• Mycobiology
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• v.50 no.6
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• pp.448-456
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• 2022

In this study, the roots and rhizosphere soil of Abies koreana and Taxus cuspidata were collected from sites at two different altitudes on Mt. Halla. Ectomycorrhizal fungi (EMF) were identified by Illumina MiSeq sequencing. The proportion of EMF from the roots was 89% in A. koreana and 69% in T. cuspidata. Among EMF in rhizosphere soils, the genus Russula was the most abundant in roots of A. koreana (p < 0.05). The altitude did not affect the biodiversity of EMF communities but influenced fungal community composition. However, the host plants had the most significant effect on EMF communities. The result of the EMF community analysis showed that even if the EMF were isolated from the same altitudes, the EMF communities differed according to the host plant. The community similarity index of EMF in the roots of A. koreana was higher than that of T. cuspidata (p < 0.05). The results show that both altitude and host plants influenced the structure of EMF communities. Conifers inhabiting harsh sub-alpine environments rely strongly on symbiotic relationships with EMF. A. koreana is an endangered species with a higher host specificity of EMF and climate change vulnerability than T. cuspidata. This study provides insights into the EMF communities, which are symbionts of A. koreana, and our critical findings may be used to restore A. koreana.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.39.1-39.1
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• 2019

We trace the cosmological origin of satellites around isolated dwarf galaxies using a very high resolution (12 pc/h) cosmological hydrodynamic zoom simulation. To realistically describe the formation and evolution of small-mass stellar satellites, our model includes a full baryonic physics treatment. We find that the mini-halos form objects resembling dwarf galaxies. The majority of their star forming gas is accreted after reionization, thus the survival of a mini-halo's gas to reionization is not an important factor. Instead, the key factor seems to be the ability for a mini-halo to cool its recently accreted gas, which is more efficient in more massive halos. Although the host galaxy is only a dwarf galaxy itself, we find that ram pressure is an efficient means by which accreted mini-halos lose their gas content, both by interacting with hot halo gas but also in direct collisions with the gas disk of the host. The satellites are also disrupted by the tidal forces near the center of the host galaxy. Compared to the disrupted satellites, surviving satellites are relatively more massive, but tend to infall later into the host galaxy, thus reducing the time they are subjected to destructive environmental mechanisms and dynamical friction.

• Proceedings of the Korean Society of Computer Information Conference
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• 2023.07a
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• pp.709-710
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• 2023

Consumer attitudes and behaviors towards brands are not only related to the perception of corporate brand image but also to factors such as the image of the country of origin, the characteristics of the host country, and consumer individual traits. This article focuses on Chinese multinational companies and aims to study the impact of brand international image and country-of-origin brand image on consumer behavior. A model is constructed with brand international image and country-of-origin brand image as antecedent variables, host country characteristics and consumer traits as moderators, and consumer behavior as the outcome. This study employs a questionnaire survey method targeting foreign residents living in China as participants. The research findings reveal that during the internationalization process, both brand international image and country-of-origin brand image have a significant positive impact on consumer behavior, while host country characteristics and consumer traits play a moderating role. The conclusions of this research enrich the theoretical understanding of brand internationalization and explore the influencing factors of consumer behavior, providing a basis for decision-making for multinational company executives.

• Parasites, Hosts and Diseases
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• v.61 no.4
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• pp.388-396
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• 2023

Entamoeba histolytica is an enteric tissue-invasive protozoan parasite causing amoebic colitis and liver abscesses in humans. Amoebic contact with host cells activates intracellular signaling pathways that lead to host cell death via generation of caspase-3, calpain, Ca²⁺ elevation, and reactive oxygen species (ROS). We previously reported that various NADPH oxidases (NOXs) are responsible for ROS-dependent death of various host cells induced by amoeba. In the present study, we investigated the specific NOX isoform involved in ROS-dependent death of hepatocytes induced by amoebas. Co-incubation of hepatoma HepG2 cells with live amoebic trophozoites resulted in remarkably increased DNA fragmentation compared to cells incubated with medium alone. HepG2 cells that adhered to amoebic trophozoites showed strong dichlorodihydrofluorescein diacetate (DCF-DA) fluorescence, suggesting intracellular ROS accumulation within host cells stimulated by amoebic trophozoites. Pretreatment of HepG2 cells with the general NOX inhibitor DPI or NOX2-specific inhibitor GSK 2795039 reduced Entamoeba-induced ROS generation. Similarly, Entamoeba-induced LDH release from HepG2 cells was effectively inhibited by pretreatment with DPI or GSK 2795039. In NOX2-silenced HepG2 cells, Entamoeba-induced LDH release was also significantly inhibited compared with controls. Taken together, the results support an important role of NOX2-derived ROS in hepatocyte death induced by E. histolytica.

