• 제목/요약/키워드: Half-Life

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Degradation of Dinobuton in Soil and Solution (Dinobuton의 토양(土壤) 및 용액중(溶液中)에서 분해(分解))

  • Hong, Jong-Uck;Kim, Jung-Ho
    • Korean Journal of Environmental Agriculture
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    • v.3 no.2
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    • pp.16-22
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    • 1984
  • This study was carried out to investigate the stability of dinobuton (2-sec-butyl-4,6-dinitrophenyl isopropyl carbonate) in distilled water and buffer solutions and its persistence in soils. When dinobuton was incubated at $30^{\circ}C$ and $60^{\circ}C$ in distilled water, the half-lives of dinobuton was 28 and 6 days, respectively. The decomposition of dinobuton was, therefore, faster at high temperature than at low temperature. The half-life of dinobuton was about 27 days in the acidic solution $(pH\; 4{\sim}6)$, whereas 10 and 4 days in the alkaline solutions of pH 9, and 10, respectively. Thus dinobuton was stable in acidic solution, and unstable in alkaline solution. Dinoseb (2-sec-butyl-4,6-dinitrophenol), which is produced in the degradation process of dinobuton, was produced in small amounts in distilled water and buffer solutions. The half-life of dinobuton in sterilized soil was about 16 days longer than in non-sterilized soil. Dinoseb was also more persistent in sterilized soil than in non-sterilized one.

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Residue Patterns of Fungicides, Flusilazole and Myclobutanil in Apples (살균제 Flusilazole 및 Myclobutanil의 사과 중 잔류양상)

  • Hwang, Jeong-In;Kim, Jang-Eok
    • Current Research on Agriculture and Life Sciences
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    • v.31 no.4
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    • pp.272-279
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    • 2013
  • The dissipation patters of the triazole fungicides flusilazole and myclobutanil in apples were investigated to establish the biological half-lives and pre-harvest residue limits (PHRLs). The residual amounts of the fungicides sprayed with single or triple doses were below the maximum residue limits (MRL) for apples established by Ministry of Food and Drug Safety. The dissipation constants of the fungicides in the apples were 0.0513 for flusilazole and 0.0244 for myclobutanil meaning their biological half-lives were calculated as 6.2-6.7 days for flusilazole and 13.3-24.8 days for myclobutanil. The PHRLs calculated using the dissipation constants indicated that the residual amounts of flusilazole and myclobutanil in the apples at the harvesting date would be below the MRLs if their residual amounts were 0.43 and 0.59 mg/kg, respectively, at 7 days prior to harvesting the apples.

Variation of Half Cell Potential Measurement in Concrete with Different Properties and Anti-Corrosive Condition (콘크리트 특성에 따른 반전위 측정값의 변화와 부식제어 조건)

  • Kim, Ki-Bum;Park, Ki-Tae;Kwon, Seung-Jun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.17 no.6
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    • pp.95-103
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    • 2013
  • Half Cell Potential (HPC) technique has been widely adopted for its quantitative evaluation of corrosion possibility. In this study, RC specimens with three different cover depths (10mm, 30mm, and 60mm) and w/c ratios (0.35, 0.55, and 0.70) are prepared and accelerated salt spray test (SST) is performed for 45 days. Steel corrosion occurs in the specimens with 0.55 of w/c and 10mm of cover depth. In the case of 0.70 of w/c and 30mm of cover depth, steel corrosion is also monitored. Considering the effect of cover depth and w/c ratio, HCP evaluation equation is proposed and the condition which can control steel corrosion is obtained. Furthermore, anti-corrosive conditions containing w/c ratio and cover depth are analyzed through Life 365 program and the conditions are compared with the results from this study.

Glial Fibrillary Acidic Protein Splice Variants in Hepatic Stellate Cells - Expression and Regulation

  • Lim, Michelle Chin Chia;Maubach, Gunter;Zhuo, Lang
    • Molecules and Cells
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    • v.25 no.3
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    • pp.376-384
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    • 2008
  • The glial fibrillary acidic protein (GFAP) is traditionally used as a marker for astrocytes of the brain, and more recently for the hepatic stellate cells (HSCs) of the liver. Several GFAP splice variants have been previously reported in the astrocytes of the CNS and in the non-myelinating Schwann cells of the PNS. In this study, we investigate whether GFAP splice variants are present in the HSCs and their expression as a function of HSCs activation. Furthermore, the regulation of these transcripts upon treatment with interferon gamma ($IFN-{\gamma}$) will be explored. Using semi-quan-titative RT-PCR and real-time PCR, we examine the expression and regulation of GFAP splice variants in HSCs as well as their respective half-life. We discover that most of the GFAP splice variants ($GFAP{\alpha}$, ${\beta}$, ${\delta}$, ${\varepsilon}$ and $\kappa$) found in the neural system are also expressed in quiescent and culture-activated primary HSCs. Interestingly, $GFAP{\alpha}$ is the predominant form in quiescent and culture-activated primary HSCs, while $GFAP{\beta}$, predominates in the SV40-immortalized activated HSC-T6. $GFAP{\delta}$, ${\varepsilon}$ and ${\kappa}$ have similar half-lives of 10 hours, while $GFAP{\beta}$ has a half-life of 17 hours. Treatment of HSC-T6 with $IFN-{\gamma}$ results in a significant 1.29-fold up-regulation of $GFAP{\alpha}$ whereas the level of the other transcripts remains unchanged. In summary, $GFAP{\alpha}$, ${\beta}$, ${\delta}$, ${\varepsilon}$ and $\kappa$ are present in HSCs. They are differentially regulated on the transcription level, implying a role of the 5' and 3' untranslated regions.

