• 천문학회보
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• 제45권1호
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• pp.38.2-38.2
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• 2020

Horizon Run 5 (HR5) is a cosmological hydrodynamical simulation which captures the properties of the Universe on a Gpc scale while achieving a resolution of 1 kpc. This enormous dynamic range allows us to simultaneously capture the physics of the cosmic web on very large scales and account for the formation and evolution of dwarf galaxies on much smaller scales. Inside the simulation box. we zoom-in on a high-resolution cuboid region with a volume of 1049 × 114 × 114 Mpc3. The subgrid physics chosen to model galaxy formation includes radiative heating/cooling, reionization, star formation, supernova feedback, chemical evolution tracking the enrichment of oxygen and iron, the growth of supermassive black holes and feedback from active galactic nuclei (AGN) in the form of a dual jet-heating mode. For this simulation we implemented a hybrid MPI-OpenMP version of the RAMSES code, specifically targeted for modern many-core many thread parallel architectures. For the post-processing, we extended the Friends-of-Friend (FoF) algorithm and developed a new galaxy finder to analyse the large outputs of HR5. The simulation successfully reproduces many observations, such as the cosmic star formation history, connectivity of galaxy distribution and stellar mass functions. The simulation also indicates that hydrodynamical effects on small scales impact galaxy clustering up to very large scales near and beyond the baryonic acoustic oscillation (BAO) scale. Hence, caution should be taken when using that scale as a cosmic standard ruler: one needs to carefully understand the corresponding biases. The simulation is expected to be an invaluable asset for the interpretation of upcoming deep surveys of the Universe.

• The Korean journal of internal medicine
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• 제39권2호
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• pp.306-317
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• 2024

Background/Aims: To determine whether metformin, which is considered a host-directed therapy for tuberculosis (TB), is effective in improving the prognosis of patients with TB and diabetes mellitus (DM), who have higher mortality than those without DM. Methods: This cohort study included patients who were registered as having TB in the National Tuberculosis Surveillance System. The medical and death records of matched patients were obtained from the National Health Information Database and Statistics Korea, respectively, and data from 2011 to 2017 were collected retrospectively. We classified patients according to metformin use among participants who used diabetes drugs for more than 28 days. The primary outcome was all-cause mortality during TB treatment. Double propensity score adjustment was applied to reduce the effects of confounding and multivariable Cox proportional hazard models were used to estimate adjusted hazard ratio (aHR) with 95% confidence interval (CI). Results: The all-cause mortality rate during TB treatment was lower (9.5% vs. 12.4%, p < 0.01) in the metformin user group. The hazard of death due to all causes after double propensity score adjustment was also lower in the metformin user group (aHR 0.76, 95% CI 0.67-0.86, p < 0.01). There was no significant difference in mortality between metformin users and non-users for TB-related deaths (p = 0.22); however, there was a significant difference in the non-TB-related deaths (p < 0.01). Conclusions: Metformin use in patients with TB-DM co-prevalence is associated with reduced all-cause mortality, suggesting the potential for metformin adjuvant therapy in these patients.

• Nutrition Research and Practice
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• 제18권5호
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• pp.721-745
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• 2024

BACKGROUND/OBJECTIVES: The high consumption of purine-rich meat is associated with hyperuricemia. However, there is limited evidence linking the consumption of red and processed meat to the genetic risk of hyperuricemia. We investigated the relationship between various combinations of red and processed meat consumption and the polygenic risk scores (PRSs) and the incidence of hyperuricemia in middle-aged Koreans. SUBJECTS/METHODS: We analyzed the data from 44,053 participants aged ≥40 years sourced from the Health Examinees (HEXA) cohort of the Korean Genome and Epidemiology Study (KoGES). Information regarding red and processed meat intake was obtained using a semiquantitative food frequency questionnaire (SQ-FFQ). We identified 69 independent single-nucleotide polymorphisms (SNPs) at uric acid-related loci using genome-wide association studies (GWASs) and clumping analyses. The individual PRS, which is the weighted sum of the effect size of each allele at the SNP, was calculated. We used multivariable Cox proportional hazards models adjusted for covariates to determine the relationship between red and processed meat intake and the PRS in the incidence of hyperuricemia. RESULTS: During an average follow-up period of 5 years, 2,556 patients with hyperuricemia were identified. For both men and women, the group with the highest red and processed meat intake and the highest PRS was positively associated with the development of hyperuricemia when compared with the group with the lowest red and processed meat intake and the lowest PRS (hazard ratio [HR], 2.72; 95% confidence interval [CI], 2.10-3.53; P < 0.0001; HR, 3.28; 95% CI, 2.45-4.40; P < 0.0001). CONCLUSION: Individuals at a high genetic risk for uric acid levels should moderate their consumption of red and processed meat to prevent hyperuricemia.

