• The Journal of Advanced Prosthodontics
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• 제5권1호
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• pp.29-35
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• 2013

PURPOSE. To longitudinally assess the quality of life in maxillectomy patients rehabilitated with obturator prosthesis. MATERIALS AND METHODS. Thirty-six subjects were enrolled in the span of 16 months, out of which six were dropouts. Subjects (age group 20-60 years) with maxillary defects, irrespective of the cause, planned for definite obturator prosthesis, were recruited. The Hindi version of European Organization for Research and Treatment of Cancer, Head and Neck version 1 of Quality of Life Questionnaire was used before surgical intervention and one month after definitive obturator. Questionnaire includes 35 questions related to the patient's physical health, well being, psychological status, social relation and environmental conditions. The data were processed with statistical package for social science (SPSS). Probability level of P<.05 was considered statistically significant. RESULTS. The quality of life after rehabilitation with obturator prosthesis was 81.48% (${\pm}13.64$) on average. On item-level, maximum mean scores were obtained for items problem with teeth ($1.87{\pm}0.94$), pain in mouth ($1.80{\pm}0.92$), trouble in eating ($1.70{\pm}0.88$), trouble in talking to other people ($1.60{\pm}1.22$), problems in swallowing solid food ($1.57{\pm}1.22$) and bothering appearance ($1.53{\pm}1.04$); while minimum scores were obtained for the items coughing ($1.17{\pm}0.38$), hoarseness of voice ($1.17{\pm}0.53$), painful throat ($1.13{\pm}0.43$), trouble in having social contacts with friends ($1.10{\pm}0.40$) and trouble having physical contacts with family or friends ($1.10{\pm}0.31$). CONCLUSION. Obturator prosthesis is a highly positive and non-invasive approach to improve the quality of life of patients with maxillectomy defects.

• 대한핵의학회지
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• 제15권2호
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• pp.1-9
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• 1981

Bone scans with $^{99m}Tc-MDP$ (methylene diphosphonate) were obtained and analysed in 574 patients with biopsy-proven malignancy, who visited Seoul National University Hospital from April, 1979 to June, 1931. Clinical staging was done in all patients without bone scan information and compared with bone scan to determine the predictive value of bone scanning. 1. Primary site of the maligancies were lung in 152, breast in 97, stomach in 43, colon in 15, esophagus in 9, liver and pancreas in 11, kidney in 14, bladder in 27, prostate in 22, thyroid in 20, skin in 11, bone in 9, head and neck in 36, ovary and uterus in 17, hematopoietic and lymphoretic ular system in 33, nervous system in 10, and others in 9 cases. Primary site was not defined in 39 cases. 2. Bone scans were positive in 186 cases (32.4%), which, included 48 cases (31.6%) of lung cancer, 27 cases (27.8%) of breast cancer, 12 cases(28%) of stomach cancer, 6 cases(40%) of colon cancer, 6 cases(43%) of kidney tumor, 4 cases(15%) of bladder cancer, 14 cases(64%) of prostate cancer, 3 cases(15%) of thyroid cancer and 66 other cases. 3. Bone scans were suspicious in 64 cases (11.2%) which included 29 cases (19.1%) of lung cancer, 10 cases (10.3%) of breast cancer, 4 cases (9.3%) of stomach cancer, one case (7%) of colon cancer, 3 cases(11%) of bladder cancer, 2 cases(10%) of thyroid cancer and 15 other cases. 4. Out of 121 cases with early stage of malignancy (which included 20 cases of lung cancer in stage I, II, 38 cases of breast cancer, 13 cases of stomach cancer, 8 cases of kidney tumor, 14 cases of thyroid cancer in stage $I{\sim}III$, and 6 cases of colon cancer, 14 cases of bladder cancer, 8 cases of prostate cancer in stage $A{\sim}C$, bone scans were positive in 5 cases (4.1%) which included 3 cases of lung cancer one case of breast cancer and one case of prostate cancer, and considered as further advanced stage. Out of 121 cases with early stage of malgnancy, bone scans were suspicious in 21 cases (17.4%) which inlcuded 9 cases of lung cancer, 4 cases of breast cancer, 2 cases of stomach cancer, one case of colon cancer, 3 cases of bladder cancer, and 2 cases of thyroid cancer. From these results, we concluded bone scan was useful in detecting bone metastasis in patients of early stage of malignancy, determining prognosis and establishing therapentic plan.

