• Communications for Statistical Applications and Methods
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• 제22권3호
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• pp.223-232
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• 2015

The area under the ROC curve (AUC), the volume under the ROC surface (VUS) and the hypervolume under the ROC manifold (HUM) are defined and interpreted with probability that measures the discriminant power of classification models. AUC, VUS and HUM are expressed with the summation and integration notations for discrete and continuous random variables, respectively. AUC for discrete two random samples is represented as the nonparametric Mann-Whitney statistic. In this work, we define conditional Mann-Whitney statistics to compare more than two discrete random samples as well as propose that VUS and HUM are represented as functions of the conditional Mann-Whitney statistics. Three and four discrete random samples with some tie values are generated. Values of VUS and HUM are obtained using the proposed statistic. The values of VUS and HUM are identical with those obtained by definition; therefore, both VUS and HUM could be represented with conditional Mann-Whitney statistics proposed in this paper.

• Journal of Oral Medicine and Pain
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• 제21권2호
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• pp.351-367
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• 1996

In the field Of individual identification in forensic Science, if the body is charred, it is sometimes impossible to identify the morphologic changes and charred tissue such as blood, muscle and bone can not be identified by forensic microbiologic method such as DNA typing. So the author used the characteristics of teeth which is relatively firm compare to other organs and stable to external environment such as heat and also possess cells needed for the DNA typing. The author conducted the experiment on teeth to detect DNA related to individual identification regarding to temperature in which other charredorgans can not be detected. The experiment was done on 64 extracted third molars consisted of unheated ones, and heated teeth to $100^{\circ}C$, $150^{\circ}C$, $200^{\circ}C$ for 45 min, 90 min, and 120 min respectively and to $250^{\circ}C$ for 45 min. DNA was extracted from each tooth and amplified fragment length polymorphism procedure(AMP-FLPs) using polymerase chain reaction(PCR) was applied and observed for the matching DNA in HumTH01 and HumCD4 locus and the followings Are the results : 1. It was able to detect matching DNA in HumTH01 and HumCD4 locus in every teeth which no heating has been done. 2. It was able to detect matching DNA in HumTH01 and HumCD4 locus in every teeth heated to $100^{\circ}C$ for 45, 90 and 120 min. 3. It was able to detect matching DNA in HumTH01 and HumCD4 locus in teeth heated to $l00^{\circ}C$, $200^{\circ}C$ for 45, 90, 120 min. 4. It was impossible to detect matching DNA in HumTH01 and HumCD4 locus in teeth heated to $250^{\circ}C$. So, it is possible to extract DNA from teeth that otherwise can not be extracted from other organs in the charred body and it can be concluded that teeth are highly reliable and applicatable as forensic odontology for individual identification.

• 분석과학
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• 제12권3호
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• pp.260-264
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• 1999

법적시료(Forensic Evidences)로 사용되는 혈흔, 정액반, 타액반 및 모발을 DNA의 분리과정 없이 FoLT (Formamide Low Temperature) PCR법으로 DNA의 특정부위를 분석하고자 하였다. FoLT PCR법으로 3종류의 STR(Short Tandem Repeat) 좌위와 성별을 확인하는 Amelogenin gene을 PCR법으로 동시에 분석하기 위하여 formamide농도와 annealing온도를 검토한 바 최적의 formamide농도는 8%(v/v)이었고 annealing온도는 $48^{\circ}C$이었다. 그리고 1% Triton X-100을 이용하여 시료를 세척한 경우에 증폭 효율이 증가하였다. 따라서 FoLT-PCR법을 이용한 경우 DNA를 분리하기 위한 전처리없이 소량의 시료를 기존의 PCR법보다 빠른 시간내에 한번의 PCR 및 전기영동으로 HumTH01, HumTPOX, HumCSF1PO 및 Amelogenin을 동시에 분석할 수 있었다.

• Journal of the Korean Data and Information Science Society
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• 제25권3호
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• pp.473-483
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• 2014

ROC 곡선과 ROC 곡면을 확장한 4차원 이상의 공간에서의 ROC 다면체는 시각적인 표현이 어렵기 때문에 활용하기 어려우나, ROC 다면체 아래 공간을 측정하는 HUM 통계량에 대하여는 AUC와 VUS 통계량을 기반으로 정의가 가능하고 값을 구할 수 있으므로 본 연구는 네 가지 범주의 분류모형의 판별력을 측정하는 확률을 정의하고 연구한다. 그리고 Basel II를 기반한 부도확률에 대한 AUC의 판별력 판단기준을 제안한 연구를 확장하여, 네 범주 분류모형의 판별력을 측정하는 HUM 통계량에 관한 판단기준을 13단계로 구분하여 제안하고 활용하는 방법을 설명한다. 다양한 분포함수에 대하여 얻은 HUM 값을 바탕으로 제안한 판단기준을 탐색하기 위하여 삼원구획그림을 활용하여 판단기준을 설명한다.

