• Journal of Yeungnam Medical Science
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• 제38권2호
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• pp.160-164
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• 2021

Oculocutaneous albinism (OCA) is a group of rare genetically heterogeneous disorders, characterized by hypopigmentation of the eyes, skin, and hair, which result in ocular abnormalities and a risk of developing skin cancer. Currently, there is no ophthalmologic procedure or drug that prevents the clinical features of OCA. Here, we report a new type of OCA in two, unrelated Korean families with the same OCA2 mutation. Affected individuals in this study are different from those of previous reports in two aspects: an inheritance pattern and clinical presentation. All reported patients with OCA have shown an autosomal recessive inheritance pattern, while our patients showed an autosomal dominant inheritance pattern. Small amounts of pigment can be acquired with age in OCA, but there is no substantial variation from adolescence to adulthood in this regard. A case where the patient attained normal pigmentation levels has never been reported. However, our patients displayed completely normal pigmentation in their late twenties. Whole exome sequencing and in-silico analysis revealed a novel mutation, OCA2 c.2338G>A p.(G780S) (NM_000275) with a high likelihood of pathogenicity. Sanger sequencing of p.G780S identified the same mutation in the affected individuals, which was not found in the family members with normal phenotype. We hypothesize that OCA2 G780S not only acts as a pathogenic variant of OCA but also induces pigmentation by enhancing the melanogenesis gene expression of other modifier genes, such as SLC45A2 and TPC2. These findings may provide further understanding of melanin biosynthesis and new treatment methods for OCA.

• 산업융합연구
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• 제19권5호
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• pp.151-157
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• 2021

빠르게 변모하는 산업화와 외모 지상주의의 사회적 흐름에 따라 메이크업은 헤어미용, 피부미용, 네일미용과 함께 성공적 사회생활과 원만한 인간관계를 형성하기 위한 중요수단으로 작용하고 있다. 이에 개인이 선호하는 메이크업 컬러를 다각도로 조사하여 미용산업의 매출 증대를 도모할 현실적 필요성이 대두되고 있다. 이에 광주광역시와 전라남도 거주하는 10대부터 40대 이상의 여성을 대상으로 외모관리 추구에 따른 메이크업 관심도와 컬러 선호도에 관하여 분석하였다. 연구 결과 서비스직, 학생, 10대 이하에서 평소에 메이크업을 많이 하는 것으로 나타났으며 '갈색계열'(70.2%)의 아이 쉐도우 컬러와 '붉은 계열'의 치크 컬러(76.8%) 및 립 컬러(62.5%)를 가장 많이 사용하는 것으로 나타났다. 본 연구를 통해 뷰티숍의 매출 증대 도모는 물론 향후 메이크업 제품 개발을 위한 기초 자료 및 메이크업 미용인의 컬러 선택을 위한 응용자료로도 활용되리라 사료한다.

• Biomolecules & Therapeutics
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• 제31권1호
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• pp.116-126
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• 2023

Mainly due to the slanted focus on the mechanism and regulation of neuronal aging, research on astrocyte aging and its modulation during brain aging is scarce. In this study, we established aged astrocyte culture model by long-term culturing. Cellular senescence was confirmed through SA-β-gal staining as well as through the examination of morphological, molecular, and functional markers. RNA sequencing and functional analysis of astrocytes were performed to further investigate the detailed characteristics of the aged astrocyte model. Along with aged phenotypes, decreased astrocytic proliferation, migration, mitochondrial energetic function and support for neuronal survival and differentiation has been observed in aged astrocytes. In addition, increased expression of cytokines and chemokine-related factors including plasminogen activator inhibitor -1 (PAI-1) was observed in aged astrocytes. Using the RNA sequencing results, we searched potential drugs that can normalize the dysregulated gene expression pattern observed in long-term cultured aged astrocytes. Among several candidates, minoxidil, a pyrimidine-derived anti-hypertensive and anti-pattern hair loss drug, normalized the increased number of SA-β-gal positive cells and nuclear size in aged astrocytes. In addition, minoxidil restored up-regulated activity of PAI-1 and increased mitochondrial superoxide production in aged astrocytes. We concluded that long term culture of astrocytes can be used as a reliable model for the study of astrocyte senescence and minoxidil can be a plausible candidate for the regulation of brain aging.

