• BMB Reports
• /
• v.53 no.10
• /
• pp.539-544
• /
• 2020

Skin aging appears to be the result of overlapping intrinsic (including genetic and hormonal factors) and extrinsic (external environment including chronic light exposure, chemicals, and toxins) processes. These factors cause decreases in the synthesis of collagen type I and elastin in fibroblasts and increases in the melanin in melanocytes. Collagen Type I is the most abundant type of collagen and is a major structural protein in human body tissues. In previous studies, many products containing collagen derived from land and marine animals as well as other sources have been used for a wide range of purposes in cosmetics and food. However, to our knowledge, the effects of human collagen-derived peptides on improvements in skin condition have not been investigated. Here we isolate and identify the domain of a human COL1A2-derived protein which promotes fibroblast cell proliferation and collagen type I synthesis. This human COL 1A2-derived peptide enhances wound healing and elastin production. Finally, the human collagen alpha-2 type I-derived peptide (SMM) ameliorates collagen type I synthesis, cell proliferation, cell migration, and elastin synthesis, supporting a significant anti-wrinkle effect. Collectively, these results demonstrate that human collagen alpha-2 type I-derived peptides is practically accessible in both cosmetics and food, with the goal of improving skin condition.

• Archives of Reconstructive Microsurgery
• /
• v.11 no.2
• /
• pp.173-178
• /
• 2002

Wound healing is the result of interaction of normal cellular and biochemical responses that restore the interrupted anatomical structure in limited period. When any response of them is impaired, it results in chronic wound. The factors that influence the wound healing process is not only limited to the fundamental disease of the individual but also the local factors, especially various growth factors secreted from the various cells involved in tissue regeneration have important role. Recent reports that the chronic wounds are depleted of these growth factors have led active studies on the alteration of local wound environment with manipulation of the growth factors and the its application in management of chronic wounds. We investigated the effect on the chronic wounds in 10 patients with various pathologic conditions to suggest the appropriate application and guideline of the indication. The chronic wounds resulting from various causes in 10 patients were treated with rhPDGF gel and good wound care. All the chronic wounds were located on the lower extremity and the average diameter was 2.5 cm. 7 patients were completely cured within 8 weeks, however the patient who received previous radiation therapy the healing was delayed to 14 weeks. Two patients with vascular ulcer were not cured with rhPDGF alone. Local application of rhPDGF has yielded complete cure of the chronic wound in 70% of the patients within 2 months. The author suggests that it would be an effective alternative treatment modality of chronic wound when it is applied with good wound care and appropriate indication.

• Human Ecology Research
• /
• v.55 no.6
• /
• pp.649-659
• /
• 2017

This study investigated the effect of a child care center directors' work stress and awareness of their servant leadership on burnout. The subjects of this study were 200 child care center directors in Incheon. They responded to 'Work Stress Scale', 'Maslach Burnout Inventory (MBI)', 'Servant Leadership Scale'. There were five subscales of Servant Leadership Scale (altruistic calling, emotional healing, wisdom, persuasive mapping, and organizational stewardship). Data were analyzed by frequency, percentage, mean, standard deviation, Pearson's correlation and hierarchical regression. Moderating effects were examined using analysis procedures of Baron and Kenny. The major results were as follows. First, child care center directors' burnout and work stress were positively correlated. Child care center directors' burnout and awareness of their servant leadership (emotional healing, wisdom, persuasive mapping, and organizational stewardship) was negatively correlated. Second, child care center directors' work stress, emotional healing, persuasive mapping and organizational stewardship affected their burnout. This means that the work stress of child care center directors increases their burnout. However, the child care center director's servant leadership is a factor in reducing burnout. Third, child care center directors' work stress and organizational stewardship had an interaction effect on burnout. The results suggests that child care center directors' organizational stewardship needs to be considered as an important factor for decreasing their own burnout. We also discussed implications and suggestions for future research and policy makers.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.14 no.5
• /
• pp.893-900
• /
• 2019

