• Clinical and Experimental Pediatrics
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• 제57권3호
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• pp.117-124
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• 2014

Purpose: Administration of antiretroviral drugs to mothers and infants significantly decreases mother-to-child human immunodeficiency virus (HIV) transmission; cesarean sections and discouraging breastfeeding further decreases this risk. The present study confirmed the HIV status of babies born to mothers infected with HIV and describes the characteristics of babies and mothers who received preventive treatment. Methods: This study retrospectively analyzed medical records of nine infants and their mothers positive for HIV who gave birth at Korea University Ansan Hospital, between June 1, 2003, and May 31, 2013. Maternal parameters, including HIV diagnosis date, CD4+ count, and HIV ribonucleic acid (RNA) copy number, were analyzed. Infant growth and development, HIV RNA copy number, and HIV antigen/antibody test results were analyzed. Results: Eight HIV-positive mothers delivered nine babies; all the infants received antiretroviral therapy. Three (37.5%) and five mothers (62.5%) were administered single- and multidrug therapy, respectively. Intravenous zidovudine was administered to four infants (50%) at birth. Breastfeeding was discouraged for all the infants. All the infants were negative for HIV, although two were lost to follow-up. Third trimester maternal viral copy numbers were less than 1,000 copies/mL with a median CD4+ count of $325{\mu}L$ ($92-729{\mu}L$). Among the nine infants, two were preterm (22.2%) and three had low birth weights (33.3%). Conclusion: This study concludes that prophylactic antiretroviral therapy, scheduled cesarean section, and prohibition of breastfeeding considerably decrease mother-to-child HIV transmission. Because the number of infants infected via mother-to-child transmission may be increasing, studies in additional regions using more variables are necessary.

• BMB Reports
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• 제51권8호
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• pp.388-393
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• 2018

The activating transcription factor (ATF) 4 belongs to the ATF/CREB (cAMP Response Element Binding bZIP [Basic Leucine Zipper]) transcription factor family, and plays a central role in the UPR (Unfolded Protein Response) process in cells. The induction of ATF4 expression has previously been shown to increase the replication of HIV-1. However, the detailed mechanism underlying this effect and the factors involved in the regulation of ATF4 function are still unknown. Here, we demonstrate first that knocking out ATF4 using siRNA shows a strong negative effect on HIV-1 production, indicating that ATF4 is a functional positive cellular factor in HIV-1 production. To determine the mechanism by which ATF4 regulates the HIV-1 life cycle, we assessed the effect of the overexpression of wild type ATF4 and its various derivatives on HIV-1 LTR-mediated transcriptional activation and the production of HIV-1 particles. This effect was studied through co-transfection experiments with either reporter vectors or proviral DNA. We found that the N-terminal domains of ATF4 are involved in HIV-1 LTR-mediated transcriptional activation, and thus in HIV-1 production.

• 대한두개안면성형외과학회지
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• 제20권3호
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• pp.191-194
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• 2019

In branchial lymphoepithelial cyst (BLEC), which is also known as branchial cleft cyst, the remnants of a branchial arch develop into a cyst, causing swelling. The first case of BLEC in the parotid gland was reported by Hildebrant in 1895. Since then, BLEC in the parotid gland has continued to be reported, but in rare cases. A 45-year-old man presented to our hospital with a swelling of the left cheek of approximately 6 months' duration. The patient underwent a superficial parotidectomy and was pathologically diagnosed with BLEC. Of note, this was the first case of non-human immunodeficiency virus (HIV)-related BLEC of the parotid gland in South Korea. BLEC is a benign condition, but its treatment depends on the presence of HIV infection. In HIV-negative patients, BLEC does not require a further work-up to evaluate metastasis. Our case report describes the diagnosis and treatment of BLEC in a patient without HIV.

