• Journal of Korean Society of Environmental Engineers
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• v.32 no.3
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• pp.256-263
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• 2010

The study was performed to evaluate the effects of chloride concentrations on the ultimate aerobic biodegradability and to use the result as the fundamental data for sea food wastewater treatment. When the organic removal efficiency by chloride concentrations (1,400~18,000 mg/L) was evaluated, microbes adapted to the saline at ${\leq}$ 6,000 mg/L of chloride but treatment efficiency was not improved at ${\geq}$ 12,000 mg/L of chloride because of delayed reaction time. Functional coefficient $Y_I$ of non-biodegradable soluble organic and inert material production coefficient Yp by microbe metabolism increased as chloride concentrations increased. Soluble organic matter ratio by chloride concentration (0~18,000 mg/L) was 10.8~13.1%, inert material production efficiency by microbes metabolism was evaluated as 7.0~24.6%. $NH_3$-N removal efficiencies were 96.2, 96.5, 90.2 and 90.3% using original wastewater HRT 18 hr, 6,000 mg/L chloride concentration HRT 22 hr, 12,000 mg/L chloride concentration HRT 30 hr, and 18,000 mg/L chloride concentration HRT 45 hr, respectively. Nitrification process was more sensitive to salt concentration than organic matter removal to salt concentration. Under ${\geq}$ 6,000 mg/L chloride concentration, conversion rate from $NO_s$-N to $NO_2$-N was low.

• Korean Parent-Child Health Journal
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• v.3 no.2
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• pp.1-17
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• 2000

The purpose of this study was to recognized the sleep activity patterns of the normal infants in Korea. The subject were 41 normal infants who were below 8 weeks old and were born in Taegu city and Kyungbuk province. The measuring instrument the sleep activity was NCASA translated by the Korean-parent-child Health Academic Association. The data that were collected from April, 18 1999 to January 1, 2000 were analysed by the SPSS 7.5 program. The results of the study was summarized as follow; 1) The mean amount of total sleeping hours per day was decreased from $16.27{\pm}1.96$ hr at the 1st week, to $15.19{\pm}2.39$ hr at the 2nd week, to $13.66{\pm}2.40$ hr at the 3 week but increased to $16.55{\pm}5.77$ hr at the 4-8 week after birth. 2) The mean frequency of feeding was increased to $9.43{\pm}2.79$ times at the 3rd week but decreased to $7.55{\pm}1.23$ times at the 4-8th week after birth. 3) The regularity of day time sleep was decreased from 50.00% to 19.79% and that of night time sleep was increased from 51.79% to 72.92%. 4) The regularity of feeding was increased from 30.42% at the 1st week to 50.07% at the 2nd week but decreased 26.34% at the 4-8th week after birth. 5) The longest period of day time sleep was decreased to $2.39{\pm}0.42$ hr at the 3rd week but increased $2.47{\pm}0.69$ hr at the 4-8th week after birth. The longest period of night time sleep was decreased to $2.58{\pm}0.67$ hr at the 2nd week but increased to $3.00{\pm}1.32$ at the 3rd week and $4.30{\pm}1.16$ hr at the 4-8th week after birth. 6) At the 1st week, the 2nd week, the 3rd week after birth, the frequency of day time feeding was positively correlated with the frequency of night time feeding($R_{1week}=0.948^{**}$, $R_{2week}=0.927^{**}$, $R_{3week}=0.779^{**})$. At the 4-8th week after birth, the frequency of night time feeding was negatively correlated with the amount of night time sleep ($R_{4week-8week}=0.875^{*}$). On the basis of above findings, the following is suggested; It is need a longitudinal and transcultural study which are designed for children's sleep and feeding.

