• Nutrition Research and Practice
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• v.13 no.6
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• pp.480-487
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• 2019

BACKGROUND/OBJECTIVES: Osteoarthritis (OA) is a major public health issue in Japan and other countries, and foods that prevent or treat OA are in strong demand. Proteins and peptides in chicken meat and bones are known for being rich in functional and nutritional ingredients for the improvement of osteoporosis. We speculated that chicken legs, a food consumed in many regions of the world, may also contain such ingredients. In this study, we aim to (i) evaluate the effect of chicken leg extract (CLE) on the promotion of cartilage matrix production and (ii) identify the active ingredient in CLE that contributes to this function. MATERIALS/METHODS: Artificial CLE digest was prepared, and the acid mucopolysaccharide production-promoting activity of the CLE digest was evaluated by alcian blue staining of ATDC5 cells. CLE was orally administered to rabbits with burr holes in the knee joint of the femur, and the degree of regeneration of cartilage matrix was evaluated. Furthermore, we investigated orally administered CLE-derived peptides in human plasma using LC-MS. From measuring the acid mucopolysaccharide production-promotion activity of these peptides, a molecule considered to be an active ingredient in the CLE digest was identified. RESULTS: CLE digest promoted acid mucopolysaccharide production and facilitated regeneration of cartilage matrix in in vitro and in vivo experiments. Four peptides including phenylalanyl-hydroxyproline (Phe-Hyp) were detected as CLE-derived peptides in human plasma. The effect of CLE was inferred to be due to Phe-Hyp, which was confirmed to be present in the CLE digest. CONCLUSIONS: It was shown that CLE stimulated the production of articular cartilage matrix both in vitro and in vivo, and that CLE could be an effective food for preventing or treating OA. Furthermore, only Phe-Hyp was confirmed as the active compound in the CLE digest, suggesting that the activity of CLE was due to Phe-Hyp.

• Journal of the Korean Society of Physical Medicine
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• v.19 no.2
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• pp.75-89
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• 2024

PURPOSE: This study aims to review the FUNfitness program, conducted by physical therapists as part of the Special Olympics Athlete Health Promotion Program, to provide basic data for the health management of individuals with intellectual disabilities. METHODS: This study collected and organized materials related to the Special Olympics Athlete Health Promotion Program, as well as training manuals for FUNfitness. Additionally, it referenced activity reports of the FUNfitness program developed through the collaboration between the American Physical Therapy Association and the Special Olympics. RESULTS: The results of this study present the definition and composition of the Special Olympics Athlete Health Promotion Program, its objectives, the definition and design objectives of the FUNfitness program, the composition and evaluation procedures of the testing and assessment items, and recommendations for referral for additional physical therapy interventions following FUNfitness education. CONCLUSION: This article describes the importance of physical therapists understanding physical therapy screening and management for the health care of individuals with intellectual disabilities, emphasizing the need for their continuous interest in promoting the health of individuals with intellectual disabilities.

• 대한예방의학회:학술대회논문집
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• 1998.10b
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• pp.327-328
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• 1998

• Journal of Korean Academy of Nursing
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• v.50 no.1
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• pp.81-100
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• 2020

Purpose: The purpose of this study was to define and clarify the concept of political competence for nurses. Methods: A hybrid model method was used to investigate the dimensions, attributes, and definitions of the concept. In the theoretical stage of the study, literature on nursing, politics, and other discipline were reviewed. In the fieldwork stage, individual in-depth interviews and focus groups interviews were conducted with politically seasoned experts or activists who had an understanding of the concept of political competence for extensive descriptions in nursing and field of health care. Results: The concept of political competence was represented in four dimensions as political knowledge, political efficacy, political interaction, and political activity. In the political knowledge dimension, there were three attributes, namely, political knowledge, political information and systematic analysis ability. The political efficacy dimension had three attributes of internal political efficacy, external political efficacy, and self-pride of nursing profession. The political interaction dimension had three attributes of organizations and community service, networking, and persuasive power. The political activity dimension had six attributes of political leadership, political expression, assertive behavior, political advocacy, political participation, and policy intervention. Conclusion: This concept development might provide a basic understanding of developing a measurement tool and for constructing a theory promoting nurses' political competence.

