• 한국인터넷방송통신학회논문지
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• 제15권6호
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• pp.209-215
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• 2015

반도체 관련 산업의 발전에 따라 반도체 제조공정에서 염산, 황산, 과산화수소, 불산, 피라니아 등과 같은 다양한 형태의 유독 가스와 화합물들이 사용되고 있고 누출 사고 역시 빈번하게 발생되고 있는 것이 사실이다. 유독 가스 누출사고 발생시 대량의 인명 피해가 발생되고 있는 것 역시 사실이다. 본 연구에서는 구미 불산 누출 사고와 같은 화학물질 누출 사고의 위험으로부터 인명을 보호하고 피해를 최소화 하기 위한 기본 해결책으로 대학에서의 MSDS 교육의 필요성에 대해 고찰하였다. 또한 GHS와 REACH 제도와 MSDS 이용의 적정성의 이해를 통해 유해 화학 물질의 노출로부터 안전을 지키는 문제에 대해 고찰하였다.

• 한국항해항만학회지
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• 제34권3호
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• pp.213-220
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• 2010

최근 IMO에서는 산적화물선 및 유조선, 대형여객선에 이어 '일반화물선의 안전(general cargo ships safety)'에 대한 논의의 필요성이 제기(IMO, 2006a)되고 있으며, 본격적인 논의를 위한 준비 작업으로 국제선급협회(IACS)를 통한 공식안전성평가(Formal Safety Assessment, 이하 FSA) 작업이 수행되고 있다. FSA란 위험도(risk)분석과 비용-효과 평가(cost-benefit assessment)를 바탕으로 인명, 해양환경 및 재산의 보호를 포함한 해사안전의 향상을 목적으로 한 구조화되고 체계적인 방법론으로서 새로운 법규의 평가, 기존법규와 새로운 (제안) 법규와의 비교, 그리고 여러 이해관계자의 공감대 형성을 통해 법규 변경/개발을 용이하게 하는 수단이다(IMO, 2007). 본 연구는 국적일반화물선의 안전성 평가를 위한 수단으로서 IMO FSA방법론의 유용성을 확인하고, 향후 IMO에서의 '일반화물선 안전'에 대한 논의에 대응하기 위한 기초자료의 확보를 목적으로 하고 있다. 본 논문에서는 국적일반화물선에 대한 FSA의 1, 2 단계에 해당하는 위험요소 식별(Hazard identification) 및 사고시나리오에 대한 위험도 분석(Risk analysis) 결과를 중심으로 소개하였다.

• 한국식품조리과학회지
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• 제19권4호
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• pp.454-462
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• 2003

본 연구는 서울시에 위치한 소규모 베이커리 2곳을 대상으로 제빵류(단팥빵, 크림빵, 케익류)의 원료 및 공정별, 제빵기구$.$용기, 제빵종사자와 작업장환경에 대한 일반세균, 대장균군 및 급식소에서 위해세균으로 정의되어 있는 E. coli, Salmonella, Yersinia, Staphylococcus와 같은 식중독균에 대한 미생물 검색을 실시함으로써 소규모 베이커리에서의 HACCP적용을 위한 기초자료를 제공하고자 하였으며, 그 결과는 다음과 같았다. 1. 채취한 시료의 일반세균수 및 대장균군수는 대부분의 시료에서 안전성 수준을 초과하였다. 2. 대장균은 A점포의 혼합기, 수도꼭지, 쓰레기통, 작업장 바닥과 손잡이, 단팥빵 및 크림 빵 성형단계의 시료에서 균이 분리되었다. 3. 살모넬라균은 A점포의 원재료인 마가린과 단팥빵 성형단계의 시료에서 검출되었다. 4. 황색포도상구균은 A점포의 계란과 빵자르는 기계 및 B점포의 크림빵 성형단계의 시료에서 검출되었고, 독소형은 enterotoxin A인 것으로 확인되었다. 5. PCR분석 결과 E. coli O157은 음성인 반면, Salmonella균은 양성임이 판명되었다. 이상의 결과가 소규모 베이커리에서의 HACCP적용을 위한 미생물학적 위해도 평가의 전반적인 면을 대표할 수 없는 연구의 제한성을 가지고는 있으나 이연구를 기초로 더욱더 체계적인 연구들이 실시되리라 기대한다.

