• Title/Summary/Keyword: HSA

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Properties of Sol-Gel Materials Synthesized from Colloidal Silica and Alkoxy Silanes (콜로이드 실리카와 알콕시 실란의 솔-젤 코팅제 합성과 특성)

  • Kang Dong-Pil;Park Hoy-Yul;Ahn Myeong-Sang;Myung In-Hye;Lee Tae-Ju;Choi Jae-Hoon;Kim Hyun-Joong
    • Polymer(Korea)
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    • v.29 no.3
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    • pp.242-247
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    • 2005
  • Two kinds of colloidal silica(CS)/silane sol solutions were prepared in variation with synthesizing parameters such as kinds of CS, ratio of CS to silane and reaction time. Such sol solutions were obtained from 1034A Cs/methyl-trimethoxysilane(MTMS) and HSA CS/MTMS solutions. In the case of 1034A CS/MTMS CS/silane sol, coating film had high contact angle and more enhanced flat surface than those in the case of HSA CS/MTMS sol. In the case of thermal stability, thermal dissociation of 1034A CS/MTMS sol did not occur up to $550^{circ}$. The thickness of coating film obtained from 1034A CS/MTMS sol increased with increasing the amount of MTMS. The hardness of coating films obtained from 1034A CS/MTMS sol decreased with increasing the amount of MTMS. Surface free energy of CS/silane sol-gel coating film decreased with increasing amount of MTMS.

A Development of Fusion Processor Architecture for Efficient Main Memory Access in CPU-GPU Environment (CPU-GPU환경에서 효율적인 메인메모리 접근을 위한 융합 프로세서 구조 개발)

  • Park, Hyun-Moon;Kwon, Jin-San;Hwang, Tae-Ho;Kim, Dong-Sun
    • The Journal of the Korea institute of electronic communication sciences
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    • v.11 no.2
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    • pp.151-158
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    • 2016
  • The HSA resolves an old problem with existing CPU and GPU architectures by allowing both units to directly access each other's memory pools via unified virtual memory. In a physically realized system, however, frequent data exchanges between CPU and GPU for a virtual memory block result bottlenecks and coherence request overheads. In this paper, we propose Fusion Processor Architecture for efficient access of main memory from both CPU and GPU. It consists of Job Manager, Re-mapper, and Pre-fetcher to control, organize, and distribute work loads and working areas for GPU cores. These components help on reducing memory exchanges between the two processors and improving overall efficiency by eliminating faulty page table requests. To verify proposed algorithm architectures, we develop an emulator based on QEMU, and compare several architectures such as CUDA(Compute Unified Device Architecture), OpenMP, OpenCL. As a result, Proposed fusion processor architectures show 198% faster than others by removing unnecessary memory copies and cache-miss overheads.

Distribution of Radionuclide Labeled Liposome in Experimental Study (방사성동위원소표지 Liposome의 분포에 대한 실험적 연구)

  • Lee, Bum-Woo;Jeong, Jae-Min;Kim, Sang-Eun;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul;Koh, Chang-Soon;Ha, Sung-Whan
    • The Korean Journal of Nuclear Medicine
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    • v.24 no.2
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    • pp.317-324
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    • 1990
  • Liposome was labelled with $^{99m}Tc$ after negative charged liposome was formed with combination of a few lipid components. $^{99m}Tc$ liposome was injected through the tail vein of C3H mice bearing fibrosarcoma and biodistribution of $^{99m}Tc$ liposome was evaluated. The results were as follows: 1) We confirmed formation of liposome which was small unillamellar and multilamellar vesicles. 2) In this experiment the optimal concentration of $SnCl_2$ was $156{\mu}g/ml$ to label liposome with $^{99m}Tc$ and labelling efficiency was 95%. 3) The labelled liposome was stable when it was incubated with human serum for 24 hours. Mean labelling efficiency was 94% at 24 hour. 4) The main uptake sites of Tc-99m liposome were liver and spleen. It showed significantly higher uptake than $^{99m}Tc$ HSA (p < 0.001). 5) $^{99m}Tc$ liposome uptake in tumor tissue was not significantly higher than $^{99m}Tc$ HSA uptake. In conclusion, $^{99m}Tc$ liposome disclosed high labelling efficiency and was highly stable. Liver and spleen were main uptake sites of $^{99m}Tc$ liposome. The uptake mechanism of $^{99m}Tc$ liposome also seemed to be different from that of $^{99m}Tc$ HSA. We conclude that $^{99m}Tc$ liposome would be a promising agents for the imaging of some tumor.

