• YAKHAK HOEJI
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• v.55 no.5
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• pp.411-418
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• 2011

The dissolution test method and an analytical procedure by HPLC were developed and validated for nafronyl oxalate capsules and tramadol hydrochloride capsules. These drugs were not yet characterized by the dissolution specifications in the Korean Pharmaceutical Codex. So, with each reference and test drugs, we did the preliminary and standard experiments based on the Korean Pharmacopeia Guideline of dissolution testing for solid oral dosage forms. The dissolution test for nafronyl oxalate capsules was carried out under sink conditions as follows: dissolution medium phosphate buffer pH 6.8, paddle rotation speed 100 rpm and vessel volume 900 ml. More than 80% of its label amount was released within 30 min in this method. Also the dissolution test for tramadol hydrochloride capsules was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 50 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 15 min in this method. The dissolution samples were analyzed with a validated HPLC analytical procedure. The analytical methodology showed acceptable values in terms of specificity, linearity, precision and accuracy. The dissolution test methods described above were adequate for the purpose and may be proposed as a pharmacopeial standard to assess the performance of nafronyl oxalate capsules and tramadol hydrochloride capsules. Furthermore, the outcomes of this study were expected to help create an environment where safe and high quality drugs would be distributed on the domestic market making contributions to advancing public health.

• Analytical Science and Technology
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• v.16 no.1
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• pp.1-11
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• 2003

This research examined the presence of hazardous materials in chemical workplace field using an integrated chemical/biological monitoring. Chemical workplace field air for volatile organic compounds (VOCs) analysis was collected using a collection tube packed with Tena.x TA adsorbent 400 mg. Workplace field air samples were analyzed by gas chromatography/mass spectrometry (GC/MS). Simultaneously, Tradescantia BNL 4430 clone was exposed in situ to monitor hazardous materials in chemical workplace field. GC/MS analysis showed the presence of various VOCs such as trichloroethylene, toluene, ethylbenzene, (m,p,o)-xylenes, styrene, 1,3,5-trimethylbenzene, and 1,2,4-trimethylbenzene. The results showed that in situ monitoring of VOCs with the Tradescantia-micronucleus (Trad-MCN) assay gave positive results in chemical workplace field and negative response at outdoor air. In conclusion, inhalation of these field air by workers may affect chronic demage to their health by inducing micronuclei formation in Tradescantia pollen mother cells. The combination of chemical/biological monitoring is very effective to evaluate hazardous materials in workplace field and can be alternatively used for screening hazardous materials.

• The Korean Journal of Pesticide Science
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• v.10 no.4
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• pp.306-312
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• 2006

The objective of this study was to compare the reduction of residues in/on mini-tomato by washing methods and to evaluate the relation of reduction rates in different pesticides. Mini-tomato was sprayed with three commercial pesticides, oxadixyl, thiophanate-methyl and chlorothalonil, and harvested for washing test as 0, 5 and 7 days elapsed. The reduction rates of oxadixyl in/on mini-tomato were 61, 11 and 4%, those of thiophanate-methyl were 89, 89 and 79%, and in case of chlorothlaonil, reduction rates were 84, 84 and 88%, respectively When mini-tomato at 0 day and 5 days after spray was washed by 0.02% of $Sur-ten^{(R)}$ solution, its pesticide residues were reduced by 81 and 55% on oxadixyl, 95 and 91% on thiophanate-methyl, and 97 and 98% on chlorothlaonil. When three wettable powdered pesticides with the same recipe were sprayed, their reduction rates in/on mini-tomato by washing with water at 0, 5 and 7 days were 76, 66 and 43% on oxadixyl, 91, 83 and 82% on thiophanate-methyl, and 65, 68 and 82% on chlorothlaonil, suggesting that the washing effect may be dependent on the amounts of active ingredients and inert types of the pesticides used.

