• Environmental Analysis Health and Toxicology
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• 제28권
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• pp.12.1-12.5
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• 2013

Objectives The role of genetic polymorphisms of tumor necrosis factor-alpha (TNF-${\alpha}$) for lung cancer development was evaluated. Methods Genotypes of the TNF-${\alpha}$ polymorphisms, -1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, were determined in 616 lung cancer cases and 616 lung cancer-free controls. Results After adjusting for body mass index and smoking, each TNF-${\alpha}$ genotype or haplotype composed of five TNF-${\alpha}$ single nucleotide polymorphisms did not show an association with lung cancer risk (p>0.05). The statistical power was found to be 88.4%, 89.3%, 93.3%, 69.7%, and 93.9% for 1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, respectively. Furthermore, the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p>0.05). In the repeated analysis with only subjects without other diseases related to inflammation, there was also no association between polymorphisms or haplotypes of the TNF-${\alpha}$ gene and lung cancer risk (p>0.05). Conclusions This study found no association between common variants of the TNF-${\alpha}$ gene and lung cancer risk.

• 한국산업보건학회지
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• 제23권3호
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• pp.307-314
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• 2013

Objectives: The aim of this study was to determine the prevalence of symptoms relating to musculoskeletal disorders (MSDs) and investigate the risk factors among researchers at university laboratories. Methods: 209 researchers were included in this study, drawn from 27 laboratories at three universities in Korea. Checklists for MSD symptoms and risk factor assessment were utilized. Results: The symptoms checklist showed reliable results with Cohen's Kappa 0.33-0.56, percent agreement 81.0-96.8%, and correlation coefficient 0.41-0.63. The overall prevalence of MSD symptoms was 68.9%, while the prevalence in specific parts of body were as follows: shoulders (47.6%), lower back (46.9%), neck (46.9%), knees (25.4%), wrists (20.1%), elbows (13.6%). The symptom prevalence among women was higher than among men (OR 2.67, 95% CI 1.37-5.18). Daily exposure time was observed to be a significant risk factor for developing MSD symptoms (OR 2.14-6.07). Conclusions: This study suggested that repetitive pipetting and static work posture are the most significant risk factors for MSD symptoms among laboratory researchers.

• 한국산학기술학회논문지
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• 제15권3호
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• pp.1641-1649
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• 2014

본 연구는 대장 용종 발생의 위험인자를 파악하기 위해 종합검진 수검자 중 대장내시경 검사와 복부초음파검사를 동시에 시행 받은 508명을 대상으로 나이, 성별, 흡연, 음주, 운동의 일반적인 특성과 신장, 체중, 혈압, 허리둘레, 체질량 지수 등의 신체 계측을 하였으며, 동시에 채혈을 통한 공복 시 혈당과 여러 가지 혈액검사를 분석하였다. 그 결과 AST, ALT, 총콜레스테롤, 지방간, 비만도 및 흡연여부가 유의하게 높은 것으로 나타났으며 대장용종이 있는 대상자가 지방간과의 관련성이 3.4배로가 가장 높았고, 다음으로 총콜레스테롤 2.3배, 흡연자가 비흡연자에 비해 2.3배나 위험성이 높게 나타났다.

• Parasites, Hosts and Diseases
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• 제52권4호
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• pp.391-397
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• 2014

We evaluated the status of Clonorchis sinensis infection and potential risk factors among residents of riverside areas (Geumgang) in Muju-gun, Jeollabuk-do (Province), Korea. From January to February 2010, a total of 349 (171 males, 178 females) stool samples were collected and examined by the formalin-ether concentration technique. Also, village residents were interviewed using questionnaires to obtain information about C. sinensis infection-related risk factors. Overall egg-positive rate of C. sinensis was 13.2%. Egg-positive rates were significantly higher in males, farmers, and residents who had lived there more than 20 years, and in residents who had eaten raw freshwater fish than in opposite groups, respectively. However, there was no significant difference between age groups, education levels, cigarette smoking, alcohol drinking, health status, past history of infection, and experience of clonorchiasis medication and examination. Logistic regression analysis was performed to determine risk factors for clonorchiasis. On univariate analysis, the odds ratios for males, farmers, those who had lived there more than 20 years, and who had eaten raw freshwater fish were 2.41, 4.44, 3.16, and 4.88 times higher than those of the opposites, respectively. On multivariate analysis, the odds ratio of residents who had eaten raw freshwater fish was 3.2-fold higher than that of those who had not. These results indicate that residents living in Muju-gun, along the Geum River, Korea, have relatively high C. sinensis egg-positive rates, and the habit of eating raw freshwater fish was the major factor for the maintenance of clonorchiasis.

• Journal of the Korean Data and Information Science Society
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• 제21권2호
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• pp.201-209
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• 2010

최근 10년간 허혈성심질환 사망은 급격히 증가하였기에 이에 대한 효과적인 예방대책이 매우 중요한 실정이다. 이에 본 연구에서는 1996년 국민건강보험공단 건강검진 수검자 2,268,018명을 약 10년간 추적하여 허혈성심질환의 주요 위험요인별 상대위험도를 콕스비례위험모형을 통해 파악하고자 하였다. 그 결과 남자에서는 체질량지수, 혈압, 흡연, 여자에서는 고혈압, 주관적 건강감 및 감마-글루타밀전이효소가 허혈성심질환과 유의한 관련성이 있었다.