• Toxicological Research
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• 제18권1호
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• pp.23-29
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• 2002

Disodium disulphite, the HPV chemical, was assigned to Korea in order to implement OECD SIDS program in 1999. It was produced about 3,200 ton/year in 1998. This report evaluates the toxic potency of disodium disulphite based on the environmental and mammalian effects as well as human exposure. Oral $LD_{50}$ in rats is 1,540 mg/kg b.w. and effects was observed to the stomach, liver and the GI track that was filled with blood. For repeated dose toxicity, the predominant effect was the induction of stomach lesion due to local irritation. The no observed adverse effect lever for local (stomach irritation) was about 217 mg/kg bw/day. There is no evidence that disodium disulphite is genotoxic in vivo. No reproductive or developmental toxicty of disodium disulphite was observed for the period up to 2 yr and over three generation. In humans, urticaria and asthma with itching, edema, rhinitis, and nasal congestion were reported. Disodium disulphite is unlikely to induce respiratory sensitization but may enhance symptom of asthma in sensitive individuals. This chemical would be mainly transported to water compartment when released to environmental compartments since it is highly water soluble (470 g/l at 20). Low K oc (2.447) indicates disodium disulphite is so mobile in soil that it may not stay in the terrestrial compartment. The chemical has been tested in a limited number of aquatic species. hem acute toxicity test to fish, 96 hr-$LC_{50}$ was > 100 mg/1. For algae, 72 hr-$XC_{50}$ was 48.1 mg/1. For daphnid, the acute toxicity value of 48 hr-$EC_{50}$ was 88.76 mg/1, and chronic value of 21day-NOEC was > 10 mg/1. Therefore, PNEC of 0.1 mg/l for the aquatic organism was obtained from the chronic value of daphnid using the assessment factor of 100. Based on these data the disodium disulphite was recommended as low priority for further post-SIDS work in OECD.

• Toxicological Research
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• 제18권1호
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• pp.13-22
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• 2002

In Korea, 2,320 tonnes of acetanilide were mostly wed as intermediates for synthesis in phar-maceuticals or additives in synthesizing hydrogen peroxide, varnishes, polymers and rubber. Only small amount of 120 kg were wed as a stabilizer for hydrogen peroxide solution for hair colouring agents in 1998. Readily available environmental or human exposure data do not exist in Korea at the present time. However, potential human exposures from drinking water, food, ambient water and in work places are expected to be negligible because this chemical is produced in the closed system in only one company in Korea and the processing factory is equipped with local ventilation and air filtering system. Acetanilide could be distributed mainly to water based on EQC model. This substance is readily biodegradable and its bioaccumulation is low. Acute toxicity of acetanilide is low since the L $D_{50}$ of oral exposure in rats is 1,959 mg/kg bw. The chemical is not irritating to skin, but slightly irritating to the eyes of rabbits. horn repeated dose toxicity, the adverse effects in rats were red pulp hyperplasia of spleen, bone marrow hyperplasia of femur and decreased hemoglobin, hematocrit and mean corpuscular hemoglobin concentration. The LOAEL for repeated dose toxicity in rats was 22 mg/kg/day for both sexes. Acetanilide is not considered to be genotoxic. In a reproductive/developmental toxicity study, no treatment-related changes in precoital time and rate of copulation, impregnation, pregnancy were shown in all treated groups. The NOAELs for reproduction and developmental toxicity (off-spring toxicity) are considered to be 200 mg/kg bw/day and 67 mg/kg bw/day, respectively. Ecotoxicity data has been generated in a limited number of aquatic species of algae (72 hr- $E_{b}$ $C_{50}$; 13.5 mg/l), daphnid (48hr-E $C_{50}$ > 100 mg/l) and fish (Oryzias latipes, 96hr-L $C_{50}$; 100 mg/l). Form the acute toxicity values, the predicted no effect concentration (PNEC) of 0.135 mg/1 was derived win an assessment factor of 100. On the basis of these data, acetanilide was suggested as currently of low priority for further post-SIDS work in OECD.in OECD.D.

