• Communications for Statistical Applications and Methods
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• v.22 no.3
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• pp.223-232
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• 2015

The area under the ROC curve (AUC), the volume under the ROC surface (VUS) and the hypervolume under the ROC manifold (HUM) are defined and interpreted with probability that measures the discriminant power of classification models. AUC, VUS and HUM are expressed with the summation and integration notations for discrete and continuous random variables, respectively. AUC for discrete two random samples is represented as the nonparametric Mann-Whitney statistic. In this work, we define conditional Mann-Whitney statistics to compare more than two discrete random samples as well as propose that VUS and HUM are represented as functions of the conditional Mann-Whitney statistics. Three and four discrete random samples with some tie values are generated. Values of VUS and HUM are obtained using the proposed statistic. The values of VUS and HUM are identical with those obtained by definition; therefore, both VUS and HUM could be represented with conditional Mann-Whitney statistics proposed in this paper.

• Journal of Oral Medicine and Pain
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• v.21 no.2
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• pp.351-367
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• 1996

In the field Of individual identification in forensic Science, if the body is charred, it is sometimes impossible to identify the morphologic changes and charred tissue such as blood, muscle and bone can not be identified by forensic microbiologic method such as DNA typing. So the author used the characteristics of teeth which is relatively firm compare to other organs and stable to external environment such as heat and also possess cells needed for the DNA typing. The author conducted the experiment on teeth to detect DNA related to individual identification regarding to temperature in which other charredorgans can not be detected. The experiment was done on 64 extracted third molars consisted of unheated ones, and heated teeth to $100^{\circ}C$, $150^{\circ}C$, $200^{\circ}C$ for 45 min, 90 min, and 120 min respectively and to $250^{\circ}C$ for 45 min. DNA was extracted from each tooth and amplified fragment length polymorphism procedure(AMP-FLPs) using polymerase chain reaction(PCR) was applied and observed for the matching DNA in HumTH01 and HumCD4 locus and the followings Are the results : 1. It was able to detect matching DNA in HumTH01 and HumCD4 locus in every teeth which no heating has been done. 2. It was able to detect matching DNA in HumTH01 and HumCD4 locus in every teeth heated to $100^{\circ}C$ for 45, 90 and 120 min. 3. It was able to detect matching DNA in HumTH01 and HumCD4 locus in teeth heated to $l00^{\circ}C$, $200^{\circ}C$ for 45, 90, 120 min. 4. It was impossible to detect matching DNA in HumTH01 and HumCD4 locus in teeth heated to $250^{\circ}C$. So, it is possible to extract DNA from teeth that otherwise can not be extracted from other organs in the charred body and it can be concluded that teeth are highly reliable and applicatable as forensic odontology for individual identification.

• Analytical Science and Technology
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• v.12 no.3
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• pp.260-264
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• 1999

A simple and rapid procedure, called FoLT-PCR(Formamide Low Temperature-Polymerase Chain Reaction) was applied to amplifying DNA directly from various forensic biological evidences including human blood, saliva, hair root, or semen without any DNA preparative steps. We added washing step with non-ionic detergent, 1% Triton X-100, and used Taq DNA polymerase instead of Tth DNA polymerase to amplify 3 STR loci and gender allele simultaneouly. Optimal concentration of formamide and annealing temperature were determined empirically to 8%(v/v), and $48^{\circ}C$ respectively. We also compared this method with standard PCR.

• Journal of the Korean Data and Information Science Society
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• v.25 no.3
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• pp.473-483
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• 2014

Even though the ROC manifold for more than three dimensional space which is an extension of the ROC curve and surface has difficulty to represent graphically, the hypervolume under the ROC manifold (HUM) statistic can be defined and obtained based on AUC and VUS measures for the ROC curve and the ROC surface. Hence the definition and characteristics of the HUM for four dimensional space are studied in this work. By extension of the standard criterion of AUC for probabilities of default based on Basel II, the 13 classes of standard criterion of HUM are proposed in order to discriminate four classification models and some application methods are discussed. In order to explore the standard criterion of HUM whose values are obtained from various distributions, ternary plot is used and explained.

