• 한국도로학회논문집
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• 제17권4호
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• pp.77-87
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• 2015

PURPOSES: It is theoretically well known all over the world, that porous hot mixed asphalt (HMA) with hydrated Lime improves moisture and rutting resistance, and reduces pothole occurrence frequency, as well as the life cycle cost (LCC). METHODS : Addictive in the two different formations of the liquid anti-stripping Agent and powder Hydrated-Lime was applied in this investigation in order to obtain relatively clear results according to their types and conditions. Firstly, the moisture conditions were set, and applied to the porous HMA mixtures with hydrated lime (anti-stripping agent). Next, it was followed by a non-destructive test with the application of three freeze-thaw cycles, which were individually carried out thrice to compare the results of the dynamic moduli. Lastly, the hydrated lime effect related to moisture sensibility to porous HMA has been verified through the analysis of the modulus results regarding the change rate of dynamic modulus per n-cycle. RESULTS: It is clear from this investigation, that the dynamic modulus is inversely proportional to the change in temperature, as the graph representing the rigidity of the thermorheologically simple (TRS) material showed gradual decline of the dynamic modulus with the increase in temperature. CONCLUSIONS: The porous HMA mixture with the anti-stripping agent (hydrated Lime) has been found to be more moisture resistant to freezing and thawing than the normal porous HMA mixture. It is clear that the hydrated lime helps the HMA mixture to improve its fatigue resistance.

• 한국도로학회:학술대회논문집
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• 한국도로학회 2002년도 학술발표회 논문집
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• pp.89-92
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• 2002

본 연구의 목적은 여러 가지의 폐자원중 슬래그 및 폐주물사의 도로포장용 골재로서의 특성을 평가하고, 이를 이용한 다양한 조합의 재활용 아스팔트 혼합물의 소성변형 특성을 평가하는 것이다. 골재특성을 평가하기 위해 입도 및 입형분석, 비중 및 흡수성, 마모저항성, 골재안정성과 같은 시험을 수행하였다. 골재로서의 특성평가 시험 결과 고로슬래그는 비교적 강도 특성이 제강슬래그에 비해 작은 경향을 나타냈다. 마샬배합설계로서 최적 아스팔트 함량이 결정되었고, 그 범위는 7.2%에서 7.5%정도 였다. 재활용 골재를 이용한 조합의 아스팔트 혼합물의 소성변형 특성을 평가하기 위해 간접인장강도시험, 회복탄성계수시험, 크리프 시험을 수행하였다. 재활용 골재를 이용한 아스팔트 혼합물의 소성변형 특성이 일반골재를 이용한 아스팔트 혼합물에 비해 다소 떨어지는 경향을 나타내었다. 다만 현재진행중인 휠트래킹 시험 결과가 나오면 재활용 골재를 활용한 아스팔트 혼합물의 소성변형특성을 좀더 구체적으로 파악할 수 있을 것으로 판단된다.

• 한국도로학회논문집
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• 제18권3호
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• pp.67-74
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• 2016

PURPOSES : This study evaluated the field applicability and laboratory performance of glass fiber-reinforced asphalt (GFRA) mixtures. METHODS : The general hot-mix asphalt (HMA) and GFRA mixtures were paved in five sites, including three national highways, one express highway, and an arterial road, to evaluate field applicability and durability. The plant mixing and construction method for the GFRA were similar to those for the general HMA. The lab performances of the field samples were relatively compared through the mechanical measures from the Marshall stability, indirect tensile strength, and dynamic stability. The field performance was surveyed after a year. RESULTS : The lab tests verified the superior lab performances of the GFRA compared to the general HMA. The Marshall stability of the GFRA increased for about 128% of the general HMA. The indirect tensile strength of the GFRA was 115% greater than that of the general HMA. The dynamic stability of the GFRA resulted in 16,180 reps/mm, which indicated that high rut resistance may be expected. No noticeable defects, such as cracks or deformation, were observed for the GFRA sections after a year. CONCLUSIONS : The lab tests and field survey for the five GFRA sites resulted in superior performances compared to the general HMA. The relatively low-cost GFRA, which required no pre-processing procedures, such as polymer modification, may be a promising alternative to the polymer-modified asphalt mixtures. The long-term performance will be verified by the superior field durability of the GFRA in the near future.

