• Archives of Plastic Surgery
• /
• v.32 no.3
• /
• pp.347-356
• /
• 2005

The wound healing process in fetus is quite different form that of adult. Regeneration plays an important role and scarless wound healing is possible in early gestational fetal period. Recently, the various effects of the hypoxia and reoxygenation in the wound healing process have been investigated by many researchers. The hypoxic state is known to alter protein synthesis and gene expression of TGF-${\beta}$, VEGF. The authors hypothesize there may be differences between fetal and adult fibroblast and this difference may play a possible role in the mechanism of scarless fetal wound healing. In this study, we investigated the growth of fibroblast, the amount of collagen deposition, the amount of protein synthesis and gene expression in TGF-${\beta}$(transforming growth factor-${\beta}$), VEGF(vascular endothelial growth factor) under the various hypoxic and reoxygenation conditions. Through these processes, we tried to determine the relationships between scarless fetal wound healing and hypoxic condition. In control group, fetal and adult fibroblasts were cultured under normoxic condition. The experimental groups were allocated into four different groups. The differences in TGF-beta, VEGF under 24, 48, 72 hours were statistically investigated. Compared to adult fibroblast group, there was a statistically significant increase (p<0.01) in the rates of protein synthesis in TGF-beta and VEGF of fetal fibroblast. In this study, these results may reflect the possibility that fetal fibroblast are more susceptible to change in oxygen and has a superior rate of angiogenesis through increased VEGF expression. The possible superiority of angiogenesis in fetal fibroblast may play an important role in scarless wound healing.

• Journal of Digital Contents Society
• /
• v.19 no.1
• /
• pp.123-131
• /
• 2018

The design of the healing space provides people with tranquility and relaxation. It restores the tired body and provides the resilience of life. We have established the importance and value of healing through the meaning of healing and foreign cases. that humans come from nature and return to nature I think it is extremely inevitable, and while living, They set their goal and finish it gradually. Then they reach the goal. You can enjoy the effect of healing by creating an atmosphere of nature that comes from nature and living in it. The use of wood inside the building is the most comfortable healing condition, and as you can see from the case of Japan, The building of Sunny Hills made of wood outside reminds me of a magpies house. Indoor desk or book case made of wood make, warmer at mosphere, and the effect of healing becomes even greater if you take the plants. In the ceiling, if you paint pictures of clouds, trees, sun, etc., and apply blue or pink color that makes you relax, then the effect of healing is doubled. Through this study, I could forming living space being in touch with nature and using natural materials which is basic of healing an bring the effect of healing.

• Journal of Environmental Science International
• /
• v.25 no.7
• /
• pp.963-972
• /
• 2016

A survey was performed to present a scheme for building a healing forest park inside a city in consideration of the fact that healing forests are located in non-urban areas because of their nature, and are therefore not conveniently accessible to urban population (n=196). As a result, among 196 respondents to the survey, 74.5% indicated that it was necessary to build an urban healing forest park. In the case of the expected usage pattern, were an urban forest park to be built, the largest proportion responded that it would be used to "walk", followed by "rest and meditation" and then "meeting/talk/date". An analysis showed that the largest proportion responded that they factor in "Accessibility" (48%), followed by "Park condition" (16.8%), and "Vegetation type" (12.2%). According to the analysis of usage preference for healing therapy, it was shown that the largest proportion preferred "Terrain therapy" (37.8%), followed by "Exercise therapy" (19.9%), and "Naturopathy" (18.9%). The factor anlaysis of usage preference regarding urban healing forest park facilities showed that the components were divided into "Operation facilities" and "Natural healing space", and the largest proportion preferred "Trails for healing", followed by "Space or forest for meditation" and "Health promotion center", and then "Facilities for a exercise therapy". In building an urban healing forest park, we think that it is effective to introduce zones and facilities in consideration of park characteristics that are centered on everyday behaviors, such as taking a walk, which differ from those of healing forests located in non-urban areas.