• Communications for Statistical Applications and Methods
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• 제22권4호
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• pp.377-387
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• 2015

The area under the ROC curve can be represented by both Mann-Whitney and Wilcoxon rank sum statistics. Consider an ROC surface and manifold equal to three dimensions or more. This paper finds that the volume under the ROC surface (VUS) and the hypervolume under the ROC manifold (HUM) could be derived as functions of both conditional Mann-Whitney statistics and conditional Wilcoxon rank sum statistics. The nullhypothesis equal to three distribution functions or more are identical can be tested using VUS and HUM statistics based on the asymptotic large sample theory of Wilcoxon rank sum statistics. Illustrative examples with three and four random samples show that two approaches give the same VUS and $HUM^4$. The equivalence of several distribution functions is also tested with VUS and $HUM^4$ in terms of conditional Wilcoxon rank sum statistics.

• Journal of the Korean Data and Information Science Society
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• 제26권6호
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• pp.1305-1315
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• 2015

ROC 곡선을 구성하는 한 개의 스코어 변수로 이루어진 분류모형을 확장하여 선형 스코어의 함수인 리스크 스코어를 고려하고, 선형 스코어의 계수를 추정하기 위한 방법으로 AUC를 최대화하는 방법을 사용한다. 이런 AUC 접근방법으로 구한 스코어의 계수 추정량은 로지스틱모형을 이용한 선형 스코어의 모수의 최대가능도 추정량보다 자료가 로지스틱 가정이 맞지 않는 일반적인 상황에서도 좋은 추정 결과를 보인다. 본 연구에서는 다항범주로 분류되어 현실적인 판별 및 예측 상황을 고려하여 AUC 접근방법을 확장한 VUS와 HUM 접근방법을 제안한다. 연결함수로는 로짓, complementary log-log와 로짓을 변형한 함수의 세 종류와 그리고 다양한 분류점의 분포인 경우에 대하여도 모의실험을 실시하였다. 본 논문에서는 다항범주 판별결과에 대하여 VUS와 HUM 접근방법도 AUC 접근방법과 유사하게 다양한 연결함수에 대하여 로지스틱모형 추정방법보다 동등하거나 더 나은 모수추정 결과를 보이는 것을 확인하였다.

• 한국의사학회지
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• 제15권1호
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• pp.63-146
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• 2002

Huh-Im(許任, 1570~1647) was an acupuncture doctor of Chosun(朝鮮) era through the late 16th century and early 17th century. Even though he was a person of low birth, he participated in the loyal medication through three loyal generations, Sunjo(宣祖), Kwanghaegun(光海君) and Injo(仁祖). He was recognized of his services and became an official, 'Dangsanggwan'(堂上官) and Kyunggi(京畿) district official several times. In the early Chosun era, acupuncture medicine was focused. During the late 16th century, Imjin(壬辰) war aroused more needs about acupuncture medicine, and acupuncture doctors showed remarkable work. Under these circumstances, Huh-Im(許任)'s fame spread throughout the country. Huh-Im(許任) wrote ChimGuKyungHumBang("鍼灸經驗方") in 1644 based on his lifetime clinical acupuncture & moxibustion experience. It was the first specialized book of acupuncture in Chosun era. This event took place 30 years after DongEuiBoGam - Acupuncture Chapter("東醫寶鑑-鍼灸篇") was published. But it was not influenced much by DongEuiBoGam - Acupuncture Chapter("東醫寶 鑑-鍼灸篇") in the form or contents. ChimGuKyungHumBang("鍼灸經驗方") and Huh-Jun(許浚)'s DongEuiBo- Gam - Acupuncture Chapter("東醫寶鑑-鍼灸篇") were the fruits of the middle Chosun, and they are complementary to each other in theory and practice. The chief distinctions of ChimGuKyungHumBang("鍼灸經驗方") are in it's compact and practical edition and a lot of his clinical acupuncture prescriptions mentioned in the book. Huh-Im(許任) not only accepted the existing books such as NaeKyung("內經"), DongInSuHyulChimGuDoKyung and Shin- Eung Kyung("神應經") with his point of view and clinical experience, but also showed creative operation of studies. Indicating incorrect acupuncture points(訛穴), acupuncture remedy based on the visceral pathogenesis(臟腑病機) and the channel pathogenesis, research on new acupuncture points, sorting out plenty of outer meridian acupuncture points(經外奇穴), creating supplementary and purging acupuncture method(鍼補瀉法) which is a change of hand treatment of KiHyoYangBang("奇效良方"), operating variety of acupuncture and moxibustion treatments, and application of acupuncture treatments on surgery field such as intumescences and emergency cases are the examples. Huh-Im(許任)'s ChimGuKyungHumBang("鍼灸經驗方") influenced on the folk remedy books(民間經驗方書) in the late Chosun era. Compact and practical characteristics of the book let acupuncture treatment be freindly to the people. It can be confirmed in JeungBoSanRimKyungJe-Emergency Chapter("增補山林經濟-救急篇") or the formation of SaAmChimBob(舍巖鍼法). ChimGuKyungHumBang("鍼灸經驗方") was introduced to Japan in 18th century and published twice. ChimGuJibSung("鍼灸集成"), known as an acupuncture medical book of late Qing dynasty(淸末, 1874), is confirmed to be an plagiarization of DongEuiBoGam-Acupuncture Chapter("東醫寶鑑-鍼灸篇") and ChimGuKyungHum- Bang("鍼灸經驗方") of 17th century Chosun. Confusions and errors arouse from mistaken editional trend of ChimGuJIbSung("鍼灸集成") which had not disclosed it's original author and the title of the book must be reformed. In this way, fruits of acupuncture of the middle Chosun era including Huh-Im(許任)'s ChimGuKyungHumBang("鍼灸經驗方") will take a right place in acupuncture medicine history.

