• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.1
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• pp.20-33
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• 2012

Objectives: This study was performed to elucidate the effects of Kanghwalsokdan-tang extract(KS) on hyper-plasy of collagen and cell damage in UVB-irradiated dermal fibroblast. Methods: To demonstrate the effects of KS on wound healing we used human dermal fibroblast(F6). We evaluated the amount of increased PICP, TIMP-1 in dermal fibroblast. PICP, TIMP-1 concentration was measured using EIA kit. Also, we measured the nitrite production, and LDH release in UVB-irradiated dermal fibroblast to elucidate the action-mechanism of KS. Results: 1. KS decreased the cell proliferation of dermal fibroblast. 2. KS decreased the biosynthesis of collagen in dermal fibroblast. 3. KS decreased the synthesis of TIMP-1 in dermal fibroblast. 4. KS had no effect on the LDH-release of UVB-irradiated dermal fibroblast. 5. KS inhibited nitrite production in UVB-irradiated dermal fibroblast. Conclusions: From the results, we concluded that KS has a protective effect on wound healing and photoaging.

• Journal of Haehwa Medicine
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• v.16 no.1
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• pp.157-166
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• 2007

Objectives : The purpose of this study is to search for more effective methods of diagnosis and treatment of Fracture. Methods : Literature review on Fracture in view of oriental and western medicine. Conclusions : Fracture is classified by anatomical location, grade, shape of line, displacement and cause. The symptom of Fracture is pain, tenderness, deformity, attitude, abnormal mobility, crepitus, neurovascular injury. Fracture is not the same in Healing process by location. The age, endocrine system, chronic debilitating disease, stabilization is effect on healing period and process. Treatment of Fracture is classified emergency care, definite treatment and rehabilitation.

• Journal of Veterinary Clinics
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• v.22 no.4
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• pp.342-347
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• 2005

This study was designed to assess the healing effects of ascorbic acid on full-thickness skin wound in dogs. Four $2.5\pm2.5cm$ full-thickness skin wounds were created bilaterally on the dorsolateral aspect in each of 5 dogs. The ten wounds were treated with ascorbic acid solution in the experimental group, and the ten wounds were treated with $0.9\%$ saline in the control group. The wound healing area was measured every other day for 3 weeks after the wounding. Statistical analysis was conducted with the paired t-test. On the $1^{st},\;3^{rd},\;5^{th},\; 7^{th},\;9^{th},\;11^{th},\;13^{th},\;15^{th},\;17^{th},\;19^{th},\;21^{st}days$, the wound healing rates were $12.6\pm9.6\%,\;9.5\pm9.8\%,\;18.9\pm9.0\%,\;39.2\pm5.4\%,\;62.2\pm4.6\%,\;86.9\pm1.9\%,\;92.9\pm1.8\%,\;96.6\pm1.6\%,\;99.1\pm0.5\%,\;99.8\pm0.2\%,\;99.9\pm0.1\%$ in the experimental group, and $9.1\pm6.0\%,\;9.2\pm6.0\%,\;12.2\pm5.0\%,\;41.3 \pm6.3\%,\;54.2\pm9.2\%,\;81.0\pm2.6\%,\;85.7\pm2.8\%,\;92.3\pm1.5\%,\;96.1\pm0.7\%,\;98.0\pm0.8\%,\;99.5\pm0.2\%$ in the control group On the $15^{th}$ day, the wound closed above $99\%$ in 2 dogs of the experimental group. On the $17^{th}$ day, the wound closed above $99\%$ in 3 dogs of the experimental group. On the $19^{th}$ day, the wound closed above $99\%$ in 5 dogs of the experimental group, and 2 dogs of the control group. On the $21^{st}$ day, the wound closed above $99\%$ in 5 dogs of the experimental group, and 4 dogs of the control group. The wound healing rate of the experimental group was $2\~4$ days faster than that of the control group. The tensile strength was $4,169\pm1,107g/cm^2$ in the experimental group, and $2,438\pm637g/cm^2$ in the countrol group on the$21^{st}$ day after wounding. Tensile strength was significantly higher in the experimental group than in the control group (p<0.05). The histopathological findings of the experimental group were similar to those of the control group on the $1^{st},\;3^{rd}\;and\;5^{th}$days. Inflammation and revascularization of the experimental group were similar to those of the control group on the $9^{th},\;13^{th}\;and\;21^{st}$days. The formation of collagen and reepithelialization were more developed the experimental group than in the control group on the $9^{th},\;13^{th}\;and\;21^{st}$days. Significantly higher wound healing rate, tensile strength and better histopathological findings were observed in the experimental group than in the control group. These results suggest that the topical application of ascorbic acid on full-thickness skin wounds can promote wound healing process.

