• Nutrition Research and Practice
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• 제7권3호
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• pp.224-232
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• 2013

The objective of this study is to identify the dietary patterns associated with the risk of hypertensions among Korean adults using data from the Korean National Health and Nutrition Examination Survey (KNHANES, 2008-2010). This study analyzes data from 11,883 subjects who participated in the health and nutrition survey, aging from 20 to 64 years. We performed factor analysis based on the weekly mean intake frequencies of 36 food groups to identify major dietary patterns. We identified three major dietary patterns in both sexes, namely "traditional", "western" and "dairy and carbohydrate" patterns. Participants in the highest quartile of western pattern scores had significantly higher blood pressure, serum total cholesterol, and triglyceride levels than those in the lowest quartile. Although not statistically significant, a trend (P for trend = 0.0732) toward a positive association between the western dietary pattern and hypertension risk was observed after adjustments for age, sex, education, income, body mass index (BMI), smoking, physical activity, and energy intake. The dairy and carbohydrate pattern was inversely related with BMI and blood pressures and positively associated with serum high-density lipoprotein (HDL)-cholesterol. After adjusting the age, sex, education, income, BMI, smoking, physical activity and energy intake, the dairy and carbohydrate pattern showed inverse associations with hypertension prevalence (OR = 0.64, 95% CI = 0.55-0.75; P for trend < 0.0001). Intakes of fiber, sodium, and antioxidant vitamins were significantly higher in the top quartile for the traditional pattern than in the lowest quartile for the traditional pattern (P for trend < 0.0001). Intakes of fiber (P for trend < 0.0001), calcium (P for trend < 0.0001), retinol (P for trend = 0.0164), vitamin $B_1$ (P for trend = 0.001), vitamin $B_2$ (P for trend < 0.0001), niacin (P for trend = 0.0025), and vitamin C (P for trend < 0.0001) were significantly increased across quartiles for the dairy and carbohydrate pattern whereas sodium (P for trend < 0.0001) intake was decreased for this pattern. In conclusion, the dairy and carbohydrate pattern may be associated with a reduced risk of hypertension whereas the western pattern may be associated with an increased risk of hypertension among Korean adults.

• Nutrition Research and Practice
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• 제8권3호
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• pp.336-341
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• 2014

BACKGROUND/OBJECTIVE: It is expected that dairy products such as cheeses, which are the main source of cholesterol and saturated fat, may lead to the development or increase the risk of cardiovascular and metabolic diseases; however, the results of different studies are inconsistent. This study was conducted to assess the association between cheese consumption and cardiovascular risk factors in an Iranian adult population. SUBJECTS/METHODS: Information from the Isfahan Healthy Heart Program (IHHP) was used for this cross-sectional study with a total of 1,752 participants (782 men and 970 women). Weight, height, waist and hip circumference measurement, as well as fasting blood samples were gathered and biochemical assessments were done. To evaluate the dietary intakes of participants a validated food frequency questionnaire, consists of 49 items, was completed by expert technicians. Consumption of cheese was classified as less than 7 times per week and 7-14 times per week. RESULTS: Higher consumption of cheese was associated with higher C-Reactive Protein (CRP), apolipoprotein A and high density lipoprotein cholesterol (HDL-C) level but not with fasting blood sugar (FBS), total cholesterol, low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and apolipoprotein B. Higher consumption of cheese was positively associated with consumption of liquid and solid oil, grain, pulses, fruit, vegetable, meat and dairy, and negatively associated with Global Dietary Index. After control for other potential confounders the association between cheese intake and metabolic syndrome (OR: 0.81; 96%CI: 0.71-0.94), low HDL-C level (OR: 0.87; 96%CI: 0.79-0.96) and dyslipidemia (OR: 0.88; 96%CI: 0.79-0.98) became negatively significant. CONCLUSION: This study found an inverse association between the frequency of cheese intake and cardiovascular risk factors; however, further prospective studies are required to confirm the present results and to illustrate its mechanisms.