• 인터넷정보학회논문지
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• 제11권2호
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• pp.129-142
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• 2010

무선선서네트워크의 주요 응용분야 중 하나가 유비쿼터스 헬스케어 시스템이다. 하지만 무선센서네트워크가 가지고 있는 과제중의 하나는 데이터 중에 나타나는 높은 손실 율이다. 바이오 센서로부터 들어오는 데이터는 기지국에 도착되지 않을 수 있으며, 이 값은 손실 값(missing value)이 된다. 본 논문은 기지국에서 데이터를 수집하고, 손실 값을 처리한 후, 증상 패턴에 따라 건강상태를 분류하여, 비상시에 적절한 행동을 취할 수 있도록 하는 헬스케어 모니터 에이전트(HMA)를 제안한다. 이 에이전트는 유비쿼터스 헬스케어 환경에 적용되며, 건강상태를 인지하기 위한 증상패턴으로 바이오 센서 및 환자의 가족력으로 부터 생성된 데이터를 사용한다. 손실 값이 나타나면 HMA는 분류하기 전에 증상패턴의 손실 값을 채우기 위한 예측 알고리즘을 수행한다. 시뮬레이션 결과 HMA를 사용한 예측알고리즘이 다른 방법들에 비해 더 정확하게 증상패턴을 분류함을 보여주었다.

• 대한한의학회지
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• 제42권3호
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• pp.165-175
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• 2021

Background: Many herbal medications have been used to treat various liver diseases. But the concerns of herbal medicine induced liver injury also existed. In this respect, we would like to report several cases with imporved elevated liver aminotransferase after treating herbal medicine including Artemisia capillaris. Case Reports: We report four patients with elevated aminotransferase levels (ATLs), which indicate hepatocellular damages. After receiving herbal medicines therapy containing Artemisia capillaris as principal component (HMA), the patients' ATLs were improved. In the first case, the patient's ATLs decreased into normal range after administration of HMA, although they have not been improved with hepatotonics for a long period. In the second case, the patient's ATLs have been elevated after taking anticoagulants. The ATLs were improved with HMA without stopping anticoagulants. In the other two cases, the patients' ATLs were also improved after taking HMA. In addition, there were no changes of previous drugs for treating the corresponding underlying diseases and no adverse events during HMA applications. Result and Conclusion: The four patients received the herbal medicine containing Artemisia capillaris as principal component and showed improvement of ATLs. These cases suggest that HMA can be considered as alternative or complementary remedies to improve various liver diseases.

• The Korean journal of internal medicine
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• 제33권6호
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• pp.1194-1202
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• 2018

Background/Aims: This study evaluated the role of hypomethylating agents (HMA) compared to best supportive care (BSC) for patients with high or very-high (H/VH) risk myelodysplastic syndrome (MDS) according to the Revised International Prognostic Scoring System. Methods: A total of 279 H/VH risk MDS patients registered in the Korean MDS Working Party database were retrospectively analyzed. Results: HMA therapy was administered to 205 patients (73.5%), including 31 patients (11.1%) who then received allogeneic hematopoietic cell transplantation (allo-HCT), while 74 patients (26.5%) received BSC or allo-HCT without HMA. The 3-year overall survival (OS) rates were $53.1%{\pm}10.7%$ for allo-HCT with HMA, $75%{\pm}21.7%$ for allo-HCT without HMA, $17.3%{\pm}3.6%$ for HMA, and $20.8%{\pm}6.9%$ for BSC groups (p < 0.001). In the multivariate analysis, only allo-HCT was related with favorable OS (hazard ratio [HR], 0.356; p = 0.002), while very poor cytogenetic risk (HR, 5.696; p = 0.042), age ${\geq}65years$ (HR, 1.578; p = 0.022), Eastern Cooperative Oncology Group performance status (ECOG PS) 2 to 4 (HR, 2.837; p < 0.001), and transformation to acute myeloid leukemia (AML) (HR, 1.901; p = 0.001) all had an adverse effect on OS. Conclusions: For the H/VH risk group, very poor cytogenetic risk, age ${\geq}65years$, ECOG PS 2 to 4, and AML transformation were poor prognostic factors. HMA showed no benefit in terms of OS when compared to BSC. Allo-HCT was the only factor predicting a favorable long-term outcome. The use of HMA therapy did not seem to have an adverse effect on the transplantation outcomes. However, the conclusion of this study should be carefully interpreted and proven by large scale research in the future.

• Radiation Oncology Journal
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• 제21권4호
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• pp.306-314
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• 2003

