• 한국콘텐츠학회논문지
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• 제16권8호
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• pp.247-256
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• 2016

본 연구는 HIV 감염인이 지각하는 사회적 지지와 사회적 낙인이 삶의 질에 미치는 영향에서 희망의 매개효과를 검증하기 위해 수행되었다. 연구대상은 HIV 감염인 197명이며, 상담간호사가 일대일 면접을 통해 사회적 낙인, 사회적 지지, 희망, 삶의 질에 대한 자료를 수집하였다. 매개효과의 분석은 AMOS 21.0 프로그램을 이용하여 구조방정식 모형을 통해 수행하였고, 간접효과의 유의성은 붓스트래핑(Bootstrapping) 방법을 사용하여 분석하였다. 연구결과, 첫째, 사회적 지지는 삶의 질에 유의한 정적 영향을 미쳤고, 사회적 낙인은 유의한 부적 영향을 미쳤다. 둘째, 사회적 지지는 희망에 유의한 정적 영향을 미쳤고, 사회적 낙인은 희망에 유의한 부적 영향을 미쳤다. 셋째, 사회적 지지와 사회적 낙인이 삶의 질에 미치는 영향에서 희망은 유의한 매개효과가 있었다. HIV 감염인의 삶의 질을 향상시키기 위하여 낙인적 시선을 개선하고 사회적 지지체계를 형성하기 위한 적극적인 전략이 요구되며, 주요한 매개역할을 하는 희망을 향상시킬 수 있는 중재프로그램을 개발하여 적용하는 것이 필요하다.

• Journal of Preventive Medicine and Public Health
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• 제56권3호
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• pp.238-247
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• 2023

Objectives: Low adherence to antiretroviral (ARV) therapy in pregnant women with human immunodeficiency virus (HIV) increases the risk of virus transmission from mother to newborn. Increasing mothers' knowledge and motivation to access treatment has been identified as a critical factor in prevention. Therefore, this research aimed to explore barriers and enablers in accessing HIV care and treatment services. Methods: This research was the first phase of a mixed-method analysis conducted in Kupang, a remote city in East Nusa Tenggara Province, Indonesia. Samples were taken by purposive sampling of 17 people interviewed, consisting of 6 mothers with HIV, 5 peer facilitators, and 6 health workers. Data were collected through semi-structured interviews, focus group discussions, observations, and document review. Inductive thematic analysis was also performed. The existing data were grouped into several themes, then relationships and linkages were drawn from each group of informants. Results: Barriers to accessing care and treatment were lack of knowledge about the benefits of ARV; stigma from within and the surrounding environment; difficulty in accessing services due to distance, time, and cost; completeness of administration; drugs' side effects; and the quality of health workers and HIV services. Conclusions: There was a need for a structured and integrated model of peer support to improve ARV uptake and treatment in pregnant women with HIV. This research identified needs including mini-counseling sessions designed to address psychosocial barriers as an integrated approach to support antenatal care that can effectively assist HIV-positive pregnant women in improving treatment adherence.

• 대한수혈학회지
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• 제23권2호
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• pp.152-161
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• 2012

배경: 2012년 1월부터 국내에 신규로 도입되는 고위험군 바이러스 검사시약은 국내 검체를 이용한 성능 시험분석을 실시하여 식품의약품안전청 허가를 득하도록 일부 규정이 개정되었다. 이러한 바이러스 진단시약의 성능시험과 품질관리 규정을 이행하기 위해서는 국내 검체에서 유래된 국가표준물질이 필요하다. 이에 본 연구에서는 바이러스 핵산증폭검사시약의 성능평가와 품질관리를 위하여 다양한 농도로 구성된 HBV, HCV와 HIV의 핵산증폭검사용 혈장유래 표준물질(plasma working standards)을 제조하고자 하였다. 방법: 수혈 부적격의 HCV RNA 양성혈장 43단위, HCV RNA 양성혈장 25단위, 그리고 HIV RNA 양성혈장 26단위에 대해 핵산 정량검사와 유전자형 검사를 실시하였다. 이를 바탕으로 국내에서 유행하는 바이러스의 유전자형을 가진 고농도의 원료혈장을 선정하였다. 또 표준물질의 다양한 농도는 국내외 검사시약의 검출범위에 근거하여 적정한 농도범위를 선택한 후, 다양한 농도로 원료물질을 희석하고, 분병 처리 한 후 정량적으로 분석하였다. 결과: HBV, HCV와 HIV의 체외진단분석기용 핵산증폭검사의 성능평가용 plasma working standards는 총 13종의 다양한 농도물질로 제조되었다. 결론: 국내에서 혈액관련 고위험군 HBV, HCV와 HIV의 체외진단용 핵산증폭검사 시약의 성능 평가에 필요한 바이러스 핵산 검사용 국가표준물질을 처음 제조하여 그 기술을 수립하였다.