• Journal of Nutrition and Health
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• 제47권3호
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• pp.193-205
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• 2014

본 연구에서 국민건강영양조사 데이터를 활용하여 우리나라 성인에서 성별 영양표시의 활용 정도에 따른 식습관, 생활 습관 및 식사 섭취 상태에 미치는 영향을 분석한 결과, 영양표시를 읽지 않고, 영양표시의 영향을 받지 않는 성인의 경우 음주 빈도가 높거나 (남성), 라면의 섭취 빈도는 높은 반면 우유, 요구르트, 두유와 같은 바람직한 식품의 섭취 빈도는 낮은 것으로 나타났다. 또한 영양표시를 활용하지 않는 대상자에서 비타민 $B_2$, 비타민 C 및 칼슘과 같은 미량영양소 섭취의 질이 낮게 나타난 의미있는 결과를 도출하였다. 이와 같은 결과는 영양표시의 이용 및 영향 여부와 같은 적절한 식태도가 영양소 섭취의 질 및 식품 선택에도 영향을 미칠 수 있음을 제안할 수 있는 근거자료가 될 수 있으며, 향후 영양표시 이용에 대한 세분화된 영양교육시 기초자료가 될 수 있을 것으로 사료된다.

• Nutrition Research and Practice
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• 제11권4호
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• pp.319-326
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• 2017

BACKGROUND/OBJECTIVE: Effective weight reduction remains a challenge throughout the world as the prevalence of obesity and its consequences are increasing. This study aimed to determine the effects of an individualized nutrition counseling program (IC) matched with a transtheoretical model (TTM) for overweight and obese subjects. SUBJECTS/METHODS: Fifty overweight and obese subjects aged 19-60 years with a body mass index ${\geq}23kg/m^2$ were enrolled in the weight reduction study. They were randomized into two groups: Intervention group received an IC matched with a TTM; control group received an educational handbook. Body weight (BW), body fat (BF), waist circumference (WC), waist to height ratio (WHtR), stages of change (SOC), processes of change (POC), food intake, and physical activity (PA) were assessed at baseline and at 4, 8, and 12 weeks after program initiation in both groups. All data were analyzed by intention-to-treat, using SPSS software for hypothesis testing. RESULTS: Forty-five female subjects were included in the 12-week trial at Ramkhamhaeng Hospital, Bangkok, Thailand. The results showed significant weight loss ($1.98{\pm}1.75kg$; 3% loss of initial weight) in the intervention group at 12 weeks, compared to a $0.17{\pm}1.67kg$ loss in the control group. There were significant differences between intervention and control groups in BF mass ($-1.68{\pm}1.78$, $-0.04{\pm}1.62kg$); percentage BF ($-1.54{\pm}2.11$, $0.08{\pm}2.05$); WC ($-5.35{\pm}3.84$, $0.13{\pm}3.23cm$); WHtR ($-0.0336{\pm}0.02$, $-0.0004{\pm}0.02$), and energy consumption ($-405.09{\pm}431.31$, $-74.92{\pm}499.54kcal/day$) in the intervention and control groups, respectively. Intragroup SOC was improved in both groups. The POC for the weight management action (WMA) process was significantly different with POC scores increasing by $16.00{\pm}11.73$ and $7.74{\pm}14.97$ in the intervention and the control groups, respectively. PA level did not change in either group. CONCLUSIONS: The IC matched with a TTM resulted in reductions in BW, BF, and WC, thus reducing likely health risks by decreasing energy intake and inducing positive behavior changes while enhancing the WMA process.

• Journal of Gynecologic Oncology
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• 제29권6호
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• pp.83.1-83.10
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• 2018

Objective: We aimed to propose a set of quality indicators (QIs) based on the clinical guidelines for cervical cancer treatment published by The Japan Society of Gynecologic Oncology, and to assess adherence to standard-of-care as an index of the quality of care for cervical cancer in Japan. Methods: A panel of clinical experts devised the QIs using a modified Delphi method. Adherence to each QI was evaluated using data from a hospital-based cancer registry of patients diagnosed in 2013, and linked with insurance claims data, between October 1, 2012, and December 31, 2014. All patients who received first-line treatment at the participating facility were included. The QI scores were communicated to participating hospitals, and additional data about the reasons for non-adherence were collected. Results: In total, 297 hospitals participated, and the care provided to 15,163 cervical cancer patients was examined using 10 measurable QIs. The adherence rate ranged from 50.0% for 'cystoscope or proctoscope for stage IVA' to 98.8% for 'chemotherapy using platinum for stage IVB'. Despite the variation in care, hospitals reported clinically valid reasons for more than half of the non-adherent cases. Clinically valid reasons accounted for 75%, 90.9%, 73.4%, 44.5%, and 88.1% of presented non-adherent cases respectively. Conclusion: Our study revealed variations in pattern of care as well as an adherence to standards-of-care across Japan. Further assessment of the causes of variation and non-adherence can help identify areas where improvements are needed in patient care.