• 복식
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• 제55권4호
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• pp.138-150
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• 2005

Phrygia headgear has an important meaning from the perspectives of costume history and cultural exchanges in ancient times. This study is to investigate the prototype of Phrygia headgear through analysis of its manufacturing methods and styles on the basis of prior studies on ancient sculptures and literatures conducted by European researchers and to examine its history and meanings. In these ways, this study will be helpful in understanding the importance of Phrygia headgear in cultural exchanges between the East and the West. Results of this study can be summarized as follows: Phrygia headgear was orn by eastern tribes, so it was a symbol of those from the east in ancient times. Phrygia headgear is frequently found in Greek artistic works of 5th to 4th century BC that depicted eastern tribes. Also, this headgear can be observed in artistic works for Mithras, Attis, or other gods. Since Phrygia headgear's shape is similar to that of Homer's helm, many researchers believe that it might be originated from Homer's helm. This headgear made of oxen scrotum(stierbeutel) or its surrounding skin has a long end at the top. This long end is round and drooping toward the front side. From such unique shape, we top. This long end is round and drooping toward the front side. From such unique shape, we top. This long end is round and drooping toward the front side. From such unique shape, we can draw a conclusion that Phrygia headgear was made of oxen scrotum and its surrounding skin. Dependingy on drooping patterns, there are various shapes, such as the round, tightly swollen one worn by Mithras, the tongue-shaped one found in Basilika S. Apolinare Nuovo's mosaic depicting three wise men, the balloon-shaped one frequently found in Greek vases depicting Scythian, and the one drooping to the side depicted in Alexandersarkophag. Further, some Phrygia headgear has covers for neck and ears. For example, Phrygia headgear worn by Persian Satrap tribe has such covers attached to the head part. Meanwhile, Phrygia headgear worn by Amazone tribe does not show such separate covers, Rather, one piece of oxen skin was tanned and finished to make such covers. Wearing Phrygia headgear can be interpreted in several ways. Use of animal's skin for wearing things is a unique aspect in ancient societies because they believed that wearing animal skin would give them power of the animal. Further, Phrygia headgear made of oxen scrotum was a symbol of reproductive power to women.

• Investigative Magnetic Resonance Imaging
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• 제10권2호
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• pp.63-69
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• 2006

목적 : 고관절주위 대퇴골 및 절구뼈에 질병이 이환되었을 때는 골수 변성이나 부종이 발생하지만 연령에 따른 정상 골수전환이나 재전환을 감별하지 못하면 진단이 어려워진다. 이에 정상 골수 전환 양상을 연령군으로 분류하여 분석해 보았다. 대상 및 방법 : 자기공명영상에서 고관절 및 고관절주위 대퇴골와 절구뼈에 이상소견이 없고 혈청검사에서 골수이상을 초래할 만한 자가면역질환이나 혈액질환이 없는 144명 288개 고관절을 대상으로 하였다. T1강조영상으로 고관절주위 대퇴골 및 절구뼈의 골수를 관찰하였으며 골수 신호강도가 근육 신호강도에 가까우면 적색골수, 지방 신호강도에 가까우면 황색골수로 간주하였다. 대퇴골 골수는 머리, 목, 그리고 큰돌기, 작은돌기 그리고 돌기사이를 포함한 돌기 부위로 나누었고 절구뼈 골수는 황색골수 전환 절반이상과 이하로 나누었다. 연령은 10년 단위로 나누었고 또한 태생부터 10살까지는 1년 단위로 나누었다. 결과 : 절구뼈 절반이하 골수전환 되고, 대퇴골 머리 목 그리고 돌기가 골수전환 된 경우가 226례 78.5%, 대퇴골 머리와 돌기만 골수전환 된 경우는 44예 15.3% 였다. 연령별 골수전환 범위는 만2세전후부터 커지기 시작하여 만20세전후에서 끝나는 양상을 보였다. 결론 : 고관절주위 대퇴골 및 절구뼈의 연령별 정상 골수전환 양상을 이해함으로써 질병으로 인한 골수 변성이나 부종을 감별하고 드물지 않게 고관절 통증을 호소하는 전이암이나 백혈병 같은 골수대체성 질환을 진단 할 수 있을 것으로 사료된다.

• The Korean Journal of Pain
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• 제3권1호
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• pp.27-33
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• 1990