• 성인간호학회지
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• 제12권4호
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• pp.497-506
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• 2000

The purpose of this phenomenological study was to explore and describe the experience of people with HIV/AIDS. Three men and three women with HIV/AIDS participated in the study. They were asked open-ended and descriptive questions in order for them to talk about their experience in their own terms. Interviews were audiotaped and transcribed to maintain data integrity and to reduce perceptual bias. The transcripts were analyzed by the Colaizzi method. Member checks from the participants were used to validate the emergent themes. Seven themes emerged from the analysis. 1. People with HIV/AIDS have a strong impact and emotional reaction when receiving positive HIV test results. 2. All people with HIV/AIDS attempt to conceal HIV infection because of fear of stigma or rejection. 3. After the initial brief traumatic reaction to HIV/AIDS diagnosis, all participants feel lonely because they had no one to express or share their own experiences. 4. People with HIV/AIDS reflect on their life, think about the death and dying process and they become depressed. 5. Most participants feel that the family members who know his/her diagnosis are a big source of support. 6. According to the normativeness of infection route of HIV, the degree of guilty feeling differs among participants. 7. Although all participants think medication is a lifeline, the adherence to medication is not maintained because of side effects, denial and concealment of HIV/AIDS. The results of this study may help nurses and other health care workers to implement more efficient nursing strategies for people with HIV/AIDS by more deeply understanding their experience.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.404-415
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• 2018

본 연구는 20-40대 HIV/AIDS의 지식 및 태도를 확인하고, 지식과 태도에 미치는 영향요인을 파악하기 위해 2011년, 2013년 지역사회건강조사 자료를 활용한 2차 자료 분석 연구이다. 연구대상자는 만 20세부터 만 49세로, 최종 분석 대상자는 182,315명이다. 수집된 자료는 t-test, ANOVA, 상관관계분석, 다중회귀분석으로 분석하였다. 연구 결과, HIV/AIDS의 지식은 정답률 69.4%로 높은 지식수준을 보이나, 개별 문항에서 감염경로에 대한 지식이 부족하며, 20대가 가장 낮은 정답율을 보였다. HIV/AIDS의 태도율은 44.3%로 부정적 태도수준을 나타났다. HIV/AIDS 지식 및 태도는 남성일수록, 미혼일수록, 소득이 높을수록 교육 수준이 높을수록, 직업이 농림어업, 주부/무직보다 관리자 및 전문가, 직업군인일수록 지식 및 태도의 점수가 높았다. 지식과 태도 사이에 양의 상관관계(r=0.27, p<.001)를 보였다. 에이즈 관련 지식 및 태도에 영향을 미치는 요인으로, 연령, 결혼상태, 소득수준, 직업, 교육수준이 있었으며 연령별로 차이가 있음을 확인하였다. 따라서, HIV/AIDS 지식수준 향상과 긍정적인 태도 구축을 위해서 일률적이고 획일적인 교육보다는 연령 및 특성별 맞춤형 교육프로그램이 필요하다.

• Archives of Plastic Surgery
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• 제38권4호
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• pp.539-542
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• 2011

Purpose: Despite the increasing number of patients with HIV (human immunodeficiency virus) infection, surgical experience with these patients remains limited in aesthetic and reconstructive surgery. The authors performed breast reconsruction with free TRAM (Transverse Rectus Abdominis Muculocutaneous) flap in HIV infected patient firstly in Korea. Methods: A 53-years-old female with HIV positive underwent delayed breast reconstruction with free TRAM flap and 6 months lateral nipple reconstruction was performed. All procedures were performed according to the HIV infection control guidelines provided by the Korea Centers for Disease Control and Prevention. Results: There were no complications such as infection, hematoma and flap loss and symmetry of breast was achieved. Conclusion: When the operation is performed in line with the guidelines of HIV infection control, breast reconstruction with free flap is possible and can obtain successful results.