• Korean Journal of Veterinary Research
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• v.43 no.3
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• pp.493-500
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• 2003

This study was performed to determine the optimal dose of ozone for wound healing. Twenty Korean black goats were allocated to 4 groups. The skin wound with $1{\times}1cm$ was induced over the hoof. For 5 minutes per day, 0.1 ppm (Group I), 1 ppm (Group II) and 6 ppm (Group III) ozone gas was applied. In control group, 5 ml of normal saline was applied daily on the wound. Wound square was determined using color image analyzer at day 0, 4 and 14. Soft tissue depth of wound was determined using radiograph. Before the application of ozone gas, $1{\times}1cm$ of skin tissue was resected and observed for histopathologic findings. To determine the healing effect, $2{\times}1cm$ of wound tissue was resected and observed for histopathologic findings at day 14. In mean squares of wound, all experimental groups revealed more reduced mean squares than control group at day 4, and especially Group II (p<0.05) and Group III (p<0.05) revealed significant reduction. At day 14, Group I and Group II (p<0.05) revealed more reduced mean squares than control group, but Group III revealed less reduced mean squares than control group. In soft tissue depth of wound, all experimental groups and control group revealed swelling at day 4, compared with day 0. At day 14, all experimental groups and control group revealed reduction, compared with day 4, and especially Group II (p<0.05) revealed significant reduction. In histopathological findings, inflammation findings in epidermis and dermis, hemorrhagic finding in epidermis were revealed in control group. In Group I, inflammation finding was reduced, compared with control group. Formation of scab and many reepithelialization of epidermis were revealed. In Group II, inflammation findings in epidermis and dermis which were observed in control group were not found, normal skin tissue was revealed. In Group III, inflammation findings in epidermis and dermis were revealed, reepithelialization of epidermis was not founded. Slow healing process was observed, compared with Group I and II. It was concluded that Group II has excellent promotion effect of wound healing.

• Journal of fish pathology
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• v.34 no.2
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• pp.233-241
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• 2021

Polydeoxyribonucleotide (PDRN) is known to accelerate wound healing process by acting on specific adenosine receptors. Differently from the PDRN substances obtained so far from piscine tissues, unique PDRN was prepared recently from Porphyra, a seaweed species. In this study, effects of the Porphyra PDRN was evaluated by inducing artificial skin wounds in Nile tilapia Oreochromis niloticus. The wound recovered almost completely in 2 weeks without any treatment, however only a partial recovery was done after one week. Facilitated healing was observed by PDRN fed for 5 days before wound induction at 10 or 20 mg/kg, against the partially recovered 1-week old wound. The healing effects were identified not only by visual observation, wound area measurement, but also by colorimetric estimations. These novel wound healing effects suggest beneficial therapeutic utility of Porphyra-derived PDRN for wound treatments in fishes occurring from various causes.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2008.10a
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• pp.166-166
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• 2008

• CELLMED
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• v.13 no.10
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• pp.10.1-10.5
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• 2023

Objective: A report investigating the positive effects of Korean language learning on the psychological healing of local students studying Korean during the period of disobedience in Myanmar. Methods: 37 students studying Korean at local foreign language universities in Myanmar and unable to attend school anymore due to their opposition to the military regime are experiencing psychological symptoms of distress and anger. Results: In this survey, Most Myanmar students responded that they receive psychological healing through self-study of the Korean language. Conclusion: It can be inferred that Korean language learning has psychological healing effects.

