• 한국임상수의학회지
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• 제34권1호
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• pp.1-6
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• 2017

Heartworm disease (HWD) in dogs is a life-threatening mosquito-borne disease resulting in right-sided congestive heart failure and inflammatory pulmonary disease. Due to complications from adulticidal therapy with melarsomine, slow kill protocol either with preventive dose of ivermectin or combined with doxycycline has been proposed for an alternative adultcidal therapy in dogs with HWD. Therefore, this study evaluated the clinical outcome of adultcidal therapy in dogs with class II stage of HWD after treating either American Heartworm Society (AHS) or slow kill protocol for 10 months. Clinical outcome after therapy was evaluated by clinical, radiographic and echocardiographic examination along with hematology before (D0) and after therapy (D300). Although clinical signs associated with HWD were all resolved after therapy in both groups, the infection was not cleared out 67% of dogs treated by slow kill protocol at the end of therapy. Furthermore, pulmonary arterial flow of acceleration time to ejection time ratio (AT/ET) and the right pulmonary artery distensibility index (RPADI) have been firstly used for detecting pulmonary hypertension in this study group. The pulmonary hypertension was more common in dogs with mild clinical signs, although tricuspid and pulmonary regurgitation were not detectable in most dogs in this study. Our study findings suggested that the slow kill protocol might not be efficacious enough to clear out HWD in dogs and more attention on the presence of pulmonary hypertension might be necessary for effective management of HWD in dogs.

• 대한수의사회지
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• 제38권10호
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• pp.886-891
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• 2002

• 대기
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• 제30권1호
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• pp.1-15
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• 2020

This study analyzed and compared development mechanisms leading to heat waves of 2016 and 2018 in Korea. The European Centre for Medium-Range Weather Forecasts Reanalysis Interim (ERA Interim) dataset and Automated Surface Observing System data are used for synoptic scale analysis. The synoptic conditions are investigated using geopotential height, temperature, equivalent potential temperature, thickness, potential vorticity, omega, outgoing longwave radiation, and blocking index, etc. Heat waves in South Korea occur in relation to Western North Pacific Subtropical High (WNPSH) pressure system which moves northwestward to East Asia during summer season. Especially in 2018, WNPSH intensified due to strong large-scale circulation associated with convective activities in the Philippine Sea, and moved farther north to Korea when compared to 2016. In addition, the Tibetan high near the tropopause settled over Northern China on top of WNPSH creating a very strong anticyclonic structure in the upper-level over the Korean Peninsula. Unlike 2018, WNPSH was weaker and centered over the East China Sea in 2016. Analysis of blocking indices show wide blocking phenomena over the North Pacific and the Eurasian continent during heat wave event in both years. The strong upper-level ridge which was positioned zonally near 60°N, made the WNPSH over the South Korea stagnant in both years. Analysis of heat wave intensity (HWI) and duration (HWD) show that HWI and HWD in 2018 was both strong leading to extreme high temperatures. In 2016 however, HWI was relatively weak compared to HWD. The longevity of HWD is attributed to atmosphere blocking in the surrounding Eurasian continent.

• 한국도로학회논문집
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• 제19권6호
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• pp.67-74
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• 2017

PURPOSES : In this study, a three-dimensional nonlinear finite element analysis (FEA) model for airport concrete pavement was developed using the commercial program ABAQUS. Users can select an analysis method and set the range of input parameters to reflect actual conditions such as environmental loading. METHODS : The geometrical shape of the FEA model was chosen by considering the concrete pavement located in the third-stage construction site of Incheon International Airport. Incompatible eight-node elements were used for the FEA model. Laboratory test results for the concrete specimens fabricated at the construction site were used as material properties of the concrete slab. The material properties of the cement-treated base suggested by the Federal Aviation Administration(FAA) manual were used as those of the lean concrete subbase. In addition, preceding studies and pavement evaluation reports of Incheon International Airport were referred for the material properties of asphalt base and subgrade. The kinetic friction coefficient between the concrete slab and asphalt base acquired from a preceding study was used for the friction coefficient between the layers. A nonlinear temperature gradient according to slab depth was used as an input parameter of environmental loading, and a quasistatic method was used to analyze traffic loading. The average load transfer efficiency obtained from an Heavy falling Weight Deflectomete(HWD) test was converted to a spring constant between adjacent slabs to be used as an input parameter. The reliability of the FEA model developed in this study was verified by comparing its analysis results to those of the FEAFAA model. RESULTS : A series of analyses were performed for environmental loading, traffic loading, and combined loading by using both the model developed in this study and the FEAFAA model under the same conditions. The stresses of the concrete slab obtained by both analysis models were almost the same. An HWD test was simulated and analyzed using the FEA model developed in this study. As a result, the actual deflections at the center, mid-edge, and corner of the slab caused by the HWD loading were similar to those obtained by the analysis. CONCLUSIONS : The FEA model developed in this study was judged to be utilized sufficiently in the prediction of behavior of airport concrete pavement.

