• 한국식품영양과학회지
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• 제32권3호
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• pp.464-468
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• 2003

홍국의 장기섭취가 자연발증 고혈압 쥐(SHR)의 혈압상승 및 혈중 콜레스테롤 조성에 미치는 영향을 조사하였다. Monascus ruber IFO 32318 균주로 제조한 홍국을 각각 0.03%, 0.1%, 0.3% 첨가한 식이를 8주간 섭취시킨 후 모든 실험군을 일반식이로 전환시켜 다시 2주간 사육하였다. 식이섭취 2주 째부터 대조군에 비해 홍국 섭취군에서 수축기혈압, 이완기 혈압 및 평균혈압의 유의적인 상승 억제효과가 나타났으며 그 효과는 식이에 첨가된 홍국의 양에 비례하였고 홍국첨가 식이를 중단하면 실험군 간의 각 혈압의 유의적인 차이는 사라졌다. 또한 홍국은 SHR의 혈중 VLDL-C의 함량을 유의적으로 저하시켰으며 TC 및 LDL-C은 홍국 첨가량이 많을수록 낮은 경향을 나타내었고 HDL-C은 대조군, group I 및 group II가 거의 동일하였으며 홍국 첨가량이 가장 많은 group III에서만 약간 높은 경향을 나타내었다. 또한 동맥경화의 지표가 되는 TC과 HDL-C의 비율 및 non-HDL-C과 HDL-E의 비율은 홍국 섭취량이 증가할수록 감소하는 경향을 보였고 LDL-C과 HDL-C의 비율 또한 홍국 섭취군이 대조군보다 유의적으로 낮은 값을 나타내었다. 이러한 모든 효과는 홍국을 식이 섭취량의 0.1% 이상 첨가한 실험군에서 뚜렷이 나타났다.

• 동의생리병리학회지
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• 제20권2호
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• pp.377-382
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• 2006

This study was performed to evaluate the effect of the herbal extract mixture of Cnidium officinale, Petasites japonicus and Coptis chinensis (CPC) on the lipids metabolism in mice with tyloxapol. ICR mice weighing between 30-40 g were divided into four groups: normal group, 600mg/kg tyloxapol injected group, $50\;{\mu}g/g$ CPC treated group 6h after tyloxapol injection (SAM1), and tyloxapol and CPC treated group (SAM2), respectively. Tyloxapol or CPC was injected intraperitoneally. Tyloxapol caused an elevation of total cholesterol (TC), triglycerides(TG), and LDL-cholesterol and a decrease of HDL-cholesterol. In addition, tyloxapol induced accumulation of lipid including cholesterol in both the liver and kidney. Serum levels of TC, TG and LDL-cholesterol were decreased whereas HDL-cholesterol was increased by CPC. CPC increased in HDL-cholesterol /total cholesterol ratio and lowered atherogenic index. The levels of TC, TG and LDL-cholesterol by CPC were rather lower in SAM2 than SAM1. CPC also inhibited lowering HDL-cholesterol by tyloxapol. CPC reduced lipid blots and cholesterol particles in both the deposition and size in the liver and kidney with tyloxapol. These results suggest that CPC might be expected to be beneficial for protection and treatment of hyperlipidemia by the disturbance of lipid metabolism.

• Journal of Nutrition and Health
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• 제38권2호
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• pp.144-150
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• 2005

The aim of this study was to analyze an association between milk consumption and serum lipid profiles in postmenopausal women in Korea. The dietary data by the Food Frequency Questionnaire were evaluated among 208 postmenopausal women who did not receive hormone therapy and their serum concentrations of triglyceride (TG), total, HDL-, and LDL-cholesterol, and alkaline phosphatase were analyzed. When the relationship between milk consumption and serum lipid profiles were analysed by linear regression, we found a negative relationship of milk consumption with ALP and a positive relationship with HDL-cholesterol. Animal calcium intake was significantly correlated with ALP and HDL-cholesterol. In addition, the serum level of HDL-cholesterol of the upper quartile (UQ) subjects who took animal calcium over 313 mg/day was significantly higher than the lower quartile (LQ) subjects who consumed milk below 101 mg/day when we compared the UQ and LQ subjects. The HDL-cholesterol level of the UQ subjects who consumed 235 ml of milk tended to be higher than the that of the LQ who consumed 53 ml. As for serum concentrations of TG, total cholesterol, and LDL-cholesterol, there was no significant difference between the UQ and LQ groups of milk consumption. Based on our study, we concluded that continual consumption of approximately one cup of milk per day was associated with low cardiovascular risks with favorable lipid profiles and ALP in postmenopausal women. (Korean J Nutrition 38(2): 144～150, 2005)

• 생명과학회지
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• 제9권4호
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• pp.430-438
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• 1999