• 환경생물
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• 제20권2호
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• pp.180-188
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• 2002

부정형성게류인 구멍연잎성게는 제주도 연안에 널리 분포하고 있음에도 불구하고 생태학적 연구들이 미비한 실정이다. 이 연구는 구멍연잎성게의 행동학적 연구로서 먹이섭취, 서식밀도 및 이동에 대한 기초자료로서 시료는 제주도의 북동쪽에 위치한 함덕에서 SCUBA를 통하여 채집 및 현장에서 직접 관찰하였다. 장내용물 관찰 결과, 장내 퇴적물 입자의 평균 입도조성은 $77.6\pm{22.2}\mu{m}$였다. 장 내용물은 유공충, 저서성 요각류, 선충류, 규조류, 알, 해조류이 파편, 골편 등의 동식물 플랑크톤으로 구성되었다. 구멍연잎성게의 서식밀도는 $1m^2$ 당 0.4 개체이며, 분포패턴은 임의분포(random distribution)에 기초하는 것으로 판단되었다$(\chi^2=85.16,\;p>0.05)$. 구멍연잎성게의 이동거리는 여름철인 1998년 8월에 6.2-64.8cm $hr^{-1}(mean=25.0\pm{13.9)}$이었고, 5월에는 $2.0-43.0cm\;hr^{-1}(mean=17.7\pm{10.7)}$로 8월에 다소 높게 나타났다. 여름기간 중 관찰된 비교적 빠른 이동속도는 먹이 섭이 활동과 관련된 것으로 추정되었다.

• Environmental Analysis Health and Toxicology
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• 제28권
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• pp.2.1-2.7
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• 2013

Objectives Tricalcium phosphate and calcium hydrogenorthophosphate are high production volume chemicals, mainly used as foodstuff additives, pharmaceuticals, lubricants, synthetic resin, and disinfectants. Phosphate has the potential to cause increased algal growth leading to eutrophication in the aquatic environment. However, there is no adequate information available on risk assessment or acute and chronic toxicity. The aim of this research is to evaluate the toxic potential of phosphate compounds in the aquatic environment. Methods An aquatic toxicity test of phosphate was conducted, and its physico-chemical properties were obtained from a database recommended in the Organization for Economic Cooperation and Development (OECD) guidance manual. An ecotoxicity test using fish, Daphnia, and algae was conducted by the good laboratory practice facility according to the OECD TG guidelines for testing of chemicals, to secure reliable data. Results The results of the ecotoxicity tests of tricalcium phosphate and calcium hydrogenorthophosphate are as follows: In an acute toxicity test with Oryzias latipes, 96 hr 50% lethal concentration ($LC_{50}$) was >100 (measured:>2.14) mg/L and >100 (measured: >13.5) mg/L, respectively. In the Daphnia test, 48 hr 50% effective concentration ($EC_{50}$) was >100 (measured: >5.35) mg/L and >100 (measured: >2.9) mg/L, respectively. In a growth inhibition test with Pseudokirchneriella subcapitata, 72 hr $EC_{50}$ was >100 (measured: >1.56) mg/L and >100 (measured: >4.4) mg/L, respectively. Conclusions Based on the results of the ecotoxicity test of phosphate using fish, Daphnia, and algae, $L(E)C_{50}$ was above 100 mg/L (nominal), indicating no toxicity. In general, the total phosphorus concentration including phosphate in rivers and lakes reaches levels of several ppm, suggesting that phosphate has no toxic effects. However, excessive inflow of phosphate into aquatic ecosystems has the potential to cause eutrophication due to algal growth.

• 한국어류학회지
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• 제8권1호
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• pp.83-89
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• 1996

동자개 P. fulvidraco의 양식 및 자원 증강에 관한 기초 자료를 얻고자 초기 생활사에 대한실험을 수행 한 결과 다음과 같은 결과를 얻었다. 수정난은 구형에 가까운 분리침성난으로 난막은 투명하고 난 표면에는 미세한 주름무늬의 점액층이 있어 쉽게 다른 물체에 부착되며, 난황은 연노랑색으로 유구는 없다. 수정 직후의 난경은 $1.4{\pm}0.03mm$(1.3~1.5mm, n=10)이었으나, 난할이 시작되는 1시간 30분 후에는 난막이 다소 팽창되어 $1.7{\pm}0.08mm$(1.6~1.8mm, n=10)이었다. 난내 발생에 있어서 수온 $25.0^{\circ}C$일 때 배반은 수정 30분 후에 형성되었고, 1시간 후에는 난할이 시작되었으며 이 후 약 30분 간격으로 난할이 계속되었다. 한편, 32세포기에서 낭배기가 끝나는 시기까지 난황의 굴곡 운동이 관찰되어 특이하였다. 부화는 약 53시간이 소요되었으며 부화 자어는 전장 4.2~4.3mm, 근절은 18~19+20~21(38~40)이었다. 부화 1주일 후에는 비공의 후연과 상악에 각각 1쌍 그리고 하악부에 2쌍의 수염이 완성되었고, 꼬리지느러미는 상 하 양엽으로 분화되기 시작하였으며, 부화 3주 후에는 체측반문, 지느러미 형태 등이 성체와 같은 치어기에 달하였다.

