• 동서간호학연구지
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• 제29권1호
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• pp.1-5
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• 2023

Traditional Korean medicine and traditional Korean (Hanbang) nursing are very similar disciplines in terms of philosophy, values, and identity. Traditional Korean medicine views that harmonious and balanced human body and mental state can be formed through the flow of Qi and blood using meridians and acupressure points. This view can be applied to research, practice, theory, and education in Hanbang nursing. The meridian is a pathway through which Qi and blood, the energy necessary for life activities, pass through. Acupressure points are important meridians where physical, mental, and psychological health conditions appear as a response. Pressing and stimulating acupressure points to facilitate and communicate the flow of qi and blood in the meridians can create positive effects and enable the treatment of various symptoms and syndromes of our bodies. Hanbang nursing nursing, which is also based on the use of meridians, may be used to control various symptoms and syndromes and prevent and treat diseases. Currently, Hanbang nursing are growing along with the professionalism of Hanbang nursing practice, vitalization of Hanbang nursing research, and the development of Hanbang nursing education and theory. The growth of Hanbang nursing requires active participation of nursing scholars and efforts to converge beyond the walls of medicine and nursing.

• 동서간호학연구지
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• 제28권1호
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• pp.1-9
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• 2022

Purpose: This descriptive research was conducted to identify the effects of work complexity, role conflict, knowledge of traditional Korean (Hanbang) nursing, and grit on the job satisfaction among traditional Korean nurses. Methods: The survey was conducted from September 7, 2020 to February 10, 2021 on 155 Hanbang nurses. Data were analyzed by t-test, one way ANOVA, Pearson's correlation coefficient, and multiple linear regression with the SPSS statistics 26.0 program. Result: The factors affecting job satisfaction of Hanbang nurses were work complexity, knowledge of Hanbang nursing, age, and experience in traditional Korean medicine hospitals. Conclusions: It is necessary to promote Hanbang nursing related education in regular and clinical area in order to improve the job satisfaction of Hanbang nurses. In addition, an organizational effort is required to increase long-term job satisfaction.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2009년도 심포지엄 및 춘계학술발표회
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• pp.363-364
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• 2009

• 생약학회지
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• 제41권1호
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• pp.26-30
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• 2010

The root of Korean ginseng (Panax ginseng C.A. Meyer) is a commonly used herbal medicine in China, Korea, Japan. However, the compositions and effects of Korean ginseng berry are not clear to date. In order to investigate the anti-aging effects in the skin, Korean ginseng berry was extracted with 70% ethanol and tested the biological effects. In the results, Korean ginseng berry extract showed an excellent anti-oxidant effect against oxidative stress and decreased MMP-1 over-expression induced by UV irradiation. Especially the main component of Korean ginseng berry extract, ginsenoside Re, increased hyaluronic acid in HaCaT keratinocytes. We improved Korean ginseng berry could be a good material for the anti-aging effect of skin.

• 대한한의학방제학회지
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• 제21권1호
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• pp.119-130
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• 2013

Objectives : Diabetes mellitus is the leading cause for vascular complications such as atherosclerosis. The present study is to investigate whether Doinseunggi-tang (DST) improves diabetic vascular dysfunction in type II diabetes. Methods : The db/db mice were treated with high fat/high cholesterol diet and DST (200 mg/kg/day) for 8 weeks. Results : DST significantly lowered blood glucose and systolic blood pressure. In addition, DST also markedly decreased total plasma cholesterol, triglyceride, and LDL-cholesterol, whereas increased the HDL-cholesterol. Vascular relaxation of aortic rings by acetylcholine or SNP was ameliorated by DST in a dose-dependent manner. Damage of vascular intima and hypertrophic of media was improved by DST. Immunohistological study revealed that DST attenuated the increase of ICAM-1, VCAM-1, and ET-1 expression in thoracic aorta. Conclusions : Taken together, DST suppressed hyperglycemia and diabetic vascular dysfunction in type II db/db mice. The present data suggests that Doinseunggi-tang may be prevent a development of diabetic atherosclerosis.

• 생약학회지
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• 제39권4호
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• pp.300-304
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• 2008

The root of Astragalus membranaceus Bunge (Leguminosae) has been used in the Korean oriental medicine for strengthening the vital energy. UV irradiation has been suggested as a major cause of photo aging in skin. In order to investigate protective effects against UV induced cellular damage, Astragali Radix was extracted with 70% ethanol and dissolved in DMSO. The protective effect was detected by MTT assay, LDH assay, and Comet assay in immortalized human keratinocyte cell line, HaCaT cell system after UV irradiation. Astragli Radix 70% EtOH extract reduced UV induced cellular damage in cell survival, membrane integrity and DNA damage.

• 한국식품저장유통학회지
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• 제12권6호
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• pp.565-571
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• 2005