• Journal of Microbiology and Biotechnology
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• v.16 no.4
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• pp.531-537
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• 2006

Lactic acid-producing bacteria (LABs) are known to have various beneficial properties for health. However, they are generally considered to have an adverse effect on teeth, since they produce acid. Nonetheless, milk and cheese containing specific LAB strains were recently found to have an inhibitory effect on dental caries in children, with an inhibitory activity towards the growth of Streptococcus mutans suggested as the responsible mechanism. Accordingly, the current study selected a probiotic candidate for oral health and studied its inhibitory mechanism against dental caries. Twenty-two LAB species belonging to eleven genuses were screened for promoting bone nodule formation using direct microscopic examination. Only one isolate, Weissella kimchii strain PL9001, increased the bone nodule formation significantly. The addition of W. kimchii strain PL9001 to bone cells prepared from mouse calvaria increased the bone nodule formation, calcium accumulation, and activity of alkaline phosphatase (the osteoblastic marker). Moreover, W. kimchii strain PL9001 inhibited the invasion of Streptococcus mutans into bone cells, and an organic extract of the culture supernatant of W. kimchii strain PL9001 inhibited the growth of Strep. mutans. Therefore, the results suggest that W. kimchii strain PL9001 can be used as a preventive measure against dental caries. This is the first time that a LAB has been shown to promote bone nodule formation and prevent the invasion of Strep. mutans into bone cells.

• International Journal of Advanced Culture Technology
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• v.11 no.3
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• pp.122-130
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• 2023

This study aimed to identify factors associated with depression by household type among the elderly in the community during the COVID-19 pandemic. The subjects were 72,812 elderly aged 65 and over who participated in the 2020 Community Health Survey. Multivariate logistic regression with complex samples was performed to analyze the data. The incidence of depression was higher in single-person households than in multi-person households. In single-person and multi-person households, depression was higher in women, those over 75 years old, those with middle school graduates or lower, those with a household monthly income of 1 million won or less, and those receiving basic living recipients. Factors related to depression among the elderly in single-person households were physical activity, sleep time, and drinking, among the changes in lifestyle due to COVID-19. Factors related to depression among the elderly in multi-person households were physical activity, sleep time, consumption of instant food, and alcohol drinking, among the changes in lifestyle due to COVID-19, and psychological concerns due to COVID-19. Promoting mental health and developing customized programs by household type is necessary to prevent depression in the elderly in the community.

• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.269-275
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• 2021

The in vitro anti-obesity activity of 12 species of tree sprouts in differentiated 3T3-L1 cells and the mechanisms underlying their activity were evaluated. (+)-Catechin and quercetin concentrations in the sprouts were analyzed by HPLC/UV at 270 and 254 nm, respectively. Euonymus alatus (EAT) and Fraxinus mandschuria (FMS) extracts at doses of 50 and 100 ㎍/mL inhibited the accumulation of lipid droplets in differentiated 3T3-L1 cells. Moreover, EAT and FMS downregulated the expression of the CCAAT/enhancer-binding protein-α, adipogenesis-related proteins peroxisome proliferator-activated receptor-γ, and adipocyte P-2α in differentiated 3T3-L1 cells. Tree sprouts with an abundant flavonoid content exerted the highest anti-obesity activity. Concentrations of total flavonoids were the highest in FMS (24.281 mg/g DW) sprouts. These findings could be used to develop health-promoting functional foods or supplements derived from tree sprouts.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.12
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• pp.1974-1979
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• 2018

