• Safety and Health at Work
• /
• v.13 no.3
• /
• pp.364-371
• /
• 2022

Background: Respiratory masks can provide healthcare workers with protection from biological hazards when they have good performance. There is a direct relationship between the visual specifications of a mask and its efficacy; thus, the aim of this study was to develop tools for qualitative assessment of the performance of masks used by healthcare workers. Methods: A mixed-methods design was used to develop a qualitative assessment tool for medical face masks (MFM) and particle filtering half masks (PFHM). The development of domains and items was undertaken using observation and interviews, the opinions of an expert panel, and a review of texts and international standards. The second phase evaluated the psychometric properties of tools. Finally, the validated Mask Qualitative Assessment Tools (MQAT) were used to assess six samples from 10 brands of the two types of masks. Results: MQAT-MFM and MQAT-PHFM shared 42 items across seven domains: "cleanliness," "design," "marking, labeling and packaging," "mask layers," "mask strap," "materials and construction," and "nose clip." MQAT-MFM included one additional item. MQAT-PHFM included another nine items associated with an eighth "Practical Performance" domain, and the valve version had another additional "Exhalation Valve" domain and six items. The evaluation indicated 80% compliance for MFM and 71% compliance for PFHM. "Marking, labeling and packaging" and "Layers" were associated with the least compliance in both types of masks and should be checked carefully for defining mask quality. Conclusion: MQAT can be used for immediate screening and initial assessment of MFM and PHFM through appearance, simple tools, and visual inspection.

• Convergence Security Journal
• /
• v.17 no.5
• /
• pp.121-132
• /
• 2017

This study is a narrative research study to understand the degree of awareness and practice of nursing college students' patients' health information protection and to grasp the relationship between them.. The subjects of this study were 122 nursing college students who experienced clinical practice in two nursing colleges in GwangJu city. Data collection was done from October 13 to 28, 2017. Using SPSS/WIN 21.0 Program, descriptive statistics, t-test, one-way ANOVA and Pearson correlation analysis were performed. As a result of the study, the degree of awareness and practicability of patient' health information protection were 4.44(SD=0.44) and 4.28(SD=0.62), respectively. There was a difference in the awareness of health information protection when they were educated about patients' health information protection at school (t=5.094, p<.001) and hospital (t=2.028, p=.045) in the case of having experience in patients' health information protection in hospitals(t=2.551, p=.012). There was a significant positive(+)correlation between patient's health information protection perception and practicing degree, and the degree of health information protection practitioner's communication domain (r=.420, p<.001). There was a significant positive correlation with the domain (r=.368, p<.001) and the referral domain (r=.304, p=.001). Based on these results, we sought to protect the personal information of patients and to provide necessary basic data to develop for standardized education program.

• The Journal of Korean Physical Therapy
• /
• v.21 no.2
• /
• pp.55-63
• /
• 2009

Purpose: This study evaluated of quality of life (QOL) and physical therapy satisfaction (PTS) in caregivers of cerebral palsy children. Methods: Eighty six caregivers in Gwang-ju were examined. The caregivers' QOL was assessed through self-reports using the WHO Quality of Life-BREF (WHOQOL-BREF), and the data was analyzed separately for each of its 5 domains. Physical therapy satisfaction was assessed using a self-reported questionnaire and the data was analyzed separately for the 2 domains. The results were processed by the mean and standard deviation and then verified by ANOVA and a t-test to determine the significant differences in the QOL and PTS. The factors affecting the QOL were processed by logistic regression. Results: Life environment domain of the QOL across the caregivers factors showed a statistically significant difference in age at natal, monthly income and education. The birth order in the cerebral palsy child factor showed a significant difference in the general, physical and emotional domain of the QOL. The PTS showed a significant difference in the delivery of therapy domain and in the birth order and walking condition of the environment domain. Caregivers education was found to be associated independently with the life environment domain of QOL. Conclusion: Because the QOL of caregivers is an important treatment goal for children with cerebral palsy, early family intervention should be considered.

• Biotechnology and Bioprocess Engineering:BBE
• /
• v.8 no.3
• /
• pp.192-198
• /
• 2003

BiP, immunoglobulin binding protein, is an ER homologue of Hsp70. However, unlit other Hsp70 proteins, regulatory protein(s) for BiP has not been identified. Here, we demo strafed the presence of potential regulatory proteins for BiP using a pull -down assay. Since BiP can bind any unfolded protein, only the ATPase domain of BiP was used for the pull -down assay in order to minimize nonspecific binding. The ATPase domain was cloned to produce recombinant protein, which was then conjugated to CNBr-activated agarose. The structural conformation and ATP hydrolysis activity of the recombinant ATPase domain were similar to those of the native protein, light proteins from metabolically labeled mouse plasmacytoma cells specifically bound to the recombinant ATPase protein. The binding of these proteins was inhibited by excess amounts of free ATPase protein, and was dependent on the presence of ATP. These proteins were eluted by ADP. Of these proteins, Grp170 and BiP where identified. while the other were not identified as known ER proteins, from Western blot analyses. The presence of the ATPase-binding proteins for BiP was first demonstrated in this study, and our data suggest similar regulatory machinery for BiP may exist in the ER, as found in prokaryotes and other cellular compartments.