• 한국안광학회지
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• 제12권3호
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• pp.39-48
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• 2007

엄밀한 조절자극과 폭주자극 값 그리고 프리즘 디옵터는 어떻게 정의되어야 하는지를 고찰하여 정리 하였다. 양안시기능 검사와 분석의 실무에서 조절자극과 폭주자극 값은 어떻게 처리되는지를 고찰하여 정리 했다. 그 결과 실무에서의 처리과정은 근거리를 렌즈면으로부터 40 cm로 하는 경우 평균 P.D가 64 mm일 때 안구의 회선점에서 시험렌즈까지 거리 $l_c$이 26.67 mm인 경우에 가장 적합하였다. 본 논문에서 이 값들을 사용하여 필요한 값들을 계산하였다. 그리고 실무에서 사용되는 (5)식의 조절자극 값이 지니는 오차를 눈의 물측 주점에서 시험렌즈까지 거리 $l_H$를 15.07 mm로 하여 계산했다. 굴절력이 $P_m$인 프리즘 가입에 의한 폭주자극 값의 변화량 P'을 순환 계산법으로 계산하였다. P'는 $P_m$, 회선점에서 프리즘까지의 거리 $p_c$, 프리즘을 가입하기 전의 폭주 값 $C_o$와 프리즘 재질의 굴절률 n에 따라 변한다. 그리고 순환 계산법과 필요한 수식들을 자세히 제시했다. P'를 증대시키는 요인에는 두 가지가 있다. 그 첫 번째는 주된 것으로서 폭주 값이 보통의 덧셈법에 따라 더해지지 않는 성질이다. 다른 하나는 영향력이 작은 것으로서 프리즘의 실제 굴절력이 빛의 입사각에 따라 다르게 되는 이유이다. 그리고 $p_c$와 $C_o$가 커짐에 따라 P'은 괄목할 만큼 작아진다. $P_m=20{\Delta}$, P.D=64 mm 그리고 n=1.7인 경우에 대해 $p_c$와 $C_o$값들에 따르는 $P^{\prime}/P_m$을 계산하여 그래프로 나타냈다. $P^{\prime}/P_m$의 굴절률 n에 대한 의존성은 무시 할만 큼 아주 작다(Fig. 6 참조). 가입 프리즘의 굴절력과 폭주자극 값의 변화량이 같게 되는 프리즘의 위치 값 $p_c$를 구했다(Table 1). 실무에서 약식으로 처리되는 조절자극과 폭주자극 값의 참 값을 구하였다. 이를 토대로 약식으로 처리된 조절자극과 폭주자극 값이 참 값의 위치에 표시 되게 하는 두 가지의 그래프 양식을 제시하였다. 하나는 기존의 것과 같은 형태(Fig. 9)이고 다른 하나는 프리즘 가입에 의한 폭주자극 값의 변화량만을 나타내는 형식이다(Fig. 11).

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4517-4525
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• 2016