This paper deals with the analysis of SON (Self Organization Network) technology in LTE networks. SON is a unique LTE feature compared to previous cellular systems UMTS and GSM, and is a cost-effective tool for achieving the best performance in a changing environment. In addition, SON has the function of automating the settings of the network, enabling centralized planning and reducing the need for manual tasks. SON is largely divided into three categories: Self-Configuration, Self-Optimization, and Self-Healing. Each large category has a detailed description, and all the technologies in each category come together to complete the technology called SON. In this paper, we analyzed intensively about ANR among the techniques of Self-Configuration in each of the three categories.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.45 no.1
• /
• pp.34-42
• /
• 2019

Objectives: Various bone graft substitute materials are used to enhance bone regeneration in the maxillofacial skeleton. In the recent past, synthetic graft materials have been produced using various synthetic and natural calcium precursors. Very recently, eggshell-derived hydroxyapatite (EHA) has been evaluated as a synthetic bone graft substitute. To assess bone regeneration using EHA in cystic and/or apicectomy defects of the jaws through clinical and radiographic evaluations. Materials and Methods: A total of 20 patients were enrolled in the study protocol (CTRI/2014/12/005340) and were followed up at 4, 8, 12, and 24 weeks to assess the amount of osseous fill through digital radiographs/cone-beam computed tomography along with clinical parameters and complications. Wilcoxon matched pairs test, means, percentages and standard deviations were used for the statistical analysis. Results: The sizes of the lesions in the study ranged from 1 to 4 cm and involved one to four teeth. The study showed significant changes in the formation of bone, the merging of material and the surgical site margins from the first week to the first month in all patients (age range, 15-50 years) irrespective of the size of the lesions and the number of teeth involved. Bone formation was statistically significant from the fourth to the eighth week, and the trabecular pattern was observed by the end of 12 weeks with uneventful wound healing. Conclusion: EHA showed enhancement of bone regeneration, and healing was complete by the end of 12 weeks with a trabecular pattern in all patients irrespective of the size of the lesion involved. The study showed enhancement of bone regeneration in the early bone formative stage within 12 weeks after grafting. EHA is cost effective and production is environment friendly with no disease transfer risks. Thus, natural bioceramics will play an important role in the reduction of costs involved in grafting and reconstruction.

• Korean Journal of Veterinary Research
• /
• v.62 no.3
• /
• pp.21.1-21.10
• /
• 2022

With the increasing population of companion dogs, the social cost derived from their behavioral problems is increasing. Therefore, it is important to understand the environment to provide experience for dogs via interactions with their owners to prevent and solve these problems. The parenting behavior of dog owners as an environmental factor has a profound impact on the behavior development of dogs, as does the parenting behavior on children. Therefore, this study aimed to develop a scale to assess the dog owner's parenting behavior. Exploratory factor analysis involving 300 participants resulted in a scale with four subscales, Positive Education, Involvement of Socialization, Intimacy, and Stable Responses, and 19 items. Confirmatory factor analysis was then performed to verify its reliability and validity. The result of parenting behaviors assessed by this scale was significantly different between a group with dogs with problematic behavior (n = 141) and those without (n = 159). Overall, a dog owner's parenting behavior involves affection and control aspects, but the role required specifically in the control aspect is distinguished from the parenting behavior with children. The findings in the present study will provide dog owners with effective education that will help prevent dogs from developing behavioral problems.

• Journal of The Korea Institute of Healthcare Architecture
• /
• v.17 no.2
• /
• pp.45-52
• /
• 2011

The visual sensory information in physical environments can induce or reduce occupants' stress. In healthcare settings, positive environmental stimulations can promote patient well-being by reducing their stress: poor health environments work against a patient's health. Changing the color in a patient room is an inexpensive process and thus finding better colors for healthcare settings is a cost effective method of improving healing environments. Color may have important implications for pediatric patients, but the investigation of Korean populations has been non-existent. The purpose of this study was to investigate Korean pediatric patients' color preferences for patient room design. The color preferences from 50 Korean pediatric patients were recorded and investigated for gender effects. A simulation method was used because of its reliability and feasibility, allowing for investigating the value of color in real contexts and controlling confounding variables. The overall color preferences from Korean pediatric patients showed that they preferred blue the most and white the least. Gender differences were found in red and purple. Girls preferred red and purple more than boys. The results from this study can help healthcare providers and designers better understand appropriate colors for Korean pediatric patient populations.

