• Title/Summary/Keyword: HER2/4

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소비자의 의복 상표충성도와 의복구매행동 (Consumer's Clothing Brand Loyalty and Clothing Buying Behavior)

  • 김순아;이영신
    • 한국의류학회지
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    • 제19권4호
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    • pp.602-614
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    • 1995
  • The purposes of this study were 1) to reveal the consumer's brand loyalty on clothing, 2) to identify the relationships between the consumer's clothing brand loyalty and consumer characteristics, product characteristics, and consumer's clothing buying behavior. Subjects were selected from the employed and unemployed housewives living in Taejon. A questionnaire was developed and administered by 316 housewives during Spring in 1992. Data were analysed by frequency, Pearson's correlation coefficient, regression and oneway- ANOVA. The result.; of the study were as follows: 1) The half of subjects had brand loyalty on clothing. 2) The relationships between consumer's clothing brand loyalty and housewives' and her husbands 'educational level and average income of a month were significant. Consumer's clothing brand loyalty and housewives 'age had significantly negative relationship. 3) Consumer's clothing brand loyalty was significantly related to price of clothing. 4) The relationships between consumer's clothing brand loyalty and satisfaction toward brands, and the store patronage behavior were significant. The relationships between consumer's clothing brand loyalty and her prepurchase information search behavior, and the amount of purchasing of clothing were not significant.

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세포교정영양요법(OCNT)을 이용한 중족골 골절 환자 사례 연구 (A Case Study on the Metatarsal Fractures Patients Using Ortho-Cellular Nutrition Therapy (OCNT))

  • 강선희
    • 셀메드
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    • 제13권12호
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    • pp.43.1-43.8
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    • 2023
  • Objective: A case report of pain relief and fracture recovery by ortho-cellular nutrition therapy in a patient with 2nd, 3rd, and 4th metatarsal fractures (closed). Methods: A Korean woman in her 50s was diagnosed with 2nd, 3rd, and 4th metatarsal fractures (closed) with severe initial pain and fractures. Surgery was recommended but could not be performed immediately due to her situations at work. Results: With OCNT performed immediately after the fracture, the pain completely disappeared, and even during subsequent recovery, recovery was faster than in other fracture cases. Conclusion: OCNT may help patients with similar problems relieve symptoms and recover.

Association of Histopathological Markers with Clinico-Pathological Factors in Mexican Women with Breast Cancer

  • Bandala, Cindy;De la Garza-Montano, Paloma;Cortes-Algara, Alfredo;Cruz-Lopez, Jaime;Dominguez-Rubio, Rene;Gonzalez-Lopez, Nelly Judith;Cardenas-Rodriguez, Noemi;Alfaro-Rodriguez, A;Salcedo, M;Floriano-Sanchez, E;Lara-Padilla, Eleazar
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권18호
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    • pp.8397-8403
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    • 2016
  • Background: Breast cancer (BCa) is the most common malignancy in Mexican women. A set of histopathological markers has been established to guide BCa diagnosis, prognosis and treatment. Nevertheless, in only a few Mexican health services, such as that of the Secretariat of National Defense (SEDENA for its acronym in Spanish), are these markers commonly employed for assessing BCa. The aim of this study was to explore the association of Ki67, TP53, HER2/neu, estrogenic receptors (ERs) and progesterone receptors (PRs) with BCa risk factors. Materials and Methods: Clinical histories provided background patient information. Immunohistochemical (IHC) analysis was conducted on 48 tissue samples from women diagnosed with BCa and treated with radical mastectomy. The Chi square test or Fisher exact test together with the Pearson and Spearman correlation were applied. Results: On average, patients were $58{\pm}10.4$ years old. It was most common to find invasive ductal carcinoma (95.8%), histological grade 3 (45.8%), with a poor Nottingham Prognostic Index (NPI; 80.4%). ERs and PRs were associated with smoking and alcohol consumption, metastasis at diagnosis and Ki67 expression (p<0.05). PR+ was also related to urea and ER+ (p<0.05). Ki67 was associated with TP53 and elevated triglycerides (p<0.05), and HER2/neu with ER+, the number of pregnancies and tumor size (p<0.05). TP53 was also associated with a poor NPI (p<0.05) and CD34 with smoking (p<0.05). The triple negative status (ER-/PR-/HER2/neu-) was related to smoking, alcohol consumption, exposure to biomass, number of pregnancies, metastasis and a poor NPI (p<0.05). Moreover, the luminal B subty was associated with histological type (p=0.007), tumor size (p=0.03) and high cholesterol (p=0.02). Conclusions: Ki67, TP53, HER2/neu, ER and PR proved to be related to several clinical and pathological factors. Hence, it is crucial to determine this IHC profile in women at risk for BCa. Certain associations require further study to understand physiological/biochemical/molecular processes.

