• 동의생리병리학회지
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• 제35권6호
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• pp.255-260
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• 2021

Crohn's disease (CD) is an idiopathic inflammatory bowel disease (IBD) with unknown etiopathogenesis. Currently there are no definitive treatment modalities for CD. This case report presents clinical remission and its maintenance of CD induced by Korean herbal medicine treatment. A 56-year-old male patient diagnosed as CD by capsule endoscopy presented to a Korean Medicine clinic with severe abdominal pain as a chief complaint. Despite taking 5-aminosalicylic acid and immunosuppressant for 2 years, his abdominal pain was worsening at the time of visit. Treatment was initiated with Jinmoo-tang based on pattern identification and continued for approximately a year with some modifications according to patient's symptom changes. He was mainly given Jinmoo-Tang for a year and clinical remission was achieved; he could stop taking western medications. For 6 years since then, he took Korean medicine from time to time when he felt his condition went down and he is still maintaining remission. There were no adverse events reported. This case report suggests that individualized Korean herbal medicine treatment may have the potential for induction and maintenance of clinical remission of CD. Further research is warranted to establish an evidence-base for such approach.

• 생명과학회지
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• 제11권4호
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• pp.385-391
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• 2001

Filamentous hemagglutinin (FHA) is considered as an essential immunogenic component for incorporation into acellular vaccines against Bordetella pertussis, the causative agent of whooping cough. Classically, antipertussis vaccination has employed an intramuscular route. An alternative approach to stimulate mucosal and systemic immune responses is oral immunization with recombinant live vaccine carrier strains of Salmonella typhimurium. An attenuated live Salmonella vaccine sgrain($\Delta$cya $\Delta$crp) expressing recombinant FHA(rFHA) was developed. Stable expressionof rFHA was achieved by the use of balanced-lethal vector-host system. which employs an asd deletion in the host chromosome to impose in obligate requirement for diaminopimelic acid. The chromosomal $\Delta$asd mutation was complemented by a plasmid vector possessing the asd$^{+}$ gene. A 3 kb DNA fragment encoding immuno dominant regionof FHA was subcloned in-frame downstream to the ATG translation initiation codon in the multicopy Asd$^{+}$ pYA3341 vector to create pYA3457. Salmonella vaccine harboring pYA3457 expressed approximately 105kDa rFHA protein. The 100% maintenance of [YA3457 in vaccine strain was confirmed by stability examinations. Additionally, a recombinant plasmid pYA3458 was constructed to overpress His(8X)-tagged rFHA in Essherichia coli. His-tagged rFHA was purified from the E. coli strain harboring pYA3458 using Ni$^{2+}$-NTA affinity purification system.>$^{2+}$-NTA affinity purification system.

• 대한간호
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• 제35권4호
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• pp.64-74
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• 1996

In general. social cognition for a disabled person seemed that he was limited aspects of emotion and psychology. Thus he was rejected. avoided. worthless and not accepted. People who have been raised in an ethnic collectivity often acquire from that experience not only basic conceps and attitudes toward health and illness but also fundamental styles of interpersonal behavior and concerns about the world. The effects of this enculuration carryover into health- care situation and also become an important influence on personal activities devoted to health maintenance and disease prevention. Our Korean culture is a state of tradition Confucianism. respects his honor and external feature. Therefore recognition of a disabled person is more specipic. This study uses Walker and Avant's process of concept analysis. The concep of recognition of disabilty can be defined as follows : Recognition of disability is a person's conscious process of sensation. perception. memory and thought and is constructed from value. attitude. emotion and expierince which is dynamics. and in everyday life is feeling that basic activity is not free and occurs interaction of envionment. Attributes of disability recognition are defined as 1) It is feeling that basic activity of his daily life is not free in everyday life. 2) It is a person's conscious process of sensation. perception. memory and thought. 3) It occurs interaction of enviornment. 4) It is constructed from value. attitude. emotion and experience. 5) it is dynamics ( changing but not stasis). Nurse is always suppoted and pushed him. She plans institutional and situational surroundings.

