• Toxicological Research
• /
• v.34 no.1
• /
• pp.49-53
• /
• 2018

Cyclohexanone ($C_6H_{10}O$, CAS No. 108-94-1) is a colorless oily liquid obtained through the oxidation of cyclohexane or dehydrogenation of phenol. It is used in the manufacture of adhesives, sealant chemicals, agricultural chemicals, paint and coating additives, solvent, electrical and electronic products, paints and coatings, photographic supplies, film, photochemicals, and as an intermediate in nylon production. Owing to the lack of information on repeated inhalation toxicity of cyclohexaone, in this study, we aimed to characterize the subacute inhalation toxicity. B6C3F1 mice were exposed to 0, 50, 150, and 250 ppm of cyclohexanone for 6 hr/day, 5 days/week for 4 weeks via whole-body inhalation in accordance with the OECD Test Guideline 412 (subacute inhalation toxicity: 28-day study). Mortality, clinical signs, body weights, food consumption, hematology, serum biochemistry, organ weights, as well as gross and histopathological findings were evaluated between the control and exposure groups. No mortality or remarkable clinical signs were observed during the study. No adverse effects on body weight, food consumption, hematology, serum biochemistry, and organ weights, gross or histopathological lesions were observed in any male or female mice in any of the exposure groups, although some statistically significant changes were observed in organ weights. We concluded that no observable adverse effect level (NOAEL) is above 250 ppm in mice exposed to cyclohexanone for 6 hr/day for 5 days/week.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.59 no.12
• /
• pp.2202-2211
• /
• 2010

The wind power prediction system is composed of a meteorological forecasting module, calculation module of wind power output and HMI(Human Machine Interface) visualization system. The final information from this system is a short-term (6hr ahead) and mid-term (48hr ahead) wind power prediction value. The meteorological forecasting module for wind speed and direction forecasting is a combination of physical and statistical model. In this system, the WRF(Weather Research and Forecasting) model, which is a three-dimensional numerical weather model, is used as the physical model and the GFS(Global Forecasting System) models is used for initial condition forecasting. The 100m resolution terrain data is used to improve the accuracy of this system. In addition, optimization of the physical model carried out using historic weather data in Jeju. The mid-term prediction value from the physical model is used in the statistical method for a short-term prediction. The final power prediction is calculated using an optimal adjustment between the currently observed data and data predicted from the power curve model. The final wind power prediction value is provided to customs using a HMI visualization system. The aim of this study is to further improve the accuracy of this prediction system and develop a practical system for power system operation and the energy market in the Smart-Grid.

• Clinical and Experimental Reproductive Medicine
• /
• v.25 no.3
• /
• pp.305-313
• /
• 1998

Steroid hormone is known to cause the dynamic changes of mammalian uterus during reproductive cycle. However there is little information about the effect of estrogen (E) and progesterone (P) on the expression of various transcription factors involved in gene expression. Thus the present study was designed to demonstrate E and/or P-induced expression of c-Fos, CREB, ATF and HSP70 in rat uterus. Rats, ovariectomized (OVX) for two weeks, were divided into 6 experimental groups, 1) OVX, 2) OVX+V, 3) OVX+E, 4) OVX+P, 5) OVX+E+V, 6) OVX+E+P, and western blotting assay for nuclear extract and immunohistochemical staining were carried out for each experimental group. Treatment of E $(10{\mu}g)$ showed to increase the expression of c-Fos, CREB, ATF, and HSP70, and maximal expression was occured at $3\sim6$ hr after E administration. P (1mg) also increased, but much less than E, the expression of c-Fos, ATF, and HSP70. However, P did not reveal any effect on the expression CREE. P treatment 4 hr after E injection decreased c-Fos, CREB, and ATF expression, but did not show any change in the E-induced HSP70 expression. In immunohistochemical study c-Fos-, CREB-, and ATF-immunoreactivities were confined to the cells of luminal epithelium of uterine endometrium. These results suggest that proliferation and differentiation of rat uterus during reproductive cycle may mediated via expression of transcription factors, such as c-Fos, CREB, ATF, and HSP70.