Objective: This study compared fatty acid compositions and antioxidant activities of high-preference cuts (loin, tenderloin, and rib) and low-preference cuts (brisket, topside, and shank) of Hanwoo (Bos taurus coreanae) cows to obtain potentially useful information for promoting the consumption of various low-preference cuts. Methods: Individual 500 g samples of fresh beef were collected from each of the six cuts from 10 Hanwoo cows (quality grade 1) and immediately freeze-dried. The dried samples were evaluated for fatty acid composition, free radical scavenging activities (hydroxyl, alkyl, and 2, 2'-diphenyl-1-picrylhydrazyl [DPPH] radical), and antioxidative enzyme activities (glutathione peroxidase [GPx], glutathione-S-transferase [GST], and superoxide dismutase [SOD]). Results: The percentages of total polyunsaturated fatty acids were significantly higher in low-preference cuts than in high-preference cuts (p<0.05). Hydroxyl, alkyl, and DPPH radical scavenging activities were significantly higher in low-preference cuts than in high-preference cuts (p<0.05). In addition, the activities of antioxidant enzymes, such as GPx, GST, and SOD, were significantly higher in low-preference cuts compared with high-preference cuts (p<0.05). Conclusion: These results may influence consumers to include more low-preference cuts in their selections based on the nutritional facts, which could help to balance the beef market in South Korea.

• Toxicological Research
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• v.32 no.2
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• pp.141-147
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• 2016

We evaluated the antioxidant activity and melanogenic effects of black soybean ethanol extracts, including Rhynchosia nulubilis bean ethanol extract (RNBEE), R. nulubilis leaf ethanol extract (RNLEE), R. volubilis bean ethanol extract (RVBEE), and R. volubilis leaf ethanol extract (RVLEE). The total polyphenol contents of RNBEE, RNLEE, RVBEE, and RVLEE were 16.0, 57.7, 365.9, and 260.1 mg/g, respectively. The total flavonoid contents of RNBEE, RNLEE, RVBEE, and RVLEE were 40.4, 91.7, 84.7, and 216.5 mg/g, respectively. The electron-donating abilities of RNBEE, RNLEE, RVBEE, and RVLEE at $1,000{\mu}g/mL$ were 32.4%, 12.7%, 83.5%, and 84.5%, respectively. RNBEE, RNLEE, RVBEE, and RVLEE at $50{\mu}g/mL$ significantly increased (p < 0.01) melanin contents by 30.4%, 32.1%, 35.5%, and 37.4%, respectively, compared to that of the control. RNBEE, RNLEE, RVBEE, and RVLEE at $50{\mu}g/mL$ significantly increased (p < 0.01) intracellular tyrosinase activity by 18.4%, 21.8%, 21.5%, and 21.1%, respectively, compared to that of the control. These results demonstrated that black soybean ethanol extracts promote melanogenesis in melan-a cells. Among the black soybean ethanol extracts, R. volubilis was found to be more effective than R. nulubilis, and leaf extract was found to be more effective than bean extract. The potential mechanism underlying the hyperpigmentation effects of black soybeans is the promotion of tyrosinase activity.

• Journal of Digital Convergence
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• v.12 no.9
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• pp.225-235
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• 2014

The purpose of this study is to examine the association between regular exercise habit, self-rated health status, health practice index, and health promotion lifestyle profile among 241 college male students from Gyeonggi-do. Subjects were divided into two groups: students majoring in physical education(PE) and students who are not majoring in PE. The average BMI were $22.77{\pm}2.74$ among PE majors and $21.57{\pm}4.30$ among the other group. PE majors showed higher results in all of physiological, subjective and social health conditions. Both groups showed low scores in health practice index, which were $2.86{\pm}1.10$ among PE majors and $2.97{\pm}1.46$ among non-PE majors, showing no difference in statistical significance. Index for health promoting lifestyle practices were somewhat higher among PE majors; however, there were no statistical significance with the results of $123.38{\pm}19.93$ among PE majors and $119.98{\pm}22.04$ among non-PE majors. The analysis on the index for health promoting lifestyle practices in sub-categories showed that PE majors showed significantly higher scores compared with non-PE majors in physical activities area and vice versa in nutrition area.