• Environmental Analysis Health and Toxicology
• /
• v.31
• /
• pp.25.1-25.9
• /
• 2016

Objectives After the initial investigations by the Korea Centers for Disease Control in 2011, over 1000 suspicious cases of humidifier disinfectant (HD) victims were subsequently reported by 2015, and numbers are still increasing dramatically in 2016 in the midst of the prosecutors' office investigation. This study attempts to summarize the current understandings of the related health effects of HD based upon a systemic review of published epidemiologic studies and toxicology investigations. Methods Published studies of HDs were searched through PubMed and TOXLINE under the search words 'humidifier disinfectant,' and related reports were identified from the references and published report list of regulatory agencies including the Korean National Institute of Environmental Research, US Environmental Protection Agency, and EU European Chemicals Agency. Results Case reports and epidemiologic studies have reported the clinical features of severe forms of HD lung damage, together with epidemiologic findings of seasonal occurrence and demographic variations, including the heightened susceptibility of young children. Toxicological studies have reported inhalation toxicities together with positive findings of in vitro genotoxicity studies. Conclusions This study examined unsolved issues based on cases of upper respiratory diseases and diseases of other organs, including cancers, among suspected victims of HDs. These issues should be clarified in future research for the management and prevention of health effects from HDs and chemicals of other related household products.

• 한국HCI학회:학술대회논문집
• /
• 2009.02a
• /
• pp.335-339
• /
• 2009

The purpose of this study is to propose a new Haptic Dial System (HDS) for Virtual Prototyping by developing upgraded systems and various Haptic effects. The Haptic Effect Design (HED) which gives users sensations like handling actual products has a function of controlling loudness by force and changing Haptic effects on GUI windows in real-time. In addition, the HED has another function of editing intervals to express Haptic effects as graphical force and notch on windows. Many kind of dial knob can be attached and removed easily for testing the performance of actual product designs. The HDS can be remotecontrolled through giving and taking the information between motor part and GUI part with TCP communication. The HDS can be applied to the output devices of Haptic effects as well as input-interfaces.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.7
• /
• pp.2325-2331
• /
• 2011

Human CDX1 and CDX2 genes play important roles in the regulation of cell proliferation and differentiation in the intestine. Hox genes clustered on four chromosomal regions (A-D) specify positional signaling along the anterior-posterior body axis, including intestinal development. Using glutathione S-transferase (GST) pulldown assays, molecular interaction measurements, and fluorescence measurements, we found that the homeodomains (HDs) of CDX1 and CDX2 directly interact with that of HOXD8 in vitro. CDX1 showed significant affinity for HOXD8, but CDX2 showed weak affinity for HOXD8. Thus far, three-dimensional structures of CDX1/2 and HOXD8 have not been determined. In this study, we developed a molecular docking model by homology modeling based on the structures of other HD members. Proteins with mutations in the HD of CDX1 (S185A, N190A, T194A, and V212A) also bound to the HD of HOXD8. Our study suggests that the HDs of CDX1/2 resemble those of HOXD8, and we provide the first insight into the interaction between the HDs of CDX1/2 proteins and those of HOXD8.

• Journal of Sasang Constitutional Medicine
• /
• v.20 no.3
• /
• pp.151-163
• /
• 2008

1. Objective This study was done to identify the anti-stress effect of Hyeongbangdojeok-san (HDS), Yanggyeoksanhwa-tang(YST) in Soyangin. 2. Methods Experimental animals were composed of YST, HDS+stress groups which were administered each by 200mg/kg, 400mg/kg and the Saline+stress group. On the 1st day, making the rats forced swim and on the 2nd day, applying Forced swimming test to the rats. After FST, the levels of Corticosterone in the blood were measured. For the study of learning retardation, memory ability and anxiety reaction, experimental animals were composed of YST, HDS+restraint stress groups which were administered each by 400mg/kg, no stress group and the Saline+restraint stress group. Restraint stress were applied 2 hours a day for 3 weeks. On the last day of the 3rd week, Elevated Plus Maze(EPM) was applied to the groups and Morris Water Maze(MWM) was applied to the groups for 7 days. 3. Results 1. As the results of measuring FST which reflects depression, the YST+stress group and the HDS+stress group showed significant effect in comparison with the Saline+stress group. The levels of Corticosterone in the blood were decreased only in the 400mg/kg YST+stress group. 2. As the results of measuring how long EPM which reflects anxiety reaction stayed in the open arm, there was the trend which can suppress anxiety reaction in the HDS+restraint stress group bur no statistical significance. But there was any suppression of anxiety reaction in the YST+restraint stress group. 3. According to the result of MWM, the saline+restraint stress group showed the learning retardation which means increased time arriving at goal compared to the normal group at the second and third day of measurement. On the contrary, a learning retardation was significantly decreased in the YST+restraint stress group at the third day of measurement. 4. Among the Probe trial test a memory loss occurred in the saline+restraint stress group, but memory ability was significantly increased in the YST+restraint stress group. 4. Conclusion: As the results above, Soyangin Yanggyeoksanhwa-tang has significant influence to the antidepression effect, the learning retardation, the anxiety reaction and also in the Hormone level. Hyeongbangdojeok-san has significant influence to the antidepression effect, in the Hormone level, bur not to the learning retardation and anxiety reaction. prefer to drink cold water, and who are suffering from chronic gastritis.

