• Journal of Animal Reproduction and Biotechnology
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• v.38 no.1
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• pp.2-9
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• 2023

Mammalian eyes have a limited ability to regenerate once neurons degenerate. This results in visual impairment that impacts the quality of life among adult populations as well as in young children leading to lifelong consequences. Various therapies are in development to restore vision, and these include gene therapy, stem cell therapy, in-vivo transdifferentiation, and transplantation of a patient's whole eye obtained from interspecies blastocyst complementation. This review discusses advances in the research as well as hurdles that need to be resolved to have a successful restoration of vision.

• Korean Journal of Applied Biomechanics
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• v.21 no.5
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• pp.529-540
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• 2011

The purpose of this study was to evaluate the kinematic characteristics of $5^{th}$ and $6^{th}$ hurdle clearances during the final of the 110-m hurdles at the IAAF World Championships, Daegu 2011. To this end, the hurdling motions of the top 4 ranked male hurdlers in the competition were analyzed. A total of 12 cameras were used to record their motions, with a sampling frequency of 120 Hz. The cameras were calibrated using $11{\times}2{\times}1\;m$ control objects that covered all of the lanes (1st~8th lanes). After analyzing all the data, we arrived at the following results. In the take-off phase, all athletes revealed similar take-off times (CT), and similar distances from the take-off to hurdleto (L1) and hurdle to landing (L2). In particular, Turner, ranked $3^{rd}$, had an inconsistent L2 and may need further training to correct it. In the flight phase, Richardson, ranked $1^{st}$, showed the longest flight distance, whereas Xiang, who was ranked $2^{nd}$, showed the highest CG height from the hurdle. For the step patterns, to increase the pitch frequency, Richardson and Xiang used shorter 3-step lengths than Turner and Oliver.

• Korean Journal of Applied Biomechanics
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• v.17 no.4
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• pp.149-156
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• 2007

The purpose of this study was to compare the world class women's hurdlers with kinematic variables Lee Yeon-Kyoung's in the 100m hurdle. Among korea elite female hurdler, Lee Yeon-Kyoung was participated as a subject. Eight JVC video cameras(GR-HD1KR) were used to film the performance of Lee Yeon-Kyoung at a frame rate of 60fields/s. The real-life three-dimensional coordinate data of digitized body landmarks were smoothed using a fourth order Butterworth low pass recursive digital filter with an estimated optimum cutoff frequency of 7.4Hz. After analyzing and comparing Lee Yeon Kyung's kinematic variables with the world top class hurdlers in the woman's 100m hurdle run, the following conclusions were obtained. 1. Lee should be able to increase the speed with over 5.4m/s from start to first hurdle and then maintain the speed range from 8.33m/s to 8.67m/s until 10th hurdle. Lee should have to maintain the speed with 8.51m/s from 10th hurdle to finish line. 2. Lee has to reach her maximum running speed at 5th hurdle and then has to shorten running time with 0.5sec between hurdles. 3. Lee should be able to run around 2.5sec from start to frist hurdle and then maintain under 1.00sec following phases. Lee should be able to maintain under 1.10sec from 10th hurdle to finish line. 4. Lee needs to control a consistent takeoff and landing distance pattern, Lee needs to lower the height of the center of gravity of the body with 0.33m when she clears the hurdles.

• International conference on construction engineering and project management
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• 2020.12a
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• pp.63-74
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• 2020

The assembly of modular construction requires a series of thoroughly-considered decisions for crane lifting including the crane model selection, crane location planning, and lift path planning. Traditionally, this decision-making process is empirical and time-consuming, requiring significant human inputs. Recently, research efforts have been dedicated to improving lift planning practices by leveraging cutting-edge technologies such as automated data acquisition, Building Information Modelling (BIM) and computational algorithms. It has been demonstrated that these technologies have advanced lift planning to some degree. However, the advancements tend to be fragmented and isolated. There are two hurdles prevented a systematic improvement of lift planning practices. First, the lack of formalized lift planning workflow, outlining the procedure and necessary information. Secondly, there is also an absence of a shared information environment, enabling storages, updates and the distribution of information to stakeholders in a timely manner. Thus, this paper aims to overcome the hurdles. The study starts with a literature review in combination with document analysis, enabling the initial workflow and information flow. These were contextualised through a series of interviews with Australian practitioners in the crane-related industry, and systematically analysed and schematically validated through an expert panel. Findings included formalized workflow and corresponding information exchanges in a traditional lift planning practice via a Business Process Model and Notation (BPMN). The traditional practice is thus reviewed to identify opportunities for further enhancements. Finally, a BIM-based lift planning workflow is proposed, which integrates the scattered technologies (e.g. BIM and computational algorithms) with the aim of supporting lift planning automation. The resulting framework is setting out procedures that need to be developed and the potential obstacles towards automated lift planning are identified.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1536-1540
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• 2012