Breast Cancer Molecular Subtypes and Associations with Clinicopathological Characteristics in Iranian Women, 2002-2011

  • Kadivar, Maryam;Mafi, Negar;Joulaee, Azadeh;Shamshiri, Ahmad;Hosseini, Niloufar
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권5호
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    • pp.1881-1886
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    • 2012
  • Breast cancer is a heterogeneous disease that is affected by ethnicity of patients. According to hormone receptor status and gene expression profiling, breast cancers are classified into four molecular subtypes, each showing distinct clinical behavior. Lack of sufficient data on molecular subtypes of breast cancer in Iran, prompted us to investigate the prevalence and the clinicopathological features of each subtype among Iranian women. A total of 428 women diagnosed with breast cancer from 2002 to 2011 were included and categorized into four molecular subtypes using immunohistochemistry. Prevalence of each subtype and its association with patients' demographics and tumor characteristics, such as size, grade, lymph-node involvement and vascular invasion, were investigated using Chi-square, analysis of variance and multivariate logistic regression. Luminal A was the most common molecular subtype (63.8%) followed by Luminal B (8.4%), basal-like (15.9%) and HER-2 (11.9%). Basal-like and HER-2 subtypes were mostly of higher grades while luminal A tumors were more of grade 1 (P<0.001). Vascular invasion was more prevalent in HER-2 subtype, and HER-2 positive tumors were significantly associated with vascular invasion (P=0.013). Using muti-variate analysis, tumor size greater than 5 cm and vascular invasion were significant predictors of 3 or more nodal metastases. Breast cancer was most commonly diagnosed in women around 50 years of age and the majority of patients had lymph node metastasis at the time of diagnosis. This points to the necessity for devising an efficient screening program for breast cancer in Iran. Further, prospective surveys are suggested to evaluate prognosis of different subtypes in Iranian patients.

Constant Correlation Factors between Temkin and Langmuir or Frumkin Adsorption Isotherms at Poly-Pt, Re, and Ni/Aqueous Electrolyte Interfaces

  • Chun Jang H.;Jeon Sang K.;Chun Jin Y.
    • 전기화학회지
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    • 제7권4호
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    • pp.194-200
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    • 2004
  • The constant correlation factors between the Temkin and the Langmuir or the Frumkin adsorption isotherms of over-potentially deposited hydrogen (OPD H) for the cathodic H2 evolution reaction (HER) at poly-Pt and Re/0.5M $H_2SO_4$ and poly-Ni/0.05 M KOH aqueous electrolyte interfaces have been experimentally and consistently found using the phase-shift method. At intermediate values of the fractional surface coverage $(\theta),\;i.e.,\;02<{\theta}<0.8$, the Langmuir and Temkin adsorption isotherms of OPD H for the cathodic HER are correlated to each other even though the adsorption conditions or processes are different from each other. At the same range of $\theta$, correspondingly, the Frumkin and Temkin adsorption isotherms of OPD H for the cathodic HER are correlated to each other. The equilibrium constants $(K_o)$ for the Temkin adsorption isotherms $({\theta}\;vs.\; E)$ are consistently ca. 10 times greater than those (K, Ko) for the corresponding Langmuir or Frumkin adsorption isotherms ($({\theta}\;vs.\; E)$. The interaction parameters (g) for the Temkin adsorption isotherms $({\theta}\;vs.\; E)$ are consistently ra. 4.6 greater than those (g) for the corresponding Langmuir or Frumkin adsorption isotherms $({\theta}\;vs.\; E)$. These numbers (10 times and 4.6) can be taken as constant correlation factors between the corresponding adsolftion isotherms (Temkin, Langmuir, Frumkin) at the interfaces. The Temkin adsorption isotherm corresponding to the Langmuir or the Frumkin adsorption isotherm, and vice versa, can be effectively verified or confirmed using the constant correlation factors. Both the phase-shift methodand constant correlation factors are useful and effective for determining or confirming the suitable adsorption isotherms (Temkin, Langmuir, Frumkin) of intermediates for sequential reactions in electrochemical systems.