• Communications for Statistical Applications and Methods
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• v.22 no.4
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• pp.377-387
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• 2015

The area under the ROC curve can be represented by both Mann-Whitney and Wilcoxon rank sum statistics. Consider an ROC surface and manifold equal to three dimensions or more. This paper finds that the volume under the ROC surface (VUS) and the hypervolume under the ROC manifold (HUM) could be derived as functions of both conditional Mann-Whitney statistics and conditional Wilcoxon rank sum statistics. The nullhypothesis equal to three distribution functions or more are identical can be tested using VUS and HUM statistics based on the asymptotic large sample theory of Wilcoxon rank sum statistics. Illustrative examples with three and four random samples show that two approaches give the same VUS and $HUM^4$. The equivalence of several distribution functions is also tested with VUS and $HUM^4$ in terms of conditional Wilcoxon rank sum statistics.

• Journal of the Korean Data and Information Science Society
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• v.26 no.6
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• pp.1305-1315
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• 2015

Consider the risk score which is a function of a linear score for the classification models. The AUC optimization method can be applied to estimate the coefficients of linear score. These estimates obtained by this AUC approach method are shown to be better than the maximum likelihood estimators using logistic models under the general situation which does not fit the logistic assumptions. In this work, the VUS and HUM approach methods are suggested by extending AUC approach method for more realistic discrimination and prediction worlds. Some simulation results are obtained with both various distributions of thresholds and three kinds of link functions such as logit, complementary log-log and modified logit functions. It is found that coefficient prediction results by using the VUS and HUM approach methods for multiple categorical classification are equivalent to or better than those by using logistic models with some link functions.

• The Journal of Korean Medical History
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• v.15 no.1
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• pp.63-146
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• 2002

Huh-Im(許任, 1570~1647) was an acupuncture doctor of Chosun(朝鮮) era through the late 16th century and early 17th century. Even though he was a person of low birth, he participated in the loyal medication through three loyal generations, Sunjo(宣祖), Kwanghaegun(光海君) and Injo(仁祖). He was recognized of his services and became an official, 'Dangsanggwan'(堂上官) and Kyunggi(京畿) district official several times. In the early Chosun era, acupuncture medicine was focused. During the late 16th century, Imjin(壬辰) war aroused more needs about acupuncture medicine, and acupuncture doctors showed remarkable work. Under these circumstances, Huh-Im(許任)'s fame spread throughout the country. Huh-Im(許任) wrote ChimGuKyungHumBang("鍼灸經驗方") in 1644 based on his lifetime clinical acupuncture & moxibustion experience. It was the first specialized book of acupuncture in Chosun era. This event took place 30 years after DongEuiBoGam - Acupuncture Chapter("東醫寶鑑-鍼灸篇") was published. But it was not influenced much by DongEuiBoGam - Acupuncture Chapter("東醫寶 鑑-鍼灸篇") in the form or contents. ChimGuKyungHumBang("鍼灸經驗方") and Huh-Jun(許浚)'s DongEuiBo- Gam - Acupuncture Chapter("東醫寶鑑-鍼灸篇") were the fruits of the middle Chosun, and they are complementary to each other in theory and practice. The chief distinctions of ChimGuKyungHumBang("鍼灸經驗方") are in it's compact and practical edition and a lot of his clinical acupuncture prescriptions mentioned in the book. Huh-Im(許任) not only accepted the existing books such as NaeKyung("內經"), DongInSuHyulChimGuDoKyung and Shin- Eung Kyung("神應經") with his point of view and clinical experience, but also showed creative operation of studies. Indicating incorrect acupuncture points(訛穴), acupuncture remedy based on the visceral pathogenesis(臟腑病機) and the channel pathogenesis, research on new acupuncture points, sorting out plenty of outer meridian acupuncture points(經外奇穴), creating supplementary and purging acupuncture method(鍼補瀉法) which is a change of hand treatment of KiHyoYangBang("奇效良方"), operating variety of acupuncture and moxibustion treatments, and application of acupuncture treatments on surgery field such as intumescences and emergency cases are the examples. Huh-Im(許任)'s ChimGuKyungHumBang("鍼灸經驗方") influenced on the folk remedy books(民間經驗方書) in the late Chosun era. Compact and practical characteristics of the book let acupuncture treatment be freindly to the people. It can be confirmed in JeungBoSanRimKyungJe-Emergency Chapter("增補山林經濟-救急篇") or the formation of SaAmChimBob(舍巖鍼法). ChimGuKyungHumBang("鍼灸經驗方") was introduced to Japan in 18th century and published twice. ChimGuJibSung("鍼灸集成"), known as an acupuncture medical book of late Qing dynasty(淸末, 1874), is confirmed to be an plagiarization of DongEuiBoGam-Acupuncture Chapter("東醫寶鑑-鍼灸篇") and ChimGuKyungHum- Bang("鍼灸經驗方") of 17th century Chosun. Confusions and errors arouse from mistaken editional trend of ChimGuJIbSung("鍼灸集成") which had not disclosed it's original author and the title of the book must be reformed. In this way, fruits of acupuncture of the middle Chosun era including Huh-Im(許任)'s ChimGuKyungHumBang("鍼灸經驗方") will take a right place in acupuncture medicine history.