• Geomechanics and Engineering
• /
• v.15 no.1
• /
• pp.615-620
• /
• 2018

In order to analyze the healing effectiveness of rock salt cracks affected by the applied stresses and time, we used the ultrasonic technology to monitor the ultrasonic pulse velocity (UPV) variations for different initial stress-damaged rock salts during self-healing experiments. The self-healing experiments were to create different conditions to improve the microcracks closure or recrystallized, which the self-healing effect of damaged salt specimens were analyzed during the recovery period about 30 days. We found that: The ultrasonic pulse velocity of the damaged rock salts increases rapidly during the first 9 days recovery, and the values gradually increase to reach constant values after 30 days. The damaged value and the healed value were identified based on the variation of the wave velocity. The damaged values of the specimens that are subject to higher initial damage stress are still keeping in large after 30 days recovery under the same recovery condition It is interesting that the damage and the healing were not in the linear relationship, and there also existed a damage threshold for salt cracks healing ability. When the damage degree is less than the threshold, the self-healing ratio of rock salt is increased with the increase in damage degree. However, while the damage degree exceeds the threshold, the self-healing ratio is decreased with the increase in damage.

• Archives of Plastic Surgery
• /
• v.35 no.5
• /
• pp.491-494
• /
• 2008

Purpose: When deciding a treatment plan in diabetic foot ulcer patients, predicting a possibility of healing wounds is important since not a few patients have poor general condition to get successful wound healing. This study was planned to find out if a serum collagen level can be used as a predictor for healing wounds in diabetic foot patients. Methods: Fifty-seven patients, who visited our clinic from January to June, 2007 for treatment of diabetic foot ulcers, were included in this study. Serum levels of type I collagen were checked using carboxy terminal type I propeptide kits. Simultaneously serum levels of vitamin C and iron, cofactors of collagen synthesis, were checked. The patients were divided into two groups; a group of successfully healed wounds and the other of unhealed wounds. Serum levels of the parameters were compared between the 2 groups. Results: The serum level of collagen was $197.65{\pm}86.26ng/ml$ in a healed group and $87.91{\pm}28.76ng/ml$ in the unhealed group(p<0.05). The serum iron and vitamin C levels were did not show significant differences. Conclusion: The serum collagen level may predict healing or nonhealing wounds in diabetic foot ulcers.

• Journal of Veterinary Clinics
• /
• v.15 no.2
• /
• pp.247-250
• /
• 1998

This study was designed to examine therapeutic effect of honeybee venom on wound healing in tail-docked dog. Blood samples were taken of jugular vein and hematological values were analyzed in condition of pre,3- and 6-day after canine caudectomy. Apitherapy group was subcutaneously treated with an Italian honeybee(Apis mellifera ligustica). Antibiotic therapeutic group was intramuscularly iaiected with a standard dosage ol'penicluin ,G procaine(20,000 Units/kg of body weight). Changes of leucocyte, erynlrocytel hematocrit, platelet and fibrinogen were not significantly different between bee sting and penicillin injection during wound healing. No changes of wound healing in tine tests, groups were onseren. Whole honeybee venom has been shown to have a antiinflammatory effect in tail-docked dog. It may be concluded that honeybee venom is effective drug being useful far wound healing and disinfection without tissue trauma in dog.

• Archives of Plastic Surgery
• /
• v.38 no.5
• /
• pp.585-589
• /
• 2011

Purpose: Microcirculation of diabetic patients is commonly comporomised, regardless of the condition of the macrocirculation. Therefore, direct tissue oxygenation measurement is recommended in determining tissue viability and predicting wound healing potential. This study was designed to determine cut-off value of the tissue oxygenation in predicting wound healing in diabetic foot patients. Methods: This study included 41 feet of 41 diabetic foot patients who were treated in the Diabetic Wound Center of author's institution between January and June, 2009. Main inclusion criteria were type 1 or 2 diabetes and a foot ulcer (duration > 3 weeks) and ulcer area (from 1 $cm^2$ to 4 $cm^2$). Measurements of the area of diabetic foot ulcer were carried out before treatment. Transcutaneous oxygen pressure ($TcpO_2$) was measured at adjacent site of ulcer. The healing wound was defined as complete wound closure within 12 weeks. Results: Average diabetic foot ulcer areas with healing and nonhealing wounds were $2.67{\pm}0.76$ and $2.59{\pm}0.75\;cm^2$, respectively. There was no significant difference in the wound area between the groups. Average foot $TcpO_2$ in healing and nonhealing wounds were $68.56{\pm}23.07$ and $30.98{\pm}16.66$ mmHg, respectively ($p$ <0.01). The rate of healing wound increased as $TcpO_2$ increased. In particular, $TcpO_2$ lower than 40 mmHg and higher than 40 mmHg showed the most significant difference (wound healing rates of 25% and 71%, respectively). Conclusion: Based on the results of the study, the minimal $TcpO_2$ value thought to be required for adequate wound healing in diabetic wounds (cut-off value) is 40 mmHg.