• Korean Institute of Interior Design Journal
• /
• v.15 no.1 s.54
• /
• pp.106-112
• /
• 2006

Buildings undergo changes by various factors according as pass at time. Due to that social requests and issues form one common sense of value and this would influence the architect's design intention. In fact, the form and function of buildings have coped with transition of the common sense of value by each times. Hospital architecture is also changed in function, scale and technology since, Kwanghyewon which was the first western style hospital in Korea was established in 1885. It is changing that the social needs for hospital which was a basic function of healing to laying emphasis on the function of precaution. According to this, the change of hospital spaces means that it can promote healing environment which is expanded from the modern concept of isolation, accommodation and urban sanitation. These changed concepts were adopted limited areas in hospitals at first however, nowadays they are expanding to other areas. So, this is caused to make the image of the hospital. From this point of view, Entry space is an example to show the changes. This study is intended to determine the overall space structure of entry area and to classify and analyze the difference.

• Journal of Environmental Science International
• /
• v.30 no.7
• /
• pp.529-536
• /
• 2021

The forest landscape has been considered to be one of the most beneficial factors, in regard to facilitating the therapeutic effects of the forest environment. The aim of this study was to review the preceding literary works on the correlation between forest landscape and its therapeutic effects and to ponder on key factors of forest landscape that promotes therapeutic results on people's psychological and physiological responses. Literature found in domestic research databases was analyzed and examined in accordance with the 'Preferred reporting items for systematic reviews and meta-analyses(PRISMA)' process. Six papers out of 1,890 were selected as key literature to support the connection. The quality of forest landscape was found to be an integral environmental factor in determining the healing effects of forests. In particular, several factors, including forest types, aquatic elements within the forest landscape, forest-use density and aesthetic elements of forest landscape were found to be crucial for enhancing the therapeutic effects on people's wellbeing. Despite the limited sample groups in the analyzed literature, the results offered a significant insight in supporting the healing effects of forests. Further studies on this subject are required to provide more scientific data for verifying the quality of the therapeutic effects of forests.

• The Korean Journal of Ecology
• /
• v.24 no.3
• /
• pp.191-202
• /
• 2001

Human being has extensively invaded, occupied, and used the natural environment as a consequence of the advance of civilization. Mankind has increasingly modified the environment for his own benefit. Such modification has not only caused the extinction of many other species but also, caused human being himself to confront to serious environmental problems. The recognition of this fact by human is expressed in the establishment and development of restoration ecology. This new study fold is, in fact, an "Eco-technology" directed towards healing of damages to the environment. The goal is to reestablish processes and functions in a damaged site, imitating the way of healing works that an integral natural system carries out. Ecological restoration uses different treatments and approaches according to extents of the existing damage and to the specific goal to be achieved. An ecological diagnosis is, therefore, required prior to restoration practice. The cost and efforts to achieve a proposed goal can be significantly reduced when a restoration plan is formulated upon the results of well-conducted ecological diagnosis. Under such perspectives, restoration ecology is a practical science, which aims to solve the problems of the real world based on the existing ecological principle. Furthermore, restoration ecology offers opportunities to test the ecological concepts and theories obtained by means of the former ecological studies. Human being exploited natural environment excessively for his comfort on one hand but damaged it inevitably on the other hand. Such intensive resource utilization and continuous environmental damaging will extend into the future and ultimately jeopardize the survival of humankind if no prompt action is taken. In the present situation, we must not continue such lives without any preparation. We have to cope with the environmental crises approaching near us by pursuing the ecological restoration that reduce the unnecessary use, recruit the deficient part, and strengthen the weak portion in our environment. Restoration ecology could be recognized as the ecology for the future in such viewpoints.