• Journal of Multimedia Information System
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• 제5권4호
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• pp.235-244
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• 2018

Potential maximum soil moisture retention (S) is a dominant parameter in the Soil Conservation Service (SCS; now called the USDA Natural Resources Conservation Service (NRCS)) runoff Curve Number (CN) method commonly used in hydrologic modeling for event-based flood forecasting (SCS, 1985). Physically, S represents the depth [L] soil could store water through infiltration. The depth of soil moisture retention will vary depending on infiltration from previous rainfall events; an adjustment is usually made using a factor for Antecedent Moisture Conditions (AMCs). Application of the method for continuous simulation of multiple storms has typically involved updating the AMC and S. However, these studies have focused on a time step where S is allowed to vary at daily or longer time scales. While useful for hydrologic events that span multiple days, this temporal resolution is too coarse for short-term applications such as flash flood events. In this study, an approach for deriving a time-variable potential maximum soil moisture retention curve (S-curve) at hourly time-scales is presented. The methodology is applied to the Napa River basin, California. Rainfall events from 2011 to 2012 are used for estimating the event-based S. As a result, we derive an S-curve which is classified into three sections depending on the recovery rate of S for soil moisture conditions ranging from 1) dry, 2) transitional from dry to wet, and 3) wet. The first section is described as gradually increasing recovering S (0.97 mm/hr or 23.28 mm/day), the second section is described as steeply recovering S (2.11 mm/hr or 50.64 mm/day) and the third section is described as gradually decreasing recovery (0.34 mm/hr or 8.16 mm/day). Using the S-curve, we can estimate the hourly change of soil moisture content according to the time duration after rainfall cessation, which is then used to estimate direct runoff for a continuous simulation for flood forecasting.

• 생태와환경
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• 제40권1호
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• pp.61-71
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• 2007

본 연구는 국내 최대의 수질정화용 인공습지인 시화호 인공습지의 개방수역(open water)에서 식물플랑크톤에 의한 광합성특성 및 유기물생산력을 조사 평가하여 효율적인 습지관리를 위해 open water관리방안의 기초자료를 제공하기 위함이다. 식물플랑크톤의 광합성특성 및 1차 생산력은 유입수의 수질특성과 체류시간이 다른 반월천습지와 동화천습지의 open water에서 조사되었다. 조사기간 동안 시화호 인공습지내 5개 open water에서 식물플랑크톤에 의한 1차 생산력은 $481{\sim}11,275mgC\;m^{-2}\;day^{-1}$의 범위로 연중 부영양화 수준을 보였고 계절과 지점에 따라 변동이 컸다. 시화호 인공습지에서 식물플랑크톤의 P-I curve 모델계수를 통한 광합성특성은 두 습지로 유입되는 유입수의 상반되는 수질특성(인과 질소 농도)에 크게 영향을 받는 것으로 나타났다. 최대광합성속도 (Pmax)는 $42{\times}1,014 mgC\;m^{-3}\;hr^{-1}$로 chi. ${\alpha}$ 농도와 양의 상관(R=0.47)을 보였다. 식물플랑크톤의 광합성효율을 나타내는 동화계수(AN)두 습지 모두 고습지와 저습지의 AN값의 차이를 보이지 않았지만 동화천습지의 AN값이 평균 8.5gC $gChl^{-1}\;hr^{-1}$로 반월천습지의 평균 5.8gC $gChl^{-1}\;hr^{-1}$보다 높은 값을 보여 인 농도가 높은 동화천습지에서 식물플랑크톤의 광합성효율이 큰 것으로 나타났다. 두 하천의 수질특성으로부터 식물플랑크톤의 광합성효율은 질소보다 인 농도 그리고 작은 TN/TP와 관련이 있는 것으로 사료된다. 낮은 광도에 대한 광합성능력을 나타내는 초기기울기와 동화계수 사이에는 높은 양의 상관(R=0.81)을 보인 것으로 보아, 낮은 광조건에서 광합성능력이 큰 식물플랑크톤이 광합성효율도 큰 것으로 나타났다. 본 연구에서 시화호 인공습지의 open water에서 식물플랑크톤에 의한 유기물생산이 매우 높은 것으로 보아 식물플랑크톤이 습지의 수질 및 수처리효율에 영향을 미칠 것을 판단된다. 습지의 수처리효율을 향상시키기 위해서는 체류시간을 짧게 해주거나 open water의 면적을 줄여 식물플랑크톤의 증식을 억제하거나 또는 증식한 식물플랑크톤이 습지외부로 유출되지 않도록 하는 관리방안이 필요할 것으로 본다.