• 분석과학
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• 제20권2호
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• pp.147-154
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• 2007

잠재지문의 효과적인 현출법의 기초자료로 활용하기 위하여 지문과 관계되는 땀의 성분분석을 실시하였다. 땀의 성분을 분석한 결과 총 단백질은 $46{\sim}122{\mu}L/mL$로 개인차가 있고, 검출된 아미노산의 분포도 개인에 따라 그 차이가 있으며, 주로 glycine($4.7{\sim}19.0{\mu}L/mL$), threonine($1.3{\sim}26.0{\mu}L/mL$), alanine($0{\sim}13.5{\mu}L/mL$), valine($0{\sim}8.0{\mu}L/mL$) 그리고 histidine($0{\sim}13.2{\mu}L/mL$) 등이 검출되었다. 양이온의 경우 Na이 3078.6~4815.6 ppm으로 가장 높은 함량을 보였고, K이 267.3~823.9 ppm이었으며, Ca(15.4~44.7 ppm)과 Mg(4.13~8.96 ppm)으로 조사되었다. 음이온 중에는 $Cl^-$(2167~4073 ppm)와 $F^-$(454~582 ppm)가 주로 검출되었다. 미량 원소는 Rb(132~824 ppb), Zn(90~1846 ppb)와 Cu(17~415 ppb)가 주로 검출 되었으며, 그 양 역시 개인 간의 차이가 크게 나타나므로 지문 현출에 다양한 방법이 요구되어 진다.

• 한국환경성돌연변이발암원학회지
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• 제24권1호
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• pp.33-39
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• 2004

To validate and to estimate the chemical hazard playa very important role to environment and human health. The detection of many synthetic chemicals including agrochemicals that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. Pyrazosulfuron-ethyl [Ethyl-5-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate, $C_{14}H_{18}N{6}O_{7}S,$ M.W. =414.39, CAS No. 93697-74-6], is one of well known rice herbicide belong in the sulfonyl urea group. To clarify the genotoxicity of this agrochemical, Ames bacterial reversion assay, in vitro chromosomal aberration assay with Chinese hamster lung (CHL) fibroblast and bone marrow micronucleus assay in mice were subjected. In Ames assay, although pyrazosulfuron-ethyl revealed cytotoxic at 5,000-140 $\mug/plate$ in Salmonella typhimurium TA100, no dose-dependent mutagenic potential in 4.4～70 $\mug/plate$ of S. typhimurium TA 98, TA 100, TA1535 and TA 1537 both in the absence and presence of S-9 metabolic activation system was observed. Using CHL fibroblasts, the 50% cell growth inhibition concentration $(IC_{50})$ of pyrazosulfuron-ethyl was determined as 1,243 $\mug/mL,$ and no chromosomal aberration was observed both in the absence and presence of S-9 mixture in the concentration range of 311-1,243 $\mug/mL.$ And also, in vivo micronucleus assay using mouse bone marrow, pyrazosulfuron-ethyl revealed no remarkable induction of MNPCE (micronucleated polychromatic erythrocytes/1000 polychromatic erythrocytes) in the dose range of 625-2,500 mg/kg body weight when administered orally. Consequently, Ames bacterial gene mutation with Salmonella typhimurium, in vitro chromosome aberration with mammalian cells and in vivo bone marrow micronucleus assay revealed no clastogenic potential of pyrazosulfuron-ethyl in this study.