원인미상의 발열(發熱)을 동반한 소양인(少陽人) 음허오열증(陰虛午熱證) 환자에 대한 십이미지황탕(十二味地黃湯) 치험(治驗) 1례 (A Case Report of Sibimijihwang-tang(十二味地黃湯) Treatment of a Soyangin Yin-Deficit Diurnal-Heat Symptomatology(陰虛惡熱證) Patient Presenting with Fever of Unknown Origin)

  • 김성기;이필재;송은영;임은철;정원희
    • 사상체질의학회지
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    • 제22권4호
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    • pp.124-129
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    • 2010
  • 1. Objectives The purpose of this case is to report the effects of Sibimijihwang-tang(十二味地黃湯) which is based on Sasang constitutional Medicine for Yin-Deficit Diurnal-Heat Symptomatology(陰虛午熱證) in Soyangin. 2. Methods We treated a Soyangin patients that had Fever Unknow Origin. We prescribed Sibimijihwang-tang(十二味地黃湯) for her physical symptoms. The improvement of her diseases was evaluated by her fever and other physical symptoms. 3. Results After the Sasang constitutional medication of Sibimijihwang-tang(十二味地黃湯) was given, the patient's fever and physical symptoms were improved. 4. Conclusions This case study show an efficient result of using Sibimijihwang-tang(十二味地黃湯) in the Yin-Deficit Diurnal-Heat Symptomatology(陰虛午熱證) of Soyangin.

Overall Survival and Clinicopathological Characteristics of Patients with Breast Cancer in Relation to the Expression Pattern of HER-2, IL-6, TNF-α and TGF-β1

  • Tripsianis, Gregory;Papadopoulou, Evropi;Romanidis, Konstantinos;Katotomichelakis, Michael;Anagnostopoulos, Kostas;Kontomanolis, Emmanuel;Botaitis, Sotirios;Tentes, Ioannis;Kortsaris, Alexandros
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권11호
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    • pp.6813-6820
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    • 2013
  • The present study was conducted to investigate the prognostic significance of co-expression patterna of HER-2, IL-6, TNF-a and TGF-${\beta}1$ in breast cancer, by correlating the number of markers with positive expression with clinicopathological characteristics indicative of tumor progression and overall survival. One hundred thirty consecutive patients with primary breast cancer were prospectively included and evaluated. Serum concentrations of the above markers were measured by ELISA. Median split was used to subdivide patients with marker positive or negative expression. The presence of ${\geq}3$ positive markers was independently associated with extended lymph node (>3) involvement (aOR, 11.94, p=0.001) and lymphovascular invasion (aOR, 12.04, p=0.018), increasing the prognostic significance of each marker considered separately. Additional prognostic information regarding survival was also provided; as the number of positive markers increased, a gradually reduction of survival time was observed. In addition, patients with 4 positive markers had significantly shorter survival (25 vs 39 months, p=0.006) and a more than 4 fold increased risk of death (aHR, 4.35, p=0.003) compared to patients with 3 positive markers. Our findings suggest that the coexpression pattern of these four markers could be used clinically as a useful marker for tumor extension and outcome of breast cancer.