• Child Health Nursing Research
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• 제13권2호
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• pp.136-146
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• 2007

Purpose: The purpose of this study was to develop a tool to assess the severity of illness in high risk newborns. Method: The research design was a methodological study. The tool was developed in 4 stages: first, preliminary items were developed based on a questionnaire about the severity of illness index that was given to 8 health professionals in Neonatal Intensity Care Units (NICU) second, a panel of specialists reduced the preliminary items using 3 validity tests; third, final items were selected from the results of a pre-test. Finally, from July 2005 to May 2006, reliability and validity were tested with a sample of 160 high risk newborns admitted to the NICU. Results: The final tool to identify the severity of illness index in high risk newborns consisted 39 items and Cronbach's alpha coefficient for internal consistency was .922. Using factor analysis, 4 factors were extracted and these factors explained 54.451% of the total variance. Conclusion: The instrument for assessing the severity of illness in high risk newborns developed in this study was identified as a tool with a high degree of reliability and validity. In this sense, this tool can be effectively utilized for assessing and implementing care for high risk newborns.

• 농촌의학ㆍ지역보건
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• 제44권3호
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• pp.138-143
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• 2019

양봉 작업은 들기 작업이 많아 근골격계 부담이 컸으며 양봉 농업인의 대부분이 지난 1년 동안 직업과 관련된 근골격계 질환 증상을 호소했다. 보조도구인 벌통리프트를 사용하면 양봉 작업으로 인한 근골격계 부담을 줄일 수 있다.

• 보건행정학회지
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• 제26권4호
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• pp.271-278
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• 2016

Background: This study purposed to analyze the relationship between regional obesity rates and regional variables. Methods: Data was collected from the Korean Statistical Information Service (KOSIS) and Community Health Survey in 2012. The units of analysis were administrative districts such as city, county, and district. The dependent variable was the age-sex adjusted regional obesity rates. The independent variables were selected to represent four aspects of regions: health behaviour factor, psychological factor, socio-economic factor, and physical environment factor. Along with the traditional ordinary least square (OLS) regression analysis model, this study applied geographically weighted regression (GWR) analysis to calculate the regression coefficients for each region. Results: The OLS results showed that there were significant differences in regional obesity rates in high-risk drinking, walking, depression, and financial independence. The GWR results showed that the size of regression coefficients in independent variables was differed by regions. Conclusion: Our results can help in providing useful information for health policy makers. Regional characteristics should be considered when allocating health resources and developing health-related programs.

• Safety and Health at Work
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• 제5권1호
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• pp.27-31
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• 2014

Background: Carpal tunnel syndrome (CTS) is a common work-related peripheral neuropathy. In addition to grip force and repetitive hand exertions, wrist posture (hyperextension and hyperflexion) may be a risk factor for CTS among workers. However, findings of studies evaluating the relationship between wrist posture and CTS are inconsistent. The purpose of this paper was to conduct a meta-analysis of existing studies to evaluate the evidence of the relationship between wrist posture at work and risk of CTS. Methods: PubMed and Google Scholar were searched to identify relevant studies published between 1980 and 2012. The following search terms were used: "work related", "carpal tunnel syndrome", "wrist posture", and "epidemiology". The studies defined wrist posture as the deviation of the wrist in extension or flexion from a neutral wrist posture. Relative risk (RR) of individual studies for postural risk was pooled to evaluate the overall risk of wrist posture on CTS. Results: Nine studies met the inclusion criteria. All were cross-sectional or case-control designs and relied on self-report or observer's estimates for wrist posture assessment. The pooled RR of work-related CTS increased with increasing hours of exposure to wrist deviation or extension/flexion [RR = 2.01; 95% confidence interval (CI): 1.646-2.43; p < 0.01: Shore-adjusted 95% CI: 1.32-2.97]. Conclusion: We found evidence that prolonged exposure to non-neutral wrist postures is associated with a twofold increased risk for CTS compared with low hours of exposure to non-neutral wrist postures. Workplace interventions to prevent CTS should incorporate training and engineering interventions that reduce sustained non-neutral wrist postures.

• Safety and Health at Work
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• 제10권1호
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• pp.3-20
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• 2019

This review aimed to identify risk factors for occupational accidents and illnesses among young workers in the Nordic countries and to attain knowledge on specific vulnerable groups within the young working force that may need special attention. We conducted a systematic review from 1994 to 2014 using five online databases. Of the 12,528 retrieved articles, 54 met the review criteria and were quality assessed, in which data were extracted focusing on identifying occupational safety, health risk factors, and vulnerable groups among the young workers. The review shows that mechanical factors such as heavy lifting, psychosocial factors such as low control over work pace, and organizational factors such as safety climate are all associated with increased injury risk for young Nordic workers. Results show that exposures to chemical substances were associated with skin reactions, e.g., hand eczema. Heavy lifting and awkward postures were risk factors for low back pain, and high job demands were risk factors for mental health outcomes. The review identified young unskilled workers including school drop-out workers as particularly vulnerable groups when it comes to occupational accidents. In addition, apprentices and young skilled workers were found to be vulnerable to work-related illnesses. It is essential to avoid stereotyping young Nordic workers into one group using only age as a factor, as young workers are a heterogeneous group and their vulnerabilities to occupational safety and health risks are contextual. Politicians, researchers, and practitioners should account for this complexity in the education, training and organization of work, and workplace health and safety culture.