• Herbal Formula Science
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• v.12 no.1
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• pp.209-223
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• 2004

Objective: This study was conducted to investigate the effects of Coptidis Rhizoma on the plasma IL-6 and $TNF-{\alpha}$ level in mice by intracerebroventricular(I.C.V.) injection of Lipopolysaccharide (LPS). Method: 6 mice were assigned to each of the Normal group, the Control group, and the individual Experimental groups. In the Normal group only saline was administered intragastrically, and in the Control group LPS was injected intracerebroventricularly 1 hr after intragastric administration of saline. In the Experimental groups Coptidis Rhizoma(0.5g/kg, 1.0g/kg, 3.0g/kg) was administered intragastrically to mice 1 hr prior to LPS (100ng/mouse) I.C.V. Injection. To measure the plasma IL-6 and $TNF-{\alpha}$ level of mice, their blood samples were collected from retro-orbital venous plexus, immediately centrifuged at $4^{\circ}C$, and plasma was removed and stored frozen at $-83^{\circ}C$ for later determination of plasma IL-6 and $TNF-{\alpha}$. Result: 1. LPS I.C.V. Injection increased plasma IL-6 level significantly in a dose-dependent manner compared with Normal group. (P<0.01) The plasma IL-6 concentration reached a significant maximal level about 1 hr after LPS(100ng/mouse) I.C.V. Injection.(P<0.001) 2. Both the 0.5g/kg(Sample A) and 1.0g/kg(Sample B) groups to which Coptidis Rhizoma was administered intragastrically 1 hr prior to LPS(100ng/mouse) I.C.V. Injection showed insignificant lower plama IL-6 level in 1 hr than Control group(P>0.05), and 3.0g/kg group(Sample C) conversely showed higher plama IL-6 level than Control group. 3. LPS I.C.V. Injection increased plasma $TNF-{\alpha}$ level significantly in a dose-dependent manner compared with Normal group.(P<0.05) The plasma $TNF-{\alpha}$ concentration reached a significant maximal level about 1 hr after LPS(100ng/mouse) I.C.V. Injection.(P<0.001) 4. All Sample groups(0.5g/kg, 1.0g/kg, and 3.0g/kg) to which Coptidis Rhizoma was administered intragastrically with each constituent-dose 1 hr prior to LPS(100ng/mouse) I.C.V. Injection showed significant lower $TNF-{\alpha}$ plama level in 1 hr than Control group.(P<0.001) These data revealed that Coptidis Rhizoma might have anti inflammatory effect by reducing the plasma $TNF-{\alpha}$ level in a dose dependent manner in mice LPS I.C.V. Injection.

• Journal of Pharmaceutical Investigation
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• v.30 no.1
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• pp.55-59
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• 2000

Bioequivalence of two cisapride tablets, test drug ($Cisple^{\circledR}$ tablet: Hanmi Pharm Co., Ltd.) and reference drug ($Prepulsid^{\circledR}$ tablet: Janssen Pharm. Co., Ltd.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty two healthy male volunteers were divided randomly into two groups and administered the drug orally at the dose of 10 mg as cisapride in a $2{\times}2$ crossover study. There was a week washout period between administrations. Blood samples were taken at predetermined time intervals for 36 hr and the plasma concentration of cisapride was determined by a HPLC method. $AUC_{0-36hr}$ (area under the plasma concentration-time curve from time zero to 36 hr), $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were estimated from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed no difference in $AUC_{0-36hr},\;C_{max}\;and\;T_{max}$ between two products. The apparent differences of these parameters between two products were less than 20% (i.e., 5.38, 6.17 and 0.00% for $AUC_{0-36hr},\;C_{max}\;and\;T_{max},$ respectively). The powers $(1-\beta)$ for $AUC_{0-36hr},\;C_{max}\;and\;T_{max}$ were over 0.9. Minimal detectable differences $(\Delta)$ at ${\alpha}=0.05,\;1-{\beta}=0.8$ were less than 20% (i.e. 17.67, 14.84 and 19.72% for $AUC_{0-36hr},\;C_{max}\;and\;T_{max},$ respectively). The 90% confidence intervals $(\delta)$ for these parameters were also within ${\pm}20%$ $(i.e.\;-4.97\;{\le}{\delta}{\le}\;15.73,\;-2.53{\le}{\delta}{\le}\;14.86\;and\;-11.55{\le}{\delta}{\le}\;11.55$ for $AUC_{0-36hr},\;C_{max}\;and\;T_{max},$ respectively). These results satisfied the criteria of KFDA guidelines for bioequivalence, indicating the two tablets of cisapride were bioequivalent.