• Journal of Preventive Medicine and Public Health
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• 제57권2호
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• pp.128-137
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• 2024

Objectives: This study was conducted to characterize the symptoms, mental health, quality of life (QoL), and associated factors following the coronavirus disease 2019 (COVID-19) infection. Methods: This cross-sectional study included 394 participants previously infected with COVID-19 in Ho Chi Minh City, Vietnam. Mental health was assessed using the 21-item Depression, Anxiety, and Stress Scale (DASS-21). Participants self-reported health-related QoL was measured with the EuroQol 5-Dimension 5-Level (EQ-5D-5L) scale. Results: Among the participants, 76.4% reported experiencing at least one symptom following COVID-19 infection. The most common symptoms were fatigue (42.1%), cognitive dysfunction (42.9%), and hair loss (27.9%). According to the DASS-21 results, the proportions of depression, anxiety, and stress were 28.7%, 26.4%, and 20.6%, respectively. The mean scores on the EQ-5D-5L and the EuroQol Visual Analog Scale were 0.94±0.11 and 84.20±13.11, respectively. Regarding QoL issues, the highest proportion of participants (32.7%) reported experiencing anxiety or depression, followed by pain or discomfort (25.4%). Multivariable logistic regression analysis revealed that factors associated with the presence of symptoms following COVID-19 infection included female (odds ratio [OR], 2.84; 95% confidence interval [CI], 1.65 to 4.91) and having QoL issues (OR, 3.25; 95% CI, 1.71 to 6.19). Conclusions: The study investigated the prevalence rates of various symptoms following COVID-19 infection. These findings underscore the need to prioritize comprehensive care for individuals recovering from COVID-19 and to implement strategies to mitigate the long-term impact of the disease on mental health and QoL.

• ALGAE
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• 제39권2호
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• pp.97-108
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• 2024

The Ralfsiaceae family, part of the Ralfsiales order and consisting of crustose brown algae, includes five genera: Analipus, Endoplura, Fissipedicella, Heteroralfsia, and Ralfsia. In this study, a novel crustose genus named Ramipedicella gen. nov. is introduced within the Ralfsiaceae based on molecular and morphological analyses. Phylogenetic analyses using both concatenated dataset (rbcL + COI-5P genes) and rbcL indicate that the crustose brown algae that we collected from Korea and Russia form a unique grouping within the Ralfsiaceae. This grouping is strongly supported by both bootstrap analysis and Bayesian posterior probabilities. The genetic differences in the rbcL and COI-5P sequences between Ramipedicella and other genera within Ralfsiaceae range from 6.7 to 9.3% for rbcL and from 15.5 to 20.8% for COI-5P. Ramipedicella is characterized by crustose thalli having new crusts growing on top of old ones with a hypothallial basal layer and erect perithallial filaments, long cells with width-to-length ratio of 1 : 1-16, single chloroplast per cell, plurangia with one to several sterile cells, one to several unangia produced from unicellular stalks or from the lateral-basal region to the paraphyses, and unangia arising sequencially in irregularly branched specialized filaments. Ramipedicella, the recently identified genus, comprises two distinct species. Ramipedicella miniloba, the type species, is distinguished by crusts with small lobes, numerous hair tufts, plurangia terminated by 1-4 sterile cells, and large oblong unangia. Ramipedicella longicellularis is identified by generally smooth crusts, absence of phaeophycean hairs, plurangia terminated by 1-2 apical sterile cells, and smaller mostly oblanceolate unangia.

• BMB Reports
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• 제57권5호
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• pp.256-261
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• 2024

In the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of immunosenescence, given the complexity of aging as a physiological process in living organisms. Our investigation focuses on Cisd2, a causative gene for Wolfram syndrome, to elucidate on immunosenescence. Cisd2 knockout (KO) mice, serving as a model for premature aging, exhibit a shortened lifespan with early onset of aging-related features, such as decreased bone density, hair loss, depigmentation, and optic nerve degeneration. Intriguingly, we found that the Cisd2 KO mice present a higher number of neutrophils in the blood; however, isolated neutrophils from these mice display functional defects. Through mass spectrometry analysis, we identified an interaction between Cisd2 and Calnexin, a protein known for its role in protein quality control. Beyond this function, Calnexin also regulates calcium homeostasis through interaction with sarcoendoplasmic reticulum calcium transport ATPase (SERCA). Our study proposes that Cisd2 modulates calcium homeostasis via its interaction with Calnexin and SERCA, consequently influencing neutrophil functions.