• 대한간호학회지
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• 제47권6호
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• pp.781-793
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• 2017

Purpose: This study aimed to understand the meaning and essence of the life experiences of uninfected women living with HIV-infected husbands. Methods: This qualitative study adopted van Manen's hermeneutic phenomenological method. Study participants were 8 females whose husband had been diagnosed with HIV for longer than 6 months, who had known about their husband's infection for more than 6 months, who were in a legal or common-law marriage and were living with their husbands at the time of interview for this study, and whose HIV antibody test results were negative. Data were collected from in-depth individual interviews with the participants from May to August 2016, and from related idiomatic expressions, literature, artwork, and phenomenological references. Results: The following essential themes were identified regarding the life experiences of uninfected women living with HIV-infected husbands: 'experiencing an abrupt change that came out of the blue and caused confusion', 'accepting one's fate and making desperate efforts to maintain one's family', 'dealing with a heavy burden alone', 'experiencing the harsh reality and fearful future', and 'finding consolation in the ordeal'. Conclusion: This study provided a holistic and in-depth understanding of the meaning and essence of the life experiences of uninfected women living with HIV-infected husbands. Thus, this study recognizes these unnoticed women as new nursing subjects. Further, the present findings can be used as important basic data for the development of nursing interventions and national policy guidelines for uninfected women living with HIV-infected husbands.

• Journal of Preventive Medicine and Public Health
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• 제57권4호
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• pp.370-378
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• 2024

Objectives: Comorbidities increase susceptibility to severe coronavirus disease 2019 (COVID-19) infections, but limited information has been published regarding human immunodeficiency virus (HIV) and COVID-19 co-infections. This study explored the relationships among socioeconomic characteristics, sexual behaviors, and COVID-19 infection rates among Korean men who have sex with men (MSM) who are also living with HIV. Methods: Data were collected through a web survey aimed at members of the largest gay portal site in Korea, supported by the National Research Foundation of Korea (n=1005). The primary independent variables included COVID-19-related vaccinations and sexual behaviors. The dependent variable was the incidence of COVID-19 infection among respondents during the pandemic. For statistical analysis, hierarchical multiple logistic regression was performed, controlling for potential confounding variables. Results: Model I indicated that older MSM were less likely to contract COVID-19 (adjusted odds ratio [aOR], 0.98; 95% confidence interval [CI], 0.96 to 0.99). Model II demonstrated that HIV-positive MSM were nearly twice as likely to be infected with COVID-19 compared to their HIV-negative counterparts (aOR, 1.97; 95% CI, 1.14 to 3.41). Furthermore, even after accounting for COVID-19 vaccination status in model III, HIV-positive MSM continued to show a higher risk of infection (aOR, 1.93; 95% CI, 1.12 to 3.35). Conclusions: The findings of this study indicate that HIV-positive MSM are at an increased risk of contracting COVID-19, even when their vaccination status is considered. Therefore, it is essential to prioritize the prevention of COVID-19 infections in HIV-positive individuals by administering appropriate antiretroviral therapy and ensuring adherence to public health guidelines.

• 정신신체의학
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• 제11권1호
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• pp.15-24
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• 2003

본 연구의 목적은 HIV감염자, 폐결핵환자, 정상인간에 스트레스지각과 삶의 질을 비교하는데 있다. 스트레스 지각 및 정신병리는 각각 스트레스 반응 척도(Stress Response Inventory)와 간이정신진단검사(SCL-90-R)를, 삶의 질은 스미스클라인비참 삶의 질 척도(SmithKline Beecham Quality of Life Scale)를 이용하여 평가하였다. HIV감염자들이 폐결핵환자, 정상인들보다 스트레스반응 점수에 있어서는 긴장, 분노, 우울, 피로, 좌절 점수가 각각 유의하게 더 높았다. 정신병리에서는 HIV감염자들이 폐결핵환자, 정상인들보다 신체화, 우울, 불안, 적대감, 공포불안, 편집증, 정신증 하위척도 점수에서 각각 유의하게 더 높았다. 삶의 질의 비교에서는 HIV감염자군이 폐결핵환자군보다 삶의 질이 유의하게 더 낮았다. HIV감염자들은 연령이 낮을수록, 교육기간이 길수록 신체화, 강박증, 대인민감성, 공포불안, 편집증, 정신증 등 정신병리 점수가 더 높았다. 이상의 결과들은 HIV감염자들이 폐결핵환자들과 정상인들에 비해 스트레스지각이 더 높고 더 많은 정신병리를 가지고 있으며 삶의 질이 저하되어 있음을 시사한다.