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A Radionuclides Suite Selection for Site Characterization and Final Status Survey in the U.S. NPPs (미국의 원전 해체관련 부지특성 및 최종상태 조사를 위한 방사성 오염 핵종 결정 방법에 대한 분석)

  • Zhao, Pengfei;Jeon, Yeo Ryeong;Kim, Yongmin;Lee, Jong Seh;Ahn, Seokyoung
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.14 no.3
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    • pp.267-277
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    • 2016
  • For the decommissioning of a nuclear power plant, a site characterization and final status survey require a site-specific suite of radionuclides that could potentially still be present in the site during or after the decontamination processes. The United States Nuclear Regulatory Commission (U.S. NRC) requires a Decommissioning Technical Base Document (DTBD) along with a Site Characterization and Historical Site Assessment (HSA) from the utility for decommissioning to proceed. Both the DTBD and HSA are preliminary components of the Radiological Site Survey investigation process and should be included in the final License Termination Plan (LTP) for site release and reuse consideration from the U.S. NRC and the utility company. This study reviews the United States Nuclear Power Plants (U.S. NPPs) decommissioning cases and is especially focused on the methodologies used for determining a site-specific suite of radionuclides before and during the site characterization and final status surveys. In 2017, Kori-1 will be ready for decommissioning and related preparations are ongoing, this review will help Korea to prepare regulatory guidelines and give technical background for the safe and successful decommissioning of NPPs.

Antiallergic Activities of Daidzein, a Metabolite of Puerarin and Daidzin Produced by Human Intestinal Microflora

  • Park, Eun-Kyung;Choo, Min-Kyung;Kim, Dong-Hyun
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.225.1-225.1
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    • 2003
  • To evaluate the antiallergic activities of puerarin and daidzin from the rhizome of Pueraria lobata, in vitro and in vivo inhibitory activities of these compounds and their metabolite daidzein were measured. Daidzein exhibited potent inhibitory activity on the B-hexosaminidase release induced by DNP-HSA and potently inhibited the PCA reaction in mice. (omitted)

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Cloning and Characterization of Bovine Titin-cap (TCAP) Gene

  • Yu, S.L.;Chung, H.J.;Jung, K.C.;Sang, B.C.;Yoon, D.H.;Lee, S.H.;Kata, S.R.;Womack, J.E.;Lee, J.H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.10
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    • pp.1344-1349
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    • 2004
  • Titin-cap (TCAP), one of the abundant transcripts in skeletal muscles, was nvestigated in this study in cattle because of its role in regulating the proliferation and differentiation of myoblasts by interacting with the myostatin gene. From the 5, and 3, RACE experiments, full-length TCAP coding sequence was identified, comprising 166 amino acids. The amino acid comparison showed high sequence similarities with previously identified human (95.8%) and mouse (95.2%) TCAP genes. The TCAP expression, addressed by northern blot, is limited in muscle tissues as indicated by Valle et al. (1997). The radiation hybrid analysis localized the gene on BTA19, where the comparative human and porcine counterparts are on HSA17 and SSC12. A few muscle-related genetic disorders were mapped on HSA17 and some growth-related QTLs were identified on SSC12. The bovine TCAP gene found in this study opens up new possibilities for the investigation of muscle-related genetic diseases as well as meat yield traits in cattle.