• The Korean Journal of Physiology and Pharmacology
• /
• v.1 no.5
• /
• pp.597-602
• /
• 1997

Cytochrome P450 2E1 (CYP2E1) is involved in the toxicity and carcinogenicity of a number of solvents and xenobiotics. Like the various types of oxidation pharmacogenetics, the activity of the enzyme shows a discernible interindividual and interethnic variation. However, no pharmacogenetic information on CYP2E1 polymorphism has been available from a Korean population. The aim of this study was to explore the pharmacogenetics of CYP2E1 polymorphism in a native Koreans after an oral 400 mg dose of chlorzoxazone administered to 128 subjects. Urine samples were collected during the subsequent 8-hour period and urinary concentrations of chlorzoxazone and 6-hydroxychlorzoxazone were determined by a high performance liquid chromatography with an ultraviolet detector. The limit of detection in the samples was found to be $0.5\;{\mu}g/ml$. The mean value of the 6-hydroxychlorzoxazone excreted in 8 hr urine expressed as the percentage was 48.2 13.8%. The frequency distribution of percentage of the administered dose excreted as the 6-hydroxy metabolite was unimodally distributed in the subjects studied. However, the values showed wide (7-fold) interindividual difference, ranged from 11.6% to 79.8% of the dose of chlorzoxazone. Thus, it was considered that the pharmacogenetic characteristics of CYP2E1 in a Korean population did not represent multimodal distribution in the 6-hydroxychlorzoxazone excreted in 8-hr urine expressed as the percentage. And the activity of the CYP2E1 in a Korean population seemed to be less compared with that of the Caucasian subjects.

• Journal of Satellite, Information and Communications
• /
• v.10 no.1
• /
• pp.17-21
• /
• 2015

In this paper, we introduce satellite communication for new wireless disaster network to be built on the basis of amateur radio HR (HAM Radio) as a wireless package system, and channel environments of a D2D terminal that tries to connect and communicate with the wireless disaster network. In this disaster network, we propose a LOS component ratio based adaptive channel modeling approach to accurately estimate a variety of channels whose the D2D terminal could have and smoothly transfer to the level of multimedia data based on the Okumura-Hata channel model. As a result of computer simulation, performance of the proposed method was compared with the that of Okumura-Hata model of open area and urban area model and we were confirmed that there is a gain of BER performance from the results of the computer simulation.

• Journal of the Korean Chemical Society
• /
• v.4 no.1
• /
• pp.1-6
• /
• 1957

The mobilities and the electrophoretic phenomena of human serum albumin, and of horse serum albumin, etc., on paper were reported, but there is no information about the mobility and the electrophoretic phenomena of ovalbumin. In this study they are determined and considered at various time durations. The mean value of this mobility is compared with the value determined by the electrophoresis in solution. Also, the mobilities of the electroendosmotic flow, which affect on the mobility seriously, are determined at various time durations. Apparatus and method used, are a closed system type and a method with electrode vessels. It is concluded that: 1) The mobilities of ovalbumin have the nearly constant mobilities at six and eight hours of time durations, but it decreases at ten hours of long time duration. Their mean value is (0.243 ${\pm}$ 0.003)cm./hr./v./cm. toward anode at pH 8.0. 2) Under these experimental conditions, ovalbumin cannot be separated into three fractions (A1, A2, A3) on paper. 3) Most of the factors, which affect on the mobility, are fixed by the initial experimental conditions, but the electroendosmotic flow due to the characteristic capillarity of paper is measured. Then, the mean value of its mobilities shows the good constancy, and the value is (0.073 ${\pm}$ 0.0003)cm/hr./v./cm. toward cathode at pH 8.0. 4) By the above facts, if the same paper and the same experimental conditions are chosen, it may be preferred to determine the mobility of the electroendosmotic flow once time, even when many observations are required.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.27 no.10
• /
• pp.106-112
• /
• 1990