A Study on the Actual State of High School Girls' Clothing in Everyday Life -Especially on Spring and Summer Wear- (여자 중.고등학생의 의복생활 실태에 관한 조사연구 -봄.여름 의복을 중심으로-)

  • 남상우
    • Journal of the Korean Home Economics Association
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    • v.26 no.2
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    • pp.39-47
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    • 1988
  • The aim of this study is to grasp the actual state of high school girls' clothing after liberalization of their uniform and to provide the reasonable guidance materials in clothing for both schools and homes. These are the results of the study 1. In the aspect of the favor of clothing and the interest in about clothes. a. They were fond of wearing "T" shirts, blue jeans in summer and pants and jackets in spring as their school wear. That implies that they enjoy wearing active and practical clothes. b. In the aspect of color, majority of them favored blue or similar colors, Also they had the tendency to love soft, simple clothe and more students preferred cloth without pattern. c. In their choice of them, they seldom paid attention to the informative-label are not their chief interest. d. More than half of girls prepare one or two suits in advance in a season, and they would prepare them deliberately This implies that their everyday life inclothing is based on the economic motive. 2. In the aspect of the purchasing clothes, a. Most of the girls bought them at the market and some of them at the direct-sales stall. b. when they purchased clothes, most girls were accompanied by their/mother and senior girls more often by their friends. c. The price and kinds of their favorite clothes such as "T" shirts and blouse was 5,000 won or so, and skirts, pants, one-piece and jackets are from the range of 5,000 won to below 10,000 won mostly. d. In regard to so-called brand-name items by popular designers, half of the girls responded that they wear some of such kinds of items because of superiority of sewing and longterm wearing, and the other half tend not to wear them due to high price.

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Pharmacokinetics of Acebutolol and Diacetolol After Oral Administration of Acebutolol in Rabbits with Folate-Induced Renal Failure (신장장애 가토에서 경구투여시 아세부토롤과 활성대사체인 디아세토롤의 약물동태)

  • Choi, Jun-Shik;Lee, Jin-Hwan
    • Journal of Pharmaceutical Investigation
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    • v.31 no.3
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    • pp.161-165
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    • 2001
  • Acebutolol (ABT) is almost absorbed after oral administration, but its bioavailability is reduced because of considerable first-pass metabolism in the gastrointestine and liver. The purpose of this study was to report the pharmacokinetic changes of ABT and its metabolite, diacetolol (DAT) after oral administration of acebutolol to control rabbits and rabbits with mild and severe folate-induced renal failure (FIRRs). Both of the area under the plasma concentration-time curve $(AUC^0_{\infty})$ of ABT and DAT were significantly increased in mild (p<0.05) and severe FIRRs (p<0.01), but the $AUC^0_{\infty}$ of DAT was more influenced than that of ABT in severe rabbits. There was a good correlation between serum creatinine and both of $AUC^0_{\infty}$ of ABT and DAT. The elimination half-life of ABT and DAT was significantly prolonged in mild (p<0.05) and severe (p<0.01) FIRRs, but the half-life of DAT was more influenced than that of ABT in severe FIRRs. The results suggest that the dosage of acebutolol should be adjusted according to the degree of renal disorder on the base of the serum creatinine concentration.

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A Study of Gamma-ray Distribution around the $^{99}Mo-^{99m}TcO_4$ Generator ($^{99}Mo-^{99m}TcO_4$ Generator의 감마선량 분포에 관한 연구)

  • Park, Soung-Ock
    • Journal of radiological science and technology
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    • v.24 no.1
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    • pp.49-53
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    • 2001
  • A number of radionuclides of interest in nuclear medicine are short lived isotopes that emit only gamma ray. The most of all Dept. of Nuclear Medicine in the hospt. are using the $^{99}Mo-^{99m}Tc$ generator for elution of the short lived isotope $^{99m}TcO_4$. A $^{99}Mo-^{99m}Tc$ generator consists of an alumina column on which $^{99}Mo$ is bound. The parent isotope($^{99}Mo$ : half life 67 hr.) decays to its daughter $^{99m}TcO_4^-$ which is a different element with a shorter half-life. $^{99}Mo$ emitted 41-keV(1.3%), 141-keV(5.6%) 181-keV(6.6%) and 366-keV(1.5%) gamma rays. But $^{99m}TcO_4$ emitted only 140-keV gamma ray. We study about the gamma ray distribution around the $^{99}Mo$ generator. And obtained the result as follows ; 1. Total counted gamma ray from generator smaller in front side than back. 2. The gamma ray emitted from $^{99}Mo$ generator without $^{99m}TcO_4$ vial increased in the back side(Mo column posited side) 3. The gamma ray only from the $^{99m}TcO_4$ vial increased in the front side. 4. Apron can protect gamma ray above 60% of total radiation from the $^{99}Mo$ generator.