• 정신신체의학
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• 제10권2호
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• pp.120-129
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• 2002

연구목적: 본 연구의 목적은 HIV감염자, 폐결핵환자, 정상인간에 스트레스지각과 삶의 질을 비교하는데 있다. 방법: 스트레스 지각 및 정신병리는 각각 스트레스 반응 척도 (Stress Response Inventory) 와 간이정신진단검사 (SCL-90-R)를, 삶의 철은 스미스클라인비챰 삶의 질 척도 (SmithKline Beecham Quality of Life Scale)를 이용하여 평가하였다. 결과: HIV감염자들이 폐결핵환자, 정상인들보다 스트레스반응 정수에 있어서는 긴장, 분노 우울, 피로, 좌절 점수가 각각 유의하게 더 높았다. 정신병리에서는 HIV감염자들이 폐결핵환자 정상인들보다 신체화, 우울, 불안, 적대감, 공포불안, 편집중, 정신증 하위척도 점수에서 각각 유의하게 더 높았다. 삶의 질의 비교에서는 HIV 감염자군이 폐결핵환자군보다 삶의 질이 유의하게 더 낮았다. 연령이 낮을수록, 교육기간이 길수록 신체화, 강박증, 대인민감성, 공포불안, 편집증, 정신증 등 정신병리 점수가 더 높았다. 결론: 이상의 결과들은 HIV감염자들이 폐결핵환자들과 정상인들에 비해 스트레스지각이 더 높고 더 많은 정신 병리를 가지고 있으며 삶의 질이 저하되어 있음을 시사한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4487-4490
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• 2012

This study aimed to screen for anal cancer and to determine its cytomorphology using liquid-based cytology (LBC) with specimens preserved in 95% ethyl alcohol. Anal swabs were collected for cytological examination from 177 adult, HIV-infected patients. After collection, sample slides were reviewed and classified according to their cytomorphology using the modified Bethesda 2001 system. An abnormal anal Pap smear was found in 26.0% of the patients. The diagnoses were: 66.7% negative for intraepithelial lesions (NIL), 14.1% with atypical squamous cells of undetermined significance (ASC-US), 10.7% (19) with low-grade squamous intraepithelial lesions (LSIL), and 1.13% with high-grade squamous intraepithelial lesions (HSIL). The cytological evaluation was an unsatisfactory result only with 6.67%. The present modified LBC using 95% ethyl alcohol as the preservative could thus be used for anal cancer screening. The number of SILs in Thai HIV-infected patients is lower than that in Western countries. We found anal cytology a satisfactory tool for early screening and detection of anal dysplasia commonly found in high-risk, HIV-infected patients.

• BMB Reports
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• 제54권11호
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• pp.551-556
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• 2021

In this study, we investigated how Staufen1 influences the HIV-1 production. The overexpression of Staufen1 increased virus production without any negative affect on the viral infectivity. This increase was not caused by transcriptional activation; but by influencing post-transcriptional steps. Using multiple Gag protein derivatives, we confirmed that the zinc-finger domains of the HIV-1 nucleocapsid (NC) are important for its interaction with Staufen1. We also found that Staufen1 colocalized in stress granules with the mature form of the HIV-1 NC protein.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.404-415
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• 2018

본 연구는 20-40대 HIV/AIDS의 지식 및 태도를 확인하고, 지식과 태도에 미치는 영향요인을 파악하기 위해 2011년, 2013년 지역사회건강조사 자료를 활용한 2차 자료 분석 연구이다. 연구대상자는 만 20세부터 만 49세로, 최종 분석 대상자는 182,315명이다. 수집된 자료는 t-test, ANOVA, 상관관계분석, 다중회귀분석으로 분석하였다. 연구 결과, HIV/AIDS의 지식은 정답률 69.4%로 높은 지식수준을 보이나, 개별 문항에서 감염경로에 대한 지식이 부족하며, 20대가 가장 낮은 정답율을 보였다. HIV/AIDS의 태도율은 44.3%로 부정적 태도수준을 나타났다. HIV/AIDS 지식 및 태도는 남성일수록, 미혼일수록, 소득이 높을수록 교육 수준이 높을수록, 직업이 농림어업, 주부/무직보다 관리자 및 전문가, 직업군인일수록 지식 및 태도의 점수가 높았다. 지식과 태도 사이에 양의 상관관계(r=0.27, p<.001)를 보였다. 에이즈 관련 지식 및 태도에 영향을 미치는 요인으로, 연령, 결혼상태, 소득수준, 직업, 교육수준이 있었으며 연령별로 차이가 있음을 확인하였다. 따라서, HIV/AIDS 지식수준 향상과 긍정적인 태도 구축을 위해서 일률적이고 획일적인 교육보다는 연령 및 특성별 맞춤형 교육프로그램이 필요하다.