Background: Sperm DNA damage is underlying aetiology of poor implantation and pregnancy rates but also affects health of offspring and may also result in denovo mutations in germ line and post fertilization. This may result in complex diseases, polygenic disorders and childhood cancers. Childhood cancer like retinoblastoma (RB) is more prevalent in developing countries and the incidence of RB has increased more than three fold in India in the last decade. Recent studies have documented increased incidence of cancers in children born to fathers who consume alcohol in excess and tobacco or who were conceived by assisted conception. The aetiology of childhood cancer and increased disease burden in these children is lin ked to oxidative stress (OS) and oxidative DNA damage( ODD) in sperm of their fathers. Though several antioxidants are in use to combat oxidative stress, the effect of majority of these formulations on DNA is not known. Yoga and meditation cause significant decline in OS and ODD and aid in regulating OS levels such that reactive oxygen speues meditated signal transduction, gene expression and several other physiological functions are not disrupted. Thus, this study aimed to analyze sperm ODD as a possible etiological factor in childhood cancer and role of simple life style interventions like yoga and meditation in significantly decreasing seminal oxidative stress and oxidative DNA damage and thereby decreasing incidence of childhood cancers. Materials and Methods: A total of 131 fathers of children with RB (non-familial sporadic heritable) and 50 controls (fathers of healthy children) were recruited at a tertiary center in India. Sperm parameters as per WHO 2010 guidelines and reactive oxygen species (ROS), DNA fragmentation index (DFI), 8-hydroxy-2'-deoxy guanosine (8-OHdG) and telomere length were estimated at day 0, and after 3 and 6 months of intervention. We also examined the compliance with yoga and meditation practice and smoking status at each follow-up. Results: The seminal mean ROS levels (p<0.05), sperm DFI (p<0.001), 8-OHdG (p<0.01) levels were significantly higher in fathers of children with RB, as compared to controls and the relative mean telomere length in the sperm was shorter. Levels of ROS were significantly reduced in tobacco users (p<0.05) as well as in alcoholics (p<0.05) after intervention. DFI reduced significantly (p<0.05) after 6 months of yoga and meditation practice in all groups. The levels of oxidative DNA damage marker 8-OHdG were reduced significantly after 3 months (p<0.05) and 6 months (p<0.05) of practice. Conclusions: Our results suggest that OS and ODD DNA may contribute to the development of childhood cancer. This may be due to accumulation of oxidized mutagenic base 8OHdG, and elevated MDA levels which results in MDA dimers which are also mutagenic, aberrant methylation pattern, altered gene expression which affect cell proliferation and survival through activation of transcription factors. Increased mt DNA mutations and aberrant repair of mt and nuclear DNA due to highly truncatred DNA repair mechanisms all contribute to sperm genome hypermutability and persistant oxidative DNA damage. Oxidative stress is also associated with genome wide hypomethylation, telomere shortening and mitochondrial dysfunction leading to genome hypermutability and instability. To the best of our knowledge, this is the first study to report decline in OS and ODD and improvement in sperm DNA integrity following adoption of meditation and yoga based life style modification.This may reduce disease burden in next generation and reduce incidence of childhood cancers.

• 정보관리학회지
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• 제34권3호
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• pp.109-124
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• 2017

여러 학문 분야에서 데이터의 공유와 재이용에 관한 관심이 증가하고 있다. 실제로 다른 연구자의 데이터를 다시 연구에 사용하고 인용을 부여하는 관행이 서서히 자리를 잡아가고 있다. 이러한 변화를 반영하여 톰슨로이터는 Data Citation Index(DCI)라는 데이터인용 색인 데이터베이스 서비스를 2012년부터 제공하기 시작하였다. DCI는 모든 학문의 전 영역에서 데이터의 인용 현황을 저널의 논문과 유사하게 집계한다. 본 연구에서는 데이터인용이 활발한 사회학 분야의 인용된 연구데이터를 분석하여 해당 분야의 특성과 지적구조를 규명하고자 하였다. 이를 위해 논문인용을 기반으로 한 사회학 분야의 지적구조와 비교하였으며, 사회학 분야의 연구데이터의 특성과 고유한 지적구조를 살펴보고자 하였다. 분석을 위한 데이터는 두 종류로 수집하였다. 첫째는 DCI에서 'Sociology'로 주제 검색을 수행하여 총 8,365건의 인용된 데이터를 수집하였다. 둘째로, 논문 인용 분석과의 비교를 위해서 Web of Science에서 'Sociology'로 주제 검색을 수행하여 총 12,132건의 데이터를 수집하였다. 이 두 데이터를 활용하여 저자키워드 동시출현단어 분석을 수행한 결과, 데이터를 기반으로 한 사회학 분야는 2영역 15군집으로 구성된 반면, 논문을 기반으로 한 사회학 분야는 3영역 17군집으로 나타났다. 내용적인 특성을 살펴보면, 전통적으로 사회학의 지적구조를 나타낸다고 볼 수 있는 논문 기반 사회학과 달리 사회학 분야의 연구데이터는 의학 분야와의 활발한 접목을 찾아볼 수 있으며, 그 중에서도 공중보건과 심리학이 중심 영역인 것으로 나타났다.