• Journal of Preventive Medicine and Public Health
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• 제26권4호
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• pp.628-649
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• 1993

국민학생들의 학습부진에 관련된 요인을 조사하여 의학적 예방 및 치료 대책을 고안해 보기 위해, 대구 시내에서 고소득층 밀집지역과 저소득층 밀집지역의 국민학교 1개씩을 선정하고, 각 학교의 2, 4, 6학년 학생 중 학업 성적이 하위 10%에 속하는 학생(학습부진군) 175명과 이에 대한 대조군으로 성적이 상위 5%에 속하는 학생(우수군) 97명을 대상으로 하여 이들에게 시력검사, 청력검사, 신체검사(체중, 신장, 두위)를 한 후, 고대 Stanford-Binet test를 이용한 지능검사와 TAI-K로 시험불안반응검사를 하고 발달소아학 전문의사가 신경학적 검진을 하였다. 아동의 어머니에게는 가정 환경, 어머니의 출산력, 아동의 출생 전후 및 과거력에서 의학적 특이사항, 그리고 행동양상에 관해 설문조사하고, 담임 선생에게 설문지를 통해 학교에서의 행동양상을 조사하였다. 아동의 두발을 적당량 채취하여 두발중 납, 카드뮴, 아연의 함량을 원자흡광분광광도계로 분석하였다. 학습부진과 각 요인과의 단순상관 관계분석에서 통계적으로 유의한 요인들을 이용한 다중지수형 회귀분석 (multiple logistic regression analysis)을 하여 학습부진의 관련요인을 찾았다. 단순분석에서 학습부진과 유의한 관련성이 있는 것은 남아인 경우, 출산순위가 높은 경우, 결손가정인 경우, 부모의 학력이 낮거나 직업이 노동직인 경우, 아동의 체중, 신장 및 두위가 작은 경우, 시력장애가 있는 경우, 지능지수가 낮은 경우, 시험불안반응점수가 높은 경우, 과잉활동성 아동인 경우로 나타났다. 다중지수형 회귀분석결과 학습부진과 관련되는 요인은 아동의 높은 출산순위 (odds ratio=2.06), 남아인 경우(odds ratio=5.91), 결손가정(odds ratio=9.29), 신장이 표준치-1 표준편차보다 작은 경우(odds ratio=11.12), 높은 시험불안점수(odds ratio=1.07), 과잉활동성 장애아동(odds ratio=9.67), 그리고 지능지수(odds ratio=0.85)였다. 두발중 중금속 함량의 분석결과 모두 학습부진과 뚜렷한 관련성이 없었으며, 납과 카드뮴의 함량은 학습부진군과 우수군 모두 남아가 여아에 비해 높았으며, 남은 학년과 역상관 관계(p<0.05)를, 아연은 정상관 관계(p<0.05)를 나타내었다. 학습부진과 유의한 관련성이 있는 요인들 중 조정가능한 것은 출산순위, 신장, 과잉활동성 장애 등으로, 가족계획을 통해 알맞은 수의 자녀를 갖도록 하고, 영유아기에서부터 사춘기에 이르기까지 적절한 영양공급을 하며, 과잉활동성 아동을 조기에 발견하여 의사의 진단을 받아 치료를 받도록 하는 것이 학습부진을 예방 및 해결하는데 도움이 될 것이다. 또한 부모와 담임 선생이 학습부진아에게 본인의 지적능력 이상의 기대나 학습의 강요로 불안을 조장하지 않도록 해야 할 것이다.

• 산업융합연구
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• 제18권4호
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• pp.111-123
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• 2020

본 연구는 현재 유행하고 있는 투블럭 커트 스타일의 정확한 이해와 효율성을 높이기 위해 투블럭 커트 스타일의 이용실태와 선호도를 분석하였다. 2019년 6월 27일부터 7월 6일까지 전남 일부지역의 20~40대 남성 441명을 대상으로 설문조사하여 430부를 본 연구에 사용하였다. SPSS 21.0 프로그램을 통해 전산 처리하여 빈도분석과 교차분석을 실시하였고, 그 결과는 다음과 같다. 헤어커트 결정요인으로 20~40대의 58.4%가 자신의 판단으로 헤어 커트를 결정하는 것으로 나타났다. 투블럭 커트 스타일은 61.2%가 관심이 있고, 54.7%가 투블럭 커트 스타일에 대한 경험이 있으며, 경험자 중 92.3%가 만족한다고 하였다. 그 이유는 59.4%가 원하는 스타일과 일치하기 때문이며, 무경험의 경우는 27.7%가 나랑 어울리지 않는 것 같아서라고 하였다. 이상의 결과를 통해 알 수 있는 것은 사회적 환경의 요구에 의해 남성들의 외모관리는 필요한 요건이 되었으며, 타인의 권유보다는 자신의 의지에 의해 헤어스타일을 생각하고 미용실을 방문하였다. 투블럭 커트 스타일은 많은 고객들이 자신에게 어울릴 것 같아서 선호하였고, 깔끔한 이미지 표현을 위한 헤어 스타일로 손질이 편리한 투블럭 커트 스타일을 하고 있다. 이에 본 연구는 앞으로도 꾸준히 선호할 것으로 전망되는 투블럭 커트 스타일의 매출증대 효과 및 학문적 기초자료를 제시하는데 기여하고자 하였으며, 향후 여성들에게도 새로운 여성 투블럭 커트 스타일을 적용하여 심도 깊은 후속연구를 제안하고자 한다.