• 디지털융복합연구
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• 제13권11호
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• pp.255-265
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• 2015

본 연구는 의학전문대학원 학생의 HIV/AIDS에 대한 지식과 태도를 조사하기 위해 시행된 횡단적 서술적 조사연구이다. 연구대상은 J도의 일 대학 의학전문대학원 3학년 학생 97명으로 2014년 8월 4일부터 12월 8일까지 자료수집이 실시되었으며, 수집된 자료는 SPSS WIN 19.0 프로그램을 이용하여 분석하였다. 연구결과 의학전문대학원 학생들의 HIV/AIDS 관련 지식과 태도는 각각 15점 만점에 평균 8.91, 7.00으로 나타났으며, 지식과 태도는 대상자들의 특성에 따라 통계적으로 유의한 차이가 없었다. 대상자들의 HIV/AIDS 관련 지식과 태도 간에는 통계적으로 유의한 양적 상관관계(r=.34, p<.01)를 보여 지식이 높을수록 태도 또한 긍정적인 경향을 보임이 확인되었다. 본 연구결과는 예비의료인 및 의료인의 HIV/AIDS 관련 지식을 증진시키고 부정적인 태도를 감소시키는 것을 목적으로 하는 효과적인 교육제공을 위한 구체적인 실행전략 개발에 유용하게 이용될 수 있다.

• Journal of Preventive Medicine and Public Health
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• 제29권2호
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• pp.331-346
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• 1996

Exploring the epidemiological trend of HIV/AIDS is required for making the national AIDS policy. In this study, the trend of HIV/AIDS incidence, rout of transmission and some characteristics of AIDS for the past 11 years in Korea using the reported cases from the national STD screening scheme were reviewed. Based on the results, the trend of main route of transmission according to the year was established by stage and the HIV/AIDS cases in this year was estimated and that to the year 2000 was projected by 'Epimodel' programme. The results were as follows : 1. Of the total infected persons, 76% were in their twenties and thirties, socioeconomically and sexually active age groups. While the transmission by sexual contact overseas was decreasing, the infection through domestic heterosexual and homosexual contact was increasing. 2. In the middle of the 1980's, the infected persons were mainly prostitutes infected through heterosexual contact with the HIV positive foreigner in this county(stage 1). And in the late of the 1980's the main source of infection was the sexual contact overseas and the domestic heterosexual contact(stage 2). Since the early of the 1990's, the infection through the heterosexual contact with non-regular sexual partner in this country has increased rapidly(stage 3), which was the evidence of the possibility of HIV epidemics. After that, it was expected that the infection through the homosexual contacts, the heterosexual contacts with commercial sex workers outside and the non-regular sexual contact inside of this country would increase continuously. In the result, the occurrence of neonatal infection by vertical transmission was expected(stage4). 3. The number of HIV/AIDS was estimated at 572 to 2,313 and the projected number of HIV/AIDS to the you 2000 was around 5,800 including 627 AIDS patients. For the further study on the estimation and projection of HIV/AIDS, it was suggested that the sampling survey on the HIV infection rate in the high risk groups and the sentinel hospital surveillance system should be conducted.

• Tuberculosis and Respiratory Diseases
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• 제47권6호
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• pp.843-849
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• 1999

저자들은 AIDS 환자에서 뉴모시스티스 카리니 폐렴과 유사한 임상소견과 방사선학적 소견을 보였으나, 기관지 폐포세척술과 경기관지 폐생검상 조직학적으로 비특이적 간질성 폐렴으로 확진된 1예를 경험하여 이를 보고하는 바이다.

• BMB Reports
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• 제51권8호
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• pp.388-393
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• 2018

The activating transcription factor (ATF) 4 belongs to the ATF/CREB (cAMP Response Element Binding bZIP [Basic Leucine Zipper]) transcription factor family, and plays a central role in the UPR (Unfolded Protein Response) process in cells. The induction of ATF4 expression has previously been shown to increase the replication of HIV-1. However, the detailed mechanism underlying this effect and the factors involved in the regulation of ATF4 function are still unknown. Here, we demonstrate first that knocking out ATF4 using siRNA shows a strong negative effect on HIV-1 production, indicating that ATF4 is a functional positive cellular factor in HIV-1 production. To determine the mechanism by which ATF4 regulates the HIV-1 life cycle, we assessed the effect of the overexpression of wild type ATF4 and its various derivatives on HIV-1 LTR-mediated transcriptional activation and the production of HIV-1 particles. This effect was studied through co-transfection experiments with either reporter vectors or proviral DNA. We found that the N-terminal domains of ATF4 are involved in HIV-1 LTR-mediated transcriptional activation, and thus in HIV-1 production.