Circular RNA hsa_circ_0075828 promotes bladder cancer cell proliferation through activation of CREB1

  • Zhuang, Chengle;Huang, Xinbo;Yu, Jing;Gui, Yaoting
    • BMB Reports
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    • v.53 no.2
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    • pp.82-87
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    • 2020
  • Circular RNAs (circRNAs), one kind of non-coding RNA, have been reported as critical regulators for modulating gene expression in cancer. In this study, microarray analysis was used to screen circRNA expression profiles of bladder cancer (BC) 5637 cells, T24 cells and normal control SV-HUC-1 cells. The data from the microarray showed that hsa_circ_0075828 (named circCASC15) was most highly expressed in 5637 and T24 cells. circCASC15 was highly expressed in BC tissues and cells. Overexpression of circCASC15 was closely associated with BC tumor stage and promoted cell proliferation significantly in vitro and in vivo. Mechanistically, circCASC15 could act as miR-1224-5p sponge to activate the expression of CREB1 to promote cell proliferation in BC. In short, circCASC15 promotes cell proliferation in BC, which might be a new molecular target for BC diagnosis and therapy.

Local Buckling and Inelastic Behaviour of 800 MPa High-Strength Steel Beams (800MPa급 고강도강 보 부재의 국부좌굴 및 비탄성 거동)

  • Lee, Cheol-Ho;Han, Kyu-Hong;Kim, Dae-Kyung;Park, Chang-Hee;Kim, Jin-Ho;Lee, Seung-Eun;Ha, Tae-Hyu
    • Journal of Korean Society of Steel Construction
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    • v.24 no.4
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    • pp.479-490
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    • 2012
  • Flexural tests on full-scale H-shaped beams, built up from high-strength steels (HSB800 and HSA800) with a nominal tensile strength of 800 MPa, was carried out to study the effect of flange slenderness of high-strength steel on flexural strength and rotation capacity. The primary objective was to investigate the appropriateness of extrapolating current stability criteria (originally developed for ordinary steel) to high-strength steel. The performance of high-strength steel specimens was very satisfactory from the strength, but not from the rotation capacity, perspective. The inferior rotation capacity of high-strength steel beams was shown to be directly attributable to the absence of a distinct yield plateau and the high yield ratio of the material. Residual stress measurements reconfirmed that the magnitude of the residual stress is almost independent of the yield stress of the base metal.

Structural Performance of High-Strength Concrete-Filled Steel Tube Steel Columns using Different Strength Steels (이종강종을 사용한 고강도 CFT 합성부재의 구조성능)

  • Choi, In Rak;Chung, Kyung Soo;Kim, Jin Ho;Hong, Geon Ho
    • Journal of Korean Society of Steel Construction
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    • v.24 no.6
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    • pp.711-723
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    • 2012
  • Structural tests were performed to investigate the structural performance of concrete-filled steel tube column using different strength steels in their flange and web with high-strength steel HSA800 and mild steel SM490, respectively. The test parameters included the strength of column flange and infill concrete, and effect of concrete infill. Connection between different grade steels were welded using the electrode appropriate for mild steel and verified its performance. To evaluate the behavior of test specimens, eccentric loading tests were performed and the results were compared with the prediction by current design codes. Axial load and moment carrying capacity of test specimens increased with the yield strength of compression flange and weld fracture occurred after the specimen shows full strength. The prediction result for axial load-bending moment relationship and effective flexural stiffness gave good agreement with the test result.

FE Analysis of Symmetric and Unsymmetric Laminated Plates by using 4-node Assumed Strain Plate Element based on Higher Order Shear Deformation Theory (고차전단변형이론에 기초한 4절점 가변형률 판 요소를 이용한 대칭 및 비대칭 적층 판의 유한요소해석)

  • Lee, Sang-Jin;Kim, Ha-Ryong
    • Proceeding of KASS Symposium
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    • 2008.05a
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    • pp.95-100
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    • 2008
  • A 4-node assumed strain finite element based on higher order shear deformation theory is developed to investigate the behaviours of symmetric and unsymmetric laminated composite plates. The present element is based on Reddy's higher order shear deformation theory so that it can consider the parabolic distribution of shear deformation through plate thickness direction. In particular, assumed strain method is adopted to alleviate the shear locking phenomena inherited plate elements based on higher order shear deformation theory. The present finite element has seven degrees of freedom per node and denoted as HSA4. Numerical examples are carried out for symmetric and unsymmetric laminated composite plate with various thickness values. Numerical results are compared with reference solutions produced by other higher order shear deformation theories.

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