• Journal of Radiation Protection and Research
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• v.23 no.3
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• pp.175-184
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• 1998

In order to calculate dose rates from steam generators to be replaced from Kori unit 1 in 1998, radionuclide inventories inside steam generator were evaluated from smear test results and measured dose rates from S/G tubes withdrawn for the metallographical examination of damaged tubes. Based on the inventories, contact dose rates and dose rates at 1 m from the surface of a steam generator were calculated using the QAD-CG computer code. Contact dose rates ranged from 11.5 mR/hr at the bottom of channel head to 37.7 mR/hr at the middle of shell barrel, and showed no significant difference with dose rates at 1 m from the surface of steam generator. Shielding effects of lead and carbon steel were compared to provide basic shielding data. Lead shield showed excellent shielding effects. Dose rate at 1 m from the middle of S/G shell barrel decreased from 38.6 mR/hr to 15.5 mR/hr with the lead shield of 2 mm thickness. However, carbon steel showed a poor shielding effect even with the thickness of 2.0 cm. This can be explained with the great differences in the attenuation effect and buildup factor between lead and carbon steel for low energy photons.

• International Journal of Highway Engineering
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• v.9 no.4
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• pp.185-192
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• 2007

Newly constructed road is a requisite to be able to carry out BMPs (Best Management Practices) under TMDL(Total Maximum Daily Load) program of the Ministry of Environment. BMPs require pollutant source control during road construction and wash off reduction plan as well as maintenance practices subsequent to construction on the purpose of discharging the minimum wash off non-point source pollutants. The objective of this study is to provide supportive discharged data in evaluating the discharged non-point pollutant load from a highway toll gate area. It can be applied to manage non-point source pollutants on roads. The results validate the first flush phenomenon that it is known to be one of the wash off characteristics in paved area. In addition, the load per unit area and load per unit rainfall duration applying EMC are calculated. The mean load per unit rainfall duration is assessed to be $533.7mg/m^2-hr$ for TSS, $396.2mg/m^2-hr$ for COD, $17.0mg/m^2-hr$ for TN, and $4.8mg/m^2-hr$ for TP. These results show the unitload taken from monitoring are higher than the unit load suggested in the TMDL. It is important to adopt real pollutant unit for road to be able to perform BMP successfully.

• Journal of Korea Water Resources Association
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• v.52 no.3
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• pp.219-226
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• 2019

Recently, research about Low-Impact Development (LID) techniques has been expanded due to problems with the effects of climate change and urbanization that have been increasing. LID technology is used to control flood damage environmentally to reduce runoff and is reduce runoff on city also restore into previous water circulation system from present developed city. However, studies about quantitative data of LID techniques are insufficient. Therefore in this study, the Curve Number (CN) was calculated with the Planter Box, which is storage type LID technology to conduct the water circulation (infiltration, runoff, overflow) analysis. Rainfall intensity scenario (60.4 mm/hr, 83.1 mm/hr, 97.4 mm/hr, 108.2 mm/hr) about water circulation analysis of Planter Box is selected on the basis of probable rainfall intensity table. According to the experimental results, the storage rate of rainwater in Building Planter Box and Street Planter Box was 43.5% to 52.9% and 33.4% to 39%, respectively. In addition, CN value is estimated to 83 at the Planter box and the runoff reduction effect by applying Horton's infiltration capacity curve showed on 51% to 98%.