• 한국환경보건학회지
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• 제49권4호
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• pp.218-227
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• 2023

Background: Since 2019, the Ministry of Environment has implemented a seasonal fine dust management system from December to March, targeting high PM_2.5 levels with the aim of reducing PM_2.5 concentrations and protecting public health. The focus of improving the seasonal management system lies in the atmospheric PM_2.5 levels. Considering the primary goal of protecting public health, it is necessary to analyze the policy effects from an exposure perspective rather than a concentration-based approach. Objectives: This study aims to quantitatively assess the improvement of indoor PM_2.5 levels and the health impacts of the seasonal management system by comparing the periods before and during its implementation in residential environments. Methods: PM_2.5 concentrations within residential environments in a metropolitan area were measured using an optical particle counter (IAQ-C7, K-weather, Ltd, Korea) at one-minute intervals during the pre-implementation period (November 21~25, 2022) and during the implementation period (December 19~23, 2022). Based on the measured PM_2.5 concentrations, a quantitative evaluation of cancer and mortality risks was conducted according to age and gender. Results: The results of comparing indoor and outdoor PM_2.5 concentrations before and during the implementation of the seasonal management system showed a decrease of approximately 56.6% and 47.9%, respectively. Health risk assessments revealed that both the safety-limit-based and safety-target-based Hazard Quotients (HQ) exceeded the threshold of 0.1 for children under 19 years of age, both before and after the implementation. The mortality risk decreased by approximately 47.9% after the implementation, with children aged 0-9 showing the highest mortality risk at 0.9%. Conclusions: The findings of this study confirmed the positive health impacts of the seasonal management system across all age groups, particularly children under 19 who are more vulnerable to fine dust exposure.

• Journal of Nutrition and Health
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• 제44권2호
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• pp.171-180
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• 2011

식품으로부터의 유해물질 노출 평가를 위해 개발한 식생활 조사지의 신뢰도와 타당도를 평가하고자 216명을 대상으로 식생활 조사를 2회 반복 실시하여 비교하였고, 3일 식사기록 결과와도 비교하였다. 1) 식품 구매 시 주로 사용하는 용기에 대해 동일한 응답을 한 비율은 전체 식품 평균 73.5%였다. 상대적으로 포장 용기가 다양하지 않은 식품에 대한 구매 용기 응답 일치도가 높게 나타났으며, 판매 시 다양한 포장 용기를 사용하는 식품에 대한 구매 용기 응답 일치도는 낮게 나타났다. 2) 식품 보관 시 주로 사용하는 용기에 대한 응답 일치도는 평균 71.9%였다. 가공된 식품을 구매하여 보관하는 식품에 대한 보관 용기 일치도가 높았으며, 조리 후 보관을 하는 식품에 대한 용기 일치도는 낮게 나타났다. 3) 주로 사용하는 조리방법에 대한 응답의 일치도는 평균 83.0%였다. 조리방법이 다양한 식품들에 대한 일치도가 낮게 나타났으며, 조리하지 않고 그대로 먹는 식품에 대한 일치도가 높게 나타났다. 4) 식품섭취빈도조사를 2회 실시하였을 때, 평균 상관계수가 0.71 (range: 0.50~0.83)이었고, 2차 식품섭취빈도조사와 식사기록법의 식품 섭취 횟수의 평균 상관계수는 0.21(range: 0.04~0.48)이었다. 5) 식품섭취빈도조사와 식사기록법으로 산출된 각 식품군별 식품 섭취 횟수를 사분위수로 나누었을 때 모든 식품군의 일치 및 근접 일치도의 합은 50% 이상이었다. 6) 본 연구에서 개발한 조사지는 식생활 항목의 신뢰도가 높고, 섭취빈도의 순위를 분류하는 타당도가 높으므로, 대규모 역학조사에서 질적인 노출수준 평가에 활용할 수 있을 것으로 사료된다.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2003년도 춘계학술대회
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• pp.194-194
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• 2003