Chicken primordial germ cells (cPGCs) are founder germ cells in embryonic stage of development that eventually give rise to sperms or oocytes. Currently cPGCs are only known cells enabling germline transmission in chicken and their cultivation protocols were recently established. Although genome modifications of chickens are now theoretically possible using cPGCs, there are still several hurdles to overcome to practically use cPGCs as mediators for chicken transgenesis. First, efficiency of gene delivery into cPGCs remains low with current methods. Second, there aregene silencing mechanisms against the expression of foreign genes in cPGCs. In this study, we successfully increased the efficiency of gene delivery in cPGCs by taking advantage of the TTAA-specific $piggybac$ transposon system. Moreover, a pipette-type electroporator significantly enhanced transfection efficiency up to 5-fold compared withcuvette-type methods. Taken together, the technological advances in our study will provide practical benefits for the application to fulfill genetic modifications of chicken genome.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.08a
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• pp.67-67
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• 2012

Graphene, two-dimensional one-atom-thick planar sheet of carbon atoms densely packed in a honeycomb crystal lattice, exhibits fascinating electrical properties, such as a linear energy dispersion relation and high mobility in addition to a wide-range optical absorption and high thermal conductivity. Graphene's outstanding tensile strength allows graphene-based electronic and photonic devices to be flexible, bendable, or even stretchable. Recently many groups have reported high performance electronic and optoelectronic devices based on graphene materials, i.e. field-effect transistors, gas sensors, nonvolatile memory devices, and plasmonic waveguides, in which versatile properties of graphene materials have been incorporated into a flexible electronic or optoelectronic platform. However, there are several fundamental or technological hurdles to be overcome in real applications of graphene in electronics and optoelectronics. In this tutorial we will present a short introduction to the basic material properties and recent progresses in applications of graphene to electronics and optoelectronics and discuss future outlook of graphene-based devices.

• ETRI Journal
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• v.30 no.1
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• pp.113-128
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• 2008

Turbo codes are extensively used in current communications standards and have a promising outlook for future generations. The advantages of software defined radio, especially dynamic reconfiguration, make it very attractive in this multi-standard scenario. However, the complex and power consuming implementation of the maximum a posteriori (MAP) algorithm, employed by turbo decoders, sets hurdles to this goal. This work introduces an ASIP architecture for the MAP algorithm, based on a dual-clustered VLIW processor. It displays the good performance of application specific designs along with the versatility of processors, which makes it compliant with leading edge standards. The machine deals with multi-operand instructions in an innovative way, the fetching and assertion of data is serialized and the addressing is automatized and transparent for the programmer. The performance-area trade-off of the proposed architecture achieves a throughput of 8 cycles per symbol with very low power dissipation.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.1103-1107
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• 2004

Last year, we introduced a TFT-LCD with RGBW color system. The primary advantage of the RGBW system is that its optical efficiency is at least 50% higher than the RGB system. However, it is not a simple task to incorporate the new color system into the infrastructure of the RGB system: the driving circuitry, fabrication of color filter, and color conversion. In this report, the practical hurdles are discussed and the solutions are presented.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.22 no.1
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• pp.15-21
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• 2014

Modern aircraft air navigation has been changed from the conventional air navigation aid to utilizing Global Navigation Satellite System. For the air navigation of fast moving aircraft, GNSS required extremely high accuracy and reliability. This study reviews the basic concept of Satellite Based Augmentation System which is discussed in the International Working Group of International Civil Aviation Organization and status of some SBAS leading State's case. In addition to that, a progress of SBAS development and implementation in the Republic of Korea was reviewed with pointing out of general hurdles and counter measures.

• BMB Reports
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• v.44 no.4
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• pp.232-237
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• 2011

Human respiratory syncytial virus (HRSV) is a major cause of upper and lower respiratory tract illness in infants and young children worldwide. Despite its importance as a respiratory pathogen, there is currently no licensed vaccine for prophylaxis of HRSV infection. There are several hurdles complicating the development of a RSV vaccine: 1) incomplete immunity to natural RSV infection leading to frequent re-infection, 2) immature immune system and maternal antibodies of newborn infants who are the primary subject population, and 3) imbalanced Th2-biased immune responses to certain vaccine candidates leading to exacerbated pulmonary disease. After the failure of an initial trial featuring formalin-inactivated virus as a RSV vaccine, more careful and deliberate efforts have been made towards the development of safe and effective RSV vaccines without vaccine-enhanced disease. A wide array of RSV vaccine strategies is being developed, including live-attenuated viruses, protein subunit-based, and vector-based candidates. Though licensed vaccines remain to be developed, our great efforts will lead us to reach the goal of attaining safe and effective RSV vaccines in the near future.