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Mechanism of Epibatidine-Induced Catecholamine Secretion in the Rat Adrenal Gland

  • Lim, Dong-Yoon;Lim, Geon-Han;Oh, Song-Hoon;Kim, Il-Sik;Kim, Il-Hwan;Woo, Seong-Chang;Lee, Bang-Hun
    • The Korean Journal of Physiology and Pharmacology
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    • v.5 no.3
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    • pp.259-270
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    • 2001
  • The present study was attempted to investigate the characteristics of epibatidine on secretion of catecholamines (CA) from the isolated perfused model of the rat adrenal gland, and to establish the mechanism of action. Epibatidine $(3{\times}10^{-8}\;M)$ injected into an adrenal vein produced a great inhibition in secretory response of CA from the perfused rat adrenal gland. However, upon the repeated injection of epibatidine $(3{\times}10^{-8}\;M)$ at 15 min-intervals, CA secretion was rapidly decreased after second injection of epibatidine. However, there was no statistical difference between CA secretory responses of both 1st and 2nd periods by the successive administration of epibatidine at 120 min-intervals. Tachyphylaxis to releasing effects of CA evoked by epibatidine was observed by the repeated administration. Therefore, in all subsequent experiments, epibatidine was not administered successively more than twice only 120 min-intervals. The epibatidine-induced CA secretion was markedly inhibited by the pretreatment with atropine, chlorisondamine, pirenzepine, nicardipine, TMB-8, and perfusion of $Ca^{2+}-free$ Krebs solution containing EGTA, while was not affected by diphenhydramine. Moreover, the CA secretion evoked by ACh for 1st period $(0{\sim}4\;min)$ was greatly potentiated by the simultaneous perfusion of epibatidine $(1.5{\times}10^{-8}\;M),$ but followed by time-dependently gradual reduction after 2nd period. The CA release evoked by high potassium $(5.6{\times}10^{-8}\;M),$ for 1st period $(0{\sim}4\;min)$ was also enhanced by the simultaneous perfusion of epibatidine, but those after 2nd period were not affected. Taken together, these experimental data suggest that epibatidine causes catecholamine secretion in a calcium dependent fashion from the perfused rat adrenal gland through activation of neuronal cholinergic (nicotinic and muscarinic) receptors located in adrenomedullary chromaffin cells. It also seems that epibatidine-evoked catecholamine release is not relevant to stimulation of histaminergic receptors.

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The Comparison of Academic Contingencies of Self-Worth and Self-Esteem on Academic Help-Seeking and Academic Concealment: The Mediating Effects of Trait Anxiety in University Students (대학생의 학업적 자기가치감 수반성과 자존감이 학업 도움 추구 및 은폐에 미치는 영향의 비교: 특성불안을 매개로)

  • Jung, Eun-Sun;Ha, Jung-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.2
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    • pp.639-650
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    • 2017
  • This study examined the role of trait anxiety in the relationships among academic contingencies of self-worth, self-esteem, academic help-seeking, and academic concealment. The participants were 254 male and female undergraduate students, and the analyses were conducted using PASW 18.0. The results were as follows. Anxiety was confirmed to be a mediating variable between the academic contingencies of self-worth, self-esteem, and academic concealment. That is, the academic contingencies of self-worth and self-esteem had an effect on academic concealment through anxiety. On the other hand, the academic contingencies of self-worth had a positive effect on anxiety. On the other hand, self-esteem had a negative effect on anxiety. The need to develop education and counseling approaches as a special intervention is discussed. The approaches are meant to reduce the academic self-worth and anxiety. In addition, it is important to promote self-esteem in education and counseling. The limitations and implication for further study are suggested.

A Radionuclides Suite Selection for Site Characterization and Final Status Survey in the U.S. NPPs (미국의 원전 해체관련 부지특성 및 최종상태 조사를 위한 방사성 오염 핵종 결정 방법에 대한 분석)

  • Zhao, Pengfei;Jeon, Yeo Ryeong;Kim, Yongmin;Lee, Jong Seh;Ahn, Seokyoung
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.14 no.3
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    • pp.267-277
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    • 2016
  • For the decommissioning of a nuclear power plant, a site characterization and final status survey require a site-specific suite of radionuclides that could potentially still be present in the site during or after the decontamination processes. The United States Nuclear Regulatory Commission (U.S. NRC) requires a Decommissioning Technical Base Document (DTBD) along with a Site Characterization and Historical Site Assessment (HSA) from the utility for decommissioning to proceed. Both the DTBD and HSA are preliminary components of the Radiological Site Survey investigation process and should be included in the final License Termination Plan (LTP) for site release and reuse consideration from the U.S. NRC and the utility company. This study reviews the United States Nuclear Power Plants (U.S. NPPs) decommissioning cases and is especially focused on the methodologies used for determining a site-specific suite of radionuclides before and during the site characterization and final status surveys. In 2017, Kori-1 will be ready for decommissioning and related preparations are ongoing, this review will help Korea to prepare regulatory guidelines and give technical background for the safe and successful decommissioning of NPPs.

