• Asian-Australasian Journal of Animal Sciences
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• v.22 no.10
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• pp.1391-1399
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• 2009

Two hundred and sixteen 68-week-old Hy-Line brown laying hens were used in a 6-week feeding trial to compare the efficacy of phytases Optiphos (OPT) and Natuphos (NAT), which were isolated from Escherichia coli and Aspergillus niger, respectively. Hens were randomly allotted into six treatments with six replications (six layers in three adjacent cages) per treatment according to their initial BW. The hens were then subjected to one of the following dietary treatments: i) Positive Control (PC; available phosphorus (AP) 0.4%); ii) Negative control (NC; AP 0.2%); iii) NAT1 (NC+250 FTU/kg NAT); iv) NAT2 (NC+500 FTU/kg NAT); v) OPT1 (NC+250 FTU/kg OPT); vi) OPT2 (NC+500 FTU/kg OPT). Feed intake, egg production, egg quality, apparent nutrient digestibility and serum P and Ca concentration were evaluated to compare the effect of the two phytases. Feed intake and eggshell thickness were not affected by the treatments. Superior effects (p<0.05) of OPT were only observed in egg production and egg weight compared with NAT. Characteristics such as eggshell breaking strength, apparent digestibility of N, Ca and P and serum P concentration were equally increased with the supplementation of both phytases (p<0.05), where no significant difference was observed in those characteristics between PC and phytase supplementation at 500 FTU/kg. Equally effective improvements (p<0.05) were also observed in egg production and DM digestibility, where no improvements were observed (p<0.05) between the PC group and the groups with phytase supplementation at 500 FTU/kg. Equal increases in the serum Ca level were observed when the groups with phytase supplementation were compared to the PC group. Overall, the results of this study suggest that NAT and OPT are equally effective at liberating phytate-bound complexes when included in 0.2% available phosphorus diets for 68-week laying hens; either source of phytase can be fed to commercial 68-week laying hens at 500 FTU/kg to correct the negative effects associated with a 0.2% available phosphorus diet. In conclusion, either source of phytase can be fed to commercial first cycle laying hens at 500 FTU/kg to effectively replace inorganic phosphorus when economically justified.

• Korean Journal of Materials Research
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• v.7 no.2
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• pp.129-135
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• 1997

This study has investigated the effects of aging treatment on thc nlechanical propcrries of blg-iiAl-x%nix - 0.1.2) alloys fabricated by the squeeze castmg process. The microstructurcs of as-squeeze cast were composed of pro eurectic $\alpha$ magnesium solid solution, super saturated $\alpha$ solid solution and $\beta(Mg_{17}AI_{12}$) compund. Agcd at both $200^{\circ}C$ and $240^{\circ}C$, Mg--6AixZn alloys showed the peak hardness due to the formation of $\beta(Mg_{17}AI_{12}$) precipitates. The tiiscontinuous precipitates of the lamella r\.pe are predominant at $200^{\circ}C$ aging tredrment. tvhilc. the finely dispersed continu ous precipitates were major type at $240^{\circ}C$ treatment. Mg-- GAI-xZn a1loi.s fabricated hy the squeeze casting process had the hetter combination of tensile strength and elongation compared to the conventionally cast alloys. As increascci zinc: contents. the tensile strength was increased 11y the soiid solutirin strengthening effect of zinc,.

• Korean Journal of Materials Research
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• v.7 no.2
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• pp.102-106
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• 1997

Micro gas sensors including thin film catal) tic type require stress-free memhrancs for etch stop of Si anisotropic etching and sublayer of sensing elements hecause stress is one of the main factors affecting breakdown of thin membranes. This paper reports the effects of deposition conditions on stress and refractive index of $SiN_{x}/SiO_{x}/(NON)$ films deposited by low pressure c11ernic;rl vapor deposition(L, t'CVI)) 2nd reactve sputtering. In the case of I.PCVI1, the stresses of $SiN_{x}$ and NON films arc $7.6{\times}10^{8}dyne/cm^2$ and $3.3{\times}10^{8}dyne/cm^2$, respectibely, and the refractive indices are 3.05 and 152, respectively. In the cxse oi the sputtered SiN, , compressi\e stress decreased in magnitude and then turned to tensility as increasing proc, ess pressure by lmtorr to 30mtorr and cicreasmg applied power density by $2.74W/cm^2$ to $1.10W/cm^2$. The hest value of film stress obt;~ined under condition of lOmtorr and $1.37W/cm^2$ in this' experiment was $1.2{\times}10^{9}dyne/cm^2$ cnnipressive. The refr~ict~ve index decreased from 2 05 to 1 89 as decreasing applied power density by lnitorr to 3Orntorr and increasing process pressure hy $2.74W/cm^2$ to $1.10W/cm^2$. Stresses of films deposited by both LPCVL) and sputtering decreased as incre;lsing temperature and showed plastic behavior as decreasing temperature.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1707-1714
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• 2012