• Journal of Environmental Health Sciences
• /
• v.49 no.3
• /
• pp.169-177
• /
• 2023

Background: The Korea Centers for Disease Control and Prevention (KCDC) has identified cases of people suspected of suffering lung disease potentially caused by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) used in humidifier disinfectants (HDs). The Korean Ministry of Environment (MoE) epidemiological investigation and toxicity test study found that HDs caused health damage such as asthma and lung disease. Objectives: The main purposes of this study were to classify the HD exposure rating and to analyze the exposure characteristics that affect exposure to CMIT/MIT HDs. Methods: The exposure characteristics and socio-demographic characteristics of victim participants using CMIT/MIT HDs were investigated through questionnaires. An inhalation no observed adverse effect level (NOAEL) for CMIT/MIT was produced based on inhalation toxicity values. Exposure ratings (class 1~class 2) were cross-tabulated with clinical ratings (acceptable~unacceptable). A correlation analysis was conducted with the main exposure characteristics that affect the exposure concentration of CMIT/MIT HDs. Results: The concentration in indoor air of CMIT/MIT was 8.75±25.40 ㎍/m³, and the exposure concentration was 2.30±6.29 ㎍/m³. The CMIT/MIT exposure rating of 67 participants with high exposures of not more than MOE 100 were evaluated as 14.5%, while the damage participants who matched the clinical rating made up 4.5%. The exposure concentration of CMIT/MIT showed a positive correlation with the daily usage amount and usage frequency, and a negative correlation with volume of the indoor environment. Conclusions: A new exposure rating could be suggested and calculated based on the MOE, and the factors affecting the exposure concentration could be identified.

• Journal of the Korean Applied Science and Technology
• /
• v.30 no.3
• /
• pp.431-443
• /
• 2013

Sulfur content of diesel fuel has been cut down to under 10 ppm ULSD (ultra low sulfur diesel) level by environmental regulation with the aim of reducing exhaust emissions. This review discusses the methods and principles of sulfur reduction in diesel and presents an overview of new approaches for ultra-deep desulfurization. The deep HDS (hydrodesulfurization) problems of diesel streams is exacerbated by the inhibiting effect of co-existing aromatics, nitrogen compounds and $H_2S$. The new approaches to deep desulfurization includes non-HDS type processing schemes such as adsorptive, extractive and oxidative desulfurization.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.39A no.2
• /
• pp.86-91
• /
• 2014

Holographic data storage (HDS) has a number of advantages, including a high transmission rate through the use of a charge coupled device array for reading two-dimensional (2D) pixel image data, and a high density capacity. HDS also has disadvantages, including 2d intersymbol interference by neighboring pixels and interpage interference by multiple pages stored in the same holographic volume. These problems can be eliminated by modulation codes. We propose a 7/9 error-correcting modulation code that exploits a Viterbi-trellis algorithm and has a code rate larger (about 0.778) than that of the conventional 6/8 balanced modulation code. We show improved performance of the bit error rate with the proposed scheme compared to that of the simple 7/9 code without the trellis scheme and the 6/8 balanced modulation code.

• Nuclear Engineering and Technology
• /
• v.28 no.6
• /
• pp.583-593
• /
• 1996

An elastic stiffness formula of a leaf type holddown spring(HDS) assembly with a uniformly tapered width from $w_0$ to $w_14$ over the length, has been analytically derived based on Euler beam theory and Castigliano's theorem. Elastic stiffnesses of the tapered-width leaf type HDSs(TW-HDSs) designed in the same dimensional design spaces as the KOFA HDSs have been evaluated from the derived formula, in addition, a parametric study on the elastic stiffness of the TW-HDSs has been carried out. Analysis results show that, as the effects of axial and shear force on the elastic stiffness of He TW-HDSs have been 0.15~0.21% of the elastic stiffness, most of the elastic stiffness is attributed to the bending moment, and that elastic stiffnesses of the TW-HDSs have been about 32~33% higher than those of the KOFA HDSs. It is found that the number of leaves composing a HDS assembly could be lessened by one under the conditions that the TW-HDSs have been adopted in KOFA.

• Transactions of the Society of Information Storage Systems
• /
• v.7 no.2
• /
• pp.85-89
• /
• 2011

In retrieving process in angle multiplexing Holographic Data Storage(HDS), It is important to search the exact recording angles. In this paper, we propose the retrieving angle searching method using pre-scan. Pre-scan method is means that rotating the galvano mirror before the retrieving process. Therefore, retrieving signals are maximized when between the galvano mirror and recoded angle are exactly matched. Through the measured signals, we will find the exact angle and compensate tangential tilt angle. The experimental results shows propose method is enough to apply the HDS.

• Journal of Information Technology Services
• /
• v.22 no.1
• /
• pp.1-14
• /
• 2023

This paper aims to share the course, performance and implications of Project-Based Learning (PBL) education in healthcare data science (HDS). The HDS team of the business group of Soonchunhyang University, which was selected for the health care field of 'University Innovation Project', considered that the health care IT-based education of the current university differs greatly from the rapidly changing health care 3.0 environment of the fourth industry, and emphasized the PBL practice-oriented specialization program as a learning model. The PBL focused on self-directed learning experiences, real analysis problems, and team-oriented classes. In other words, it was implemented with three specialized strategies: 'Field Inside Education', 'Fusion-type Track Education', and 'Training to strengthen resilience and change response'. This collaborative, practical learning experience, etc. resulted in significant results. The results were recognized as being rated A by the Korea Research Foundation and the comprehensive evaluation, and the results were significantly elevated through the analysis of the student survey and the results index.