• Korean Journal of Oriental Medicine
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• v.15 no.3
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• pp.63-74
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• 2009

Background and Purpose : Oncheongeum(溫淸飮) composed of Samultang(四物湯) and Hwangryunhaedoktang(黃連解毒湯) was mainly used for healing metrorrhagia in the Qing dynasty of China. At present, Oncheongeum is used for treating a broad spectrum of diseases such as skin disease, stomatitis, behcets disease, diabetes mellitus and, especially in Japan, atopic dermatitis. To our knowledge, however, neither the precise constituents and their effects of Oncheongeum nor the criteria for the prescription of Oncheongeum were defined. To address this issue, we searched and performed analysis of Korean, Chinese and Japanese articles reporting the clinical and experimental studies of Oncheongeum. Methods : We searched articles in the national assembly library of Korea by using keyword 'Oncheongeum' korean. Similarly, we did chinese articles in the CNKI and japanese ones in the CiNii, respectively. Results : We found 13 korean articles about Oncheongeum in the national assembly library, 34 chinese articles in the CNKI, and 23 japanese in the CiNii. The papers were divided into clinical and experimental articles. The clinical articles were mainly published from China and Japan, and their subjects were predominantly on skin diseases. Conclusions : There were a lot of case reports about Oncheongeum used in the clinical studies. In order to better understand the effects of Oncheongeum, systematic review of the studies seems essential. The efficacy of Oncheongeum reported in the clinical studies should be supported by experimental data. Not much were clinical reports in Korea, although we are expecting more to come. It is possible to not only analyse but compare Oncheongeum with other prescriptions used for atopic dermatitis. More comprehensive and comparative analysis of three countries' prescriptions might provide a way of how to standardize prescriptions, which leads oriental medicine to an evidence based medicine.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.10
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• pp.6102-6113
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• 2014

This is an empirical study of the factors impacting on supervisee's satisfaction on coaching and supervision in Korea. The study set four independent variables (supervisor, supervisee, contents, and organization), a moderator variable (relationship between the supervisor and supervisee) and a dependent variable (supervision satisfaction) based on the theoretical background on supervision. The data was collected from a survey of 112 certified coaches who had experienced supervision. As a results of the hypotheses tests, the supervisor and organization factors affected the supervision satisfaction. The relationship between the supervisor and supervisee moderates the impact of the supervisor and supervisee on the supervision satisfaction. They reported that the effectiveness of the coaching supervision in Korea was strongly dependent on the supervisors. These results were attributed to the short history of the coaching supervision and the lack of experience related to it. They also suggested that a great deal of research on coaching supervision will be needed to develop a clear identity/framework of coaching supervisor and its methods.

• Journal of Korean Society of Rural Planning
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• v.25 no.4
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• pp.57-64
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• 2019

The purpose of this study was to investigate the general characteristics of the elderly who participate in the planting activities of weekend farms and the effect of the planting activity levels on the subjective health, depression, and human relationships of the elderly. Data were collected and analyzed using subjective health, depression, and human relationship measures that can represent physical, mental, and social health. The main results were as follows. The educational level, the status of spouses, and the number of diseases of the general characteristics of the elderly who participated in the weekend farm showed significant differences in all subjective health, depression, and human relationships. Plant cultivation activity level was positively correlated with the subjective health of the elderly and had a significant effect. The higher the level of plant cultivation activity, the more positively it affected the human relationship. Plant cultivation activity was negatively correlated with the depression of the elderly.

