• Journal of Gastric Cancer
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• v.20 no.4
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• pp.421-430
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• 2020

Purpose: Currently, there is no clear evidence to support any specific treatment as a principal therapy for stage IV gastric cancer outlet obstruction (GCOO) patients. This study evaluated the outcomes of palliative gastrectomies and survival prognostic factors in patients with stage IV resectable GCOO. Materials and Methods: We retrospectively reviewed the medical records of 48 stage IV GCOO patients who underwent palliative gastrectomies between June 2010 and December 2019. Palliative gastrectomies were performed only in patients with resectable disease. Early surgical outcomes and prognostic factors were analyzed using univariate and multivariate analyses. Results: There were no specific risk factors for postoperative complications, except for being underweight. Severe postoperative complications developed in five patients, and most of the patients underwent interventional procedures and received broad-spectrum antibiotics for intra-abdominal abscesses. The multivariate survival analysis showed that palliative chemotherapy is a positive prognostic factor, while the specific type of hematogenous and lymphatic metastasis is a negative prognostic factor. Conclusions: We recommend that the treatment method for stage IV GCOO should be selected according to each patient's physical condition and tumor characteristics. In addition, we suggest that palliative gastrectomies can be performed in stage IV resectable GCOO patients without unfavorable prognostic factors (types of hematogenous and lymphatic metastases).

• Parasites, Hosts and Diseases
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• v.59 no.6
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• pp.547-556
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• 2021

Our objective was to investigate whether inflammatory microenvironment induced by Trichomonas vaginalis infection can stimulate proliferation of prostate cancer (PCa) cells in vitro and in vivo mouse experiments. The production of CXCL1 and CCL2 increased when cells of the mouse PCa cells (TRAMP-C2 cell line) were infected with live T. vaginalis. T. vaginalis-conditioned medium (TCM) prepared from co-culture of PCa cells and T. vaginalis increased PCa cells migration, proliferation and invasion. The cytokine receptors (CXCR2, CCR2, gp130) were expressed higher on the PCa cells treated with TCM. Pretreatment of PCa cells with antibodies to these cytokine receptors significantly reduced the proliferation, mobility and invasiveness of PCa cells, indicating that TCM has its effect through cytokine-cytokine receptor signaling. In C57BL/6 mice, the prostates injected with T. vaginalis mixed PCa cells were larger than those injected with PCa cells alone after 4 weeks. Expression of epithelial-mesenchymal transition markers and cyclin D1 in the prostate tissue injected with T. vaginalis mixed PCa cells increased than those of PCa cells alone. Collectively, it was suggested that inflammatory reactions by T. vaginalis-stimulated PCa cells increase the proliferation and invasion of PCa cells through cytokine-cytokine receptor signaling pathways.

• Korean Journal of Radiology
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• v.22 no.12
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• pp.2026-2033
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• 2021

Objective: The aim of this study was to compare the diagnostic performances of digital tomosynthesis (DTS) and conventional radiography in detecting osteonecrosis of the femoral head (ONFH) using computed tomography (CT), as the reference standard and evaluate the diagnostic reproducibility of DTS. Materials and Methods: Forty-five patients (24 male and 21 female; age range, 25-77 years) with clinically suspected ONFH underwent anteroposterior radiography, DTS, and CT. Two musculoskeletal radiologists independently evaluated the presence and type of ONFH. The diagnostic performance of radiography and DTS in detecting the presence of ONFH and determining the types of ONFH were evaluated. The interobserver and intraobserver reliabilities of each imaging modality were analyzed using Cohen's kappa. Results: DTS had higher sensitivity (89.4%-100% vs. 74.5%-76.6%) and specificity (97.3%-100% vs. 78.4%-83.8%) for ONFH detection than radiography. DTS showed higher performance than radiography in identifying the subtypes of ONFH with statistical significance in one reader (type 1, 100% vs. 30.8%, p = 0.004; type II, 97.1% vs. 73.5%, p = 0.008). The interobserver agreement was excellent for DTS and moderate for radiography (kappa of 0.86 vs. 0.57, respectively). The intraobserver agreement for DTS was higher than that of radiography (kappa of 0.96 vs. 0.69, respectively). Conclusion: DTS showed higher diagnostic performance and reproducibility than radiography in detecting ONFH. DTS may be used as a first-line diagnostic modality instead of radiography for patients suspected of having ONFH.

