는 성별, 연령, 소득수준, 흡연, 구강검진, 치실사용 등으로 나타났다. 이상의 결과를 종합해 보면 한국 성인의 사회 경제적 요인 및 생활양식은 치아우식증에 영향을 미치는 것으로 확인되었으며, 성인의 치아우식증 예방 및 구강건강을 향상시키기 위해서는 건강한 생활습관을 실천할 수 있는 구강건강교육 및 실천 프로그램의 개발이 필요하다고 생각되었다.

• 생명과학회지
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• 제24권3호
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• pp.311-317
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• 2014

Rimed vacuole을 가진 원위 근육병(distal myopathy with rimmed vacuoles, DMRV)은 제2형 유전성 봉입체 근육병으로도 불리며 초기 성인기에 발병하여 원위부의 근력약화를 보이는 임상양상과 rimmed vacuole의 근육병리소견을 특징으로 하는 상염색체 열성의 근육병이다. 이러한 DMRV의 원인은 UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) 유전자의 돌연변이임이 밝혀져 있다. 저자들은 원위부 근력약화를 호소하는 환자에서 전체 엑솜 염기서열분석을 이용하여 GNE 유전자의 복합 이형접합성 돌연변이(p.Asp176Val 및 p.Val572Leu)를 확인하여 DMRV를 진단할 수 있었다. 본 연구는 근육병의 정확한 분자진단에 있어서 전체 엑솜 염기서열분석의 유용성을 보여주었기에 이를 보고하는 바이다.