The Effects of R&D Project Managers' Leadership on Product Development Performance: Focused on the Mediating Effects of Project Sponsor Roles (R&D 프로젝트 관리자의 리더십이 제품개발 성과에 미치는 영향: 프로젝트 스폰서 역할의 매개효과를 중심으로)

  • Lee, Rok;Jun, In-Sun;Park, Ju-Gyeong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.1
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    • pp.70-80
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    • 2020
  • This study examined the effects of the R&D project managers' leadership on the product development performance. A survey was carried out empirically on a group of 175 experts associated with project management R&D operations in the field of manufacturing, construction engineering, shipbuilding, plant, and IT. The survey results showed that the effects of the R&D project managers' leadership on the product development performance were not significant, and the mediating effects of the project sponsor roles were significant. This means that the leadership of leaders, which requires efficient control and management based on complicated intergroup relationships and roles, is important in a project involving experts from the professional field. This suggests that the efficient leadership of leaders can improve the performance through the cooperation of members in the organization and aggregation of their core competencies in a limited time. Overall, the key results of this study mean that project leaders should play an active mediating role to maximize their leadership and enhance the role of project sponsors. In addition, the mediating role of project sponsors has an effect on the leadership of project managers, affecting the project performance quality.

A Study of Indoor Air Quality of School Classrooms (일부 학교 교실의 실내공기질 특성에 관한 연구)

  • Jung, Joon-sig;Park, Duck-shin;Jeon, Hyung-jin;Song, Hyea-suk;Lee, Min-jong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.5
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    • pp.3643-3652
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    • 2015
  • The aim of this study is to analyze the IAQ concentrations of school rooms. In this study we measured and characterized IAQ at 440 school rooms from May 2009 to November 2012. At some school rooms, the $PM_{10}$ concentrations exceeded the IAQ guidelines ($100{\mu}g/m^3$) of the Ministry of Education. $CO_2$ concentrations at high schools were 1.18 and 1.06 times higher than that of the elementary and middle schools, respectively. $CO_2$ concentrations of some school rooms were exceeded the IAQ guidelines (1,000 ppm). Moreover, TBC concentrations at elementary school rooms were 1.23 and 1.33 times higher than that of the middle schools and high schools, respectively. TBC and HCHO concentrations did not exceed the IAQ guidelines. The classroom/non-classroom ratio of $PM_{10}$ was 1.06, while that $CO_2$ was 1.04, HCHO was 0.62, and TBC was 1.16.

An Experimental Study on Corrosion Behavior in Steel of Concrete Applied with Arc Metal Spray Method Surface Treatment Technology Using EIS (EIS를 이용한 아크 금속용사 표면처리기법이 적용된 강재의 콘크리트 내 부식 거동에 관한 실험적 연구)

  • Yoon, Chang-Bok;Park, Jang hyun;Lee, Han-Seung
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.24 no.3
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    • pp.87-95
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    • 2020
  • As an experimental study on the corrosion behavior of steel materials to which ATMS method using EIS was applied in concrete, immersion of Ca(OH)2 saturated aqueous solution and NaCl aqueous solution simulating the environment inside concrete The corrosion behavior was tested. The equivalent circuit was derived through the analysis of the Nyquist plot, and the interfacial resistance and the polarization resistance of the Ca(OH)2 aqueous solution were compared, and Al ATMS was the best interfacial resistance and Zn ATMS was the best polarization resistance. After burying ATMS steel material of cement mortar, the initial immersion impedance measurement value was the highest in the Zn ATMS test body in the impedance measurement by the immersion time by immersing it in the NaCl aqueous solution. Al ATMS test piece has the highest impedance and is highly reliable. This is because Al, which has a high ionization tendency, is continuously oxidized in a strong alkaline environment to form a film and protect the steel from permeation of chlorine ions.

Study on the Effect of Fineness and Substitution Rate of Natural Zeolites on Chemical Reaction and Physical Properties of Cement Mortar (천연 제올라이트의 분말도와 치환율이 시멘트모르타르의 화학반응 및 물리적 특성에 미치는 영향에 관한 연구)

  • Yoon, Chang-Bok;Lee, Han-Seung
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.24 no.3
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    • pp.96-103
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    • 2020
  • As a basic study for the application of natural zeolite as a concrete admixture, the compressive strength, activity factor, Ca(OH)2 quantitative analysis and XRD experiments were investigated. It is thought that SiO2, which is abundant in natural zeolite, affects the strength development by reacting with the hydration product of cement in all specimens in which natural zeolite was added according to powder level and substitution rate. As the substitution rate increases, the compressive strength decreases, which is considered to be due to the decrease in the amount of C3S and C2S minerals in the clinker, which affects the strength expression compared to the cement content of the reference mortar. The XRD crystal structure did not show a significant difference from the reference mortar, and it was confirmed that the Z2-10 (Blaine: 15,600㎠ / g) specimen with 10% substitution of natural zeolite was the best among the experimental levels. Substitution amount for use as concrete admixture is 10% substitution is most ideally seen.

