• 약학회지
• /
• 제59권5호
• /
• pp.201-206
• /
• 2015

The aim of the present study was to optimize in vitro method for the prediction of drug-induced liver injury using human liver microsomes (HLM). Cytotoxicity test of cyclophosphamide and acetaminophen in HepG2 cells cultured with HLM showed that the newly established condition using 0.375 mg/ml HLM for 24 hr incubation was comparable or more sensitive than the previously established condition using 0.75 mg/ml HLM for 12 hr incubation. Although the cytotoxic effect of troglitazone was completely attenuated by 0.75 mg/ml HLM, it was augmented by 0.375 mg/ml HLM in the presence of the NADPH-generating system. The cytotoxic effect of chlormezanone, a withdrawn drug due to hepatotoxicity in human, was increased by HLM in the presence of the NADPH-generating system. In contrast, the cytotoxic effect of methapyrilene, a withdrawn drug due to hepatotoxicity in rats, was decreased by HLM in the presence of the NADPH-generating system. The present study suggests that the optimized in vitro method using HLM can be useful for the prediction of drug-induced hepatotoxicity.

• 아동학회지
• /
• 제27권3호
• /
• pp.169-187
• /
• 2006

A hierarchical linear model(HLM) provides advantages over existing traditional statistical methods (e.g., ordinary least squares regression, repeated measures analysis of variance, etc.) for analyzing multilevel/longitudinal data or diary methods. HLM can gauge a more precise estimation of lower-level effects within higher-level units, as well as describe each individual's growth trajectory across time with improved estimation. This article 1) provides scholars who study children and families with an overview of HLM (i.e., statistical assumptions, advantages/disadvantages, etc.), 2) provides an empirical study to illustrate the application of HLM, and 3) discusses the application of HLM to the study of children and families. In addition, this article provided useful information on available articles and websites to enhance the reader's understanding of HLM.

• 한국가금학회지
• /
• 제10권1호
• /
• pp.30-34
• /
• 1983

브로일러 사료에 있어서 피혁분의 어분대치 가능성을 검토하기 위하여 브로일러용 초생추 (♀) 240수를 사용하여 6주간의 사양시험을 실시하였다. 양질의 어분과 대치한 피혁분의 사용수준은 0%, 1%, 2%, 4%, 6%이었으며 시험경과 얻어진 성적은 다음과 같다. 1. 본 시험에 사용된 피혁분의 단백질함량은 74.41%, 조회분함량 17.9%, 크롬함량 2.0%이었고 pepsin소화율은 85%이었다. 2. 증체량. 사료섭취량 및 사료효율은 피혁분 4%수준까지든 별 차이를 보이지 않았으나 6%수준에서는 현저히 (p＜0.05) 떨어지는 결과를 보였다. 이러한 결과는 브로일러 사료에서 피혁분을 어분과 대치하여 4%수준까지 사용가능함을 시사한다.

• Journal of Electrical Engineering and Technology
• /
• 제9권3호
• /
• pp.1125-1131
• /
• 2014

Application of residential demand response (DR) programs are currently realized up to a limited extent due to customers' difficulty in manually responding to the time-differentiated prices. As a solution, this paper proposes an automatic home load management (HLM) framework to achieve the household minimum payment as well as meet the operational constraints to provide customer's comfort. The projected HLM method controls on/off statuses of responsive appliances and the charging/discharging periods of plug-in hybrid electric vehicle (PHEV) and battery storage at home. This paper also studies the impacts of different time-varying tariffs, i.e., time of use (TOU), real time pricing (RTP), and inclining block rate (IBR), on the home load management (HLM). The study is effectuated in a smart home with electrical appliances, a PHEV, and a storage system. The simulation results are presented to demonstrate the effectiveness of the proposed HLM program. Peak of household load demand along with the customer payment costs are reported as the consequence of applying different pricings models in HLM.

• 한국인쇄학회지
• /
• 제6권1호
• /
• pp.75-86
• /
• 1988

This is a experiment about change of highlight point by HBU and HLM of auxiliary function of gradation in color scanner. The result of change - over by HBU and HLM are summerized as follows. Therefore, the determination for the effective point and the amount of HBU and HLM are decided by the Table 1 and Table 2.

• 한국시스템다이내믹스연구
• /
• 제8권2호
• /
• pp.253-273
• /
• 2007

To measure the effect of school zone on housing cost, Linear Regression Model is widely used, and school zone is known as a key determinant of housing cost in Korea. However, when the Hierarchical Linear Model (HLM) is applied with the same data, school effect on housing cost becomes statistically non-significant. It is because HLM effectively separates the effect of individual housing's attributes from the group effect. In sum, the housing cost of Kangnam, where good public schools are located, is apparently is higher than that of Kangbuk. However, the school effect on housing cost (Level 2) becomes non-significant when individual housing's attributes (Level 1) are controlled with HLM.