Grb2 is an adapter protein involved in the signal transduction and cell communication. The Grb2 is responsible for initiation of kinase signaling by Ras activation which leads to the modification in transcription. Ligand based pharmacophore approach was applied to built the suitable pharmacophore model for Grb2. The best pharmacophore model was selected based on the statistical values and then validated by Fischer's randomization method and test set. Hypo1 was selected as a best pharmacophore model based on its statistical values like high cost difference (182.22), lowest RMSD (1.273), and total cost (80.68). It contains four chemical features, one hydrogen bond acceptor (HBA), two hydrophobic (HY), and one ring aromatic (RA). Fischer's randomization results also shows that Hypo1 have a 95% significant level. The correlation coefficient of test set was 0.97 which was close to the training set value (0.94). Thus Hypo1 was used for virtual screening to find the potent inhibitors from various chemical databases. The screened compounds were filtered by Lipinski's rule of five, ADMET and subjected to molecular docking studies. Totally, 11 compounds were selected as a best potent leads from docking studies based on the consensus scoring function and critical interactions with the amino acids in Grb2 active site.

• Journal of Korean Medical classics
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• v.6
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• pp.189-227
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• 1993

I have studied life of Yoon-Dong-Li(尹東里), who applied Un-Ki(運氣) theory to medicine during Suk-Jong(肅宗) to Joong-Jo(正祖) in Yi-Dynasty and also studied his existing writings named ${\ll}$Cho-Chang-kyeol${\gg}$ (草窓訣). The referenced original work prints were based on 1980's print of Chung-Ku oriental medical society and National Central Library and The academy a korean studies possessed print. Studied with these books, I have concluded as follows. 1. Yoon-Dong-Li(尹東里) courtesy name is Ja-Mi(子美), pen name is Cho-Chang(草窓). He was born in 1705, Suk-Jong(肅宗) 31yrs, and died in 1784, Jeong-Jo(正祖) 8yrs in Yi-Dynasty. He had lineage of third-generationed-doctor and learned medicine from his uncle, Yoon-Woo-Kyo(尹雨敎). His father Yoon-Yi-Kyo(尹이敎) gaved him second influence. 2. Confucianal physician in Ming Dynasty You-Bu(劉溥) respected Ju-Ryeom-Kye(周溓溪), confucianist in Song-Dynasty and You-Bu(劉溥) does not removed grass in front of window (because in chinese, Cho-Charig(草窓) means grass in front of window), and named himself Cho-Chang(草窓). Yoon-Dong-Li(尹東里) followed this suit so called himself Cho-Chang (草窓). 3. The main contents of ${\ll}$Cho-Chang-Kyeol${\gg}$ (草窓訣), (運氣衍論) was written in 1725, when Yoon-Dong-Li(尹東里) was 21yrs old and printed in 1736. The other part of ${\ll}$Cho-Chang-Kyeol${\gg}$ (草窓訣), (用藥篇) was written in 1746. These two parts were not written in the satre time. The (運氣衍論) was written llyears earlier than (用藥). Two parts were combined another day and named (草窓訣). 4. Existing ${\ll}$Cho-Chang-Kyeol${\gg}$ (草窓訣) is transcribed printing with the con tent of "Five elements motion and the six kind of natural factors theory" (五運六氣設). Each edition is generally similar in content, but also has different points each other so naw we hardly finds a complete set of works. 5. ${\ll}$Cho-Chang-Kyeol${\gg}$ (草窓訣) is a first technical book which treats of Un-Ki(運氣) theory in korea. 6. The contents of (運氣衍論) of ${\ll}$Cho-Chang-Kyeol${\gg}$ (草窓訣) is mechanism of diease according to excess and insuffciency of five elements motion and six kinds of nalural faclors.and symploms and priscriptions, includes variated priscriptions. 7. Two parts in (運氣衍論) of ${\ll}$Cho-Chang-Kyeol${\gg}$ (草窓訣), 'Sang-tong' (相通) and 'Kak-Tong' (各通), threats of mochanisim of the disease according to five elements. with the principle of inter-promoting and inter-acting, in the change of ten heavenly stems and five elements motion. 8. In the (用藥篇) of ${\ll}$Cho-Chang-Kyeol${\gg}$ (草窓訣) describes priscription for clinical application according to Un-Ki(運氣) and also records about misuse of medicine. 9. In the ${\ll}$Cho-Chang-Kyeol${\gg}$ (草窓訣), most of priscription are common using one, which also found in ${\ll}$Dong-$\breve{U}$i-Bo-Garm${\gg}$ (東醫寶鑑) and there are few of priscriptions hy Yoon-Dong-Li(尹東里).