• Journal of People, Plants, and Environment
• /
• v.22 no.4
• /
• pp.355-364
• /
• 2019

This study was conducted to find out the effects of agro-healing activities and strolling on the physiological conditions of patients with chronic metabolic diseases. A total of 11 subjects participated in agro-healing activities, and their average age was 49.6±11.3. Changes in their salivary cortisol were compared and analyzed before and after participating in the agro-healing activity program, and it was found that the stress hormone decreased after participating in the program. Differences in brain wave between before and after participating in agro-healing activities and strolling were measured, and the ratio of alpha to high beta (RAHB) of subjects increased in most of the measured points after participating in agro-healing activities. In addition, the increase in the value in the temporal lobe (T3) that controls mortor skills and occipital lobe (O2) that controls visual functions indicates that the activities were effective in improving relaxation and stability. The relative low beta (RLB) power spectrum of subjects also statistically significantly decreased in the right occipital lobe (O2) that controls visual functions, the relative mid beta (RMB) and relative high beta (RHB) power spectrum decreased in the left temporal lobe (T3) and the right occipital lobe (O2). These results indicate that the activities were effective in improving relaxation under no stress and tension. The systolic and diastolic blood pressure of subjects after participating in agro-healing activities decreased from the prehypertension level to the normal level. These results indicate that horticultural activities and visual elements in healing farms, such as agro-healing activities and strolling, have positive impacts on patients with chronic metabolic diseases accompanied with diabetes or high blood pressure by increasing the brain activity and psycho-physiological conditions of participants.

• The Korean Journal of Rehabilitation Nursing
• /
• v.14 no.2
• /
• pp.118-128
• /
• 2011

Purpose: The purpose of this study was to explore the experiences of bereavement for main family members who had made and followed DNR decision for their family members. Method: This qualitative study was based on a grounded theory, and used in-depth interview techniques with the bereaved 10 main family members who had been treated and died under DNR order. Results: The causal condition of the family member was 'Releasing', and the main consequent phenomenon were 'Blaming self and ruminating'. The contextual condition was 'The memory of the deceased'. The action/reaction strategy was 'Purifying'. The intervening condition was 'Supporting system', and the consequence was 'Acceptance'. The experience after bereavement of the family member on DNR decision were rational processes that purified themselves and healed the guilt feeling about the decision from reflective assessment and response about DNR decision. Based on this results, the substantive theory 'Reflective self healing' was derived. Conclusion: The main family members in following DNR decision are more likely to have unhealthy emotional condition than others in normal bereavement process. But they overcame the grief of bereavement through reflective self healing process.

• Journal of The Korea Institute of Healthcare Architecture
• /
• v.16 no.3
• /
• pp.37-48
• /
• 2010

This study analyzes the present condition of the elements of a healing environment of the waiting rooms in outpatient clinics of children' hospitals (3 hospitals in Seoul) so as to propose a design to build a healing environment within the children' hospital. And analyzing the importance, satisfaction and preference of the healing environment in the waiting rooms, this paper has come to the following conclusions: 1)The study shows that the space structure of outpatient clinics in children' hospitals are composed of 1 story or 2 stories and designed in a duplication design or a dispersed alcove design. 2)The waiting room of the SC Hospital, with an area of 66.56$m^2$, and the waiting room of the SU Hospital, with an area of 38.78$m^2$ received the highest score for its space. 3)As most patients visit the hospital with their guardian, the waiting room should also be someplace families can rest and share information with others. 4)It is essential to build an environment that eliminates stress elements that patients may come to face by minimizing noise and elements that obstruct the view for mental stability. 5)The results show that those who took part in the survey preferred the following, respectively, healing environment design for the waiting room in the outpatient clinic at children' hospital: Pleasantness>Easiness in finding one' destination>Artificial materials>Natural materials>Environment like that at home>Co-promotion spaces>Space that supports the patients'activities>Openness>Sociality>Safety/Security>Approachability and Privacy. The results also show that healing conditions respect these preferences.