성상신경절차단이 혈역학적 변화 및 차단부위의 피부온도에 마치는 영향을 알아보기 위하여 두경부와 어깨 및 상지에 통증을 호소하는 환자 45명 (남자 16명, 여자29명)을 대상으로 편측 성상신경절차단을 시행해 보았던 바 다음과 같은 결과를 얻었다. 1) 혈압의 변화 : 우측 성상신경절차단과 좌측 성상신경절차단의 어느 경우에서도 수축기 및 이완기 혈압에 마치는 영향은 거의 없었다. 2) 맥박수의 변화 : 우측 성상신경절차단후 30분과 60분에 각각 의의있는 맥박수의 감소를 나타내었으나 (p<0.05), 좌측 차단후에는 통계학적으로 의의있는 맥박수의 감소를 나타내지 않았다. 3) 차단측 상지피부온도의 변화 : 우측 성상신경절차단후에는 5분부터, 좌측차단후에는 10분부터 의의있는 피부온도의 상승 (p<0.01)을 보이기 시작하여 차단후 30분에 양측 모두에서 피부온도가 최대로 상승되었다가 60분에는 30분치에 비해 다소 하락하였다. 4) 시술환자 45명중 4명에서 성상신경절차단의 징후는 나타났으나 차단측상지의 피부온도 상숭은 동반되지 않았다. 이상의 결과로 미루어보아 제 6 경추 전결절에서 1.0% lidocaine 10 ml로 편측 성상신경절차단시에는 심순환계에 특별한 영향을 마치지 않았으며 또한 상지질환의 치료목적시에는 반드시 차단즉 상지피부온도의 상승을 확인하여야만 효과있는 차단이 이루어졌다고 판정할 수 있을 것으로 사료된다.

• 대한치과보철학회지
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• 제50권3호
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• pp.184-190
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• 2012

연구 목적: 이 연구는 상악 전치부와 하악 구치부 치근단 방사선촬영시 이동형 구내방사선촬영기와 벽걸이 구내방사선촬영기로 촬영한 경우에서 환자의 방사선량을 알아보고자 하였다. 연구 재료 및 방법: 방사선량 측정은 선량 측정용 두경부 마네킨의 23부위에 열형광선량계 소자를 위치시키고 해당 치근단 방사선촬영을 하였다. 열형광선량계 판독기로 흡수선량을 구하였고 방사선 조사된 조직의 비율을 곱하여 방사선 가중선량을 구하였다. 국제방사선방호위원회에서 2007년에 공지한 조직 가중계수를 이용하여 각 방사선촬영의 유효선량을 구하였다. 결과: 환자의 흡수선량은 이동형 구내방사선촬영기로 촬영한 상악 전치부와 이동형 및 벽걸이 구내방사선촬영기로 촬영한 하악 구치부 치근단방사선촬영의 경우 하악체에서 가장 높았다. 유효선량은 상악 전치부 치근단 방사선촬영에서는 이동형 촬영기로 촬영한 경우 $4{\mu}Sv$, 벽걸이 촬영기로 촬영한 경우 $2{\mu}Sv$였고 우측 하악 구치부 치근단 방사선촬영에서는 각각 $6{\mu}Sv$, $2{\mu}Sv$였다. 결론: 벽걸이 구내방사선촬영기보다 이동형 구내방사선촬영기로 촬영한 치근단 방사선촬영에서의 유효선량이 더 많기 때문에 술자는 구내방사선촬영기에 따른 방사선 노출 정도를 충분히 인지하고 이를 사용하여야 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6357-6362
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• 2014

Background: Globally, the overall incidence of cancer is increasing as a result of ageing populations and changing lifestyles. Cancer is one of the leading causes of death, especially in the developed nations. Cancers affecting the young population are generally considered uncommon. This study assessed the demography and trends of cancers of the young in Brunei Darussalam, a small and developing Southeast Asia nation. Materials and Methods: All patients diagnosed with cancers between 2000 and 2012 were identified from the cancer registry maintained by the State Histopathology Laboratory. Cancers of the young was defined as any cancers diagnosed under the age of 40 years. Demographic data and the type of cancers were collected and analysed using SPSS Statistics 17.0. Results: Among the 6,460 patients diagnosed with cancer over the study period, 18.7% (n=1,205) were categorized as young with an overall decline in the proportion from 26.6% in 2000 to 18.8% in 2012 (p<0.001 for trend). Among all cancers of the young, the most common systems affected were gynecological (24.1%), hematological/lymphatic (15.8%), subcutaneous/dermatological/ musculoskeletal (10.5%), breast (10.5%) and gastrointestinal (9.9%). Overall, among the different systems, neurological (54.9%) had the highest proportion of cancers of the young followed by gynecological/reproductive (30.6%), hematological/lymphatic (39.9%), endocrine (38.7%), subcutaneous/dermatological/ musculoskeletal (22.3%) and the head and neck region (20.1%). There was a female predominance (66.9%) and the incidence was significantly higher among the Malays (20.1%) and expatriates (25.1%) groups compared to the Chinese (10.7%) and indigenous (16.8%) groups (p<0.001 for trend). Conclusions: Cancers of the young (<40 years) accounted for almost a fifth of all cancers in Brunei Darussalam with certain organ systems more strongly affected. There was a female preponderance in all racial groups. Over the years, there has been a decline in the overall proportion of cancers of the young. Selective screening programs should nevertheless be considered.