• Journal of the Korean Society of Safety
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• v.34 no.6
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• pp.13-21
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• 2019

Leakage accidents in businesses dealing with hazardous chemicals can have a great impact on the workers inside the workplace, as well as residents outside the workplace. In fact, there were cases where hazardous chemicals leaked from many businesses. As a result, the Chemicals Control Act(CCA) was enacted in 2015, the Ministry of Environment introduced an Off-site Risk Assessment(ORA). The purpose of the ORA is to secure safety from the installation of the design of the workplace facilities so that chemical accidents of hazardous chemical handling facilities do not cause human or physical damage outside the workplace. In general, the ORA qualitatively determines where a protected facility is within the scope of the accident scenario. However, elderly who belong to the sensitive group is more sensitive than the general group under the same chemical accident effect, and the extent of the damage is serious. According to data from the Korea National Statistic Office, the number of elderly people is expected to increase steadily. Therefore, a quantitative risk analysis considering the elderly is necessary as a result of a chemical accident. In this study, accident scenarios for 14 locations were set up to perform emergency evacuation due to toxic gas leakage of Cl₂(Chlorine) and HF(Hydrogen Fluoride), and the effects of exposure were analyzed based on the evacuation velocity difference of age 20s and 60s. The ALOHA(Areal Locations of Hazardous Atmospheres) program was used to calculate the concentration for assessing the effects. The time of exposure to toxic gas was calculated based on the time it took for the evacuation to run from the start point to the desired point and a methodology was devised that could be applied to the risk calculation. As a result of the study, the relative risk of the elderly, the sensitive group, needs to be determined.

• Korean Journal of Food Science and Technology
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• v.46 no.3
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• pp.283-287
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• 2014

This study determined the hazardous heavy metal content of mushrooms from markets in Seoul, Korea. One hundred and fifty mushroom samples were digested by the microwave method then the hazardous heavy metal (Pb, Cd, As, Cr, Ni and Hg) content was determined by the inductively coupled plasma-mass spectrometry (ICP-MS) and mercury analyzer. The average values of heavy metals in the samples were as follows: (mean [minimum-maximum], ${\mu}g/kg$); Pb 7.8 (1.9-30.0), Cd 45.3 (0.7-292.4), As 54.6 (24.2-229.3), Cr 42.6 (8.4-334.3), Ni 22.4 (up to 180.4), and Hg 8.9 (2.0-25.0). The contents of hazardous heavy metal in mushrooms were lower than those reported previously and also lower than the Provisional Tolerable Weekly Intake (PTWI) limit prescribed by the FAO/WHO. Thus, it could be suggested that the hazardous heavy metals levels in the mushrooms of retail market were adequately safe for consumption.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.6
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• pp.737-743
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• 2021

In this paper, the current status of marine industrial facilities, regulatory legal systems, and emission status of hazardous and noxious substances (HNS) in these facilities were analyzed, and the direction of improvement of the regulatory system was presented accordingly. As a result of the analysis, it is estimated that about 1,100 marine industrial facilities are subject to the Marine Environment Management Act of 2007. It is estimated that 190 kinds of hazardous substances are discharged from these marine industrial facilities and are highly likely to flow into the ocean, of which 20 are estimated to be discharged into the water system. However, due to the lack of relevant laws and regulation, it is difficult to clearly determine whether the discharged material corresponds to an exceptional discharged material, making it difficult to effectively enforce regulations in the field. For this reason, effective regulatory enforcement is difficult in the regulatory field. The marine environment management law should clearly stipulate the exceptional emission standards and types of substances, and clarify the selection system, risk assessment system, and emission information collection and monitoring system for related Hazardous and Noxious Substances.

• Journal of the Korean Institute of Gas
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• v.25 no.3
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• pp.39-45
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• 2021

Scrubbers that treat hazardous materials at workplaces have high treatment efficiency; however, the design is complex, and pumps need to be operated 24 hours a day, which can be costly. Therefore, to minimize the operating costs, small businesses do not install scrubbers, or operate them while circulation pumps are suspended. Hence, this study investigated the application of low-cost, high-performance scrubbers that can be used economically in small businesses. Low-cost, high-efficiency scrubbers are applied to bubble columns to utilize devices for hazardous chemical absorption treatment purposes, and for the development of these scrubbers, absorption performance was reviewed and the optimal application method was studied under certain conditions. The changes in the absorption performance of hazardous gas were studied in certain environments by varying the physical conditions, and the optimal application methods were analyzed. The results showed that, while it was possible to treat some of the gas flowing into the low cost, high performance scrubber, the treatment capacity was reduced. Performance degradation was prevented by supplying an absorption liquid, and a certain level of absorption was maintained depending on the amount of circulation. Based on this, three types of site application methods of low cost, high performance scrubbers were presented. In addition, the appropriate timing of circulation and anti freezing measures were also discussed.