Symbolism and Formal Embodiment Lighted in Seokgasan of Seong-im in the Early Joseon (조선 초 성임의 석가산에 조명된 상징성과 형태적 구현)

  • Yoon, Young-Jo;Yoon, Young-Hwal
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.30 no.1
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    • pp.159-169
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    • 2012
  • Seokgasan(石假山) is originated in Goryeo, is a Korean traditional technique handed down to Joseon and Seokgasan is the Korean creative culture of gardening by artificial stones, which replicates small artificial mountain of natural landscape in the garden. The object of this study is Seokgasan made by Seong-im(成任), who was a civil minister in Joseon and lived from 1421 to 1484, in his residence located in Inwang Mountain, Hanyang and the purpose of this study is to investigate the historical meaning and symbol of Seokgasan made by Seong-im on the base of the relative old literatures and embody its shape and structure. According to the result of this study on Seokgasan of Seong-im, it can find out some facts as follows; Seokgasan of Seong-im in the early Joseon succeeded to the structural form of Seokgasan of the artificial rock mountain type connected pond, which was made-up firstly in the garden of the Palace of Manwoldae in the Middle Goryeo, and it was called firstly as 'Seokgasan' in the garden of Seong-im's house. Seong-im's Seokgasan in the early Joseon had more concentrated philosophical meanings, including the idea of taoist immortal, than those in the Goryeo dynasty and was be emblematic of an imaginative space. Also there were lots of gardens modeled on the famous mountains and famous lakes in China much the same as the Goryeo dynasty. In addition, there was an exceptional purpose for building Seokgasan which could not be found in the Goryeo dynasty. That was practicality for emotional stability and cure. Seong-im's Seokgasan is record-relics with high value of landscape architecture history, which can identify its historical meanings, shapes and structural frames succeeded from the Goryeo dynasty.

Design and Implementation of a Reusable and Extensible HL7 Encoding/Decoding Framework (재사용성과 확장성 있는 HL7 인코딩/디코딩 프레임워크의 설계 및 구현)

  • Kim, Jung-Sun;Park, Seung-Hun;Nah, Yun-Mook
    • Journal of KIISE:Computing Practices and Letters
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    • v.8 no.1
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    • pp.96-106
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    • 2002
  • this paper, we propose a flexible, reusable, and extensible HL7 encoding and decoding framework using a Message Object Model (MOM) and Message Definition Repository (MDR). The MOM provides an abstract HL7 message form represented by a group of objects and their relationships. It reflects logical relationships among the standard HL7 message elements such as segments, fields, and components, while enforcing the key structural constraints imposed by the standard. Since the MOM completely eliminates the dependency of the HL7 encoder and decoder on platform-specific data formats, it makes it possible to build the encoder and decoder as reusable standalone software components, enabling the interconnection of arbitrary heterogeneous hospital information systems(HISs) with little effort. Moreover, the MDR, an external database of key definitions for HL7 messages, helps make the encoder and decoder as resilient as possible to future modifications of the standard HL7 message formats. It is also used by the encoder and decoder to perform a well formedness check for their respective inputs (i. e., HL7 message objects expressed in the MOM and encoded HL7 message strings). Although we implemented a prototype version of the encoder and decoder using JAVA, they can be easily packaged and delivered as standalone components using the standard component frameworks like ActiveX, JAVABEAN, or CORBA component.

A Study on the Formation of Hydrate Plugging due to water molecules in High Pressure and Low Temperature Gas Pipeline (고압$\cdot$저온 가스 배관에서 수분에 의한 하이드레이트 플러깅 형성)

  • Lee J. H.;Baek Y. S.;Sung W. M.
    • Journal of the Korean Institute of Gas
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    • v.6 no.1 s.17
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    • pp.38-45
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    • 2002
  • Hydrates are solid cryctallines resembling ice in appearance, which are consist of a gas molecule surrounded by a cage of water molecules. Because of containning a large amount of methane, hydrates have been considered as a future energy resource. However, the formation of hydrates in the oil and gas industries has been known as a serious problem for a long time. The formation of hydrate in pipeline is common in seasonally cold or sub-sea environments with low temperatures and high pressures. Especially, hydrate plug formation becomes a real menace to flow assurance in inadequately protected transmission lines. This study was carried out for the purpose of understanding mechanism of hydrate plugging and examining formation conditions of hydrate in high pressure gas pipeline. In this study, we measured hydrate equilibrium conditions under the various flowing conditions with the methane. The results were presented both the plugging tendency and the effect of flowing velocity.

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