This study was designed to investigate the effects of sea tangle (Laminaria japonica) extract and fucoidan components on chronic degenerative diseases. Sprague-Dawley(SD) male rats (210$\pm$5g) were fed experimental diets: Dasi-Ex group: dasima extract powder of 4.0% added to control diet; Fuco-I, II and III groups: fucoidan powder of 1, 2 and 3% added to Dasi-Ex group for 45 days. Triglyceride (TG) levels in serum were significantly lower (10~15%) in Fuco-I, II and III groups compared with control group. Total cholesterol levels were significantly decreased (7~10% and 15~ 35%) in brain mitochondria and microsomes of Fuco-II and III group compared with control group. LDL-cholesterol levels were remarkably decreased (20~30%) in Dasi-Ex and Fuco-I, II, III groups, but HDL-cholesterol levels were significantly increased (10~12%) in Fuco-II and III groups only compared with control group. The ratios of HDL/total cholesterol resulted in a marked increase (3 5~55%) in Dasi-Ex and Fuco-I, II, III groups, but atherogenic indices were remakably decreased (40~50%) in Dasi-Ex and Fuco-I, II, III groups compared with control group. Membrane fluidities were remarkably increased (45~70% and 38~42%, respectively) in brain mitochondria and microsomes of Fuco-II and III groups compared with control group. Administrations of fucoidan added to dasima effectively decreased TG, total and LDL-cholesterol, and atherogenic index, while also effectively increased HDL-cholesterol, HDL/total cholesterol ratio, and membrane fluidity, suggesting chronic degenerative diseases were very effectively prevented by the administration of fucoidan component.

• 약학회지
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• 제45권5호
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• pp.468-475
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• 2001

Fenofibrate is a fibric acid derivative that is a strong reducer of triglyceride. Micronozed formulation of fenofibrate has improved bioavailability compared to non-micrornized formulation. This study performed a retrospective comparison of micrornized and non-micrornized fenofibrate (28 in micronized and 51 in non-micronized group) by comparing the means of changes in total triglyceride, total cholesterol, HDL-cholesterol and TC/HDL ratio in type 2 diabetics with dyslipidemia The result skewed that after 12 weeks of treatment both drugs produced a significant reduction in total triglyceride levels (62% with micronized, 37% with non-micronized). The mean decrease observed for total triglyceride levels were significantly lower for micronized fenofibrate (p<0.001). Both drugs showed a significant reduction for total cholesterol levels (-22% with micronized, -14% with non-micronized fenofibrate). The mean decrease observed for total cholesterol was not significantly different between the two drugs (p>0.05). HDL-cholesterol levels increased by 24% and 15%) with micronized and non-micronized, respectively and the differences from the baseline were statistically significant for both drugs (p<0.05). The mean change of HDL-cholesterol was not significantly different between the two drugs. There was a statistically significant reduction in TC/HBL-cholesterol ratio from baseline for both drugs (7.1 to 4.8 with micronized and 5.1 to 4.5 with non-micronized), and the reduction of TC/HDL-cholesterol ratio tended to be significantly greater with micronized fenofibrate (p<0.05). This study shows that short-term treatment with micronized fenofibrate is more effective than non-micronized fenosbrate in type 2 diabetes patients with dyslipidemia.

• Journal of the Korean Data and Information Science Society
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• 제23권6호
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• pp.1103-1115
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• 2012

본 연구는 고지혈증에 대해 양파추출물을 투여한 무작위 대조군 전-후 실험설계 연구 12편을 대상으로 체중, 간 무게, 신장 무게, 심장 무게, 혈당, 총콜레스테롤, 트리글리세리드, HDL-콜레스테롤, LDL-콜레스테롤의 평균비교를 통해 양파의 효능에 대해 알아보았다. 고정효과모형을 적용시킨 결과 체중과 심장 무게를 제외한 간 무게, 신장 무게, 혈당, 총콜레스테롤 농도, 트리글리세리드 농도, LDL-콜레스테롤 농도는 유의한 감소를 보였고, HDL-콜레스테롤 농도는 유의하게 증가하였다. 갈브레스 그림으로 동질성 여부를 알아보았고 동질성을 만족하지 않은 변수에 대해 랜덤효과모형을 적용시킨 결과 간 무게와 혈당, 총 콜레스테롤 농도, 트리글리세리드 농도의 감소에 대해 유의한 효과를 나타냈고, HDL-콜레스테롤 농도는 유의하게 증가하였다. 각 변수에 대해 출판편의의 존재를 알아보았고, 출판편의의 존재를 확인 후 절단과 보충 방법으로 대체값을 추정하였다.