• Tuberculosis and Respiratory Diseases
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• v.71 no.6
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• pp.454-458
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• 2011

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia occurring in Western nations. In CLL it is well known that the risk of a secondary malignancy is higher than in the normal population. But in Korea, CLL is a rare type of leukemia, so there have been only a few reported cases with a secondary malignancy. CLL is characterized by progressive defects in both cell-mediated and humoral immunity. It is known that defects in the immune system of patients with CLL contribute to the development of a secondary malignancy. We experienced a case of a 71-year-old man who suffered from a chronic cough and was diagnosed with small cell lung cancer coexisting with CLL. Until this case, there was no reported case in Korea of small cell lung cancer coexisting with CLL. We now report a case of small cell lung cancer coexisting with CLL and present a literature review.

• Proceedings of the KIEE Conference
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• 2002.07b
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• pp.595-597
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• 2002

This paper presents an optimum design, which is able to determine optimal geometric and electric parameters of Switched Reluctance Motor so as to fit respective operating conditions specified in various industrial fields. Those works describe an approach to maximize the average torque while keeping the torque ripple within 10${\sim}$100(%) of respective limited values. This optimum design is obtained by uniting an optimization algorithm of PQRSM to a time stepping finite element method.

• Journal of Information Display
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• v.6 no.2
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• pp.1-6
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• 2005

We demonstrated stability-enhanced liquid crystal (LC) displays using pixel-isolated LC mode in which LC molecules are isolated in pixel by horizontal polymer layer and vertical polymer wall. The device shows good electro-optic properties against external point or bending pressure due to the polymer structures. The polymer wall acts as supporting structure from mechanical pressure and prevents the cell gap from bending. Moreover, the polymer layer acts as an adhesive to ensure a tight attachment of the two substrates. We present herein various methods for producing polymer structures by using an anisotropic phase separation from LC and polymer composites or patterned micro-structures for stable flexible liquid crystal displays.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10a
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• pp.724-726
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• 1998

본 논문에서는 방대한 양의 데이터를 실시간으로 처리하기 위한 병렬 디지털 신호처리시스템을 제안한다. 버스와 메모리의 구조가 다른 네 가지 신호처리부 모델을 제안하고 그들의 성능을 분석한다. 신호처리부의 분석은 소나 알고리즘을 실행하는데 소요되는 하드웨어 지연시간과 버스 지연시간의 합을 척도로 한 성능 분석과 보드의 복잡도를 비교하는 방법을 통하여 이루어졌다. 성능분석한 결과, 지역 메모리와 공유 메모리를 함께 사용하는 모델이 가장 효율적인 것으로 나타났다.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.555-559
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• 2003

EK를 고정화하기 위해 니켈 친화결합 방법과 공유 결합형 고정화 방법을 수행하였으며 니켈 친화결합이 공유 결합형 고정화보다 높은 고정화 수율과 activity를 나타냈다. 풀림과 재접힘을 이용한 효소의 활성 회복은 공유결합형 고정화가 니켈 친화결합보다 높은 결과를 나타내었다. 또한 기질의 분자량 크기에 따른 절단율의 차이가 없었으므로 레진 공극 내부로의 확산도 차이에 의한 절단반응의 차이는 없는 것으로 나타났고, 기질 종류에 따른 EK의 활성은 작은 기질이 큰 기질보다 높은 활성을 보였다.

• 대한예방의학회:학술대회논문집
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• 2005.10a
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• pp.332-332
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• 2005

• Journal of Chest Surgery
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• v.19 no.2
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• pp.313-318
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• 1986

A rare anomaly, Cor triatriatum dexter combined with pulmonary stenosis and patent foramen ovale in a 2-years- old female is presented. Abnormal embryologic development of the right sinus venosus valve caused partial membranous septation of the right atrium. Most cases have been recorded at necropsy either as an incidental finding or in association with severe congenital heart disease. In this case, Cor triatriatum dexter was diagnosed preoperatively by cineangiography and echocardiography.