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Individualization of Heparin and Protamine Dosage using a Dose-response Curve during Extracorporeal Circulation (체외순환중 용량반응곡선을 이용한 헤파린과 프로타민 투여량의 결정)

  • Won, Yong-Sun;No, Jun-Ryang
    • Journal of Chest Surgery
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    • v.24 no.3
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    • pp.253-260
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    • 1991
  • The adequacy of anticoagulation with heparin during cardiopulmonary bypass, and precise neutralization with protamine at the conclusion of cardiopulmonary bypass, were important. In sixty children undergoing cardiopulmonary bypass, ACT and heparin dose-response curve were studied. Total dose of heparin before bypass were 2.80$\pm$0.74 mg/kg and the amount of protamine administered after bypass were 3.0$\pm$1.23 mg/kg. So protamine: heparin ratio was 1.07: l.c After administration of protamine which dose is calculated with heparin dose-response curve, ACTs were returned to normal range[mean 114.8 $\pm$13 second]. The heparin sensitivity and its half-life do not have relationship with age, weight, height, surface area and urine amount during operation. And there are too much individual variations in heparin sensitivity and its half-life. So conventional heparin protocols can overestimate or underestimate the amount of heparin and protamine. Heparin dose-response curve makes it possible to maintain anticoagulation in a safe range during bypass with adequate amount of heparin individually. At the conclusion of bypass, this curve can be used to predict the precise amount of protamine amount of protamine needed for neutralization of the heparin. But heparin dose-response curve to be used clinically, further studies will be needed about relationship between ACT and heparin level in the high range, influence of hemodilution and hypothermia to ACT and discrepancy between true adequate amount of protamine and calculated amount by heparin dose-response curve.

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Effect of Particle Size on the Physicochemical and Nutritional Properties of Egg Yolk Porridge (입자 크기에 따른 난황죽의 이화학적 및 영양학적 특성)

  • Kim, Hye-Ran;Kim, Mee-Ree
    • Journal of the East Asian Society of Dietary Life
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    • v.20 no.1
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    • pp.77-83
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    • 2010
  • The study was conducted to investigate the effect of particle size on the physicochemical properties of egg yolk-rice porridge. The pH of egg yolk-rice porridge was decreased when compared to that of the control, while the lightness and yellowness was increased as the rice particle size increased. The viscosity of whole particle egg yolk porridge was highest among the three porridges at $40^{\circ}C$. The protein content of the egg yolk-rice porridge was increased three-fold, when compared to that of the rice porridges. The total amino acid content of egg yolk-rice porridge was 1,500.6 mg/100 g, while that of rice was 1,147.5 mg/100 g. The Lys and Thr content of the amino acid content of egg yolk-rice porridge were also increased. Sensory evaluation results revealed that the half particle size rice egg yolk-rice porridge had the highest scores in color, taste and over-all preference. Based on these results, the half particle size egg yolk-porridge had good quality with respect to both the physicochemical and nutritional properties.

High operating temperature stable OLEDs with reduced reflectivity cathodes

  • Popovic, Zoran D.;Aziz, Hany;Vamvounis, George;Hu, Nan-Xing;Paine, Tony
    • 한국정보디스플레이학회:학술대회논문집
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    • 2003.07a
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    • pp.21-24
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    • 2003
  • The understanding of the mechanism of device degradation has been accomplished recently, for devices using $AlQ_3$ electron transport and emitter molecule. In this presentation the experimental evidence for the degradation mechanism of $AlQ_3$ based devices will be reviewed, showing that the hypothesis of an unstable $AlQ_3^+$ cation explains a large amount of experimental data. This hypothesis, however, explains not only the room temperature device degradation in time but also sheds light on temperature stability of OLEDs. Dependence of half-life of a series of devices with an emitter layer composed of a mixture of $AlQ_3$ and different hole transport molecules (mixed emitter layer) will be discussed when they are operated at elevated temperatures. These results can also be explained in the framework of an unstable $AlQ_3^+$ species. An OLED structure containing a doped mixed emitter layer will be described, which shows extraordinary stability, half-life of 1200 hours at operating temperature of 70 C and initial luminance of 1650 $cd/m^2$. We will also discuss a novel Black $Cathode^{TM}$ OLED with reduced optical reflectivity, which is also stable at elevated temperatures. The new cathode utilizes a conductive light-absorbing layer made of a mixture of metals and organic materials.

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