• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.5
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• pp.469-474
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• 2014

The high temperature gas-cooled reactor (HTR-10) is designed to produce electricity and hydrogen. Graphite is used as reflector, support structures, and a moderator in reactor core; it has good resistance to neutron and is a suitable material at high temperatures. Friction is generated in the graphite structures for the core reflector, support structures, and moderator because of vibration from the HTR-10 fuel cycle flow. In this study, the wear characteristics of the isotropic graphite IG-110 used in HTR-10 were evaluated. The reciprocating wear test was carried out for graphite against graphite. The effects of changes in the contact load and sliding speeds at room temperature and $400^{\circ}C$ on the coefficient of friction and specific wear rate were evaluated. The wear behavior of graphite IG-110 was evaluated based on the wear surfaces.

• Interdisciplinary Bio Central
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• v.4 no.3
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• pp.8.1-8.7
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• 2012

The motor neuron degeneration 2 (mnd2) mice carry a point mutation of A to T nucleotide transversion at the serine 276 residue of high temperature requirement A2 (HtrA2), resulting in losses of an AluI restriction enzyme site (5'AGCT3') and the HtrA2 serine protease activity. Moreover, dysfunctions of HtrA2 are known to be intimately associated with the pathogenesis of neurodegenerative diseases, including Parkinson's disease. Thus, this mnd2 mouse is an invaluable model for understanding the physiological role of HtrA2 and its pathological role in neurodegenerative diseases. Nevertheless, many molecular and cellular biologists in this field have limited experience in working with mutant mouse models due to the necessity of acquired years of the special techniques and knowledges. Herein, using the mnd2 mouse model as an example, we describe easy-to-use standard protocols for web-based analyses of target genes, such as HtrA2, and a novel approach for simple and accurate PCR-AluI-RFLP-based genotype analysis of mnd2 mice. In addition, band resolution of AluI-RFLP fragments was improved in 12% polyacrylamide gel running in 1X Tris-Glycine SDS buffer. Our study indicates that this PCR-AluI-RFLP genotype analysis method can be easily applied by the molecular and cellular biologist to conduct biomedical science studies using the other mutant mouse models.

• Journal of Microbiology and Biotechnology
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• v.32 no.6
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• pp.792-799
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• 2022

As a vital problem in reproductive health, recurrent spontaneous abortion (RSA) affects about 1% of women. We performed this study with an aim to explore the molecular mechanism of interleukin-23 (IL-23) and find optimal or effective methods to improve RSA. First, ELISA was applied to evaluate the expressions of IL-23 and its receptor in HTR-8/SVneo cells after IL-23 treatment. CCK-8, TUNEL, wound healing and transwell assays were employed to assess the proliferation, apoptosis, migration and invasion of HTR-8/SVneo cells, respectively. Additionally, the expressions of apoptosis-, migration-, epithelial-mesenchymal transition- (EMT-) and p38 MAPK signaling pathway-related proteins were measured by western blotting. To further investigate the relationship between IL-23 and p38 MAPK signaling pathway, HTR-8/SVneo cells were treated for 1 h with p38 MAPK inhibitor SB239063, followed by a series of cellular experiments on proliferation, apoptosis, migration and invasion, as aforementioned. The results showed that IL-23 and its receptors were greatly elevated in IL-23-treated HTR-8/SVneo cells. Additionally, IL-23 demonstrated suppressive effects on the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells. More importantly, the molecular mechanism of IL-23 was revealed in this study; that is to say, IL-23 inhibited the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells via activating p38 MAPK signaling pathway. In conclusion, IL-23 inhibits trophoblast proliferation, migration, and EMT via activating p38 MAPK signaling pathway, suggesting that IL-23 might be a novel target for the improvement of RSA.

• Nuclear Engineering and Technology
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• v.52 no.4
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• pp.674-680
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• 2020

We used MCNP6 computer code to model HTR-10 core reactor. We used two types of fuel; UO₂ and (Th+Pu)O₂ mixture. We determined the critical height at which the reactor approached criticality in both two cases. The neutronic and burnup parameters were investigated. The results indicated that the core fueled with mixed (Th+Pu)O₂, achieved about 24% higher fuel cycle length than the UO₂ case. It also enhanced safeguard security by burning Pu isotopes. The results were compared with previously published papers and good agreements were found.

• Bulletin of the Korean Chemical Society
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• v.32 no.5
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• pp.1692-1696
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• 2011

The reactions of 1H-1,2,4-triazole (Htr) with $MX_2$ ($ZnCl_2$ for 1; $CdBr_2$ for 2) resulted in two coordination polymers, [Zn(tr)Cl]$_n$ (1) and $[Cd(Htr)_2Br_2]_n$ (2). The structural analyses indicate that 1 and 2 feature a 2D layer and 1D triple chain, respectively. In 1, neighouring Zn atoms are connected by ${\mu}_3-1$ ${\kappa}N$: 2 ${\kappa}N$: $4{\kappa}N-tr^-$ anionic ligand into 6- and 16-membered rings, further grow into a 2D sheet. Cd atoms in 2 are bonded by two ${\mu}_2-Br^-$ bridges and neutral ${\mu}_2$-1 ${\kappa}N$: 2 ${\kappa}N$-Htr to form a 1D triple chain. The fluorescent characterizations of 1, 2 and the free Htr ligand feature simlilar emission peakes at 444, 446 and 423 nm respectively, which can be assigned to intra-ligand ${\pi}-{\pi}^*$ transition of (H)tr. The energy gaps of 5.90 eV for 1, 5.16 eV for 2, and 5.93 eV for Htr suggest that the compounds behave as insulators.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.38 no.3
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• pp.219-227
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• 1993

