• Information Systems Review
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• v.7 no.1
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• pp.81-96
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• 2005

Because the web sites are in common today, the access to the web for disabled people and old aging people, what we call accessibility, becomes more important. Even though efforts to reduce the informational gap resulted from the lack of the accessibility have been carried out, the studies in this field in Korea are not still in popular. In this study, previous research on the measurements for the accessibility is reviewed and then a new model measuring accessibility is suggested. To increase the validity of the measurement, both an automated tool and a manual test are employed. First we used the 'A-Prompt', one of the popular automated validation tools and analyzed web sources, and applied manual tests by HPR Screen Reader. With the error rates calculated, the accessibility of the government web sites between Korea and the United States was compared and finally the conclusions were drawn.

• Journal of the Korea Society of Computer and Information
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• v.11 no.5 s.43
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• pp.165-173
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• 2006

Network Mobility Basic Support protocol enables mobile network to change their point of attachment to the Internet, but causes some problems such as suboptimal muting and multiple encapsulations. The proposed scheme, combining Prefix Delegation protocol with HMIPv6 concept can provide more effective route optimization and reduce the amount of packet losses and the burden of location registration for handoff. It also uses hierarchical mobile network prefix (HMNP) assignment and provides tree-based routing mechanism to allocate the location address of mobile network nodes (MNNs) and support micro-mobility. In this scheme, Mobility Management Router (MMR) not only maintains the binding informations for all MNNs in nested mobile networks, but also supports binding procedures to reduce the volume of handoff signals oyer the mobile network. The performance is evaluated using NS-2.

• BMB Reports
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• v.36 no.1
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• pp.82-94
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• 2003

Although debates still exist whether Helicobacter pylori infection is really class I carcinogen or not, H. pylori has been known to provoke precancerous lesions like gastric adenoma and chronic atrophic gastritis with intestinal metaplasia as well as gastric cancer. Chronic persistent, uncontrolled gastric inflammations are possible basis for ensuing gastric carcinogenesis and H. pylori infection increased COX-2 expressions, which might be the one of the mechanisms leading to gastric cancer. To know the implication of long-term treatment of antiinflammatory drugs, rebamipide or nimesulide, on H. pylori-associated gastric carcinogenesis, we infected C57BL/6 mice with H. pylori, especially after MNU administration to promote carcinogenesis and the effects of the long-term administration of rebamipide or nimesulide were evaluated. C57BL/6 mice were sacrificed 50 weeks after H. pylori infection. Colonization rates of H. pylori, degree of gastric inflammation and other pathological changes including atrophic gastritis and metaplasia, serum levels and mRNA transcripts of various mouse cytokines and chemokines, and NF-${\kappa}B$ binding activities, and finally the presence of gastric adenocarcinoma were compared between H. pylori infected group (HP), and H. pylori infected group administered with long-term rebamipide containing pellet diets (HPR) or nimesulide mixed pellets (HPN). Gastric mucosal expressions of ICAM-1, HCAM, MMP, and transcriptional regulations of NF-${\kappa}B$ binding were all significantly decreased in HPR group than in HP group. Multi-probe RNase protection assay showed the significantly decreased mRNA levels of apoptosis related genes and various cytokines genes like IFN-$\gamma$, RANTES, TNF-$\alpha$, TNFR p75, IL-$1{\beta}$ in HPR group. In the experiment designed to provoke gastric cancer through MNU treatment with H. pylori infection, the incidence of gastric carcinoma was not changed between HP and HPR group, but significantly decreased in HPN group, suggesting the chemoprevention of H. pylori-associated gastric carcinogenesis by COX-2 inhibition. Long-term administration of antiinflammatory drugs should be considered in the treatment of H. pylori since they showed the molecular and biologic advantages with possible chemopreventive effect against H. pylori-associated gastric carcinogenesis. If the final concrete proof showing the causal relationship between H. pylori infection and gastric carcinogenesis could be obtained, that will shed new light on chemoprevention of gastric cancer, that is, that gastric/cancer could be prevented through either the eradication of H. pylori or lessening the inflammation provoked by H. pylori infection in high risk group.

• Journal of Korean Society on Water Environment
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• v.23 no.5
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• pp.781-788
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• 2007

The Carbon source to enhance the denitrification is essential matter in the advanced sewage treatment. For the high level of nutrient removal, external carbons such as ethanol, methanol, volatile fatty acids and so on should be needed. In this study, the methods to increase the sludge solubilization and acidification rate were compared with waste activated sludges and food waste leachate. Ultrasonication and acids were used for the pretreatment of organic particles in sludges. As a results, the optimal temperature and HRT were $60^{\circ}C$ and 5 days, respectively. HAc, HPr, HBr, and other VFAs for acid fermentations reduced up to 22, 16, 14, and 48% with HRT reduction. For the increase of solubilization, 28% of solids destruction rate was shown at 0.3 watts/mL.