• The Journal of Engineering Geology
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• v.3 no.2
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• pp.115-124
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• 1993

Hydrogeological survey related to groundwater condifiors was performed at the study area in Gyukpo, BuanGun, ChunlabukDo to express the relationships between groundwater conditions and the geologic structures such as joints, faults and beddings in bedrock About 200 joints and sjgnfficant faults were measured in this area. Typically, The fracture analysis on cores of 7 boreholes was tried to quantify fracture numerically. Groundwater level was periodically measured for three months. The packer tests of about 175 were carried out in 7 boreholes. As the result, Fractures are locaHy developed as ground water bearing zone and an average hydraulic conductivity of bedrock is $1{\times}10^{-5}cm/sec$ in this area the hydraulic conductivity of this area is correlated with fracture frequency value of F15 and is also well correlated with fracture developed and depth. In accordance with depth, fracture frequency and hydraulic conductivity are decreased. Hydraulic conductivity of granite along depth shows an obiouse change in values but that of sedimentary rocks do not shows changeless. Groundwater movement in the bedrocks of the study area affected not by joints but faults developed in the different rock boundary. In the northern part of this area, The differences of hydraulic conductivity between granite and sedimentary rocks give rise abrsspt at difference in groundwater leveL In the southern part of the study area, there is no different in groundwater level of both same rock types.

• Journal of the korean academy of Pediatric Dentistry
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• v.26 no.3
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• pp.528-537
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• 1999

The purpose of this study was to analyze and compare the bond strengths between stainless steel plate and zinc phosphate cement, polycarboxylate cement and glass ionomer cement, which are frequently used for cementation of stainless steel crowns. Three cementing materials were glued to the poles standing above stainless steel plate, bovine teeth, light cured glass ionomer restorative material and amalgam. And the tensile bond strengths between them were measured with universal testing machine and the results were statistically processed using ANOVA and Student t-test. The obtained results were as follows : 1. On stainless steel plate, glass ionomer cement and polycarboxylate cement showed higher tensile bond strengths compared to zinc phosphate cement, with no significant difference between the former two. 2. On the surface of bovine teeth and glass ionomer restorative material, glass ionomer cement showed highest bond strength, followed by polycarboxylate cement and zinc phosphate cement in order. 3. For amalgam restoration, polycarboxylate cement and glass ionomer cement showed higher tensile bond strengths than zinc phosphate cement, with no significant difference between the former two.

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.6
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• pp.927-931
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• 2010

The objective of this study was to evaluate the effect of defatted grape seed extract (DGSE) on adipocyte differentiation in 3T3-L1 preadipocytes. DGSE at 100 ${\mu}g$/mL significantly suppressed lipid accumulation and glycerol-3-phosphate dehydrogenase activity in hormonally stimulated adipocytes, an indicator of adipocyte differentiation. In order to understand the anti-adipogenic effects of DGSE, the changes in the expression of several adipogenic transcription factors including peroxisome proliferator-activated receptor (PPAR) $\gamma$, CCAAT/enhancer-binding protein (C/EBP) $\alpha$ and $\beta$ were investigated using immunoblotting. DGSE suppressed the expression of PPAR$\gamma$, C/EBP$\alpha$, and C/EBP$\beta$ proteins compared with control adipocytes in a dose-dependent manner. This results indicated that DGSE may alter fat mass by directly affecting adipogensis in maturing preadipocytes and thus may have applications for the treatment of obesity.

• Journal of Animal Science and Technology
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• v.50 no.6
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• pp.799-806
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• 2008

This experiment was carried out to investigate the effect of feeding limestone to high and low Ca layer diets on laying performance and eggshell quality in laying hens. Five hundred and twenty-eight HyLine brown layer allotted to six treatments consisting of high and low Ca diets. Limestone added to two kinds of basal diet with 1, 2 and 3 fold compared to conventional diet. Egg production was not different regardless Ca level and amount of added limestone in overall periods. However, the increment of egg observed in high Ca diet and added 10g limestone group during later period. Ca and limestone intake were increased as increasing feeding limestone. Eggshell strength and thickness were improved in high Ca consumption group. It was concluded that feeding Ca sources to conventional diets was helpful improving eggshell quality and reducing feed cost per egg mass by increasing proportion of Ca intake.

• The Korean Journal of Cytopathology
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• v.9 no.1
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• pp.37-44
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• 1998

OBJECTIVE: False negatives of cervical smears due to screening errors pose a significant and persistent problem. AutoPap 300 QC System, an automated screening device, is designed to rescreen conventionally prepared Pap smears initially screened by cytotechnologists as normal. Clinical experience and sensitivity of the AutoPap 300 QC System were assessed and compared with current 10% random qualify control technique. MATERIALS AND METHODS: In clinical practice, a total of 18,592 "within normal limits" or "benign cellular changes" cases classified by The Bethesda System were rescreened by the Autopap System. In study for sensitivity of The AutoPap System to detect false negatives, a total of 1,680 "within normal limits" or "benign cellular changes" cases were rescreened both manually and by the AutoPap System. The sensitivity of the AutoPap System to these false negatives was assessed at 10% review rate to compare 10% random manual rescreen. RESULTS: In clinical practice, 38 false negatives were identified by the AutoPap System and we had achieved 0.2% reduction in the false negative rate of screening error. In study for sensitivity, 37 false negatives were identified by manual rescreening, and 23 cases(62.2%) of the abnormal squamous cytology were detected by the AutoPap System at 10% review rate. CONCLUSONS: The AutoPap 300 QC System is a sensitive automated rescreening device that can detect potential false negatives prior to reporting and can reduce false negative rates in the laboratory. The device is confirmed to be about eight times superior to the 10% random rescreen in detecting false negatives.