• IMMUNE NETWORK
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• v.23 no.1
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• pp.7.1-7.27
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• 2023

The mammalian intestines harbor trillions of commensal microorganisms composed of thousands of species that are collectively called gut microbiota. Among the microbiota, bacteria are the predominant microorganism, with viruses, protozoa, and fungi (mycobiota) making up a relatively smaller population. The microbial communities play fundamental roles in the maturation and orchestration of the immune landscape in health and disease. Primarily, the gut microbiota modulates the immune system to maintain homeostasis and plays a crucial role in regulating the pathogenesis and pathophysiology of inflammatory, neuronal, and metabolic disorders. The microbiota modulates the host immune system through direct interactions with immune cells or indirect mechanisms such as producing short-chain acids and diverse metabolites. Numerous researchers have put extensive efforts into investigating the role of microbes in immune regulation, discovering novel immunomodulatory microbial species, identifying key effector molecules, and demonstrating how microbes and their key effector molecules mechanistically impact the host immune system. Consequently, recent studies suggest that several microbial species and their immunomodulatory molecules have therapeutic applicability in preclinical settings of multiple disorders. Nonetheless, it is still unclear why and how a handful of microorganisms and their key molecules affect the host immunity in diverse diseases. This review mainly discusses the role of microbes and their metabolites in T helper cell differentiation, immunomodulatory function, and their modes of action.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.5
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• pp.403-411
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• 2024

The global spread of flaviviruses has triggered major outbreaks worldwide, significantly impacting public health, society, and economies. This has intensified research efforts to understand how flaviviruses interact with their hosts and manipulate the immune system, underscoring the need for advanced research tools. RNA-sequencing (RNA-seq) technologies have revolutionized our understanding of flavivirus infections by offering transcriptome analysis to dissect the intricate dynamics of virus-host interactions. Bulk RNA-seq provides a macroscopic overview of gene expression changes in virus-infected cells, offering insights into infection mechanisms and host responses at the molecular level. Single-cell RNA sequencing (scRNA-seq) provides unprecedented resolution by analyzing individual infected cells, revealing remarkable cellular heterogeneity within the host response. A particularly innovative advancement, virus-inclusive single-cell RNA sequencing (viscRNA-seq), addresses the challenges posed by non-polyadenylated flavivirus genomes, unveiling intricate details of virus-host interactions. In this review, we discuss the contributions of bulk RNA-seq, scRNA-seq, and viscRNA-seq to the field, exploring their implications in cell line experiments and studies on patients infected with various flavivirus species. Comprehensive transcriptome analyses from RNA-seq technologies are pivotal in accelerating the development of effective diagnostics and therapeutics, paving the way for innovative treatments and enhancing our preparedness for future outbreaks.

• ALGAE
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• v.39 no.3
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• pp.149-161
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• 2024

Epiphytic algae are important components of marine ecosystems. Despite the importance of epiphytic algae in marine ecosystems, our knowledge of these taxa is still limited. The marine red algal genus Reinboldiella, which is distributed mainly in the northwestern Pacific region, is characterized by tiny thalli that are epiphytic on various other red algae. Six species of the genus have been reported in Japan, Taiwan, and Korea. In this study, 50 Korean Reinboldiella specimens, previously known as Reinboldiella schmitziana, were collected from 11 localities and reexamined to verify their taxonomic status. We describe a new species, Reinboldiella koreana sp. nov., based on rbcL phylogeny and morphological observations. A total of four grateloupiacean species (Pachymeniopsis lanceolata, P. elliptica, Grateloupia turuturu, and G. asiatica) were identified as host species of R. koreana sp. nov. Due to the restricted host range of R. koreana sp. nov., a phylogenetic tree was reconstructed using the cox1 marker to confirm the co-phylogenetic relationships between the epiphytic algae and their grateloupiaceanhosts. Two of the four cox1 haplotypes of R. koreana were found in different host species, regardless of which haplotype they were. It indicates that there are no co-phylogenetic relationships between R. koreana and host species.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.3879-3884
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• 2014