• Archives of Plastic Surgery
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• v.37 no.4
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• pp.317-322
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• 2010

Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

• Nutritional Sciences
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• v.9 no.1
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• pp.3-8
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• 2006

Functional damage to microvascular endothelial cells by hyperglycemia is thought to be one of the critical risk factor.; in the impaired wound healing seen with diabetes mellitus. It is also thought that oxidative stress plays a significant role in this endothelial cell dysfunction. The present study examined the differential effects of flavonoids on endothelial cell dysfunction under high glucose conditions. Human endothelial cells exposed to 30 mmol/L glucose for 7 d were pre-treated with various flavonoids and pulse-treated with 0.2 mmol/L $H_2O_2$ for 30 min. High glucose markedly decreased cell viability with elevated oxidant generation and nuclear condensation. $H_2O_2$ insult exacerbated endothelial cytotoxicity due to chronic exposure to high glucose. (-)Epigallocatechin gallate and quercetin improved glucose-induced cell damage with the disappearnnce of apoptotic bodies, whereas apigenin intensified the glucose cytotoxicity. In addition, cell viability data revealed that these flavonoids of (-)epigallocatechin gallate and quercetin substantially attenuated both high glucose- and $H_2O_2$- induced dual endothelial damage. These results suggest that (-)epigallocatechin gallate and quercetin may be beneficial agents for improving endothelial cell dysfunction induced by high glucose and may prevent or reduce the development of diabetic vascular complications.

• Journal of Sasang Constitutional Medicine
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• v.30 no.4
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• pp.33-52
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• 2018

Objectives The purpose of this study was to analyze the clinical characteristics of patients with hyperhidrosis who visited a Korean medicine hospital, and provide information on treated hyperhidrosis, based on Sasang Constitutional medicine. Methods A retrospective review was made of the electronic medical record (EMR) charts for 157 Korean patients with hyperhidrosis (90 male, 67 female), who first visited hospital from January 1, 2013 to December 31, 2017. The following information was collected: sex, age, height, weight, body mass index (BMI) and clinical data (diagnosis, area of onset, duration of illness, aggravating factors, medication, healing process, et al). Results There were many patients with hyperhidrosis, in the other of So-Yang type (57.3%), Tae-Eum type (35.0%) and So-Eum type (7.6%). The proportion of male was higher than female. The most common area of hyperhidrosis was hands and feet (44.0%), followed by generalized whole body (27.4%) and head and face (25.5%). The cure rate of hyperhidrosis was 32.2%, and effectiveness rate of that was 72.7%. In individual patients, the better the usual health condition expressed by original symptoms, the higher the possibility of treatment success, with shortened duration of treatment and reduced total drug dose. The most frequent treatment modality in patients was that consistently improved, and this duration of treatment was statistically significantly shorter than that experienced worsening of excessive sweating during treatment period (p<0.001). Conclusions This study provides some original information on the Korean patients with hyperhidrosis, and suggests the suitability of Sasang Constitutional medicine as treatment methods for hyperhidrosis.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.45 no.5
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• pp.276-284
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• 2019

Objectives: This study sought to compare efficiency results between the use of a customized implant (CI) and a reconstruction plate (RP) in mandibular defect reconstruction in an animal model. Materials and Methods: Fifteen rabbits underwent surgery to create a defect in the right side of the mandible and were randomly divided into two groups. For reconstruction of the mandibular defect, the RP group (n=5) received five-hole mini-plates without bone grafting and the CI group (n=10) received fabricated CIs based on the cone-beam computed tomography (CBCT) data taken preoperatively. The CI group was further divided into two subgroups depending on the time of CBCT performance preoperatively, as follows: a six-week CI (6WCI) group (n=5) and a one-week CI (1WCI) group (n=5). Daily food intake amount (DFIA) was measured to assess the recovery rate. Radiographic images were acquired to evaluate screw quantity. CBCT and histological examination were performed in the CI subgroup after sacrifice. Results: The 1WCI group showed the highest value in peak average recovery rate and the fastest average recovery rate. In terms of reaching a 50% recovery rate, the 1WCI group required the least number of days as compared with the other groups ($2.6{\pm}1.3days$), while the RP group required the least number of days to reach an 80% recovery rate ($7.8{\pm}2.2days$). The 1WCI group showed the highest percentage of intact screws (94.3%). New bone formation was observed in the CI group during histological examination. Conclusion: Rabbits with mandibular defects treated with CI showed higher and faster recovery rates and more favorable screw status as compared with those treated with a five-hole mini-plate without bone graft.