• 보존과학연구
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• 통권17호
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• pp.100-122
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• 1996

We preformed many treatments to preserve Kim-gu's relics (Baekbum-ilgi and the clothes stained with blood). The first we performed re-paper mount of binding area of baekbumilgi, and fumigated all relics to sterilize microorganism. Then all relics were sealed with biaxially oriented polyvinyalcohol film(BO-PVA film) and $N_2$ gas filled up in the BO-PVA film bags. We investigated the paper condition of Baekbum-ilgi, its brightnees was 25-35%, water content was 9.4%, and acidity was pH 4.3. These results indicated that the paper was very weak. On the other hand, We analyzed his blood type and genetic type with the solidified blood of the clothes. In result, his blood type was AB and were classified 6 genetic types such that HUMTH01 was 7-9 type, HumTPOX was 9-11 type, HumCSF1PO was 12-13 type, HumF13A01 was 4-4type, HumFESFPS was 12-12, and HumvWA was 18-18 type.

• 대한한의학회지
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• 제30권2호
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• pp.46-55
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• 2009

In this study a correspondence between Lee-HyungYik (李馨益)'s Burnchim (燔鍼) and InJo (仁祖)'s illness was made and Lee-HyungYik (李馨益)'s Burnchim (燔鍼) was examined in detail. The data researched was an article about Lee-HyungYik's Burnchim treatment that appeared in the Daily Records of the Royal Secretariat ["承政院日記"]. Based on this article, comparisons and contrasts with the contents of Shin-Eung Kyung ("神鷹經")'s ChimGuKyungHumBang (鍼灸經驗方) were made. As a result, it was found that Lee-HyungYik's Burnchim can be categorized as a kind of Burning Acupuncture Therapy [火鍼] and that his method succeeds that of Shin-Eung Kyung. It can be seen as a specialized version of the treatment methods for 'Kansa & Thirteen Acupoints' ('間使 and 十三穴'). This method was used to treat QueSa (鬼邪), which corresponds to the fact that InJo was agonizing over the imprecation incident in the palace at that time. The specific method of Burnchim is similar to that of HuaChimchinlZyung mentioned in ChimGuKyung-HumBang; it is highly possible that the method introduced in ChimGuKyungHumBang is a description of Lee-HyungYik's Burnchim.

• 사상체질의학회지
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• 제14권2호
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• pp.1-9
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• 2002

I think that the study on the ${\ulcorner}$DongMuSunSaSaSangYakSungSangHumGoGa${\lrcorner}$ of ${\ulcorner}$DongMuYooGo${\lrcorner}$ is basic material explaining the character of sasang-herb and prescription. Through the study on the ${\ulcorner}$DongMuSunSaSaSangYakSungSangHumGoGa${\lrcorner}$'s origin and meaning, I can take the result as follows. The first, that is composed of total 237 herbs of 90 spleen-herb (Soeumin-herb), 61 kidney-herb (Soyangin-herb), 67 lung-herb (Taeeumin-herb) and 19 liver-herb (Taeyangin-herb). The second, the origin of that is ${\ulcorner}$JeJungSinPyun${\lrcorner}$, ${\ulcorner}$BangYakHapPyun${\lrcorner}$ and ${\ulcorner}$EuiHakIpMum${\lrcorner}$. And DongMu classified traditional YakSungGa as spleen-herb, kidney-herb, lung-herb and liver-herb which is suitable to Sasangin, not created that. So we can know that the first understanding for DongMu' s herb is focused on the traditional YakSungGa. The third, DongMu's unique terminology of spleen-herb, kidney-herb, lung-herb and liver herb show his sight of symptom, disease and pharmacology, that is focused on small JangBu. The forth, through herb-nature gathered from traditional YakSungGa, that purposed to classfying each constitutional herb. So we can know his idea that the choice of herb is not in general efficacy but in personal constitution. As mentioned abovet, that can refer to an herbal argument of DongMu and ${\ulcorner}$DongMuYooGoYakSungGa${\lrcorner}$ that make known to be common can refer to an prescriptional argument of DongMu.