• Korean Institute of Interior Design Journal
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• v.18 no.5
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• pp.191-199
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• 2009

Recently general hospitals in Korea are focusing on healing environment which care for patients on the side of spirit and psychology without medical treatment. For the reason, architects are planning a public space on a large scale in which can be held cultural performances and artistic events. Those of social activities can be effective healing environment according to the "Anthroposophical medicine" studied by Rudolf Steiner. To the patient, Social healing environment is relation with normal life and back to the life. The case of a large-scale public space on hospital in foreign country shows the effect of healing environment through social community. So it is valuated as a social healing environment and community space. Even though the large-scale public space has been being increased in our circumstance, there is no evaluation of use on it. So there is no idea how people are satisfied with public space to stay and form a concourse by themselves. The purpose of this study is to find out the desire of people, who use the large-scale public space by analysis of observation research and interview in the general hospitals. And finally this study suggests the factors which can realize social healing environment on the planning of public space in hospital architecture.

• Korean Journal of Veterinary Research
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• v.39 no.5
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• pp.974-985
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• 1999

Osteoporosis is defined as a decrease in bone mass that leads to an increased risk of fracture. The therapeutic effect of $1{\alpha}$,25 dihydroxycholecalciferol, the hormonal form of vitamin $D_3$ that mediates calcium translation in intestine and bone, on the healing process of fracture has still been controversial. These studies were designed to understand the healing process of normal fibular fracture, the osteoporotic changes after ovariectomy, and the therapeutic effects of $1{\alpha}$,25 dihydroxycholecalciferol on the osteoporotic fracture in rats. The simple transverse fractures of rat fibulae were produced with a rotating diamond saw. The changes of the biochemical and mechanical indices of rats were investigated. The mechanical study based on bending test revealed the healing of the fibular fracture in the 5th week after simple transverse fracture. The osteoporosis impaired more the healing of osteoporotic fibular fracture than normal non-osteoporotic fibular fracture. The healing process of osteoporotic fracture was facilitated by the treatment with $1{\alpha}$,25 dihydroxycholecalciferol, however, was delayed more than the healing process of normal fracture. The bone strength based on the bending test also confirmed this tendency. The bone strengths in the 5th week after fracture of normal bone, osteoporotic bone, and $1{\alpha}$,25 dihydroxycholecalciferol-treated osteoporotic bone were 75%, 41%, and 67%, respectively, in comparison with those of intact bone. In conclusion, $1{\alpha}$,25 dihydroxycholecalciferol was effective in promoting the osteoporotic fracture healing.

• Journal of Veterinary Clinics
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• v.23 no.1
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• pp.55-60
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• 2006

Aucuba japonica has variable pharmacological effects such as hepatoprotective, choleretic, hemodynamic, antimicrobial, and anti-inflammatory activities. This study was performed to investigate the effects of Aucuba japonica extract on oral wound healing. Aucubin was extracted from Aucuba japonica, and injected on either side of buccal mucosa of male mice. Artificial full thickness wounds were made on the site with 1.5 mm biopsy punch under sterile technique. The specimens had taken on day 1, 3, and 5 with 4 mm biopsy punch. Light microscopic examination and quantitative histologic analysis were performed for reepithelization, inflammatory cell infiltration. Reepithelization of the aucubin (0.1%) group was earlier than the control group. And the number of inflammatory cells of the aucubin group was lesser than the control group. In view of the results so far achieved, the aucubin extracted from Aucuba japonica may be useful for oral wound healing and it can be applied as a topical agent on the oral wound. Further research should be performed on the mechanism of aucubin on oral wound healing and proper formulation for effective topical agents.