• The Korean Journal of Pain
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• 제7권2호
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• pp.162-169
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• 1994

Blockade of cervicothoracic sympathetic ganglion (stellate ganglion controls pain on face, head, neck, shoulder, upper limbs, and upper chest, including their viscera and sympathetically maintained pain. This procedure also increases blood flow to the above areas and relieves hyperreactivity of sympathetic nervous system. Clinically, repeated stellate ganglion blocks with local anesthetic agent may become difficult with complications such as accidental intravascular or subdural injection, recurrent laryngeal nerve or bracheal plexus paralysis, pneumothorax and edema on injection site. Therefore, at times long-term cervicothoracic ganglion block with neurolytics is necessitated but its applications are prohibited by the critical structures surrounding ganglion. There are also few reports of neurolytic stellate ganglion block. This study was performed to observe the complications, gross changes of surrounding structures, and microscopic findings of ganglion cells after neurolytic block and to certify the possibility of clinical use of neruolytic stellate ganglion block. The unilateral superior cervical sympathetic ganglion of rabbit was blocked with absolute ethyl alcohol 0.4 ml at the level of cricoid cartilage. Normal ganglion was used as a control and 5 animals were sacrificed at each intervals of 7, 15 and 50 days after block. The results were as follows; 1) All experimental animals showed no specific changes of behavior, motor function. No necrotic tissues were present in the block area during the observation period. There were some gross scar tissues along the fascia of muscles surrounding the needle injection site, but gross atrophy of muscles or injured major vessels were not found. 2) Microscopically, structures of normal ganglion of rabbit were very similar to those of humans. Seven days after absolute ethyl achohol injection there were marked edema of ganglion cells and nuclei with irregular nuclear membrane. Some of the ganglion cells lost their nuclei and showed degenerative changes. Fifteen days after block, cell edema were decreased and loss of the Nissl's body was prominant. The ganglion cell structures looked close to normal but the cytoplasm and nucleus were generally contracted 50 days after block. These results suggest absolute ethyl alcohol injection on cervical sympathetic ganglion with above method mainly blocks pre- and post-synaptic fibers and the long-term neurolytic blockade of this ganglion may be possible in rabbits.

• Radiation Oncology Journal
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• 제31권3호
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• pp.118-124
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• 2013

Purpose: The optimal treatment of advanced maxillary sinus cancer has been challenging for several decades. Intra-arterial chemotherapy (IAC) for head and neck cancer has been controversial. We have analyzed the long-term outcome of neoadjuvant IAC followed by radiation therapy (RT) and surgery. Materials and Methods: Twenty-seven patients with advanced maxillary sinus cancer were treated between 1989 and 2002. Five-fluorouracil (5-FU, $500mg/m^2$) was infused intra-arterially, and followed by RT (total 50.4 Gy/28 fractions). A planned surgery was performed 3 to 4 weeks after completion of IAC and RT. Results: At a median follow-up of 77 months (range, 12 to 169 months), the 5-year rates of overall survival in all patients were 63%. The 5-year rates of overall survival of stage T3/T4 patients were 70.0% and 58.8%, respectively. Seven of fourteen patients with disease recurrence had a local recurrence alone. The 5-year actuarial local control rates in patients with stage T3/T4, and in all patients were 20.0%, 32.3%, and 27.4%, respectively. Overall response rate after the completion of IAC and RT was 70.3%. During the follow-up, seven patients (25.9%) showed mild to moderate late complications. The tumor extent (i.e., the involvement of either orbit and/or base of skull) appeared to be related with local recurrence. Conclusion: Neoadjuvant IAC with 5-FU followed by RT and surgery may be effective to improve local tumor control in the patients with advanced maxillary sinus cancer. However, local failure was still the major cause of death. Further investigations are required to determine the optimal treatment schedule, radiotherapy techniques and chemotherapy regimens.

• 폴리머
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• 제38권2호
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• pp.164-170
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• 2014

본 연구에서는 신경세포인 슈반세포(SC)의 증식에 가장 적합한 생체재료를 연구하였다. 락타이드 글리콜라이드 공중합체(PLGA)에 탈미네랄 골분(demineralized bone particle, DBP), 소장점막하조직(small intestine submucosa, SIS), 그리고 실크를 각각 20% 첨가하여, 용매 증발법으로 각각의 필름을 제조하고, SC세포의 부착과 증식을 확인하기 위해 MTT, SEM 그리고 RT-PCR 분석을 실시하였다. 또한 필름의 친수성을 확인하기 위해 접촉각을 측정하였다. 분석 결과, PLGA/DBP 20% 필름에서 높은 친수성을 보였으며, SC의 부착과 증식률이 다른 군에 비해 크게 증가한 것을 확인할 수 있었다. 따라서 PLGA/DBP 필름은 중추신경재생 재료로 활용할 수 있을 것으로 사료된다.