• 한국해양공학회지
• /
• 제35권5호
• /
• pp.327-335
• /
• 2021

Microcracks can rapidly grow and develop in high-strength steels used in offshore structures. It is important to render these microcracks harmless to ensure the safety and reliability of offshore structures. Here, the dependence of the aspect ratio (As) of the maximum depth of harmless crack (a_hlm) was evaluated under three different conditions considering the threshold stress intensity factor (Δk_th) and residual stress of offshore structural steel F690. The threshold stress intensity factor and fatigue limit of fatigue crack propagation, dependent on crack dimensions, were evaluated using Ando's equation, which considers the plastic behavior of fatigue and the stress ratio. a_hlm by peening was analyzed using the relationship between Δk_th obtained by Ando's equation and Δk_th obtained by the sum of applied stress and residual stress. The plate specimen had a width 2W = 12 mm and thickness t = 20 mm, and four value of As were considered: 1.0, 0.6, 0.3, and 0.1. The a_hlm was larger as the compressive residual stress distribution increased. Additionally, an increase in the values of As and Δk_th(l) led to a larger a_hlm. With a safety factor (N) of 2.0, the long-term safety and reliability of structures constructed using F690 can be secured with needle peening. It is necessary to apply a more sensitive non-destructive inspection technique as a non-destructive inspection method for crack detection could not be used to observe fatigue cracks that reduced the fatigue limit of smooth specimens by 50% in the three types of residual stresses considered. The usefulness of non-destructive inspection and non-damaging techniques was reviewed based on the relationship between a_hlm, a_NDI (minimum crack depth detectable in non-destructive inspection), a_{cr N} (crack depth that reduces the fatigue limit to 1/N), and As.

• 한국컴퓨터정보학회논문지
• /
• 제26권5호
• /
• pp.111-117
• /
• 2021

이 연구의 목적은 개인 수준의 문화적 자본과 국가 수준의 사회 복지 지출이 노인의 생활만족도에 영향을 미치는지 실증적 분석을 통해 설명하는데 있다. 본 연구의 방법은 65세 이상의 노인 3,297명의 대상과 OECD국가 중 총9개 국가를 대상으로 HLM(다층모형)분석을 실시하였다. 분석결과 첫째, 생활만족도와 사회계급은 유의미한 영향이 확인되었다. 따라서 노인의 생활만족도를 증진하기 위해서는 사회계층의 차이를 좁힐 수 있는 정책적·실천적 개입 방안이 마련되어져야 할 것이다. 둘째, 노령연금과 유족연금은 생활 만족도에 큰 영향이 확인되지 않았다. 하지만 상호작용 결과, 사회계급은 생활만족도에 유의한 영향을 미치고 있으며 이는 소득불평등도가 낮을수록 생활만족도에 더 정적인 영향을 미치는 것으로 확인되었다. 결론적으로, 개인과 국가 모두 노인의 생활만족도를 증진시키기 위해 다각적인 관점으로 노력해야 함을 시사하고 있다.

• Journal of Information Technology Applications and Management
• /
• 제17권4호
• /
• pp.19-38
• /
• 2010

This paper investigates the effect of stress on knowledge creation. The goal stress of resource inadequacy and job stress had negative influences on knowledge creation. However, the cohesion and mastery climate of team had positive influence on knowledge creation. Therefore this paper verifies the moderate role of the cohesion and mastery climate of team on the relationship between stress and knowledge creation. The model developed was tested using data collected from knowledge based industry with 375 members in 69 teams in 12 different firms. A Hierarchical Linear Model (HLM) was used to test the hypotheses generated from the model. Results show that job stress had a negative influence on knowledge creation as we expected but the goal stress didn't. The mastery climate of team affected knowledge creation positively and moderated the relationship between the goal stress and knowledge creation. Furthermore, the team cohesion had a positive influence on knowledge creation. The study provided some implications that practitioners should consider the stress when they design jobs for team members and suggest them the way to manage their job stress when they work.

• 한국컴퓨터정보학회논문지
• /
• 제22권12호
• /
• pp.163-170
• /
• 2017

The purpose of this study is to introduce policy and theoretical implications by analyzing affecting factors for the elder's happiness. For this study, we analyzed data using HLM. Data include a world value survey(hereafter, WVS) as personal level analysis data and also OECD's Social Expenditure Database(hereafter, SOCX) and database from the World Bank as national level analysis data. The subjects of personal level analysis were the elder who are over 65-years od age, and they were total 3,297 people, and while the subjects of national level analysis were total 9 OECD countries. For the data analysis, hierarchial linear model(HLM) analysis was done by using HML 7.0 program. As a result of analysis, First, for the elderly's happiness, they should improve self-disposition, members of social groups, and social class. Second, the old-age pension and the survivor's pension had no meaningful effect on the happiness. but it was found that self - disposition, social class, gender, and health status showed meaningful interaction effect according to old - age pension, survivor pension, per capita GDP, income inequality. This suggests that efforts to improve the happiness of the elderly should be made at the individual level and the national level at the same time.