Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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The ProtectiveEffect of Oryeongsan, Geumgwe-sinkihwan, and Jwagwieum on Renal Injury in Rats with Unilateral Ureteral Obstruction

편측성 요관폐색으로 유발된 신장 질환 백서 모델에서 오령산, 금궤신기환, 좌귀음의 보호효과

  • Byung Hyuk Han (Hanbang Cardio-Renal Syndrome Research Center, Wonkwnag University) ;
  • Je Kuk Yu (Professional Graduate School of Korean Medicine, Wonkwang University) ;
  • Youn Jae Jang (Hanbang Cardio-Renal Syndrome Research Center, Wonkwnag University) ;
  • Hye Yoom Kim (Hanbang Cardio-Renal Syndrome Research Center, Wonkwnag University) ;
  • Jung Joo Yoon (Hanbang Cardio-Renal Syndrome Research Center, Wonkwnag University) ;
  • Nam Geun Cho (Professional Graduate School of Korean Medicine, Wonkwang University) ;
  • Ho Sub Lee (Hanbang Cardio-Renal Syndrome Research Center, Wonkwnag University) ;
  • Dae Gill Kang (Hanbang Cardio-Renal Syndrome Research Center, Wonkwnag University)
  • 한병혁 (원광대학교 한방심신증후군연구센터) ;
  • 유제국 (원광대학교 한의학전문대학원) ;
  • 장윤재 (원광대학교 한방심신증후군연구센터) ;
  • 김혜윰 (원광대학교 한방심신증후군연구센터) ;
  • 윤정주 (원광대학교 한방심신증후군연구센터) ;
  • 조남근 (원광대학교 한의학전문대학원) ;
  • 이호섭 (원광대학교 한방심신증후군연구센터) ;
  • 강대길 (원광대학교 한방심신증후군연구센터)
  • Received : 2023.07.20
  • Accepted : 2023.08.11
  • Published : 2023.08.31
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Abstract

Ureteral obstruction can be causes of renal dysfunction and renal injury at late period of kidney pathology. The purpose of this study was to determine the protective effects of Oryeongsan (ORS), Geumgwe-sinkihwan (GSH), and Jwagwieum (JGE) in rats with unilateral ureteral obstruction (UUO). The animal models were divided into five groups randomly at the age of 5 weeks; Control group: SD male rats (n=10), UUO group: SD male rats with UUO surgery (n=10), ORS group: SD male rats with UUO surgery + ORS 200 mg/kg/day (n=10), GSH group: SD male rats with UUO surgery + GSH 200 mg/kg/day (n=10), JGE group: SD male rats with UUO surgery + JGE 200 mg/kg/day (n=10). Treatment with ORS, GSH, and JGE significantly ameliorate creatinine clearance(Ccr). The present results also showed that ORS, GSH, and JGE improved the morphological aspects of renal tissues. These prescriptions also reduced the expression levels of cytokines such as TNF-α, IL-1β, and IL-6. In Kidney, UUO increased the expression levels of inflamasome markers such as NLRP3, ASC, and Caspase-1. However, ORS, GSH, and JGE suppressed these levele. Treatment with these prescriptions reduced kidney inflammation markers such as Neutrophil Gelatinase Associated Lipocalin (NGAL) and kidney injury molecule -1 (KIM-1). Therefore, these findings suggest that ORS, GSH, and JGE has a protective effect on renal injury by alleviating renal inflammation and improving renal function in rats with UUO.

Keywords

Acknowledgement

본 논문의 연구는 원광대학교 (2022)의 지원을 받아 수행되었으며 이에 감사드립니다.

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