• 보존과학연구
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• s.17
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• pp.100-122
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• 1996

We preformed many treatments to preserve Kim-gu's relics (Baekbum-ilgi and the clothes stained with blood). The first we performed re-paper mount of binding area of baekbumilgi, and fumigated all relics to sterilize microorganism. Then all relics were sealed with biaxially oriented polyvinyalcohol film(BO-PVA film) and $N_2$ gas filled up in the BO-PVA film bags. We investigated the paper condition of Baekbum-ilgi, its brightnees was 25-35%, water content was 9.4%, and acidity was pH 4.3. These results indicated that the paper was very weak. On the other hand, We analyzed his blood type and genetic type with the solidified blood of the clothes. In result, his blood type was AB and were classified 6 genetic types such that HUMTH01 was 7-9 type, HumTPOX was 9-11 type, HumCSF1PO was 12-13 type, HumF13A01 was 4-4type, HumFESFPS was 12-12, and HumvWA was 18-18 type.

• The Journal of Korean Medicine
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• v.30 no.2
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• pp.46-55
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• 2009

In this study a correspondence between Lee-HyungYik (李馨益)'s Burnchim (燔鍼) and InJo (仁祖)'s illness was made and Lee-HyungYik (李馨益)'s Burnchim (燔鍼) was examined in detail. The data researched was an article about Lee-HyungYik's Burnchim treatment that appeared in the Daily Records of the Royal Secretariat ["承政院日記"]. Based on this article, comparisons and contrasts with the contents of Shin-Eung Kyung ("神鷹經")'s ChimGuKyungHumBang (鍼灸經驗方) were made. As a result, it was found that Lee-HyungYik's Burnchim can be categorized as a kind of Burning Acupuncture Therapy [火鍼] and that his method succeeds that of Shin-Eung Kyung. It can be seen as a specialized version of the treatment methods for 'Kansa & Thirteen Acupoints' ('間使 and 十三穴'). This method was used to treat QueSa (鬼邪), which corresponds to the fact that InJo was agonizing over the imprecation incident in the palace at that time. The specific method of Burnchim is similar to that of HuaChimchinlZyung mentioned in ChimGuKyung-HumBang; it is highly possible that the method introduced in ChimGuKyungHumBang is a description of Lee-HyungYik's Burnchim.

• Journal of Sasang Constitutional Medicine
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• v.14 no.2
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• pp.1-9
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• 2002

I think that the study on the ${\ulcorner}$DongMuSunSaSaSangYakSungSangHumGoGa${\lrcorner}$ of ${\ulcorner}$DongMuYooGo${\lrcorner}$ is basic material explaining the character of sasang-herb and prescription. Through the study on the ${\ulcorner}$DongMuSunSaSaSangYakSungSangHumGoGa${\lrcorner}$'s origin and meaning, I can take the result as follows. The first, that is composed of total 237 herbs of 90 spleen-herb (Soeumin-herb), 61 kidney-herb (Soyangin-herb), 67 lung-herb (Taeeumin-herb) and 19 liver-herb (Taeyangin-herb). The second, the origin of that is ${\ulcorner}$JeJungSinPyun${\lrcorner}$, ${\ulcorner}$BangYakHapPyun${\lrcorner}$ and ${\ulcorner}$EuiHakIpMum${\lrcorner}$. And DongMu classified traditional YakSungGa as spleen-herb, kidney-herb, lung-herb and liver-herb which is suitable to Sasangin, not created that. So we can know that the first understanding for DongMu' s herb is focused on the traditional YakSungGa. The third, DongMu's unique terminology of spleen-herb, kidney-herb, lung-herb and liver herb show his sight of symptom, disease and pharmacology, that is focused on small JangBu. The forth, through herb-nature gathered from traditional YakSungGa, that purposed to classfying each constitutional herb. So we can know his idea that the choice of herb is not in general efficacy but in personal constitution. As mentioned abovet, that can refer to an herbal argument of DongMu and ${\ulcorner}$DongMuYooGoYakSungGa${\lrcorner}$ that make known to be common can refer to an prescriptional argument of DongMu.