• 디지털콘텐츠학회 논문지
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• 제12권1호
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• pp.115-122
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• 2011

최근 하루가 다르게 발전하는 IT기술에 비해 우리나라 호텔기업의 컴퓨터시스템은 기존의 시스템에 머물러 있는 경향이 있다. 호텔의 정보시스템을 지속적으로 업그레이드시키는 일이 곧 고객만족으로 연결되는 만큼 질적 서비스 향상에 발맞춰 전산 시스템도 개발되고 유지 관리 되어야 한다. 이에 본 연구에서는 호텔에 컴퓨터가 어떻게 도입되어 왔으며 그 목적과 효과를 살펴보면서 현재 도입하여 활용되고 있는 호텔정보시스템에 대해 고찰하고 문제점을 살펴보았다. 또한 그 문제점을 일반 정보시스템의 관점에서 분석하여 우리나라 호텔에 컴퓨터시스템을 보다 효율적으로 활용할 수 있는 방안을 제시하였다.

• 사상체질의학회지
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• 제12권2호
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• pp.1-7
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• 2000

Greeting the 100 year celebration of the death of Master Dong-mu, through investigating his thoght on Scholarship and Philosophy, and his new view of human being based on Sasang, I tried to reevaluate him as a Confucianist of practical mind. The conclusions were as followings ; 1. Dong-mu's recognition system of things is that based on the mind of summarizing things in view of Affair-Mind-Body-Object originated from Confucianism, and It developed 'the Marvel of Easiness & simpleness based on Yin-yang' into 'the Marvel of Easiness & simpleness based on Sasang' 2 Through understanding old Confucianism newly, Dong-mu summarized human being as having a natural character in view of Nature and Order and an autonomical character in view of Knowledge and Deed, and emphasized an autonomical character in view of Knowledge and Deed 3. In view of Knowledge and Deed, Dong-mu presented How to Say and Behave, and took it as a model of behavior in the new Confucianism. Also he presented the view of Knowledge and Deed based on Constitutions, and took it as a new mind of treatment. 4. Dong-mu can be estimated highly, in that he completed a new confucian view-point of Human being in the period of philosophic chaos, and executed the mind of General health maintenance and the mind of control others through a confucian self-control.

• Genomics & Informatics
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• 제20권2호
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• pp.24.1-24.8
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• 2022

Hypomyelinating leukodystrophy type 2 (HLD2), is an inherited genetic disease of the central nervous system caused by recessive mutations in the gap junction protein gamma 2 (GJC2/GJA12). HLD2 is characterized by nystagmus, developmental delay, motor impairments, ataxia, severe speech problem, and hypomyelination in the brain. The GJC2 sequence encodes connexin 47 protein (Cx47). Connexins are a group of membrane proteins that oligomerize to construct gap junctions protein. In the present study, a novel missense mutation gene c.760G>A (p.Val254Met) was identified in a patient with HLD2 by performing whole exome sequencing. Following the discovery of the new mutation in the proband, we used Sanger sequencing to analyze his affected sibling and parents. Sanger sequencing verified homozygosity of the mutation in the proband and his affected sibling. The autosomal recessive inheritance pattern was confirmed since Sanger sequencing revealed both healthy parents were heterozygous for the mutation. PolyPhen2, SIFT, PROVEAN, and CADD were used to evaluate the function prediction scores of detected mutations. Cx47 is essential for oligodendrocyte function, including adequate myelination and myelin maintenance in humans. Novel mutation p.Val254Met is located in the second extracellular domain of Cx47, both extracellular loops are highly conserved and probably induce intramolecular disulfide interactions. This novel mutation in the Cx47 gene causes oligodendrocyte dysfunction and HLD2 disorder.