• Structural Monitoring and Maintenance
• /
• v.1 no.2
• /
• pp.231-247
• /
• 2014

This paper focuses on the dynamic behaviour of Mirandola City Hall (a XV century Renaissance Palace) that was severely damaged during May 2012 Emilia earthquake in Northern Italy. Experimental investigations have been carried out on this monumental building. Firstly, detailed investigations have been carried out to identify the identification of the geometry of the main constructional parts as well as the mechanical features of the constituting materials of the palace. Then, Ambient Vibration Tests (AVT) have been applied, for the detection of the main dynamic features. Three output-only identification methods have been compared: (i) the Frequency Domain Decomposition, (ii) the Random Decrement (RD) and the (iii) Eigensystem Realization Algorithm (ERA). The modal parameters of the Palace were difficult to be identified due to the severe structural damage; however the two bending modes in the perpendicular directions were identified. The comparison of the three experimental techniques showed a good agreement confirming the reliability of the three identification methods.

• YAKHAK HOEJI
• /
• v.47 no.4
• /
• pp.252-259
• /
• 2003

Self-medication is a representative phenomenon in the domain of popular care, originated from perspective of medical pluralism and the pharmacy profession is said to be in the most appropriate position of health care professions to activate self-medication. As any healthcare reform impacts in a country, 2000 institutional separation between medicine and pharmacy implemented in Korea brought a lot of changes in behavior of drug use not only to physicians and pharmacists but also to consumers (patients). In this paper, the reality of self-medication since the institutional separation between medicine and pharmacy was analyzed, based on the empirical data which were collected by the Korea Institute for Health and Social Affairs in 2002. The major finding is that the domain of popular care including self-medication was significantly shrunk, while that of professional care was proportionally expanded. As a result, the following four points were strongly recommended for the purpose of promoting self-medication: i) upgrading the pharmacy education system from 4 year to 6 year level, ii) improvement of continuing education and introduction of GPP (Good Pharmacy Practice), iii) activating 'pharmacal encounter' (i.e., pharmacist-consumer relationship) and iv) promotion of socio-economic research activities and proactive participation in the international self-medication movement of pharmacists in Korea.

• Biomedical Science Letters
• /
• v.26 no.1
• /
• pp.47-50
• /
• 2020

Recently, decades of robust researches on degenerative brain disorder have been highlighted on the interactive connection of gut and brain. In terms of inflammatory cytokine production, others have shown that Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) is involved with Leucine-Rich Repeat Kinase 2 (LRRK2). HEK293T cells were transiently co-transfected with Myc-tagged LRRK2 and Flag-tagged NOD2 and then followed by co-immunoprecipitation assay. In this study, we provide the novel finding of physical protein-protein interaction between NOD2 and LRRK2. G2019S variant has shown stronger interactions against NOD2 than those of wild type LRRK2. In an axis of NOD2-LRRK2 communication, it is believed to pave a new way in the understanding of the bidirectional molecular mechanism of brain disorder, including Parkinson's disease into gut inflammatory disease, including Crohn's disease.

• Health Policy and Management
• /
• v.22 no.4
• /
• pp.628-653
• /
• 2012

Purpose : This study attempted to find out the relationship between leadership style, knowledge transfer in nursing officers' job, considering the task characteristics. Methods : The data were collected from the military hospital during November 1st to November 17th, 2008 using a structured questionnaire and analyzed with the statistical method of frequency, correlation, and regression analysis, in SPSS 12.0 program package. Results/Conclusion : The results of empirical analysis shows that the levels of job tension and job focused task domain affect the job characteristics of the nursing officers' organization. The job characteristics have a moderating effect on the relationship between leadership style and knowledge transfer. The research is very useful in finding out the job characteristics which well depict military nursing organizations. This research suggests that a desirable leadership styles affect the knowledge transfer in the job characteristics type.

• Psychiatry investigation
• /
• v.15 no.11
• /
• pp.1011-1018
• /
• 2018

The analysis of extracellular vesicles has been accelerated because of the technological advancements in omics methods in recent decades. Extracellular vesicles provide multifaceted information regarding the functional status of the cells. This information would be critical in case of central nervous system cells, which are confined in a relatively sealed biological compartment. This obstacle is more dramatic in psychiatric disorders since their diagnosis primarily depend on the symptoms and signs of the patients. In this paper, we reviewed this rapidly advancing field by discussing definition of extracellular vesicles, their biogenesis and potential use as clinical biomarkers. Then we focused on their potential use in psychiatric disorders in the context of diagnosis and treatment of these disorders. Finally, we tried to combine the RDoC (Research Domain Criteria) with the use of extracellular vesicles in psychiatry research and practice. This review may offer new insights in both basic and translational research focusing on psychiatric disorders.

• KSBB Journal
• /
• v.24 no.4
• /
• pp.403-409
• /
• 2009

H2AX, a crucial component of chromatin, is implicated in DNA repair, cell cycle check point and tumor suppression. The aim of this study was to identify direct binding partners of H2AX to regulate cellular responses to above mechanisms. Literature reviews and bioinformatical tools were attempted intensively to find binding partners of H2AX, which resulted in identifying two potential proteins, breast cancer-1 (BRCA1) and BRCA1-associated RING domain 1 (BARD1). Although it has been reported in vivo that BRCA1 co-localizes with H2AX at the site of DNA damage, their biochemical mechanism for H2AX were however only known that the complex monoubiquitinates histone monomers, including unphosphorylated H2AX in vitro. Therefore, it is important to know whether the complex directly interacts with H2AX, and also which regions of these are specifically mediated for the interaction. Using in vitro GST pull-down assay, we present here that BRCA1 and BARD1 directly bind to H2AX. Moreover, through combinational approaches of domain analysis, fragment clonings and in vitro binding assay, we revealed molecular details of the BRCA1-H2AX and BARD1-H2AX complex. These data provide the potential evidence that each of the BRCA1 nuclear localization signal (NLS) and BARD1 BRCA1 C-terminal (BRCT) repeat domain is the novel mediator of H2AX recognition.