Background: In chronic hepatitis B (CHB), the presence of hepatic steatosis (HS) seems to be associated with known host and viral factors which may influence the long-term prognosis of chronic hepatitis B (CHB), probably leading to cirrhosis and hepatocellular carcinoma (HCC). Different from chronic hepatitis C (CHC), factors associated with HS in CHB are not clearly explored. Materials and Methods: 160 CHB patients were divided into two groups depending on the results of liver biopsy. Group I consisted of 71 patients with confirmed steatosis. Group II comprised 89 patients without steatosis. The groups were compared in terms of basal characteristics, body mass index (BMI), liver enzymes (ALT, AST, ALP), serum fasting blood sugar (FBS) and lipids, hepatitis B e antigen (HBeAg), viral load, and histological findings. Results: In terms of host factors, male gender, older age, BMI, high serum FBS and lipid levels were associated with HS. On the other hand, ALT levels, the HAI scores of necroinflammation and stage of fibrosis did not associate with HS. On multivariate analysis, parameters of sex, BMI, cholesterol and FBS levels were independently associated with HS. Regarding viral factors, HBeAg negativity was significantly associated with HS (81.7%, p value 0.006), but not HBV DNA level (p value 0.520). Conclusions: HS in CHB appears to be unrelated to the status of HBV replication. However, fibrosis progression in CHB is related to variable host factors. HS may be enhanced through these factors in HBV chronic patients.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.79.2-79.2
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• 2015

The $M_{BH}-{\sigma}$ relation for galaxies is a stand-out illustration of the co-evolution of galaxies and their central supermassive black holes (SMBHs); however, how this co-evolution occurs and whether this relation holds for SMBHs of the early universe is still a matter of debate. In order to study this at higher redshifts, quasi-stellar objects (QSOs) are the best targets, due to their large sample size and effective $M_{BH}$ estimation. Nevertheless, it is difficult to examine properties of their host galaxies, simply due to the sheer brightness of the QSO itself. Here, we discuss a distinctive method in studying these QSO host galaxies, via gravitational lensing (GL). GL offers a unique approach in determining the mass of the lens object, in this case the host galaxy. QSOs from the SDSS quasar catalog were searched in the Hubble Space Telescope archives, and GL features around them were visually inspected. One such candidate is SDSS J1114-00; to increase its robustness as a GL system candidate, it was observed with the Inamori-Magellan Areal Camera & Spectrograph (IMACS) on the Magellan Baade Telescope at Las Campanas Observatory, to check whether the GL features have identical colors, meaning they are likely to originate from the same source. After confirmation of such GL systems, a sufficiently large sample will enable us to examine the $M_{BH}-{\sigma}$ relation at various redshifts, and in turn, investigate the co-evolution of SMBHs and their host galaxies.

• Publications of The Korean Astronomical Society
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• v.27 no.4
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• pp.301-303
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• 2012

We present the result of our near infrared J- (${\lambda}=1.25{\mu}m$), H- (${\lambda}=1.63{\mu}m$), and $K_s$-band (${\lambda}=2.14{\mu}m$) imaging of ultraluminous ($L_{IR}$ > $10^{12}L_{\odot}$) and luminous ($L_{IR}=10^{11-12}L_{\odot}$) infrared galaxies (ULIRGs and LIRGs), to investigate their relationship through properties of their host galaxies. We find that (1) for single-nucleus ULIRGs and LIRGs, their spheroidal host galaxies have similar properties, but ULIRGs display a substantially higher level of nuclear activity than LIRGs, suggesting that their infrared luminosity difference comes primarily from the different level of current nuclear activity. We infer that LIRGs and ULIRGs have similar progenitor galaxies, follow similar evolutionary processes, and may evolve into optically-selected QSOs. (2) Largely-separated multiple-nuclei ULIRGs have significantly brighter host galaxies than single-nucleus ULIRGs and LIRGs in $K_s$-band, indicating that multiple-nuclei ULIRGs have a bias towards mergers of intrinsically large progenitor galaxies, in order to produce high infrared luminosity ($L_{IR}$ > $10^{12}L_{\odot}$) even at the early merging stage. (3) We derive dust extinction of host galaxies of ULIRGs and LIRGs to be $A_V$ ~ 14 mag in the optical or equivalently $A_K$ ~ 0.8 mag in the near-infrared $K_s$-band, based on the comparison of host galaxy's luminosities in the J-, H-, and $K_s$-bands.