• Journal of Nutrition and Health
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• 제30권3호
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• pp.336-348
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• 1997

The objectives of this study were to examine the growth pattern of infants by anthropometric measurement according to the 5 feeding practices of infants with the subject of two hundred healthy newborn babies from their birth till sixty month of age at intervals of two months. Breast group(BF, n=38), formula group(FF, n=102) and mixed group(ME, n=14) were fed breast milk, formula milk, breast and formula milk, from birth till 6 mo. of age, respectively. Convert 1 group (C1F, n=14) and covert 2 group(CF, n=32) were fed breast milk and mixed milk at 2 mo. of age afterthat switched to formula milk, respectively. From these, the following results were made. All the infants of this study showed superiority to Korean standard growth rate in regards to each growth item for each month age. In the case of males, at their birth, the subscapular skinfold thickness and the total skin fold thickness in the BF group was significantly larger than in MF group and FF group(p<0.05). At 6th month age, the chese circumference of MF group was 45.9cm, and significantly larger than those of BF, FF and C2F groups(p<0.05). In the case of females, at theri birth and 2nd month age, there was no difference among all the feeding groups in regards to each growth rate. At 4th month age, the Kauf index of C1F group was 16.21 and significantly lower than those of four groups(p<0.05). And total skinfold thickness in BF group was larger than in C1F group. The increase rate per month age of all growth items were larger at 2nd month age than at the later months both in males and in females. And until 2nd month age males showed more increase than females in regards to each growth item but after 2nd month age, this sapect did not show up. Multiple linear regression was used to determine predictive factors for infant growth. It was expected that at 6th month age, in the measurement of head circumference and chest circumference and cross-sectional fat area, BF-males were bigger by 22-39% of the explanation index than the infants of other groups. As a result, in spite of the significant lower intakes of energy and nutrients in breast-fed infants than in formula-fed infants, breast-fed infants showed more growth than the average of Korean infant standard growth rate at every month age, and showed no significant growth difference among feeding groups.

• Journal of Dairy Science and Biotechnology
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• 제27권1호
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• pp.1-12
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• 2009

In 2008, baby formula containing melamine was found to be responsible for a large outbreak of renal failure in infants in China. A total of 294,000 infants were hospitalized, and at least 6 babies died due to ingestion of the tainted formula. Melamine contains high levels of nitrogen (>60%), which is used as an indicator of protein content. Therefore, high levels of melamine in infant formula were thought to be the result of deliberate contamination m an attempt to increase its apparent protein content. Following inspections by China's national inspection agency, assorted products from at least 22 dairy manufacturers across China were found to have varied levels of melamine (range: 0.096196.61 mg/kg). Melamine co-exposure with cyanuric acid can induce acute melamine-cyanurate crystal nephropathy, which can lead to renal failure at much lower doses than if either compound were ingested alone. However, currently, there are very few data on melamine analogues other than cyanuric acid. At an expert meeting of the WHO and FAO held to review toxicological aspects of melamine and cyanuric acid on December 14, 2008, a new tolerable daily intake (TDI) of melamine was established that could be applied to the entire population, including infants. Therefore, a risk assessment of the various theoretical melamine contamination levels in infant formula and selected representative foods (other than infant formula and sole-source nutrition products) is urgently needed for Korean babies and children up to 7 years of age. Although the undetectable level regulation for infant formula may be low enough to guarantee the safety of babies under the age of 1 year (including premature babies), the melamine standard of 2.5 ppm for foods other than baby formula could be insufficient to protect the 95th percentile population aged 1~2 years because of this demographic's high consumption of milk, yogurt, and soy milk (hazard index = 1.79). Because TDIs are chronic values intended to protect an individual over his/her lifetime, occasional modest ingestion in excess of the TDI is not likely to be a health concern. However, children aged 1~2 years may have renal systems that are comparatively more sensitive to the crystallization of melamine and its analogues. Therefore, governmental jurisdictions may need to practice more prudent management of food items that could raise the melamine exposure for this population.