본 연구는 품질특성과 기능성이 우수한 고추장을 제조하기 위해서, 고춧가루, 찹쌀, 메주, 엿기름, 소금, 물과 3종류의 한약재(당귀,목통,골담초)의 물추출물을 첨가하여 재래식 방법으로 한방고추장을 제조한 후, $5^{\circ}C$와 $20^{\circ}C$에서 90일간 저장하면서 고추장의 품질특성을 수분함량, 색도, 관능검사로서 조사하였다. 고추장의 수분함량은 저장 초기에 $33\~38\%$였으며 저장기간이 길어질수록 증가하여 저장 90일후에는 $48\~51\%$까지 증가하였다. 고추장의 색도는 명도(L), 적색도(a), 황색도(a) 모두 저장기간의 경과에 따라 감소하는 경향을 나타내었으며 $20^{\circ}C$에 저장한 경우가 $5^{\circ}C$에 저장한 경우보다 감소의 폭이 컸다. 고추장의 명도는 $5^{\circ}C$와 $20^{\circ}C$ 모두 대조군과 한약재 첨가군 간에 유의적인 차이를 나타내지 않았으나, 적색도는 $20^{\circ}C$에 저장했을때 목통과 골담초 첨가 고추장이 유의적으로 낮았으며 황색도는 $5^{\circ}C$에 저장한 골담초 첨가 고추장이 대조군보다 유의적으로 낮았다(p<0.05). 한방고추장의 관능검사 결과, $5^{\circ}C$와 $20^{\circ}C$ 모두 90일간 저장한 고추장이 60일간 저장한 경우보다 기호도가 높았으며 한약재 첨가군이 대조군보다 기호도가 높은 편이었고 특히 목통을 첨가한 고추장이 색상, 단맛, 종합평가에서 유의적으로 높은 기호도를 나타내었다(p<0.05).

• 대한한의학방제학회지
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• 제32권1호
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• pp.11-28
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• 2024

Objectives : GunRyeong-Tang(GRT) is a traditional herbal prescription that combines Oryeongsan and Sagunja-tang. This study employed network analysis methods on the components of GRT and target genes related to diabetes complications to predict the improvement effects of GRT on diabetes complications. Methods : The collection of active compounds of GRT and related target genes involved the utilization of public databases and the PubChem database. We selected diabetes complication-related genes using GeneCards and confirmed their correlation through comparative analysis with the target genes of GRT. We constructed a network using Cytoscape 3.9.1 and conducted topological analysis. To predict the mechanism, we performed functional enrichment analysis based on Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results : Through network analysis, 234 active compounds and 1361 related genes were collected from GRT. A total of 9,136 genes related to diabetes complications were collected, and 1,039 target genes overlapping with the components of GRT were identified. The core genes of this network were TP53, INS, AKT1, ALB, and EGFR. In addition, GRT significantly reduced the H9c2 cell size and the expression of myocardial hypertrophy biomarkers (ANP, BNP), which were increased by high glucose (HG). Conclusions : Through this study, we were able to predict the activity and mechanism of action of GRT on diabetes and diabetic complications, and confirmed the potential of GRT as a treatment for diabetes complications through the effect of GRT on improving myocardial hypertrophy for diabetic cardiomyopathy.

• 대한한의학방제학회지
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• 제31권3호
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• pp.133-144
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• 2023

Ureteral obstruction can be causes of renal dysfunction and renal injury at late period of kidney pathology. The purpose of this study was to determine the protective effects of Oryeongsan (ORS), Geumgwe-sinkihwan (GSH), and Jwagwieum (JGE) in rats with unilateral ureteral obstruction (UUO). The animal models were divided into five groups randomly at the age of 5 weeks; Control group: SD male rats (n=10), UUO group: SD male rats with UUO surgery (n=10), ORS group: SD male rats with UUO surgery + ORS 200 mg/kg/day (n=10), GSH group: SD male rats with UUO surgery + GSH 200 mg/kg/day (n=10), JGE group: SD male rats with UUO surgery + JGE 200 mg/kg/day (n=10). Treatment with ORS, GSH, and JGE significantly ameliorate creatinine clearance(Ccr). The present results also showed that ORS, GSH, and JGE improved the morphological aspects of renal tissues. These prescriptions also reduced the expression levels of cytokines such as TNF-α, IL-1β, and IL-6. In Kidney, UUO increased the expression levels of inflamasome markers such as NLRP3, ASC, and Caspase-1. However, ORS, GSH, and JGE suppressed these levele. Treatment with these prescriptions reduced kidney inflammation markers such as Neutrophil Gelatinase Associated Lipocalin (NGAL) and kidney injury molecule -1 (KIM-1). Therefore, these findings suggest that ORS, GSH, and JGE has a protective effect on renal injury by alleviating renal inflammation and improving renal function in rats with UUO.

• 대한한의학방제학회지
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• 제31권3호
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• pp.157-169
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• 2023

Gracilaria Verrucosa (GV), a seaweed used in traditional Korean medicine, was studied for its effects on MI-induced heart failure in rats. MI is caused by a blocked coronary artery, leading to severe cardiac dysfunction. The study used a rat model to assess cardiac changes over time and evaluate the impact of GV on heart failure. Ischemia was induced through LAD ligation surgery, and the extent of ischemic area was measured as a prognostic factor. GV extract administration significantly improved cardiac morphology and reduced cardiac weight compared to the MI group. GV treatment also improved cardiac function, as evidenced by positive effects on chamber dilation during MI-induced heart failure. Parameters such as ejection fraction (EF) and fractional shortening (FS) were measured. The MI group showed decreased EF and FS compared to the sham group, while these parameters improved in the GV group. GV treatment also reduced levels of LDH, CPK, and CK-MB in the serum, indicating reduced myocardial damage. Histological analysis revealed that GV treatment attenuated cardiac hypertrophy and fibrosis, with reduced collagen deposition in the myocardium. Immunohistochemistry analysis showed suppressed expression of TGF-β1 and collagen 1, involved in fibrosis. In conclusion, GV showed potential in improving cardiac function in a rat model of MI-induced heart failure. It alleviated myocardial damage, attenuated cardiac hypertrophy and fibrosis, and suppressed fibrotic markers. Further studies are needed to explore its clinical efficacy and underlying mechanisms in cardiac diseases beyond animal models.