• 한국수자원학회논문집
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• 제54권9호
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• pp.693-704
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• 2021

본 연구는 폭염과 하천수질과의 상관성을 평가하기 위한 것이다. 기상청 91개의 기상관측소의 일 최고기온 과 환경부 수질관측망 918개에 대한 13개의 하천수질인자(DO, BOD, COD, TOC, TN, DTN, NH4-N, NO2-N, NO3-N, TP, DTP, PO4-P, Chl-a)를 대상으로 분석하였다. 최고기온과 수질인자에 대한 상관성 분석을 수행하였으며, DO, Chl-a, T-N의 상관계수(R²)가 0.782, 0.609, 0.691로 가장 높은 상관성을 나타내었다. 폭염과 수질인자 간의 공간적 영향 분석을 위해, 일 최고기온을 이용하여 폭염강도(heat wave intensity, HWI)와 폭염지속시간(heat wave duration, HWD)를 산정하였다. 공간적 영향 평가는 핫스팟 분석과 공간통계분석을 실시하였다. 핫스팟 분석결과 폭염지수(HWD, HWI)는 낙동강 하류유역에 대해 높은 공간상관성을 나타내었으며 수질인자 중 Chl-a, TN이 동일한 결과를 나타내었다. 폭염에 따른 수질 영향 지역 공간 통계분석 결과 공간적인 변동성이 가장 뚜렷하게 나타나는 수질인자는 DO인 것으로 분석되었다.

• 한국도로학회논문집
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• 제16권3호
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• pp.9-20
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• 2014

PURPOSES : This study is to compare load transfer efficiency of key joint and dowel joint for airport concrete pavement. METHODS : As AC150/5320-6D of FAA's [Advisory Circular] was changed into AC150/5320-6E, Key joint type of rigid pavement were excluded from Construction Joints. LTE(Load Transfer Efficiency) of dowel joint and key joint were compared by times and seasons through pavement temperature measurement, ocular investigation and HWD measurement. RESULTS : For the joint performance grade of No. 2(The second) runway of airport, 12% of poor rate was observed in key joint and 2% of poor rate in dowel joint. Poor rate of key joint was increased to 17%, if only No. 3~No. 6 slabs, which are mostly loaded from the airplanes, were applied for the study. In apron area, LTE poor rate of key joint was high in winter, and LTE poor rate of dowel joint was at least above 'Fair' grade. In summer, 'Fair' for key joint, 'Acceptable' for dowel joint appeared. CONCLUSIONS : As results, dowel joint was superior than key joint for LTE. Deviations of seasons and times were smaller in dowel joint's result. And LTE in winter was lower than LTE in summer.

• 한국도로학회논문집
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• 제15권1호
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• pp.95-102
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• 2013

PURPOSES: The existing method evaluating the existence of the hollows in concrete pavement does not consider the stiffness of pavement. In addition, the method uses unreasonable logic judging the hollow existence by the deflection caused by zero loading. In this study, the deflection of slab corner due to heavy weight deflectometer (HWD) was measured in concrete pavement sections where underground structures are located causing the hollows around them. METHODS: The modulus of subgrade reaction obtained by comparing the actual deflection of slab to the result of finite element analysis was calibrated into the composite modulus of subgrade reaction. The radius of relative stiffness was calculated, and the relationship between the ratio of HWD load to the radius of relative stiffness and the slab deflection was expressed as the curve of secondary degree. RESULTS: The trends of the model coefficients showing width and maximum value of the curve of secondary degree were analyzed by categorizing the pavement sections into three groups : hollows exist, additional investigation is necessary, and hollows do not exist. CONCLUSIONS: The results analyzed by the method developed in this study was compared to the results analyzed by existing method. The model developed in this study will be verified by analyzing the data obtained in other sections with different pavement structure and materials.

