• Molecules and Cells
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• v.42 no.1
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• pp.56-66
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• 2019

Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif. The HIT superfamily can be divided to five classes with functions in galactose metabolism, DNA repair, and tumor suppression. HINTs are highly conserved from archaea to humans and function as tumor suppressors, translation regulators, and neuropathy inhibitors. Although the structures of HINT proteins from various species have been reported, limited structural information is available for fungal species. Here, to elucidate the structural features and functional diversity of HINTs, we determined the crystal structure of HINT from the pathogenic fungus Candida albicans (CaHINT) in complex with zinc ions at a resolution of $2.5{\AA}$. Based on structural comparisons, the monomer of CaHINT overlaid best with HINT protein from the protozoal species Leishmania major. Additionally, structural comparisons with human HINT revealed an additional helix at the C-terminus of CaHINT. Interestingly, the extended C-terminal helix interacted with the N-terminal loop (${\alpha}1-{\beta}1$) and with the ${\alpha}3$ helix, which appeared to stabilize the dimerization of CaHINT. In the C-terminal region, structural and sequence comparisons showed strong relationships among 19 diverse species from archea to humans, suggesting early separation in the course of evolution. Further studies are required to address the functional significance of variations in the C-terminal region. This structural analysis of CaHINT provided important insights into the molecular aspects of evolution within the HIT superfamily.

• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.187-194
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• 2022

Protein Arginine Methyltransferase 5 (PRMT5), a significant member of the PRMT family, is a promising anticancer target. In this study, novel small compounds that act against the PRMT5 target are found by combining virtual screening with ChEMBL database medicines and Density Functional Theory. The ChEMBL database compounds were screened to retrieve the hit molecules, which further subjected for DFT analysis. Finally we have evaluated that ChEMBL- approved drugs such as Lifitegrast, Abiraterone acetate and Solifenacin may be potential inhibitors for PRMT5.

• Journal of Family Resource Management and Policy Review
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• v.12 no.4
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• pp.47-62
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• 2008

This study investigated the experience of physical violence among adolescents and the domestic variables explaining sibling violence. Data were collected from 501 adolescents in 2007 and analyzed using SPSS 16.0. The statistics used for analysis were the T-Test, two-way ANOVA, and regression. Findings indicated that 45% of the sample population had experienced sibling violence and the most common acts were "hit with hand or objects". The violence of parents toward their children, gender, and the frequency of conflict between siblings were associated with sibling violence. From these results, the study proposed that education about sibling violence should be included in social work programs.

• The Transactions of the Korea Information Processing Society
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• v.4 no.9
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• pp.2269-2279
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• 1997

SVLIW (Superscalar VLIW) processor, a family of VLIW processors schedules very long instruction words at runtime. If a very long instruction word that is to be issued occurs data dependence relations and/or resource conflicts with those words that were under execution, a long NOP word is issued instead of the word until all the data dependence relations and/or resource conflicts have been resolved. Thus, LNOPs can be removed in object codes for SVLIW processors. In this paper, we measure an improvement of the cache hit ratio caused by removing LNOPs in the object code. We also analyze an improvement of the processor performance due to higher cache hit ratio of the processor. Benchmark tests promise that the performance of SVLIW processors is improved more than 5% compared with that of traditional VLIW processors.

• Journal of Families and Better Life
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• v.23 no.4 s.76
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• pp.1-15
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• 2005

Korean society is experiencing rapid changes which are certain to shape the lives of the older people and their families. So, the purpose of this study was to improve the quality of the elderly welfare service in Korea. Even though the interest about the elderly welfare in Korea is rapidly on the increase, the reality of Korean Society still leaves much to be desired, quantitatively as well as qualitatively. Pay attent to this point, now going to grasp the situation of not the handicapped elder people but the general elder people actual life condition and demand for welfare. So this study focused on the demand of not out-of home service but in-home care service. It was based on the data from by Korea National Statistical Office, having observed 6,139 elderly people. The results were as follows. They hope to get the elderly welfare services about health examination service, nursing survice, supporting service for household. That was, the most of them wanted in-home care service than out-of home care service. To ensure effective care to the elderly, it needed development and settlement of welfare service in face of their daily living. And, even though they recognized that they should cover the elderly life expenses themselves, the rate was hit that indicated their adult children as a parents supporter. This means that we should consider not only to the elder people but also to the family which contained the old people as the elderly welfare service. As a remedy, we can find the cooperation between elder welfare service at the social welfare organization and counsel, education at the family strengthen center. To improve the quality of the elderly welfare service in Korea, the elderly welfare service should focus not only on the physical and spiritual health maintenance but also active understanding living environment and growing ability to arbitrate between individual and living.

• Journal of Applied Tourism Food and Beverage Management and Research
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• v.10
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• pp.187-202
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• 1999

We desperately recognize from the economic situation in IMF crisis that only competive goods and serviced. It is anticipated that this difficult situation will probably be continued till 1999. Therefore, it is necessary to think over real aspects of eating=outdoors in IMF period and to provide an opportunity to confront with this crisis. Analysis a recent tendency of domestic eating-outdoors business, there appears, first of all, dual types of eating-outdoors; the one is a sort of 'Cost Sale', which provides some special menu with lowest prices, and the other is a type of 'Family Restaurant', which regards the atmosphere of the place as one of the most essential elements. Both types are getting more popular today. As the result, neither of the alternative cannot recover the current Depression. It is natural that no other conditions can compete with good tastes, fancy atmosphere, and good prices. As a matter of fact, however, it is quite difficult to run this type of bussiness adjusted the above whole conditions. Therefore owners of eating-house must decide to run either ' Cost Sale' or 'Family Restaurant' first and investigate some problems and conditions accordingly. In ane way, the owner intensively visits to some eating houses which is similar style in size and management to that of his style in size and management to that of his and look over what is good and what is bad Right after this investigation, it is efficient for he or she to improve his or her business style in size and management in a short period. It is helpful to check some complements; improvement of signboards, cleaning up of the interior, selecting suitable menu, adjusted prices, tastes, and service quality etc. Although eating-outdoors business is hard hit by IMF, We hope that it would rapidly be brisk in 2000, becaused by that time the basis of each industry would be high qualified, and rich technology would be accumulated.