The International Agency for Research on Cancer (IARC, 1989) has classified whole diesel exhaust as probably carcinogenic to humans. Diesel exhaust particulate matter (DPM) adsorbs different chemical substances including PAHs and nitroarenes. DPM is emphasized because it is a major component of diesel exhaust, it is suspected of contributing to a health hazard. Diesel exhaust is a complex mixture of carbon particles and associated organics and inorganics, and it is not known what fraction or combination of fractions cause the health effects [cancer effects, noncancer effects (respiratory tract irritation/inflammation and changes in lung function)] that have been observed with exposure to diesel exhaust. In order to identify which chemical classes are responsible for the majority of the observed biological activities, we performed a particular biological/chemical analysis. Respirable particulate matter (PM2.5: <2.5mm) was collected from diesel engine exhaust using a high-volume sampler equipped with a cascade impactor. Particulate oganic matter was extracted by the dichloromethane/sonication method and the crude extract was fractionated according to EPA recommended procedure into seven fractions by acid-base partitioning and silica gel column chromatography. We examined genotoxic potentials of diesel exhaust particulate matter using novel genotoxicity tests, which are rapid, simple and sensitive methods for assessing DNA-damage at the DNA and chromosomal level (comet assay, in vitro MN test and Ames test). Higher genotoxic potency was observed in non polar fractions and several PAHs were detected by GC-MS, such as 1,2,5,6 dibenzanthracene, chrysene, 1,2-benzanthracene, phenanthrene and fluoranthene.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1127-1130
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• 2013

Background: The standard national protocol for treatment of acute lymphoblastic leukemia (ALL) in children was implemented in 2006. A systematic evaluation of the treatment outcome is needed. This study examined the relapse-free survival among childhood ALL cases treated with this protocol and related factors. Materials and Methods: A descriptive study was conducted in children aged between 0-15 years, newly diagnosed with ALL between March 2006 and March 2011 at Srinagarind Hospital, Department of Pediatrics, Faculty of Medicine, Khon Kaen University. The patients were treated on the basis of stratified risk as per the Thai national protocol. Data were compiled from the hospital records. The Kaplan-Meier method was used to describe relapse-free survival and the Cox proportional hazard model to investigate the associated factors. Results: Of the 103 children recruited, 86 (83.5%) achieved complete remission. The total follow-up time was 3132.5 person-months. Eighteen (20.9%) relapsed. The incidence density was 0.6 per 100 person-months (95%CI: 0.4, 0.9). The respective relapse-free rates at 1, 3 and 5 years were 93.0% (95%CI: 85.1, 96.8), 84.5% (95%CI: 74.0, 90.9) and 64.1% (95%CI: 45.6, 77.8). A factor associated with the relapse-free rate was age under 1 year (HR=6.0; 95%CI: 1.1, 33.8). Conclusions: The rate of being relapse-free in ALL children treated under the Thai national protocol at Srinagarind Hospital was better than with former protocols; however, it is still not as good as in developed countries. Further review of the treatment approach of ALL is needed.

• 한국산업보건학회지
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• 제8권2호
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• pp.196-208
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• 1998

To improve the quality of environmental measurements and evaluation of the workplace air in the pigment manufacturing industries, we analyzed metal(chromium, cadmium, lead, iron, cobalt, manganese, antimony, titanium, arsenic, and selenium) concentrations by ICP-AES in sixty seven samples of inorganic bulk pigments which are produced and/or used in Korea. We also collected MSDS which has to be supplied by manufacturer and/or supplier and posted in the workplace according to the Hazard Communication Standards, and compared the number of metals listed in each MSDS with the number of metals determined by ICP-AES. Results were as followed; 1. Among seventeen yellowish-colored samples, chromium(2~19%) and lead(0.1~61%) were the two major metals. In thirteen reddish-colored samples, iron was the major component with 37~81%. Cobalt and manganese were detected in blue-colored samples with less than 1%, while antimony and titanium were the major two metals in white-colored pigments with 178~300 ppm and with 36~65%, respectively. 2. In area samples collected in workplace air(one pigments producing factory and five retailer stores), iron and manganese were detected but the concentrations not exceeded the TLVs(1 and $5mg/m^3$, respectively). In three of fifteen samples, the concentrations of lead exceeded the TLV ($0.05mg/m^3$). 3. Two out of seven companies provided MSDS, and the average provision rate was 22.4%. And the coincidence rate of the number of metals referenced in MSDS and determined by ICP-AES mostly accorded, but in one sample, different metal was detected from MSDS. In summary, metals have to be concerned in evaluation of the workplace air dealing with compounds of inorganic pigments dust are cobalt, chromium, iron, manganese, lead and antimony, and these are simultaneously determined by ICP-AES. Taking this opportunity, it is needed to reinforce that the personnel is to be concerned about prevention of workers' ill health regarding to provision of MSDS.