• 대한기계학회논문집A
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• 제39권11호
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• pp.1169-1174
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• 2015

위험도 평가 기술은 주로 플랜트의 많은 운영설비 중 대형사고나 피해를 유발할 수 있는 위험설비를 선별하는 목적으로 개발되었다. 현재 발전소에 설치되어 있는 설비관리시스템에는 초기 버전의 위험도 평가 모듈이 설치되어 있으나 문진 위주로 구성되어 통계적 기법에 기반을 둔 고장 확률 평가보다는 평가자의 주관적인 판단에 따라 평가 결과가 좌우되었다. 또한 발전회사 서버에 기반하였기 때문에 평가자가 공간 및 시간의 제약을 받을 수 밖에 없고 현장 활용에 한계가 있었다. 본 논문에서는 문진 대신 해석적 분석을 이용한 기본 고장확률을 계산하고 현장 검사 결과 및 검사 효용도를 분석할 수 있는 독립형 위험도 평가 소프트웨어를 개발하였다. 독립형으로 현장 운용이 가능하며 최적 정비주기 예측 및 현장검사 결과에 대한 입출력 기능이 있기 때문에 정비에 직접 참여하는 현장 사용자뿐만 아니라 발전 설비의 수명연장 및 교체를 결정해야 하는 엔지니어에게 유용한 정보를 제공할 것이다.

• 전력전자학회논문지
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• 제25권5호
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• pp.376-384
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• 2020

An energy storage system is composed of lithium-ion batteries in modern applications. Batteries are regarded as storage devices for renewable and residual energy. The failure of batteries can cause the performance reduction and explosion of battery systems. High maintenance cost is essential when dealing with the problem of battery safety. Therefore an accurate health diagnosis is required to ensure the high reliability of battery systems. A battery pack is a combination of single cells in series and parallel connections. A battery pack has to consider various factors to assess battery health. Battery health involves conventional factors and additional factors, such as cell-to-cell imbalance. For large applications, state-of-health (SOH) can be inaccurate because of the lack of factors that indicate the state of the battery pack. In this study, six characterization factors are proposed for improving the SOH estimation of battery packs. The six proposed characterization factors can be regarded as health indicators (HIs). The six HIs are applied to the principal component analysis (PCA) algorithm. To reflect information regarding capacity, voltage, and temperature, the PCA algorithm extracts new degradation factors by using the six HIs. The new degradation factors are applied to a multiple regression model. Results show the advancement and improvement of SOH estimation.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2151-2154
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• 2003

Internet is deeply rooted in everyday life and many things are performed using internet in real-world, therefore internet users increased because of convenience. Also internet accident is on the increase rapidly. The security vendor developed security system to protect network and system from intruder. Many hackings can be prevented and detected by using these security solutions. However, the new hacking methods and tools that can detour or defeat these solutions have been emerging and even script kids using these methods and tools can easily hack the systems. In consequence, system has gone through various difficulties. So, Necessity of intruder trace-back technology is increased gradually. Trace-back technology is tracing back a malicious hacker to his real location. trace-back technology is largely divided into TCP connection trace-back and IP packet trace-back to trace spoofed IP of form denial-of-service attacks. TCP connection trace-back technology that autonomously traces back the real location of hacker who attacks system using stepping stone at real time. In this paper, We will describe watermark trace-back system using TCP hijacking technique to supplement difficult problem of connection maintenance happened at watermark insertion. Through proposed result, we may search attacker's real location which attempt attack through multiple connection by real time.

• 조명전기설비학회논문지
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• 제19권3호
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• pp.127-133
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• 2005

PLC는 산업용 제어시스템에서 가장 많이 사용되며, 중요한 역할을 하고 있다. 이러한 PLC에서 사용되는 언어에 대한 연구도 활발히 이루어지고 있다. PLC에서는 LD언어가 가장 많이 사용되고 있다. LD언어는 데이터의 흐름을 알 수 없고, 유지보수가 어렵다. 반면에 SFC는 제어의 흐름을 이해하기 쉽고 유지보수가 용이하지만 조건과 인터록 기술에 문제점이 있다. 본 논문에서는 매니지먼트 스텝을 사용한 인터록의 기술에 대한 방법을 제안하였고, 실례를 통해 그의 타당성을 확인하였다.