전기 방사를 이용한 1D / 2D 하이브리드 구조 고활성 MoS2 / CNF 수소 발생 촉매의 합성 및 특성 분석 (MoS2/CNFs derived from Electrospinning and Heat treatment as the Efficient Electrocatalyst for Hydrogen Eovlution Reaction in Acidic Solution)

  • 이정훈;박유세;장명제;박성민;이규환;최우성;최승목;김양도
    • 대한금속재료학회지
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    • 제56권12호
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    • pp.885-892
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    • 2018
  • Molybdenum disulfide ($MoS_2$) based electrocatalysts have been proposed as substitutes for platinum group metal (PGM) based electrocatalyst to hydrogen evolution reaction (HER) in water electrolysis. Here, we studied $MoS_2/CNFs$ hybrid catalyst prepared by electrospinning method with heat treatment for polymer electrolyte membrane(PEM) water electrolysis to improve the HER activity. The physicochemical and electrochemical properties such as average diameter, crystalline properties, electrocatalitic activity for HER of synthesized $MoS_2/CNFs$ were investigated by the Scanning Electron Microscope (SEM), X-ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Transmission Electron Microscopy (TEM), Raman Spectroscopy (Raman) and Linear Sweep Voltammetry (LSV). The as spun ATTM/PVP nanofibers were prepared by sol-gel and electrospinning method. Subsequently, the $MoS_2/CNFs$ was dereived from reduction heat treatment of ATTM at the ATTM/PVP nanofibers and carbonization heat treatment. Synthesized $MoS_2/CNFs$ electrocatalyst had an average diameter of $179{\pm}30nm$. We confirmed that the $MoS_2$ layers in $MoS_2/CNF$ electrocatalyst consist of 3~4 layers from the Raman results. In addition, We confirmed that the $MoS_2$ layers in $MoS_2/CNF$ catalyst consist of 7.47% octahedral 1T phase $MoS_2$, 63.77% trigonal prismatic 2H phase $MoS_2$ with 28.75% $MoO_3$ through the XRD, Raman and XPS results. It was shown that $MoS_2/CNFs$ had the overpotential of 0.278 V at $10mA/cm^2$ and tafel slope of 74.8 mV/dec in 0.5 M sulfuric acid ($H_2SO_4$) electrolyte.

학교 안전사고에 대한 대법원 판례 분석 (An Analysis of a Precedent of the Supreme Court about School Safety Accidents)

  • 김달효
    • 수산해양교육연구
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    • 제19권2호
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    • pp.168-179
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    • 2007
  • There are many students in school. So school safety accidents are happened by accident. But, if teachers know and understand about school safety accidents exactly, the school safety accidents can be reduced. The conclusion of this study is as follow. First, generally teacher has a duty and responsibility to protect and care students in educational activities. And teacher has a responsibility to protect and care students only in the cases of predictability. Second, teacher must do his/her best about a duty of attention. If teacher do his/her best about a duty of attention, he(she) has not the responsibility about the accident. Third, teacher needs to have more concern student who has a controversial figure. And teacher needs to have an evidence that he/she did his/her best for the student ordinary times. Fourth, the criteria of teacher's legal or illegal punishment to students is (1) the motivation and details for punishment, (2) the methods and degree for punishment, (3) a part of body for punishment, (4) the degree of damage for punishment. Fifth, teacher need to learn the program about school safety accidents systematically.

The Therapeutic Value of Ultrasound-Guided Irrigation in Sialodochitis: A Case Report

  • Ahn, Chi-Hyuk;Auh, Q-Schick;Lee, Yeon-Hee
    • Journal of Oral Medicine and Pain
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    • 제43권2호
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    • pp.52-55
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    • 2018
  • In the present case study, we reported a female patient with sialodochitis fibrinosa in which a conservative ultrasound (US)-guided irrigation method was used to relieve her symptoms. A 30-year-old female patient visited Kyung Hee University Dental Hospital with chief complaints of persistent swelling and discomfort in the left facial area. Her primary symptom was facial swelling that was accompanied by neuropathological symptoms, such as itching, tingling, and warmth that usually continued for 3 to 4 days. During clinical examination of orofacial area, mild swelling and fever were noted in the left face including parotid region, and mild induration could be felt at the corresponding site; sialadenitis of the left parotid gland was tentatively diagnosed. Herein, we performed intraductal irrigation of the left parotid gland in three times per month and prescribed some medication. Thus, her signs and symptoms have been improved, and she did not experience a recurrence for 12-month follow-up to date. This study can support the usefulness of the US-guided irrigation method to treat the sialodochitis fibrinosa without remarkable side effects.