• Journal of Forest and Environmental Science
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• v.37 no.3
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• pp.260-268
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• 2021

This study was conducted to grasp users' preferences and behavior of forest paths and to provide basic data for forest path construction in the future. Among forest path users, males and females over 20 years old were surveyed on forest path preferences, motives for visiting, using time and distance, companions, and sources for obtaining information on forest paths. A total of 587 people participated in the questionnaire, and cross-analysis was conducted simultaneously using the SPSS statistical program. In analyzing the preference of forest paths, it was found that male and the general public preferred trekking path for activities while female and foresters preferred forest path for relaxation and healing (p<0.05). As for the motives for visiting forest paths, the response that they visited for a walk/rest was the highest in gender, occupation, and age group. As for the number of annual visits, less than 5 was the highest in overall, and foresters tended to visit forest path more often than the general public, and the number of visits to the forest paths increased with age (p<0.01). The most common route to acquire information about forest paths is the Internet, while the Internet use is relatively low in those over 60s (p<0.05). The response ratio of accompanying their family in visiting forest paths were the highest, while the response in their 20s and 60s was the most in accompanying their friends (p<0.05).

• Biomedical Science Letters
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• v.27 no.3
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• pp.142-153
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• 2021

Liver fibrosis is a wound-healing response to chronic liver injury, which is caused by the continuous and excess deposition of extracellular matrix (ECM). The aim of this study is to investigate whether Uncaria rhynchophylla water extract (UR) can ameliorate thioacetamide (TAA)-induced liver fibrosis. The liver fibrosis model was induced on C57BL/6 mice by intraperitoneal injection with TAA three times a week for 8 weeks. UR (200 mg/kg) or silymarin (50 mg/kg) was administered orally daily for 8 weeks. Biochemical analyses including AST, ALT, MPO, and Ammonia levels were measured in serum. In the mice liver tissues, western blot and histological staining were analyzed. As a result, UR dramatically reduced the levels in serum AST, ALT, MPO, and Ammonia levels. UR treatment regulated NADPH oxidase factors expression, and antioxidant enzymes except for GPx-1/2 were significantly increased via Nrf2 activation. Furthermore, pro-inflammatory mediators, such as COX-2 and iNOS were markedly suppressed through the inhibition of NF-κB activation. Expressions of ECM-related protein including α-SMA and Collagen I were noticeably decreased. The additional histological evaluation confirmed that hepatocyte damage and collagenous fiber accumulation were attenuated. Taken together, these data suggest that UR possessed hepatoprotective effects in TAA-induced liver fibrosis via the NF-κB inactivation and Nrf2 activation. Therefore, UR may act as a potential therapeutic drug against liver fibrosis.

• Journal of Korean Society of Rural Planning
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• v.28 no.2
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• pp.33-40
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• 2022

The purpose of this study is to review the effect of previous research data with virtual reality-based Physical Activity Therapy Programs(PATPs) in adult on the physical fitness factors. Research articles were retrieved from 2008 to 2021 with the Research Information Sharing Service(RISS) and Pubmed database. The main search terms were 'care', 'therapy', 'healing', 'exercise' or 'physical activity', and 'virtual reality'. The criteria for selecting articles of this study were the originality, duplication, Randomized controlled trial(RCT) experiment and subject. Finally, 18 papers were selected among 318 articles, which were excluded if any of the criteria was not satisfied. Most of papers(15) were conducted in the last 5 years, because of the high interest due to the development of virtual reality implementation technology and COVID-19 pandemic. The participants were mainly patients(8), and the types of diseases were stroke(2). The physical fitness factors were mostly balance ability(7), muscle strength(7), and range of motion(6). All the physical fitness factors were significantly improved after PATPs. However, 11 studies were conducted for less than 4 weeks, including 6 studies were performed a bout of acute exercise. Also, 14 studies did not clearly present the intensity of PATPs. In addition, there were 9 studies, that simply applied games without specialized programs. In conclusion, it seems that virtual reality-based PATPs have a positive effect on physical fitness factors. However, VR-based PATPs should be specialized and developed in order to verify their effectiveness for the further research.