• International Journal of Costume and Fashion
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• 제11권1호
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• pp.63-83
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• 2011

This study aims to prove the changes, development and social background of Korean male cosmetics over the period of 2000-2010. There were total 574 articles written about male make-up and cosmetics in Chosun Daily, Joongang Daily and Donga Daily, which are the top three Korean local daily newspapers in terms of sales revenue for that period. These articles were analyzed together with social background research from various books and daily newspapers. The analysis of articles was divided into different categories; such as foundation cosmetics, color cosmetics, hair, and the social background. It was found that the articles related to foundation cosmetics were written the most, the articles related to male appearance management were second, articles on other items including how to manage the skin being the least. As for the social background of Korean male cosmetics, first of all, a change in social recognition can be pointed out. The traditional understanding of gender roles has changed, men's appearance management has started to be regarded as a competitive talent, and at the same time, the esthetic viewpoint for men also has changed. One example is the newly made popular term, "flower-handsome man", which shows the new trend of favoring males with nice skin. Second, the expansion of mass culture can be pointed out. As consumers can get information and fashion trends easier and faster, the fashion spreads fast, and this has led to the generalization and popularization of the sense of beauty. Third, the development of scientific technology and medical science can be pointed out. Thanks to the progress in those areas. the extension of youthfulness has become possible and the cosmetics industry was also affected greatly, as shown in the market spread of functional products for anti-ageing and wrinkle control as the interest in anti-ageing has grown. There are benefits from the development of scientific technology, but the problem of environmental pollution has appeared due to machinery and industrialization and thus the issue of well-being has been raised. Rising interest in naturalism, pro-environmentalism and organic cosmetics has influenced the cosmetics industry. In addition, the quantity of ultraviolet rays exposed to our skin has increased due to the air pollution caused by the destruction of environment, leading to increased usage of sun block lotion. Lastly, the influence of consumer society and the expansion of consumerism culture can be pointed out. In the modern society, consumption acts not only as the use of products and services but it also has an important role of mediating individuals with others and the society. The market for male cosmetics has been expanding and the number of men putting on make-up has been increasing rapidly. Therefore, this study is meaningful in that the analysis of the mode of change and the social background are an essential process in order to provide a direction for the future market for male cosmetics.

• 한국산학기술학회논문지
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• 제14권11호
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• pp.5737-5744
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• 2013

이 연구는 14세의 여중학생의 초경 경험과 정신건강과의 연관성을 파악하고자 수행되었다. 연구 대상으로 제 8차 (2012년) 청소년건강행태 온라인 조사에 참여한 여중생 1학년 5,991명을 선별하였다. 데이터는 spss프로그램을 사용하여 빈도분석, t-test, chi-square, 로지스틱 회귀분석을 통하여 분석하였다. 대상자중 4,473명의 초경경험 여학생군(여학생의 평균 초경연령은 12.8세)과 1,518명의 비 초경경험 여학생군을 확인하였다. 초경경험과 정신건강의 로지스틱 분석결과, 지각 스트레스(OR=1.39, 1.20-1.62, p<0.001), 인지 우울증(OR=1.25, 1.10-1.42, p<0.05), 자살 생각(6OR=1.60, 1.38-1.87, <0.001), 자살 계획(OR=1.66, 1.33-2.81, p<0.001)과 자살 시도 (OR=1.42, 1.09-1.86, p<0.05)에 대한 위험 비 (OR)[95% confidence interval (CI)]는 초경 경험군에서 초경 비 경험군보다 높았다, 이러한 결과는 초경의 경험이 여중생의 정신건강에 연관성이 있음을 보여주고 있으며, 초경의 경험이 여자 청소년의 정신건강에 영향을 주는 중요한 요인이었음을 시사한다.