• Archives of Pharmacal Research
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• v.22 no.6
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• pp.559-564
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• 1999

In order to discover new cancer chemopreventive agents from natural or synthetic products, a structurally diverse class of chemopreventive agents was evaluated using in vitro biomarker of inhibition of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cultured mouse epidermal 308 (ME)308 cells. As a results, apigenin, benzylisothiocyanate, curcumin, diallyl disulfide, N-(4-hydroxyphenyl)retinamide (4-HPR), menadione, miconazole, nordihydroguaiaretic acid (NDGA) and phenethyl isothiocyanate showed potent inhibitory effects in this process. A chemically diverse group of compounds was included in the evaluation, such as flavonoids, retinoids, isothiocyanates, sulfur-containing compounds and phenolic antioxidant compounds. These data are suggestive to understand the cancer chemopreventive potential mediated by these substances.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.1
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• pp.33-42
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• 2011

In this study, we investigated the natural convection on the outer surface of a vertical pipe by performing mass transfer experiments using fluids with high Pr number using the concept of analogy between heat and mass transfer. A cupric acid-copper sulfate electroplating system was adopted as the mass transfer system. Tests were performed for $Ra_H$ numbers from $1.4{\times}10^9$ to $4{\times}10^{13}$, Pr numbers from 2,094 to 4,173, and diameters from 0.005 m to 0.035 m. The test results for laminar flow conditions were in good agreement with the correlations reported by King, Jakob and Linke, McAdam, and Bottemanne, and those for turbulent conditions with the correlations presented by Fouad for a vertical plate and also proved the dependence on Pr numbers. The obtained correlations were $Nu_H=0.55Ra^{0.25}_H$ for laminar and $Nu_H=0.12Ra^{0.28}_HPr^{0.1}$ for turbulent. The transition between laminar and turbulent occurs at $Ra_H$ of about $10^{12}$.

• Journal of Navigation and Port Research
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• v.39 no.3
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• pp.149-156
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• 2015

The Dynamic Positioning System consists of 7 elements which are namely Power system, Human machine interface, DP Computer, Position Reference System(PRS), Sensors, Thruster system and DP Operator. Incidents like loss of position(LOP) on DP vessel usually occur due to errors in these 7 elements. The purpose of this study is to find out safety operation method of DP vessel through qualitative and quantitative analyze of DP LOP incidents which are submitted to IMCA every year. The 612 DP LOP incidents submitted from 2001 to 2010 were analyzed to find out the main cause of the incidents and its rate among other causes. Consequently, the highest rate of incidents involving DP elements are PRS errors. DP computer, Power system, Human error and thruster system came next. The PRS has been analyzed and a flowchart was drawn through expert brainstorming. Also, the conditional probability has been analyzed through Bayesian Networks based on this flowchart. Consequentially, the main causes of drive off incidents were DGPS, microwave radar and HPR. Also, this study identified the main causes of DGPS errors through Bayesian Networks. These causes are signal blocked, electric components failure, relative mode error, signal weak or fail.

• Korean Journal of Microbiology
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• v.53 no.4
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• pp.292-296
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• 2017

In eukaryote, THO/TREX complex plays a critical role in transcriptional elongation, pre-mRNA processing, and nuclear mRNA export. This complex is evolutionally well- conserved, but there are some differences in composition and function according to organisms. Here we showed that spTex1, a component of THO/TREX complex, is not essential for growth and mRNA export in a fission yeast, Schizosaccharomyces pombe, which is more similar to higher eukaryote than budding yeast. Deletion and overexpression of the spTex1 gene do not lead to any detectable growth phenotype and accumulation of poly(A)+ RNA in the nucleus. And the spTex1-GFP protein is localized mainly in the nucleus. Yeast two-hybrid and Co-immunoprecipitation analysis showed that the spTex1 protein interacted with spHpr1 (THOC1) and spTho2 (THOC2), main subunits of THO complex. We conclude that the S. pombe Tex1 is a component of THO/TREX complex, but does not plays important roles in growth and bulk mRNA export from the nucleus.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2015.07a
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• pp.60-62
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• 2015

Dynamic Positioning System(DPS)은 동력, DP control 장치, DP 컴퓨터, 위치참조시스템(PRS), 센서, thruster 시스템 및 DP 운용자(DPO) 7가지로 구성되어 있다. DP 선박은 이들 구성요소들에 문제가 발생하면 그 기능을 상실할 수 있다. 본 연구에서는 2001~2010년까지 10년 동안 IMCA 보고된 DP 선박 관련사고 612건에 대한 분석을 바탕으로 DPS의 7가지 구성요소와 관련된 사고 원인을 파악하고 이들 중 가장 높은 비율을 차지하는 원인을 정성적, 정량적으로 상세 분석하여 요소별 관계와 주요 작용 요소를 확인하고자 한다. 이를 통해 DP 선박의 LOP사과 관련 분석에 있어 베이지안 네트워크의 활용성을 확인해 보았다. 10년 평균 가장 높은 비율을 차지한 DPS 사고원인 요인은 PRS이었으며 이를 전문가 브레인스토밍을 통해 작성된 flowchart를 바탕으로 베이지안 네트워크를 통해 상세 분석해 본 결과 PRS의 각 요소별 조건부 확률 확인할 수 있었다. DP 선박의 drive off를 발생시키는데 주요한 영향을 미치는 것은 DGPS, microwave radar 및 HPR 이었고 DGPS에 주요한 영향을 미치는 에러 요인은 signal blocked, electric components failure, relative mode error 및 signal weak or fail 이었다.

• Korean Journal of Human Ecology
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• v.19 no.6
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• pp.993-1002
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• 2010

This study sought to determine wether the reliability of the KIP-C is affected by mothers' scores on of MMPI. Particiapants in this study were 100 mothers whose children visited the a children's psychiatric hospital. They were sorted into two groups; diagnosis consistent group and diagnosis inconsistent groups. the diagnosis inconsistent group showed significantly higher scores on L(p<.001) and K(p<.001) scales, while the diagnosis consistent group had higher scores on F, Ma and Si scales. When comparing the KPI-C of the groups, the diagnosis consistent groups showed significantly higher scores in ANX, SOM and HPR scales(p<.05). A correlation analysis of the validity scales of MMPI and the scales of KPI-C also showed significant correlation. It was also shown that the characteristics of the mothers' personality have important effects on their perception of their children's problems. In particular, the stronger the mothers defensive characteristics, the lower the reliability of their perception of their children's problems. Reciprocally, reliability was higher when the mothers acknowledged their problems.