• Journal of Digital Convergence
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• v.20 no.5
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• pp.653-659
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• 2022

In this study, the awareness of hazardous chemicals and the need for education of dental hygienists were investigated. The subject of this study was an online survey of 103 dental hygienists working in medical institutions from June to August 2021 and analyzed using the SPSS 21.0 program. As a result, work experience was positively correlated with perception (r=.280, p<0.01) and work (r=.303, p<0.01), and work experience with perception (r=.411, p<0.01).Hazardous chemical information showed a positive correlation with practice (r=.371, p<0.01). As a result of the education requirement survey, only 27.2% had experience in hazardous chemical education, and 96.1% of the awareness of the need for education was highly surveyed. As for the desired method of education, 49.5% of them were online education, and the desired time for education was 1 hour. Therefore, in order to create a safe working environment for dental hygienists and to secure the safety of hazardous chemicals, it was necessary to expand educational opportunities at universities, medical institutions, and maintenance education, and to increase accessibility through online education.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.33 no.1
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• pp.12-18
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• 2023

Objectives: Personal protective equipment (PPE) is an essential means for protecting workers against hazardous agents or risks that threaten their safety and health. Governmental organizations related to safety and health in the workplace regulate the PPE rules to protect workers and to minimize damage from hazardous agents. This study discussed current PPE rules overseen by the Korea Ministry of Environment and explores future perspectives on the matter. Methods: This study was based on a review of PPE regulations with which every stakeholder should comply in the workplace. Both South Korean regulations enforced by the Ministry of Employment and Labor and the Ministry of Environment and cases from other countries were reviewed. Results: Regulations related to the PPE required for handling chemical substances in the workplace are enforced by the Occupational Safety and Health Act, Enforcement Decree, Enforcement Rules, and Notification of Protective Equipment Certification under the Ministry of Employment and Labor. The Ministry of Environment also regulates the PPE standards for 97 substances requiring preparation for accidents and adjustment of work conditions, but a recent amendment (partially amended on September 30, 2022) loosened some unreasonable or excessive provisions. It requires workers simply to carry or otherwise keep PPE handy instead of wearing it for some tasks in which hazardous chemicals are not handled directly. Conclusions: It is important to regularly review provisions that need to be improved or supplemented to help all stakeholders. Considerations should be also made to build a reasonable regulatory system that can induce more mature safety management in each workplace.

• Journal of Soil and Groundwater Environment
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• v.12 no.6
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• pp.107-117
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• 2007

Dispersion characteristics and envirounmental impactes of the stream sediments were investigated and geochemical disaster in the Namhae-Hwagye area was predicted. Stream sediments having no possibility of contamination effect and representing drainage basins were collected. Major and hazardous elements concentrations were determined by XRF, ICP-AES and NAA analysis methods. Acid decomposition for the ICP-AES have been used $HClO_4$ and HF with $200^{\circ}C$ heating at 1'st and after that $HClO_4$, HF and HCl with $200^{\circ}C$ heating at 2'nd stage. Hazardous elements concentrations for the stream sediments in the Namhae area were Cu $5.66{\sim}168\;ppm$, Pb $18.0{\sim}40.7\;ppm$, Cr $21.6{\sim}147\;ppm$, Co $4.86{\sim}25.3\;ppm$. Hazardous elements concentrations for the stream sediments in the Hwagye area were Cu $16.4{\sim}41.2\;ppm$, Pb $26.5{\sim}37.5\;ppm$ Cr $79.6{\sim}153\;ppm$, Co $15.7{\sim}29.5\;ppm$. Concentration of Cu and Co in the stream sediments show a negative correlation with $SiO_2$ in all study area. According to E.I.(Enrichment Index) of stream sediments was not enriched in study area. And average E.I. was 0.35 (Namhae) and 0.56 (Hwagye) respectively. The stream sediments were enriched as in order of Pb > Cr > Co > Cu. And the average of Enrichment Factor (E.F.) was 0.46 to 2.84, respectively. E.F. concentration of Cu and Co were nearly similar enrichment characteristic but E.F. concentration of Cr were higher enrichnent characteristic in Namhae than Hwagye area. Pb was highly enriched in all study area but the tolerable level that used to investigate the enrichment degree of hazardous elements, was not exposed to harmful hazardous elements.