Broadcast-seeded rice in submerged paddy frequently lodge in the field. In general, the causes of lodging in rice cultivation differ with different cultural methods. This study was conducted to investigate the causes of lodging in broadcast-seeded rice (BSR) and hand-transplanted rice (HTR) under four nitrogen (N) levels. Lodging in BSR was mainly a root lodging due to shallow root distribution, while that in HTR showed a bending type owing to deep rooting system. At the upper soil layer (0-5cm from the surface of ground) the root distribution of BSR (65.2%) was much larger than that of HTR (51.6%), whereas at the 5-10cm soil layer the root distribution of BSR (18.5%) was much smaller than that of HTR (28.0%). The depth of buried culm base was much shallower in BSR (1.2cm) than in HTR (4.0cm). The plant height, fresh weight, lodging index, culm diameter and thickness in HTR were much greater than those in BSR, and the breaking strength of lower internode was similar in the two cultivation methods indicating that HTR would have more lodging causes than BSR. In spite of . the more advantages to lodging resistance in BSR it severely lodged in the field. The main lodging-inducing factors of BSR were the shallow root distribution and shallow depth of buried culm base. Besides these, the higher ratio of gravity center of culm was an important factor. This result suggested that for the fundamental prevention of lodging in BSR, an ideotype of rice plant with ' a deep-rooted behavior ' should be developed.

• Journal of Soil and Groundwater Environment
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• v.29 no.1
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• pp.63-71
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• 2024

Hydrothermal Reaction (HTR) was applied for the stabilization of contaminated soil with heavy metals, and then the test determined the optimal conditions for HTR. After HTR, the concentration of heavy metals in the contaminated soil increased. However, it was observed that the leachability potential significantly decreased as determined by TCLP and SPLP tests. This decrease was attributed to a decline in fractions 1-2 and an increase in fractions 3-4 as revealed by sequential extraction procedure. Due to the mineralogical characteristics of the dredged soil, distinct changes were not evident in the five-stage fraction. Therefore, it is deemed necessary to understand the chemical and mineralogical characteristics of the target soil for HTR application in order to selectively address contaminants. Comparison among operating conditions determined the optimal condition to be at 240℃ for one hour.

• Journal of Korea Multimedia Society
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• v.10 no.4
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• pp.462-469
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• 2007

ATM protocol has the techniques such as cell discarding priority, traffic shaping and traffic policing. ATM based MPLS(Multiprotocol Label Switching) is discussed for its provisioning QoS commitment capabilities, traffic engineering and smooth migration for BcN using conventional ATM infra in Korea. This paper proposes preventive congestion control mechanism for detecting HTR(Hard To Reach) LSP(Label Switched Path) in ATM based MPLS systems. In particular, we decide HTR LSP using real time signaling information(etc., PTI,AIS/RDI) for applying HTR concept in circuit switching to ATM based MPLS systems and use those session gap and percentage based control algorithm that were used in conventional PSTN call controls. We concluded that it maximized the efficiency of network resources by restricting ineffective machine attempts. Proposed control can handle 208% call processing and more than 147% success call, than those without control. It can handle 187% BHCA(Busy Hour Call Attempts) with 100 times less than use of exchange memory.

• Biomedical Science Letters
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• v.21 no.4
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• pp.181-187
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• 2015

Osteoporosis is one of the diseases caused by accumulation of effects from complex interactions between genetic and environmental factors. Aging is the major cause for osteoporosis, which normally increases skeletal fragility and bone fracture especially among the elder. "Omics" refers to a specialized research field dealing with high-throughput biological data, such as genomics, transcriptomics, proteomics or metabolomics. Integration of data from multi-omics has been approved to be a powerful strategy to colligate biological phenomenon with multiple aspects. Actually, integrative analyses of "omics" datasets were used to present pathogenesis of specific diseases or casual biomarkers including susceptible genes. In this study, we evaluated the proposed relationship of novel susceptible genes (TREML2, HTR1E, and GLO1) with osteoporosis, which genes were obtained using multi-omics integration analyses. To this end, SNPs of the susceptible genes in the Korean female cohort were analyzed. As a result, one SNP of HTR1E and five SNPs of TREML2 were identified to associate with osteoporosis. The highest significant SNP was $rs6938076^*$ of TREML2 (OR=0.63, CI: 0.45~0.89, recessive P=0.009). Consequently, the susceptible genes identified through the multi-omics analyses were confirmed to have association with osteoporosis. Therefore, multi-omics analysis might be a powerful tool to find new genes associated with a disease. We further identified that TREML2 has more associated with osteoporosis in females than did HTR1E.

• Nuclear Engineering and Technology
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• v.52 no.5
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• pp.1051-1065
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• 2020

Safety analysis of nuclear power plant (NPP) especially in accident conditions is a basic and necessary issue for applications and commercialization of reactors. Many previous researches and development works have been conducted. However, most achievements focused on the safety reliability of primary pressure system vessels. Few literatures studied the structural safety of huge concrete structures surrounding primary pressure system, especially for the fourth generation NPP which allows existing of through cracks. In this paper, structural safety reliability of concrete structures of HTR-PM in accidental double-ended break of hot gas ducts was studied by Exceedance Probability Method. It was calculated by Monte Carlo approaches applying numerical simulations by Abaqus. Damage parameters were proposed and used to define the property of concrete, which can perfectly describe the crack state of concrete structures. Calculation results indicated that functional failure determined by deterministic safety analysis was decided by the crack resistance capability of containment buildings, whereas the bearing capacity of concrete structures possess a high safety margin. The failure probability of concrete structures during an accident of double-ended break of hot gas ducts will be 31.18%. Adding the consideration the contingency occurrence probability of the accident, probability of functional failure is sufficiently low.