• 대한의생명과학회지
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• 제16권4호
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• pp.317-322
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• 2010

This study has been done with 1,431 subjects who visited Health Promotion Centers of the hospitals in Gumi for National Health Screening Program for People at Transitional Ages from April to December 2007. Serum biochemical tests related with metabolic syndrome were performed. Among biochemical factors related with metabolic syndrome, the mean values of serum glucose, AST, ALT, triglyceride and HDL cholesterol except LDL cholesterol were significantly higher in males than in females, so a significant difference by sex was observed (P<0.001). AST, ALT, triglyceride and HDL were thought to be significantly affecting serum GGT for males. In contrast, ALT and HDL cholesterol were important factors for females (P<0.001). For both sexes, serum glucose and LDL cholesterol did not produce any meaningful effect on serum GGT. In males AST, ALT and HDL cholesterol were associated with high risk of abnormality of serum GGT and in females AST, ALT and LDL cholesterol were related with high risk of abnormality of serum GGT. Therefore, AST and ALT showed a significant effect on abnormality of serum GGT in both males and females. It was observed that males exhibited significantly high correlation between metabolic syndrome related biochemical factors and serum GGT than females, and their influence on abnormality of serum GGT was also higher in males than in females. Therefore, serum GGT tests performed for health screening are considered to be useful for managements of cardiovascular diseases and metabolic syndrome as well as liver function test.

• 한국식품위생안전성학회지
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• 제14권1호
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• pp.122-128
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• 1999

The cholesterol-lowering effect of a fermented milk was studied for long-term period (56 weeks) in 206 Korean adults (106 normal cholesterol group and 100 hypercholesterol group) 300 $m\ell$ of the fermented milk was taken daily to all subjects for 10 weeks. 24 subjects drinking the fermented milk for 56 weeks and 42 subjects no-drinking for 40 weeks and then re-drinking from 50 th week for 6 weeks were followed up. Paired t-test, Duncan's multiple range test, and GLM repeated measure were used for statistical analysis. The level of total blood cholesterol and LDL after drinking the fermented milk for 10 weeks were decreased significantly in both group and affected by total cholesterol level at baseline, BMI, smoking and drinking. there is no significant change in triglyceride, HDL, and LDL/HDL ratio by drinking the fermented milk. The fermented milk intake for long-term period (56 weeks) did not show any more effect after 10 week on the level of TC, TG, HDL, LDL.

• 대한한방내과학회지
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• 제25권4호
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• pp.86-92
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• 2004

In order to determine the effect of intravenous He-Ne laser irradiation, values of serum total cholesterol, Triglyceride, LDL-cholesterol and HDL-cholesterol were measured. Twenty three patients with hyperlipidemia who visited Gunpo Oriental Medical Center of Wonkwang University were treated with He-Ne laser irridiation and analyzed by Paired T-test of SPSS program. The following results were obtained : The serum Total cholesterol and LDL-cholesterol of patients treated with He-Ne laser irradiation showed a significant(P<0.05) decrease, and the serum Triglyceride and HDL-cholesterol of patients treated with He-Ne laser irradiation showed no significant(P<0.05) effects.

• 생명과학회지
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• 제14권4호
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• pp.531-536
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• 2004

신령버섯 균사체 액체배양액이 고콜레스테롤 식이를 섭취한 흰쥐의 지질대사에 미치는 영향을 조사하고자, 생후 7주령의 숫쥐에 표준식이를 급여한 정상군, 표준식이에 15% 돈지와 0.5% 콜레스테롤을 첨가한 식이를 급여한 대조군, 대조식이에 신령버섯 균사체 액체배양액을 음료수에 30% 및 40%로 혼합 급여한 군(30% 및 40% 신령버섯군) 등 4군으로 나누어 6주간 사육한 결과는 다음과 같다. 실험동물의 체중 증가량, 식이섭취량 및 식이효율은 대조군과 30%와 40% 신령버섯군이 유사하였다. 간, 신장 및 부고환지방의 무게는 대조군과 신령버섯군들이 비슷하였다 간의 콜레스테롤 농도, 간과 혈청의 중성지질 농도는 대조군과 신령버섯군들이 비슷한 수준으로 감소효과가 나타나지 않았다. 혈청의 총 콜레스테롤과 LDL-콜레스테롤 농도 및 동맥경화지수는 대조군에 비해 30% 및 40% 신령버섯군이 유의하게 감소되었다. 총콜레스테롤에 대한 HDL-콜레스테롤의 비율은 대조군에 비해 신령버섯군들이 유의하게 증가되었다. HDL-콜레스테롤 농도는 대조군과 신령 버섯군들이 비슷한 수준으로 신령 버섯섭취에 따른 영향은 나타나지 않았다. 분으로 배설된 지방은 대조군에 비해 40% 신령버섯군이 유의하게 증가되었다. 이상의 결과로 보아 고콜레스테롤 식이를 급여한 흰쥐에 신령버섯 균사체 액체배양액을 30%나 40% 급여시 혈청의 총 콜레스테롤, LDL-콜레스테롤 농도 및 동맥경화지수를 낮추고, 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율을 증가시키는 것으로 나타났다.