목적: K562 세포의 방사선에 의한 세포 사망은 mitotic catastrophe 현상이 위주로 나타나지만 herbimycin A (HMA)에 의하여 apoptosis 반응이 촉진되는 반면 genisteln에 의하여 두 가지 형태의 세포사망이 모두 억제된다. 본 연구에서는 HMA와 genistein에 의한 K562세포의 방사선 유도 세포주기 조절 변화와 세포 사망 양상의 연관성을 조사하였다. 대상 및 방법: 지수증식기의 KS62 세포에 6 MV 선형가속기(Clinac 1,m C, Varian)를 이용하여 200~300 cGy/min의 선량률로 10 Gy를 균일하게 조사하였다. HMA와 genistein은 각각 250 nM와 25$\mu$M농도로 방사선 조사 후 즉시 투여하였다. 실험에서는 세포주기, 오절인자의 발현 및 활성, 노화 및 분화정도 등에 있어서의 시간에 따른 변화를 조사하였다. 결과: 방사선 단독조사에서 KS62세포는 G2기의 정체를 보였으나 정상적인 053을 가지는 세포와는 달리 지속적인 세포주기의 정체를 보이지 않았다. G2정체가 유지되는 동안 cyclin Bl의 점진적인 증가를 관찰할 수 있었으며, 이는 염색체의 복제가 완료되지 않은 상태에서 M기로 진행하여 미성숙한 염색체 응축과 mitotic catastrophe 현상이 나타나는 것과 일치한다. 방사선 조사와 함께 HMA를 투여한 경우에는 G2정체가 빠르게 해소되었으며 동시에 Gl기에서 세포가 정체되는 양상을 보였다. 세포주기 조절인자 cdc2 kinase 활성 증가와 cyclln I와 A 발현 및 CDK2 활성의 감소 등의 현상으로 설명되며, 이는 apoptosis의 증가와 연관성을 갖는다. 반면 genistein의 경우에는 cyclin Bl과 떨cfsc 발현 및 cdc2활성이 모두 감소하는 등 G2정체를 계속 유지하였다. 이와 함께 방사선에 의한 노화와 megakaryocyte로의 분화도 지속되는 것을 관찰할 수 있었다. 결론: HMA와 genistein에 의한 KS62세포의 방사선 유도 세포사망의 변화는 세포주기 조절과 밀접하게 연관되어 있음을 확인하였다. 이는 다양한 방사선 유도 세포사망의 기전을 이해하는 데 독창적인 모델을 제공하며, 방사선을 이용한 암 치료법의 개발에 새로운 표적을 제공할 수 있을 것이다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2005년도 창립60주년 기념 추계 학술대회
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• pp.201.2-201.2
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• 2005

• 한국도로학회논문집
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• 제16권2호
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• pp.19-24
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• 2014

PURPOSES : The study objective was to evaluate rheology and physical properties of SBS-modified warm-mix asphalt (WMA) binders in comparison with hot-mix asphalt (HMA) binders. METHODS : Four different SBS polymers were used to prepare polymer-modified asphalt (PMA) binders, and three different warm-mix additives (WAD) were used to prepare a total of 12 WMA PMA binders. The kinematic viscosity was measured at 115, $135^{\circ}C$. The PG was determined using DSR and BBR. The pass/fail (P/F) temperatures for high and low PG grading were evaluated for HMA PMA and WMA PMA binders. RESULTS : PG 76-22 binders could be prepared by modifying the base binder (PG 64-22) using 4.5 wt% of SBS. The kinematic viscosity (KV) of SBS PMA was increased by 3 times higher than that of base asphalt. The SBS PMA with WAD showed 10% lower KV than that of the normal SBS PMA at $115^{\circ}C$ The high P/F temperatures showed almost no difference between HMA PMA and WMA PMA binders. The high P/F temperature showed very high correlations with KV ($R^2$ > 0.97). The result of SBS modification caused increase of low P/F temperature by $2.7^{\circ}C$ on average. CONCLUSIONS : Since the PMA with WAD showed 10% lower KV than normal (HMA) PMA at $115^{\circ}C$, reducing PMA mixture temperature down to a WMA level was possible in this study. The higher KV binders showed the higher P/F temperature. There was almost no change in high P/F temperature due to the use of WAD. The SBS PMA, showing an increased low P/F temperature, might show somewhat poorer performance at low-temperature, even though the lower PG grade was staying at the same level, i.e., $-22^{\circ}C$.

• 한국도로학회논문집
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• 제14권4호
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• pp.9-18
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• 2012

PURPOSES : This study evaluated the field applicability and laboratory performance of warm-mix asphalt (WMA) as an alternative technology in asphalt pavement. METHODS : The pilot road using two different types of WMA mixture and one HMA mixture was constructed in Waegwan-Seokjeok road construction site and the mixtures were sampled at the asphalt plant for laboratory testings. The field applicability was assessed in environmental aspects, such as $CO_2$ emission, and in aspects of constructibility using the existing equipment and procedure, i.e., thickness and density measurement. The laboratory testings included the moisture susceptibility test by AASHTO T283, dynamic modulus test, triaxial repeated load permanent deformation test, and the fatigue test. RESULTS : The temperatures for production and compaction of WMA were $20{\sim}30^{\circ}C$ lower than those for HMA and therefore, the noxious gas emission were significantly reduced. The field density of WMA pavements was similar or better than that of HMA pavement. From the laboratory testings, it was found that WMA mixtures exhibit comparable performance to HMA mixture in moisture susceptibility, permanent deformation, and fatigue performance. CONCLUSIONS : With these results, it would be concluded that WMA could replace the existing HMA technology without any significant issue. To support this conclusion, it is necessary to track the long-term performance of WMA in pilot road.