Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Metabolic Syndrome Related with Serum Biochemical Factors Affecting Serum GGT at Transitional Ages in Gumi

  • 석성자 (서라벌대학 임상병리과)
  • Received : 2010.08.12
  • Accepted : 2010.12.27
  • Published : 2010.12.31
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Abstract

This study has been done with 1,431 subjects who visited Health Promotion Centers of the hospitals in Gumi for National Health Screening Program for People at Transitional Ages from April to December 2007. Serum biochemical tests related with metabolic syndrome were performed. Among biochemical factors related with metabolic syndrome, the mean values of serum glucose, AST, ALT, triglyceride and HDL cholesterol except LDL cholesterol were significantly higher in males than in females, so a significant difference by sex was observed (P<0.001). AST, ALT, triglyceride and HDL were thought to be significantly affecting serum GGT for males. In contrast, ALT and HDL cholesterol were important factors for females (P<0.001). For both sexes, serum glucose and LDL cholesterol did not produce any meaningful effect on serum GGT. In males AST, ALT and HDL cholesterol were associated with high risk of abnormality of serum GGT and in females AST, ALT and LDL cholesterol were related with high risk of abnormality of serum GGT. Therefore, AST and ALT showed a significant effect on abnormality of serum GGT in both males and females. It was observed that males exhibited significantly high correlation between metabolic syndrome related biochemical factors and serum GGT than females, and their influence on abnormality of serum GGT was also higher in males than in females. Therefore, serum GGT tests performed for health screening are considered to be useful for managements of cardiovascular diseases and metabolic syndrome as well as liver function test.

Keywords

References

  1. Cho YG, Song HJ, Chung HJ, Cho JJ, Paek YJ, Park KH, Byun JS. The Association between Gamma-glutamyltransferase and Metabolic Syndrome in Korean Male Workers. Korean J Acad Fam Med. 2007. 28: 45-50.
  2. Choi SM, Kim KY, Lee TY, Jung JG, Lee OK. Incidence and Related Factors of the Metabolic Syndrome. Korean J Society of Health Promotion. 2009. 26: 35-46.
  3. Expert Panel on Detection, Evaluation and Treament of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adults Treatment Panel III) JAMA 2001. 285: 2486-2497. https://doi.org/10.1001/jama.285.19.2486
  4. Ford ES, Giles WH. A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care 2003.26: 575-581. https://doi.org/10.2337/diacare.26.3.575
  5. Gweon S, Koo SM, Cho BK, Jcong ER, Weon S, Ryu JK, Lee BR, Chae SC, Jun JE, Park WH, Bae KS. Nomal Values of Serum Lipids in Healthy Adults by Sex and Age. Korean J Medicine. 1996.50: 159-171.
  6. Isomaa B, Almgren P, Tuomi T, Forse B, Lathi K, Nissen M, Taskinen MR, Groop L. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001. 24: 683-689. https://doi.org/10.2337/diacare.24.4.683
  7. Kim JH. Prevalence and Related Factors of Metabolic Syndrome in Health Screening Participants. master's dissertation, 2009.
  8. Korea National Statistical Office; 2008, 4 (2) Korea National Health and Nutrition Examination Survey. 2009.
  9. Lee DH, Jacobs DR Jr., Gross M, Kiefe CI, Roseman J, Lewis CE, Steffes M. Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clinical Chemistry 2003.49: 1358-1366. https://doi.org/10.1373/49.8.1358
  10. Lee MY, Weon CS, Ko CH, Lee BJ, Lee Y, Kim MJ, Shin YK, Chung CH. Relations between serum gamma-glutamyltransferase and prevalence of diabetes mellitus. Korean J Medicine. 2004.67: 498-505.
  11. Lim JS, Kim YJ, Chun BY, Yang JH, Lee DH, Kam S. The Association between Serum GGT Level within Normal Range and Risk Factors of Cardiova scular Diseases. Korean J Pre Medicine. 2005. 38: 101-106.
  12. Lym YL, Hwang SW, Shim HJ, Oh EH, Chang YS, Cho BL. Prevalence and Risk Factors of the Metabolic Syndrome as Defined by NCEP-ATP III. Korean J Acad Fam Med. 2003. 24: 135-143.
  13. Mun JH. The risk factors of Metabolic syndrome and the association between Metabolic syndrome. doctoral dissertation, 2004.
  14. Nakanishi N, Nishina K, Li W, Sato M, Suzuki K, Tatara K. Serum gamma-glutamyltransferase and development of impaired fasting glucose or type 2 diabetes in middle-aged Japanes men. Journal of Internal Medicine 2003. 254: 287-295. https://doi.org/10.1046/j.1365-2796.2003.01198.x
  15. Rantala AO, Lilja M, Kaurna H, Savolainen MJ, Reunanen A, Kesanieme YA. Gamma-glutamyl transpeptidase and the metabolic syndrome. Journal of Internal Medicine 2000. 248: 230-238. https://doi.org/10.1046/j.1365-2796.2000.00723.x
  16. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988.37: 1595-1607. https://doi.org/10.2337/diabetes.37.12.1595
  17. Seok SJ, Shin DM. Analysis of serum lipids of medical check-up subjects by age and sex, doctoral. Korean J Clinical Laboratory Science. 2006. 38: 105-110.
  18. Statistics Korea. 2008 Annual Report on the Cause of Death Statistics, 2009.
  19. WHO West Pacific Region. The Asia-Pacific Perspective: Redefining Obesity and its Treatment. IOTF. Feb. 2000.
  20. Yamamoto A, Temba H, Horibe H, Mabuchi H, Saito Y, Matsuzawa Y, Kita T, Nakamura H. Life style and cardiovascular risk factors in the Japanese population from an epidemiological survey on serum insulin levels in Japan 1990 part I; influence of life style and excess body weight on HDL-cholesterol and other lipid parameters in men. J Atheroscler Thromb 2003. 10: 165-175. https://doi.org/10.5551/jat.10.165
  21. Yokoyama H, Hirose H, Moriya S, Saito I. Significant correlation between insulin resistance and serum gamma-glutamyl transpeptidase (gama-GTP) activity in non-drinkers. Alcoholism 2002.26: 91-94.