• Korean Journal of Remote Sensing
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• v.38 no.5_3
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• pp.979-989
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• 2022

We examined changes in the shell valve movements (SVMs) of Mytilus edulis and Crassostrea gigas using a Hall element sensor to investigate the early detection of the toxic dinoflagellate Alexandrium pacificum. No increase or decrease was observed in SVMs caused by the non-toxic algae Isochrysis galbana in both M. edulis and C. gigas. However, when M. edulis and C. gigas were exposed to A. pacificum, which causes paralytic shellfish poisoning, the average SVMs for 12 hours before and after exposure increased from 1.25 times/hr to 2.13 times/hr and 2.23 times/hr to 8.91 times/hr, respectively. After exposure to A. pacificum, the SVMs of M. edulis increased rapidly within 1 hour and then decreased gradually. However, C. gigas showed high SVMs until 4 hours after exposure. SVMs of C. gigas appeared to be more sensitive to toxic dinoflagellate than those of M. edulis. Therefore, these results are expected to be used as basic data for the establishment of a biological monitoring system for early detection of the toxic dinoflagellate A. pacificum.

• Nutrition Research and Practice
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• v.16 no.5
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• pp.604-615
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• 2022

BACKGROUND/OBJECTIVES: This study aimed to investigate cancer-specific survival (CSS) and associated risk factors in elderly gastric cancer (EGC) patients. SUBJECTS/METHODS: EGC patients (≥ 70 yrs) who underwent curative gastrectomy between January 2013 and December 2017 at our hospital were included. Clinicopathologic characteristics and survival data were collected. Receiver operating characteristic (ROC) analysis was used to extract the best cutoff point for body mass index (BMI). A Cox proportional hazards model was used to determine the risk factors for CSS. RESULTS: In total, 290 EGC patients were included, with a median age of 74.7 yrs. The median follow-up time was 31 (1-77) mon. The postoperative 1-yr, 3-yr and 5-yr CSS rates were 93.7%, 75.9% and 65.1%, respectively. Univariate analysis revealed risk factors for CSS, including age (hazard ratio [HR] = 1.08; 95% confidence interval [CI], 1.01-1.15), intensive care unit (ICU) admission (HR = 1.73; 95% CI, 1.08-2.79), nutritional risk screening (NRS 2002) score ≥ 5 (HR = 2.33; 95% CI, 1.49-3.75), and preoperative prognostic nutrition index score < 45 (HR = 2.06; 95% CI, 1.27-3.33). The ROC curve showed that the best BMI cutoff value was 20.6 kg/m². Multivariate analysis indicated that a BMI ≤ 20.6 kg/m² (HR = 2.30; 95% CI, 1.36-3.87), ICU admission (HR = 1.97; 95% CI, 1.17-3.30) and TNM stage (stage II: HR = 5.56; 95% CI, 1.59-19.43; stage III: HR = 16.20; 95% CI, 4.99-52.59) were significantly associated with CSS. CONCLUSIONS: Low BMI (≤ 20.6 kg/m²), ICU admission and advanced pathological TNM stages (II and III) are independent risk factors for CSS in EGC patients after curative gastrectomy. Nutrition support, better perioperative management and early diagnosis would be helpful for better survival.

• Journal of Pharmaceutical Investigation
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• v.33 no.3
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• pp.201-208
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• 2003

Pharmacokinetics and oral bioavailability of levosulpiride was determined in Korean healthy male volunteers. Thirty subjects received a single oral dose (25 mg) of a tablet in a randomized $2{\times}2$ cross-over design. The plasma concentrations of levosulpiride were measured by HPLC and compared with those reported in the literature. Pharmacokinetic parameters for $Isomeric^{\circledR}$ tablet (levosulpiride 25 mg) were revealed as follows: $AUC_{inf}\;737.1{\pm}176.9\;ng{\cdot}hr/ml,\;C_{max}\;56.4{\pm}20.1\;ng/ml,\;T_{max}\;4.2{\pm}1.6\;hr,\;K_a\;1.00{\pm}1.09\;hr^{-1},\;K_{el}\;0.08{\pm}0.02\;hr^{-1},\;and\;t_{1/2}\;8.8{\pm}1.9\;hr$. The rate constant of the absorption phase was obtained based on the first-order kinetics. In the aspect of bioavailability, $Isomeric^{\circledR}$ tablet was bioequivalent to the other product $(Levopride^{\circledR}\;tablet)$ available in the Korea market. Intersubject variations and race differences were show in comparison with the published data in the literature, even though there was a linear relationship between dose ad extent of bioavailability.