The progress of oxidation of a porous silicon layer(PSL) was studied by examining the temperature dependence of the oxidation and the infrared absorption spectra. Thick OPSL(oxidized porous silicon layer). which has the same properties as thermal $SiO_{2}$ of bulk silicon, is formed in a short time by two steps wet oxidation of PSL at $700^{\circ}C$, 1 hr and $1100^{\circ}C$, 1 hr. Etching rate, breakdown strength of the OPSL are strongly dependent on the oxidation temperature, oxidation atmosphere. And its breakdown field was ${1\MV/cm^-2}$ MV/cm The oxide film stress was determined through curvature measurement using a dial gauge. During oxidation at temperature above $1000^{\circ}C$ in dry $O_{2}$, stress on the order of ${10^9}\dyne/{cm^2}{-10^10}\dyne/{cm^2}$ are generated in the OPSL.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.42 no.6 s.336
• /
• pp.41-52
• /
• 2005

In wireless networks there are various errors, caused by multi-path fading and interference between devices which lower the network Performance. Especially, performance of IEEE 802.IS.3 High-Rate WPAN (Wireless Personal Area Network) which is operated in ISM unlicensed frequency band is easily affected by channel errors. In this paper, we propose a scheduling algorithm which takes channel errors into consideration in scheduling asynchronous data traffic. The proposed scheduling algorithm can allocate CTA(Channel Time Allocation) proportionally in accordance with the requested channel time of each device. It also prevents waste of channel time by allocating CTA of the channel-error devices to other channel-error free devices. After recovering from the channel error, the devices are compensated as much as they conceded during channel error status. Simulation results show that the proposed scheduling algorithm is superior to the existing SRPT(Shortest Remain Processing Time) and RR(Round Robin) in throughput and fairness aspects.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.4
• /
• pp.1745-1754
• /
• 2016

Background: The prime output of Hospital Based Cancer Registries is stage and treatment based survival to evaluate patient care, but because of challenges of obtaining follow-up details a separate study on Patterns of Care and Survival for selected sites was initiated under the National Cancer Registry Programme of India. The results of stage and treatment based survival for head and neck cancers by individual organ sites are presented. Materials and Methods: A standardized Patient Information Form recorded the details and entered on-line at www.hbccrindia.org to a central repository - National Centre for Disease Informatics and Research. Cases from 12 institutions diagnosed between 1 January 2006 and 31 December 2008 comprised the study subjects. The patterns of treatment were examined for 14053 and survival for 4773 patients from five institutions who reported at least 70% follow-up as of 31 December 2012. Results: Surgical treatment with radiation for cancer tongue and mouth showed five year cumulative survival (FCS) of 67.5% and 60.4% respectively for locally advanced stage. Chemo-radiation compared to radiation alone showed better survival benefit of around 15% in both oro and hypo-pharyngeal cancers and their FCS was 40.0%; Hazard Ratio (HR):1.5;CI=1.2-1.9) and 38.7%; (HR):1.7; CI=1.3-2.2). Conclusions: The awareness about the requirement of concurrent chemo-radiation in specifically cancers of the oro and hypopharynx has to be promoted in developing countries. The annual (2014) estimate number of new Head and Neck cancers with locally advanced disease in India is around 140,000 and 91,000 (65%) patients do not receive the benefit of optimal treatment with ensuing poorer survival.

• Journal of Cadastre & Land InformatiX
• /
• v.47 no.2
• /
• pp.39-47
• /
• 2017

The SAR payload of the KOMPSAT-5 is equipped with an X-band (9.66GHz) microwave-based sensor. Especially, since it has a fixed antenna that can be electronically steered with respect to the azimuth and elevation planes, various applications are expected. This study evaluates the production performance and the accuracy of the DEM by producing DEM using the HR and UH mode images of KOMPSAT-5. To evaluate the production performance of the DEM, the sensitivity of DEM was assessed through a baseline analysis and $2{\pi}$ ambiguity; it was found to have good production performance. In addition, to evaluate the accuracy of the produced DEM, 30 check points were compared with SRTM data. As a result, STDEV ${\pm}15-20m$ accuracy was obtained. If the accuracy of the DEM is improved by adjusting the parameters of the filtering method or phase unwrapping method in the future, it will be possible to widely use the KOMPSAT-5 image for environmental and disaster monitoring.