• Journal of the Korean Wood Science and Technology
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• 제36권4호
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• pp.44-51
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• 2008

본 연구에서는 국산 소나무재 심재부와 변재부 목분 탄화물의 물리 화학적 성질에 미치는 탄화 온도의 영향을 원소 분석, 질소-흡착 실험, SEM을 이용하여 분석하였다. 탄화물의 표면 구조 및 특성은 탄화 온도에 크게 의존하였으며 그 의존성은 변재부(swd)와 심재부(hwd)에 관계없이 정성적으로 거의 비슷하였다. 그러나, 심변재부간 경도, 성분 및 조직학적 차이 등의 영향 때문에 hwd를 탄화한 경우가 swd를 탄화한 경우보다 비표면적은 크고, 평균 pore 지름은 작았다. 예비 탄화 단계에서 대부분의 분해 반응이 일어나므로, 탄화물의 주성분은 탄소였다. 탄화 온도가 $700^{\circ}C$가 될 때까지는 미미하나마 탄화 반응이 지속적으로 일어났으며, 비표면적은 지속적으로 증가하였다. $800^{\circ}C$ 이상에서는 pore filling 및 narrowing 효과에 의하여 비표면적은 감소하였고, 특히 $900^{\circ}C$ 이상에서는 공극의 안쪽에 뿌리를 둔 육각 기둥 형태의 새로운 탄소 구조체가 형성되었다. 탄화물의 흡착 등온선은 type I, 흡착 등온선에서 보인 이력 루프는 type H4로 분류되었다.

• 대기
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• 제29권5호
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• pp.671-687
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• 2019

This study evaluates the long-term seasonal predictability of summer (June, July and August) heatwaves over South Korea using 30-year (1989~2018) Hindcast data of the Pusan National University Coupled General Circulation Model (PNU CGCM)-Weather Research and Forecasting (WRF) chain. Heatwave indices such as Number of Heatwave days (HWD), Heatwave Intensity (HWI) and Heatwave Warning (HWW) are used to explore the long-term seasonal predictability of heatwaves. The prediction skills for HWD, HWI, and HWW are evaluated in terms of the Temporal Correlation Coefficient (TCC), Root Mean Square Error (RMSE) and Skill Scores such as Heidke Skill Score (HSS) and Hit Rate (HR). The spatial distributions of daily maximum temperature simulated by WRF are similar overall to those simulated by NCEP-R2 and PNU CGCM. The WRF tends to underestimate the daily maximum temperature than observation because the lateral boundary condition of WRF is PNU CGCM. According to TCC, RMSE and Skill Score, the predictability of daily maximum temperature is higher in the predictions that start from the February and April initial condition. However, the PNU CGCM-WRF chain tends to overestimate HWD, HWI and HWW compared to observations. The TCCs for heatwave indices range from 0.02 to 0.31. The RMSE, HR and HSS values are in the range of 7.73 to 8.73, 0.01 to 0.09 and 0.34 to 0.39, respectively. In general, the prediction skill of the PNU CGCM-WRF chain for heatwave indices is highest in the predictions that start from the February and April initial condition and is lower in the predictions that start from January and March. According to TCC, RMSE and Skill Score, the predictability is more influenced by lead time than by the effects of topography and/or terrain feature because both HSS and HR varies in different leads over the whole region of South Korea.

• 대한한방내과학회지
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• 제43권6호
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• pp.1089-1104
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• 2022

Objective: The aim of this study was to identify the efficacy and underlying mechanism of cloves as an osteoarthritis (OA) treatment in a monosodium iodoacetate (MIA)-induced rat OA model. Osteoarthritis (OA) is nowadays one of the most prevalent degenerative joint diseases. Methods: Sprague-Dawley rats treated with MIA (50 μL; 80 mg/mL) were used as in vivo OA models. Cloves (100 and 200 mg/kg b.w.) were administered orally once daily for 2 weeks from 7 days after MIA injection. Changes in hindpaw weight distribution (HWD) were measured as a joint discomfort index. Activation markers related to inflammatory responses and cartilage degeneration in the right knee joints were evaluated by serum analysis and western blotting. Results: HWD decreased in the MIA control group but showed a dose-dependent elevation after clove treatment. Clove treatment inhibited inflammatory factors by PI3K/Akt/NF-κB signaling pathways, while also activating antioxidant factors through Sirt1/AMPK signaling pathways. Clove treatment also suppressed matrix metalloproteinase (MMP) overexpression and significantly increased the levels of tissue inhibitors of metalloproteinases (TIMPs). Conclusions: Treatment with cloves effectively reversed MIA-induced effects. Therefore, clove treatment could have the potential to protect against or treat OA.