• Journal of Korean Society on Water Environment
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• v.34 no.6
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• pp.602-620
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• 2018

Korean benthic macroinvertebrate community from 959 sites and 14 environmental factors that could affect the biological distribution were surveyed and analyzed. The 438 taxa were divided into six groups according to TWINSPAN. Based on the environmental factor values corresponding to each taxon, the average and range of environmental factors for each biological group tended to increase or decrease in eight environmental factors (altitude, slope, current velocity, fraction of fine particles in substrates, turbidity, $BOD_5$, T-N and T-P). As a result of discriminant analysis (hit ratio: 69.6 %), environmental factors that significantly influence the distribution of each biological group were $BOD_5$, altitude, catchment area, T-N, T-P and fraction of fine particles in substrates. The discriminant functions 1 and 2 classified the existing six biological groups (clustered by TWINSPAN) into five (group 1: highland highly sensitive group; group 2: lowland sensitive group, group; 3 and 4: lowland slightly tolerant group; group 5: lowland tolerant group; group 6: lowland highly tolerant group). Most of the benthic macroinvertebrates were identified in the species level. However, a few others were identified in genus or family level, too. Even the organisms belonging to the same genus or family may prefer different environmental factors in the species level, the identification of characteristic of the habitat environment preferred by organism and species level identification of these organisms are utmost. The results of this study may be used as basic information on environmental factors which can be considered in preservation and restoration research for biodiversity.

• Human Ecology Research
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• v.55 no.3
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• pp.275-287
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• 2017

The recent Great Recession of 2008 was a period of sharp economic decline throughout the late 2000s. All socio-demographic groups were impacted by the economic downturn, however, Hispanic households were particularly hard hit. It is not a recent phenomenon that minority groups often have greater problems related to credit and debt repayments. A better understanding of these racial/ethnic differences in credit and debt has been hindered by the propensity of many studies to pool all racial/ethnic minorities together and compare them to white households. Using a Heckman-type selection model with a combination of the 2010 and 2013 Survey of Consumer Finances datasets to study household debt repayment problems, we found that racial/ethnic groups have been differently impacted by the recent Great Recession in terms of debt repayment problems. Hispanic households were less likely to hold debt; however, those with debt were just as likely as white households and African American households to be delinquent in repayments. This finding is contrary to prior research that indicated Hispanics with debt were less likely than white and African American households to be delinquent on repayments prior to the Great Recession of 2008. We propose possible explanations for the increase in debt repayment problems, that includes increased assimilation into the U.S. culture of credit use, the circumstance of being more recent home buyers prior to the decline, and living in states that suffered the greatest decline in housing value.

• Journal of Korean Academy of Nursing
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• v.23 no.1
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• pp.130-141
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• 1993

This study was to find out variables influenced on the medication patterns (voluntary medication, in-voluntary medication) of antipsychotics taken by schizophrenic outpatients. Purposes of this study were to be identified that there was the significant difference between the group of voluntary medication and involuntary, and that which variables had infuence on outpsychotics medication. The sample consisted of 30 patients takeing their pills voluntary (voluntary medication group), and 15 patients involuntary(involuntary medication group) at a psychiatry hospital and a psychiatric unit of a The findings of the study are as follows : university hospital in Daegu. Data were collected from September to October, 1991 through interview using questionare about antipsychotics medication. Data were analyzed by the technique of two group discriminant function analysis using SPSS pc$^{+}$ 1) Discriminant function discriminating between voluntary medication and involuntary medication was significant at the level of 10% significance (sig.=.055, p〈.10) Hit-ratio was very high (91. 1％) 2) One of General variables, SEX, was significant of discriminating between two medication patterns at the level of 10% significance. 3) One of Family Environmental Variables, BROTH(a number of brother), were significant between two medication patterns. (p〈.10) 4) One of Therapeutic Environmental Variables, FAMHX, was significant between two medication patterns at the level of 10% significance. 5) One of Variables Related to Drug and Medication, NECESS, was significant between two medication patterns. (p〈.05) 6) Variables Related to Disease was not significant between two medication patterns.s.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.10033-10038
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• 2014

The aim of this study was to determine the prevalence of tobacco use, beliefs and risk awareness and psychosocial correlates of tobacco use among university students in 24 low, middle and emerging economy countries. Using anonymous questionnaires, data were collected from 16953 undergraduate university students (mean age 20.9, SD=2.9) from 25 universities in 24 countries across Asia, Africa and the Americas. Results indicate that overall 13.3% of the university students were current tobacco users, 22.4% for men and 6.6% for women, ranging from 3.8% in Singapore to 32.5% in Cameroon. The risk awareness of the smoking lung cancer link was 83.6%, while the risk awareness of the smoking heart disease link was 46.5%. Multivariate logistic regression found that older age, male gender, having a wealthy family background, living in a low income country, residing off campus on their own, poor beliefs in the importance not to smoke, awareness of the smoking heart disease link, hit by a sexual partner, depressive symptoms, and substance use (binge drinking and illicit drug use) were associated with current tobacco use.